A. Venkitaraman

PROFILE

Homepage
No homepage is listed.
ORCID
No ORCID is listed.
Affiliations
No affiliations are listed.
Aliases
Ashok R. Venkitaraman, Ashok R Venkitaraman, A. R. Venkitaraman, A R Venkitaraman, Ashok Raraakrishnan Venkitaraman, Ashok Venkitaraman, A Venkitaraman, Ashok r. Venkitaraman
Publication record
211 papers · 15,469 citations · H-index 63

PAPERS

Rewiring of chromatin loops in adipogenesis reveals targets for obesity and diabetes intervention
20250 citationsauthor #23
Selective Aurora A-TPX2 Interaction Inhibitors Have In Vivo Efficacy as Targeted Antimitotic Agents
202412 citationsauthor #24
Ketogenic diet promotes tumor ferroptosis but induces relative corticosterone deficiency that accelerates cachexia
20239 citationsauthor #13
Domain-specific p53 mutants activate EGFR by distinct mechanisms exposing tissue-independent therapeutic vulnerabilities
202312 citationsauthor #27
Ketogenic diet promotes tumor ferroptosis but induces relative corticosterone deficiency that accelerates cachexia.
202373 citationsauthor #15
A transcriptional response to replication stress selectively expands a subset of Brca2-mutant mammary epithelial cells
20235 citationsauthor #8
Rapid recruitment of p53 to DNA damage sites directs DNA repair choice and integrity
202268 citationsauthor #10
A transcriptional response to replication stress selectively expands a subset of BRCA2-mutant mammary epithelial cells
20220 citationsauthor #7
A fragment-based approach leading to the discovery of inhibitors of CK2α with a novel mechanism of action
20222 citationsauthor #6
Latest Happenings
20210 citationsauthor #1
Target identification for small-molecule discovery in the FOXO3a tumor-suppressor pathway using a biodiverse peptide library
202111 citationsauthor #21
A mitochondrial response to oxidative stress mediated by unscheduled RNA-DNA hybrids (R-loops)
20217 citationsauthor #2
Publisher Correction: A systems view of spliceosomal assembly and branchpoints with iCLIP
20211 citationsauthor #11
BRCA2 deficiency reveals that oxidative stress impairs RNaseH1 function to cripple mitochondrial DNA maintenance
202131 citationsauthor #5
Cancer-causing BRCA2 missense mutations disrupt an intracellular protein assembly mechanism to disable genome maintenance
202123 citationsauthor #5
Inhibition of HIV-1 immune modulation by small molecules targeting viral Nef-host CD80 interface
20210 citationsauthor #11
Early Neutrophilia Marked by Aerobic Glycolysis Sustains Host Metabolism and Delays Cancer Cachexia
202119 citationsauthor #15
Single-Cell Biochemical Multiplexing by Multidimensional Phasor Demixing and Spectral Fluorescence Lifetime Imaging Microscopy
20213 citationsauthor #3
A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death
202035 citationsauthor #22
A kinase-independent function for AURORA-A in replisome assembly during DNA replication initiation
202022 citationsauthor #3
Pulsatile MAPK Signaling Modulates p53 Activity to Control Cell Fate Decisions at the G2 Checkpoint for DNA Damage
202055 citationsauthor #3
Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation
202026 citationsauthor #18
Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation
20201 citationsauthor #18
Author Correction: A systems view of spliceosomal assembly and branchpoints with iCLIP
20201 citationsauthor #11
Abstract 2559: Functional characterization of a RECQL4 mutation in Rothmund Thomson Syndrome
20190 citationsauthor #6
Enhancing Biochemical Resolution by Hyperdimensional Imaging Microscopy
201922 citationsauthor #2
Development of a Novel Cell-Permeable Protein–Protein Interaction Inhibitor for the Polo-box Domain of Polo-like Kinase 1
20197 citationsauthor #16
Fast single-cell biochemistry: theory, open source microscopy and applications
201926 citationsauthor #6
NEW FLIM TECHNOLOGIES FOR SINGLE-CELL BIOCHEMICAL SENSING AT HIGH SPATIO-TEMPORAL AND BIOCHEMICAL RESOLUTION
20190 citationsauthor #4
Structure‐Guided Synthesis and Evaluation of Small‐Molecule Inhibitors Targeting Protein–Protein Interactions of BRCA1 tBRCT Domain
20195 citationsauthor #11
Abstract ES12-1: BRCA2 and control of transcription: R-loop dynamics
20190 citationsauthor #1
1 A systems view of spliceosomal assembly and branchpoints with iCLIP 1 2
