{"corpus_id":97895249,"paper_sha":"bbdef83870af7e2f78b5fe550c4cd1318b33ac5b","doi":"10.1021/CM049587X","arxiv_id":null,"pmid":null,"pmcid":null,"mag_id":2051357892,"dblp_id":null,"acl_id":null,"title":"Homogeneous Fluorescence-Based DNA Detection with Water-Soluble Conjugated Polymers","year":2004,"publication_date":"2004-09-11","venue":"","journal":{"name":"Chemistry of Materials","pages":"4467-4476","volume":"16"},"journal_issn":null,"journal_title":null,"publication_types":[],"pubmed_pub_types":null,"s2_fields_of_study":["Materials Science","Chemistry"],"reference_count":0,"citation_count":513,"influential_citation_count":2,"is_open_access":false,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":null,"chemicals":null,"comments_corrections":null,"source_flags":1,"s2_open_access_pdf_url":null,"s2_open_access_landing_url":null,"s2_open_access_license":null,"s2_open_access_status":null,"pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"Methods for real-time, high-sensitivity polynucleotide detection are of vast scientific and economic importance. Homogeneous biosensor assays that take advantage of the collective response of water-soluble conjugated polymers and the self-assembly characteristic of aqueous polyelectrolytes have shown potential for improvements over small molecule methods. Cationic polythiophenes transduce oligonucleotide hybridization into a colorimetric output based on conformational changes of the polymer upon interaction with single-stranded DNAs or double-stranded DNAs. Cationic poly(fluorene-co-phenylene) materials serve as donors in fluorescence energy-transfer assays which display signal amplification. Signal transduction in aqueous media is controlled by specific electrostatic interactions.","claims":[{"public_id":"cl_8d4edbcde9573154c53ea9aa9c7e6533","status":"active","text":"Cationic poly(fluorene-co-phenylene) materials function as fluorescence-energy-transfer donors and produce signal amplification in aqueous biosensor assays.","confidence":0.95,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_8d4edbcde9573154c53ea9aa9c7e6533"},{"public_id":"cl_aa05f925cf72c8b5f6145c4b6b0fd727","status":"active","text":"Cationic polythiophenes transduce oligonucleotide hybridization into a colorimetric output through conformational changes induced by interactions with single-stranded DNA or double-stranded DNA.","confidence":0.96,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous 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