{"corpus_id":9218576,"paper_sha":"c23e4c6e2596553b260a68e4cbbec7e5f36f5a8e","doi":"10.1371/journal.pone.0039726","arxiv_id":null,"pmid":22802942,"pmcid":"3389038","mag_id":2154730276,"dblp_id":null,"acl_id":null,"title":"Profiling Plasma Peptides for the Identification of Potential Ageing Biomarkers in Chinese Han Adults","year":2012,"publication_date":"2012-07-03","venue":"PLoS ONE","journal":{"name":"PLoS ONE","pages":null,"volume":"7"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article","Research Support, Non-U.S. Gov't"],"s2_fields_of_study":["Biology","Medicine"],"reference_count":45,"citation_count":37,"influential_citation_count":1,"is_open_access":true,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Adolescent","mj":false,"ui":"D000293"},{"d":"Adult","mj":false,"ui":"D000328"},{"d":"Aged","mj":false,"ui":"D000368"},{"d":"Aged, 80 and over","mj":false,"ui":"D000369"},{"d":"Aging","mj":false,"qs":[{"q":"blood","mj":true,"ui":"Q000097"}],"ui":"D000375"},{"d":"Apolipoprotein A-I","mj":false,"qs":[{"q":"blood","mj":false,"ui":"Q000097"}],"ui":"D016632"},{"d":"Biomarkers","mj":false,"qs":[{"q":"blood","mj":true,"ui":"Q000097"}],"ui":"D015415"},{"d":"Female","mj":false,"ui":"D005260"},{"d":"Fibrinogen","mj":false,"qs":[{"q":"analysis","mj":true,"ui":"Q000032"}],"ui":"D005340"},{"d":"Humans","mj":false,"ui":"D006801"},{"d":"Male","mj":false,"ui":"D008297"},{"d":"Middle Aged","mj":false,"ui":"D008875"},{"d":"Peptides","mj":false,"qs":[{"q":"blood","mj":true,"ui":"Q000097"}],"ui":"D010455"},{"d":"Serum Albumin","mj":false,"qs":[{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D012709"},{"d":"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","mj":false,"ui":"D019032"},{"d":"Transcriptome","mj":false,"ui":"D059467"}],"chemicals":[{"n":"Apolipoprotein A-I","ui":"D016632","reg":"0"},{"n":"Biomarkers","ui":"D015415","reg":"0"},{"n":"Peptides","ui":"D010455","reg":"0"},{"n":"Serum Albumin","ui":"D012709","reg":"0"},{"n":"fibrinogen Aalpha","ui":"C464794","reg":"0"},{"n":"Fibrinogen","ui":"D005340","reg":"9001-32-5"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0039726&type=printable","s2_open_access_landing_url":"https://www.semanticscholar.org/paper/c23e4c6e2596553b260a68e4cbbec7e5f36f5a8e","s2_open_access_license":"CCBY","s2_open_access_status":"GOLD","pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"Advancing age is associated with cardiovascular disease, diabetes mellitus and cancer, and shows significant inter-individual variability. To identify ageing-related biomarkers we performed a proteomic analysis on 1890 Chinese Han individuals, 1136 males and 754 females, aged 18 to 82 years, using weak cation exchange magnetic bead based MALDI-TOF-MS analysis. The study identified 44 peptides which varied in concentration in different age groups. In particular, apolipoprotein A-I (ApoA1) concentration gradually increased between 18 to 50 years of age, the levels of fibrinogen alpha (FGA) decreased over the same age span, while albumin (ALB) was significantly degraded in middle-aged individuals. In addition, the plasma peptide profiles of FGA and four other unidentified proteins were found to be gender-dependent. Plasma proteins such as FGA, ALB and ApoA1 are significantly correlated with age in the Chinese Han population and could be employed as indicative ageing-related biomarkers.","claims":[{"public_id":"cl_350591631e40a81ed63bb87c96ea5fa7","status":"active","text":"Albumin was significantly degraded in middle-aged individuals.","confidence":0.93,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_350591631e40a81ed63bb87c96ea5fa7"},{"public_id":"cl_8c9f88e54168b8a6a68113f23f6916f8","status":"active","text":"Apolipoprotein A-I concentration increased progressively from 18 to 50 years of age, while fibrinogen alpha levels decreased over the same age span.","confidence":0.97,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous 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