20190 citationsauthor #11
ZNF281 is recruited on DNA breaks to facilitate DNA repair by non-homologous end joining
201928 citationsauthor #7
A systems view of spliceosomal assembly and branchpoints with iCLIP
201926 citationsauthor #11
How do mutations affecting the breast cancer genes BRCA1 and BRCA2 cause cancer susceptibility?
201985 citationsauthor #1
Structural features underlying the activity of benzimidazole derivatives that target phosphopeptide recognition by the tandem BRCT domain of the BRCA1 protein
20192 citationsauthor #12
A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation
201923 citationsauthor #12
BRCA2 controls DNA:RNA hybrid level at DSBs by mediating RNase H2 recruitment
2018208 citationsauthor #13
BRCA2 Regulates Transcription Elongation by RNA Polymerase II to Prevent R-Loop Accumulation
2018138 citationsauthor #4
Checkpoint non-fidelity induces a complex landscape of lineage fitness after DNA damage
20180 citationsauthor #2
Enhancing biochemical resolution by hyper-dimensional imaging microscopy
20181 citationsauthor #2
Targeting Phosphopeptide Recognition by the Human BRCA1 Tandem BRCT Domain to Interrupt BRCA1-Dependent Signaling
201817 citationsauthor #16
Single-molecule localization microscopy reveals molecular transactions during RAD51 filament assembly at cellular DNA damage sites
201827 citationsauthor #4
Multiplexed biochemical imaging reveals caspase activation patterns underlying single cell fate
20186 citationsauthor #6
A systems view of spliceosomal assembly and branchpoints with iCLIP
20189 citationsauthor #9
Modulating Protein-Protein Interactions of the Mitotic Polo-like Kinases to Target Mutant KRAS
201728 citationsauthor #19
Impact of Alternative Splicing on the Human Proteome
2017150 citationsauthor #7
A Class of Environmental and Endogenous Toxins Induces BRCA2 Haploinsufficiency and Genome Instability
2017180 citationsauthor #11
Computationally-guided optimization of small-molecule inhibitors of the Aurora A kinase–TPX2 protein–protein interaction
201713 citationsauthor #7
Aurora A Kinase in Complex with AA35 and JNJ-7706621 in Space Group P6122
20160 citationsauthor #14
High-resolution structure of the presynaptic RAD51 filament on single-stranded DNA by electron cryo-microscopy
201689 citationsauthor #7
Aurora A Kinase in Complex with AA30 and JNJ-7706621 in Space Group P6122
20160 citationsauthor #14
Aurora A Kinase in Complex with ATP in Space Group P6122
20160 citationsauthor #14
Aurora A Kinase in Complex with AA35 and ATP in Space Group P6122
20160 citationsauthor #14
Apo-structure of humanised RadA-mutant humRadA22F
20160 citationsauthor #9
RNA Processing and Genome Stability: Cause and Consequence.
201696 citationsauthor #2
Structure of the Stapled Peptide Bound to Mdm2
20160 citationsauthor #7
Aurora A Kinase in Complex with JNJ-7706621 in Space Group P6122
20160 citationsauthor #14
Aurora A Kinase in Complex with AA30 and ATP in Space Group P6122
20160 citationsauthor #14
Aurora A Kinase in Complex with AA29 and JNJ-7706621 in Space Group P6122
20160 citationsauthor #14
Structure of humanised RadA-mutant humRadA22F in complex with 1-Indane-6-carboxylic acid
20160 citationsauthor #9
n of CK 2 a from an anchor outside the active site †
20160 citationsauthor #7
Structure of humanised RadA-mutant humRadA22F in complex with peptide FHTA
20160 citationsauthor #9
Oncogenic KRAS triggers MAPK-dependent errors in mitosis and MYC-dependent sensitivity to anti-mitotic agents
201621 citationsauthor #2
Aurora A Kinase in complex with ATP in space group P41212
20160 citationsauthor #14
Aurora A in complex with ATP and AA35.
20160 citationsauthor #14
Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2
201675 citationsauthor #15
Micro(mi) RNA-34a targets protein phosphatase (PP)1γ to regulate DNA damage tolerance
20157 citationsauthor #2
ATPS-93CHEMO-NAÏVE GLIOBLASTOMA PATIENTS CONTAIN GENETICALLY HETEROGENEOUS SUB-CLONES CAPABLE OF TUMOUR PROPAGATION AND SPATIALLY HETEROGENEOUS DRUG-RESISTANT CELL POPULATIONS
20150 citationsauthor #10
Contributions to drug resistance in glioblastoma derived from malignant cells in the sub-ependymal zone.
201560 citationsauthor #11
