{"corpus_id":8789184,"paper_sha":"d8620cdcae9938db4e6067fd9b42ac5ea67874d1","doi":"10.3390/toxins7041126","arxiv_id":null,"pmid":25835385,"pmcid":"4417959","mag_id":2025266947,"dblp_id":null,"acl_id":null,"title":"Three Valuable Peptides from Bee and Wasp Venoms for Therapeutic and Biotechnological Use: Melittin, Apamin and Mastoparan","year":2015,"publication_date":"2015-04-01","venue":"Toxins","journal":{"name":"Toxins","pages":"1126 - 1150","volume":"7"},"journal_issn":null,"journal_title":null,"publication_types":["Review","JournalArticle"],"pubmed_pub_types":["Journal Article","Research Support, Non-U.S. Gov't","Review"],"s2_fields_of_study":["Biology","Medicine"],"reference_count":186,"citation_count":319,"influential_citation_count":18,"is_open_access":true,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Animals","mj":false,"ui":"D000818"},{"d":"Apamin","mj":true,"qs":[{"q":"pharmacology","mj":false,"ui":"Q000494"},{"q":"therapeutic use","mj":false,"ui":"Q000627"}],"ui":"D001030"},{"d":"Humans","mj":false,"ui":"D006801"},{"d":"Intercellular Signaling Peptides and Proteins","mj":false,"ui":"D036341"},{"d":"Melitten","mj":true,"qs":[{"q":"pharmacology","mj":false,"ui":"Q000494"},{"q":"therapeutic use","mj":false,"ui":"Q000627"}],"ui":"D008555"},{"d":"Peptides","mj":true,"qs":[{"q":"pharmacology","mj":false,"ui":"Q000494"},{"q":"therapeutic use","mj":false,"ui":"Q000627"}],"ui":"D010455"},{"d":"Wasp Venoms","mj":true,"qs":[{"q":"pharmacology","mj":false,"ui":"Q000494"},{"q":"therapeutic use","mj":false,"ui":"Q000627"}],"ui":"D014862"}],"chemicals":[{"n":"Intercellular Signaling Peptides and Proteins","ui":"D036341","reg":"0"},{"n":"Peptides","ui":"D010455","reg":"0"},{"n":"Wasp Venoms","ui":"D014862","reg":"0"},{"n":"Melitten","ui":"D008555","reg":"20449-79-0"},{"n":"Apamin","ui":"D001030","reg":"24345-16-2"},{"n":"mastoparan","ui":"C037500","reg":"72093-21-1"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":"https://www.mdpi.com/2072-6651/7/4/1126/pdf?version=1427876843","s2_open_access_landing_url":"https://www.semanticscholar.org/paper/d8620cdcae9938db4e6067fd9b42ac5ea67874d1","s2_open_access_license":"CCBY","s2_open_access_status":"GOLD","pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"While knowledge of the composition and mode of action of bee and wasp venoms dates back 50 years, the therapeutic value of these toxins remains relatively unexploded. The properties of these venoms are now being studied with the aim to design and develop new therapeutic drugs. Far from evaluating the extensive number of monographs, journals and books related to bee and wasp venoms and the therapeutic effect of these toxins in numerous diseases, the following review focuses on the three most characterized peptides, namely melittin, apamin, and mastoparan. Here, we update information related to these compounds from the perspective of applied science and discuss their potential therapeutic and biotechnological applications in biomedicine.","claims":[{"public_id":"cl_3a397a1c675cf1a49d737d871822406b","status":"active","text":"Melittin, apamin, and mastoparan are the three most characterized peptides from bee and wasp venoms with potential therapeutic and biotechnological applications in biomedicine.","confidence":0.9,"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_3a397a1c675cf1a49d737d871822406b"}],"concepts":[{"public_id":"co_1e62c8d5213a9ddb263ad8c7f801d98d","status":"active","name":"apamin","description":"A peptide from bee venom, characterized for its potential therapeutic and biotechnological applications.","types":["peptide","toxin"],"aliases":[],"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_1e62c8d5213a9ddb263ad8c7f801d98d"},{"public_id":"co_5483fe87ad94cb473da8196968d19991","status":"active","name":"melittin","description":"A major peptide component of bee venom, studied for therapeutic and biotechnological use.","types":["peptide","toxin"],"aliases":[],"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_5483fe87ad94cb473da8196968d19991"},{"public_id":"co_f4fd24ef4d8718f7329e3db204cf80d6","status":"active","name":"mastoparan","description":"A peptide from wasp venom, characterized for its potential therapeutic and biotechnological applications.","types":["peptide","toxin"],"aliases":[],"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_f4fd24ef4d8718f7329e3db204cf80d6"}],"external_ids":{"DOI":"10.3390/toxins7041126","ArXiv":null,"PubMed":25835385,"PubMedCentral":"4417959","MAG":2025266947,"DBLP":null,"ACL":null},"open_access":{"is_open_access":true,"pdf_url":"https://www.mdpi.com/2072-6651/7/4/1126/pdf?version=1427876843","landing_url":"https://www.semanticscholar.org/paper/d8620cdcae9938db4e6067fd9b42ac5ea67874d1","source":"semantic_scholar","pdf_url_source":"semantic_scholar_open_access_pdf","license":"CCBY","status":"GOLD","reason":null},"reference_availability":{"status":"available","references_indexed":true,"full_text_available":false,"full_text_source":null,"count_basis":"semantic_scholar_metadata","extraction_status":"not_applicable","reason":null},"source":{"provider":"episteme2","base_corpus":"semantic_scholar_dump","freshness_mode":"unknown","basis":["semantic_scholar_metadata","postgres_metadata"],"limits":["paper metadata is based on indexed upstream scholarly datasets","claims and concepts are available only for extracted papers","absence of claims or concepts means no extracted graph data is available in this response"],"status":"available","degraded":false,"degraded_reasons":[],"diagnostics":{"status":"available","degraded":false,"degraded_reasons":[],"metadata_status":"available","graph_status":"available","abstract_status":"available"},"source_flags":5},"paper_id":634701,"paper_uid":"368518da-6d11-4c5f-b691-bb2d3477fe42","canonical_identity":{"paper_id":634701,"paper_uid":"368518da-6d11-4c5f-b691-bb2d3477fe42","identity_status":"available","lookup_basis":"semantic_scholar_external_id","compatibility_path":"corpus_id"},"url":"https://sah.borca.ai/papers/8789184"}