{"corpus_id":88987615,"paper_sha":"12f706d8cef30ae34a473a58b17c2d5c15f08799","doi":"10.2460/ajvr.1973.34.11.1409","arxiv_id":null,"pmid":4748724,"pmcid":null,"mag_id":2441886022,"dblp_id":null,"acl_id":null,"title":"Inhibition of estrus in the dog with testosterone implants.","year":1973,"publication_date":"1973-11-01","venue":"American Journal of Veterinary Research","journal":{"name":"American journal of veterinary research","pages":"\n          1409-19\n        ","volume":"34 11"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article"],"s2_fields_of_study":["Medicine"],"reference_count":0,"citation_count":13,"influential_citation_count":0,"is_open_access":false,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Androstenedione","mj":false,"qs":[{"q":"administration & dosage","mj":false,"ui":"Q000008"},{"q":"pharmacology","mj":false,"ui":"Q000494"}],"ui":"D000735"},{"d":"Animals","mj":false,"ui":"D000818"},{"d":"Capsules","mj":false,"ui":"D002214"},{"d":"Clitoris","mj":false,"qs":[{"q":"drug effects","mj":false,"ui":"Q000187"}],"ui":"D002987"},{"d":"Disorders of Sex Development","mj":false,"qs":[{"q":"chemically induced","mj":false,"ui":"Q000139"},{"q":"veterinary","mj":false,"ui":"Q000662"}],"ui":"D012734"},{"d":"Dog Diseases","mj":false,"qs":[{"q":"chemically induced","mj":false,"ui":"Q000139"}],"ui":"D004283"},{"d":"Dogs","mj":false,"qs":[{"q":"physiology","mj":true,"ui":"Q000502"}],"ui":"D004285"},{"d":"Estrus","mj":false,"qs":[{"q":"drug effects","mj":true,"ui":"Q000187"}],"ui":"D004971"},{"d":"Female","mj":false,"ui":"D005260"},{"d":"Lactation","mj":false,"ui":"D007774"},{"d":"Mammary Glands, Animal","mj":false,"qs":[{"q":"drug effects","mj":false,"ui":"Q000187"}],"ui":"D008321"},{"d":"Methods","mj":false,"ui":"D008722"},{"d":"Pregnancy","mj":false,"ui":"D011247"},{"d":"Silicone Elastomers","mj":false,"ui":"D012826"},{"d":"Skin","mj":false,"ui":"D012867"},{"d":"Testosterone","mj":false,"qs":[{"q":"administration & dosage","mj":true,"ui":"Q000008"},{"q":"adverse effects","mj":false,"ui":"Q000009"},{"q":"pharmacology","mj":false,"ui":"Q000494"}],"ui":"D013739"},{"d":"Vagina","mj":false,"qs":[{"q":"drug effects","mj":false,"ui":"Q000187"}],"ui":"D014621"},{"d":"Vaginal Smears","mj":false,"ui":"D014626"},{"d":"Weaning","mj":false,"ui":"D014886"}],"chemicals":[{"n":"Capsules","ui":"D002214","reg":"0"},{"n":"Silicone Elastomers","ui":"D012826","reg":"0"},{"n":"Testosterone","ui":"D013739","reg":"3XMK78S47O"},{"n":"Androstenedione","ui":"D000735","reg":"409J2J96VR"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":null,"s2_open_access_landing_url":null,"s2_open_access_license":null,"s2_open_access_status":null,"pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"\nOne possible method to obtain reversible long-term contraception in the bitch is the subcutaneous implantation of testosterone in capsules fabricated from silicone rubber and calculated to release different daily doses of testosterone.\nThirteen bitches were kept in anestrus for 420 to 480 days. In 7 bitches, the testosterone-containing implants were removed at the end of 420 to 480 days and bitches resumed a normal estrous cycle. Six bitches were bred, and they whelped and weaned normal pups.\nA predictable, effective estrus-inhibiting dose of testosterone was 759 μg./4.5 kg. of body weight per day.\nAndrostenedione, at the dose levels used, was ineffective for inhibiting estrus in the bitch.","claims":[{"public_id":"cl_778ce022dca677d8353730b879218629","status":"active","text":"A predictable estrus-inhibiting testosterone dose was 759 μg per 4.5 kg of body weight per day.","confidence":0.97,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_778ce022dca677d8353730b879218629"},{"public_id":"cl_9a14a4912ac214b81d8c310ccbf8d3da","status":"active","text":"Androstenedione was ineffective for inhibiting estrus in the bitch at the dose levels used.","confidence":0.96,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_9a14a4912ac214b81d8c310ccbf8d3da"},{"public_id":"cl_93c6c59a2ae291c557a494c2226ee8e1","status":"active","text":"Breeding after testosterone-implant treatment produced normal pups that were whelped and weaned.","confidence":0.93,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_93c6c59a2ae291c557a494c2226ee8e1"},{"public_id":"cl_191f80d3348edd95c712a736207a24f7","status":"active","text":"Subcutaneous testosterone implants in silicone rubber capsules can maintain bitches in anestrus for 420 to 480 days and permit resumption of a normal estrous cycle after implant removal.","confidence":0.98,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous 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(12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_345ac65d36970f9f07868ea7dafc3457"},{"public_id":"co_4b837dae4fcc223d8bce5c31ae3ab598","status":"active","name":"normal pups","description":"Offspring described as normal after breeding the treated bitches.","types":["outcome"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_4b837dae4fcc223d8bce5c31ae3ab598"},{"public_id":"co_6ec923ecb1f343bf52bc8330e066cf32","status":"active","name":"anestrus","description":"A period without estrous cycling or visible heat.","types":["reproductive state"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_6ec923ecb1f343bf52bc8330e066cf32"},{"public_id":"co_84b77ed330fd8ed54e3172cef0003641","status":"active","name":"body weight","description":"The animal's mass used to normalize the testosterone dose.","types":["measurement"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_84b77ed330fd8ed54e3172cef0003641"},{"public_id":"co_9902e8cc3a1447f644c72f212c9a6e15","status":"active","name":"silicone rubber capsules","description":"Silicone rubber implant capsules used as the testosterone delivery vehicle.","types":["material","delivery vehicle"],"aliases":["silicone rubber"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_9902e8cc3a1447f644c72f212c9a6e15"},{"public_id":"co_9b793a5e7fe16c46fb06afd4f45500eb","status":"active","name":"testosterone implants","description":"Implanted testosterone delivery systems used to suppress estrus.","types":["method"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_9b793a5e7fe16c46fb06afd4f45500eb"},{"public_id":"co_a5e12d5828b6de6294f8b0b90ae0a23f","status":"active","name":"whelped and weaned","description":"Completed parturition and nursing until offspring were weaned.","types":["reproductive outcome"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous 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