Fast and simple spectral FLIM for biochemical and medical imaging.
201542 citationsauthor #8
Regulation of constitutive and alternative mRNA splicing across the human transcriptome by PRPF8 is determined by 5′ splice site strength
201593 citationsauthor #9
Overcoming Chemical, Biological, and Computational Challenges in the Development of Inhibitors Targeting Protein-Protein Interactions
2015136 citationsauthor #4
Double Strain-Promoted Macrocyclization for the Rapid Selection of Cell-Active Stapled Peptides.
201590 citationsauthor #9
Cancer Suppression by the Chromosome Custodians, BRCA1 and BRCA2
2014273 citationsauthor #1
Small-Molecule Inhibitors That Target Protein–Protein Interactions in the RAD51 Family of Recombinases
201433 citationsauthor #3
Tumour Suppressor Mechanisms in the Control of Chromosome Stability: Insights from BRCA2
201424 citationsauthor #1
A cancer-associated mutation inactivates a region of the high-mobility group protein HMG20b essential for cytokinesis
20148 citationsauthor #2
Investigating peptide sequence variations for 'double-click' stapled p53 peptides.
201437 citationsauthor #5
p 53 shapes genome-wide and cell type-specific changes in microRNA expression during the human DNA damage response
20143 citationsauthor #7
95 Identification of synthetic lethality compounds from natural products for cancers
20140 citationsauthor #7
Diversity-oriented synthesis as a tool for identifying new modulators of mitosis
201474 citationsauthor #8
High content screening of diverse compound libraries identifies potent modulators of tubulin dynamics.
201413 citationsauthor #5
Selective nuclear export of specific classes of mRNA from mammalian nuclei is promoted by GANP
201475 citationsauthor #7
Linear Aliphatic Dialkynes as Alternative Linkers for Double‐Click Stapling of p53‐Derived Peptides
201435 citationsauthor #4
Homeostatic control of polo-like kinase-1 engenders non-genetic heterogeneity in G2 checkpoint fidelity and timing
201437 citationsauthor #7
p53 shapes genome-wide and cell type-specific changes in microRNA expression during the human DNA damage response
201421 citationsauthor #6
BRCA 2 Cancer Suppression by the Chromosome Custodians , BRCA 1 and
20140 citationsauthor #1
Chromosome instability and carcinogenesis: Insights from murine models of human pancreatic cancer associated with BRCA2 inactivation
201316 citationsauthor #3
Humanised monomeric RadA in complex with 5-methyl indole
20130 citationsauthor #6
Abstract 5016: The human sub-ependymal zone harbors glioblastoma precursors and represents a distinct therapeutic target.
201316 citationsauthor #10
Humanised monomeric RadA in complex with napht-2-ol
20130 citationsauthor #6
Maximizing the Biochemical Resolving Power of Fluorescence Microscopy
201320 citationsauthor #3
Humanised monomeric RadA in complex with 2-amino benzothiazole
20130 citationsauthor #6
A-Type Lamins Maintain the Positional Stability of DNA Damage Repair Foci in Mammalian Nuclei
201358 citationsauthor #6
Humanised monomeric RadA in complex with indazole
20130 citationsauthor #6
Abstract A24: A cascade of masked nuclear export signals regulates the BRCA2 tumor suppressor pathway
20130 citationsauthor #10
Humanised monomeric RadA in complex with napht-1-ol
20130 citationsauthor #6
Humanised monomeric RadA in complex with 4-methylester indole
20130 citationsauthor #6
Human inositol polyphosphate multikinase regulates transcript-selective nuclear mRNA export to preserve genome integrity.
201387 citationsauthor #9

TIMELINE

1984 28 citations

1987 12 citations

1990 94 citations

1992 83 citations

1994 56 citations

1998 791 citations

1999 63 citations

2000 323 citations

2001 795 citations

2002 2,453 citations

2003 2,034 citations

2004 857 citations

2005 622 citations

2006 518 citations

2007 104 citations

2008 458 citations

2009 1,195 citations

2010 531 citations

2011 838 citations

2012 445 citations

2013 417 citations

2014 633 citations

2015 428 citations

2016 281 citations

2017 371 citations

2018 406 citations

2019 224 citations

2020 140 citations

2021 95 citations

2022 70 citations

2023 99 citations

2024 12 citations

2025 0 citations

Unknown 0 citations

A. Venkitaraman

PROFILE

PAPERS

TIMELINE

COAUTHOR MAP

CONCEPT FOOTPRINT