{"corpus_id":85456697,"paper_sha":"b3a5320d2d30c052ef87ae66f450b70cc2efe6af","doi":"10.3390/molecules24061123","arxiv_id":null,"pmid":30901869,"pmcid":"6470739","mag_id":2924930352,"dblp_id":null,"acl_id":null,"title":"Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application","year":2019,"publication_date":"2019-03-01","venue":"Molecules","journal":{"name":"Molecules","pages":null,"volume":"24"},"journal_issn":null,"journal_title":null,"publication_types":["Review","JournalArticle"],"pubmed_pub_types":["Journal Article","Review"],"s2_fields_of_study":["Medicine","Chemistry"],"reference_count":113,"citation_count":1075,"influential_citation_count":29,"is_open_access":true,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Antioxidants","mj":false,"qs":[{"q":"chemistry","mj":false,"ui":"Q000737"},{"q":"pharmacology","mj":true,"ui":"Q000494"}],"ui":"D000975"},{"d":"Catalase","mj":false,"qs":[{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D002374"},{"d":"Glutathione","mj":false,"qs":[{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D005978"},{"d":"Oxidative Stress","mj":false,"qs":[{"q":"drug effects","mj":false,"ui":"Q000187"}],"ui":"D018384"},{"d":"Quercetin","mj":false,"qs":[{"q":"chemistry","mj":false,"ui":"Q000737"},{"q":"pharmacology","mj":true,"ui":"Q000494"}],"ui":"D011794"},{"d":"Reactive Oxygen Species","mj":false,"qs":[{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D017382"},{"d":"Signal Transduction","mj":false,"ui":"D015398"},{"d":"Structure-Activity Relationship","mj":false,"ui":"D013329"},{"d":"Superoxide Dismutase","mj":false,"qs":[{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D013482"}],"chemicals":[{"n":"Antioxidants","ui":"D000975","reg":"0"},{"n":"Reactive Oxygen Species","ui":"D017382","reg":"0"},{"n":"Quercetin","ui":"D011794","reg":"9IKM0I5T1E"},{"n":"Catalase","ui":"D002374","reg":"EC 1.11.1.6"},{"n":"Superoxide Dismutase","ui":"D013482","reg":"EC 1.15.1.1"},{"n":"Glutathione","ui":"D005978","reg":"GAN16C9B8O"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":"https://www.mdpi.com/1420-3049/24/6/1123/pdf?version=1553157799","s2_open_access_landing_url":"https://www.semanticscholar.org/paper/b3a5320d2d30c052ef87ae66f450b70cc2efe6af","s2_open_access_license":"CCBY","s2_open_access_status":"GOLD","pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"Quercetin is a bioactive compound that is widely used in botanical medicine and traditional Chinese medicine due to its potent antioxidant activity. In recent years, antioxidant activities of quercetin have been studied extensively, including its effects on glutathione (GSH), enzymatic activity, signal transduction pathways, and reactive oxygen species (ROS) caused by environmental and toxicological factors. Chemical studies on quercetin have mainly focused on the antioxidant activity of its metal ion complexes and complex ions. 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