{"corpus_id":94242022,"paper_sha":"d5da3cf98eea9bc2408f1b48ce3577a7e660464a","doi":"10.1021/OL060846T","arxiv_id":null,"pmid":null,"pmcid":null,"mag_id":1966544292,"dblp_id":null,"acl_id":null,"title":"Catalyst-Free Conjugated Addition of Thiols to α,β-Unsaturated Carbonyl Compounds in Water","year":2006,"publication_date":"2006-05-04","venue":"","journal":{"name":"Organic Letters","pages":"2433-2436","volume":"8"},"journal_issn":null,"journal_title":null,"publication_types":[],"pubmed_pub_types":null,"s2_fields_of_study":["Chemistry"],"reference_count":26,"citation_count":267,"influential_citation_count":2,"is_open_access":false,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":null,"chemicals":null,"comments_corrections":null,"source_flags":1,"s2_open_access_pdf_url":null,"s2_open_access_landing_url":null,"s2_open_access_license":null,"s2_open_access_status":null,"pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"[reaction: see text] Catalyst-free conjugate addition of thiols to alpha,beta-unsaturated carbonyl compounds in water is reported. beta-Sulfido carbonyl compounds were formed at room temperature, in short times and with excellent chemoselectivity. Competitive dithiane/dithiolane formation, transesterification, and ester cleavage were not observed. Water played a dual role in simultaneously activating the alpha,beta-unsaturated carbonyl compound and the thiol. This new methodology constitutes an easy, highly efficient, and green synthesis of beta-sulfido carbonyl compounds.","claims":[{"public_id":"cl_0373bf5397a6de52ea77e7cf04e272ee","status":"active","text":"Catalyst-free conjugate addition of thiols to α,β-unsaturated carbonyl compounds in water produces β-sulfido carbonyl compounds at room temperature in short reaction times with excellent chemoselectivity.","confidence":0.98,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_0373bf5397a6de52ea77e7cf04e272ee"},{"public_id":"cl_9b46c4fcd20b9475fa0f06b32ede4bfa","status":"active","text":"Competitive dithiane/dithiolane formation, transesterification, and ester cleavage were not observed under the reported conditions.","confidence":0.95,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous 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