W. Kolch

Oncotherapeutic Strategies in Early Onset Colorectal Cancer
202325 citationsauthor #4
Interactome dynamics of RAF1-BRAF kinase monomers and dimers
20238 citationsauthor #5
Small Gene Networks Delineate Immune Cell States and Characterize Immunotherapy Response in Melanoma
20232 citationsauthor #13
Dynamic regulation of RAS and RAS signaling
202345 citationsauthor #1
Memory of stochastic single-cell apoptotic signaling promotes chemoresistance in neuroblastoma
202321 citationsauthor #28
Reversing pathological cell states: the road less travelled can extend the therapeutic horizon.
202312 citationsauthor #2
Proteome analysis of patients with early onset colorectal cancer in Ireland.
20230 citationsauthor #9
Deciphering the tumour immune microenvironment cell by cell
20237 citationsauthor #10
Proteomic Mapping of the Interactome of KRAS Mutants Identifies New Features of RAS Signalling Networks and the Mechanism of Action of Sotorasib
20237 citationsauthor #3
B-cell and complement signature in severe hidradenitis suppurativa that does not respond to adalimumab.
20226 citationsauthor #12
B-cell-derived transforming growth factor-β may drive the activation of inflammatory macrophages and contribute to scarring in hidradenitis suppurativa.
20226 citationsauthor #12
Control of cell state transitions
202265 citationsauthor #11
Author Correction: Cell fate decisions are specified by the dynamic ERK interactome
202282 citationsauthor #12
A comparative analysis of extracellular vesicles (EVs) from human and feline plasma
202215 citationsauthor #14
CRABP2 - A novel biomarker for high-risk endometrial cancer.
202212 citationsauthor #8
Kinase Suppressor of RAS 1 (KSR1) Maintains the Transformed Phenotype of BRAFV600E Mutant Human Melanoma Cells
20228 citationsauthor #13
Proteasomal down-regulation of the proapoptotic MST2 pathway contributes to BRAF inhibitor resistance in melanoma
20227 citationsauthor #7
Analysis of Alternative mRNA Splicing in Vemurafenib-Resistant Melanoma Cells
20229 citationsauthor #2
Targeting KRAS in Pancreatic Cancer
202229 citationsauthor #4
Personalized Medicine for Neuroblastoma: Moving from Static Genotypes to Dynamic Simulations of Drug Response
20219 citationsauthor #5
498 Metastatic high grade serous ovarian cancer has an immune excluded tumor microenvironment – explaining failure of immunotherapy to date
20210 citationsauthor #7
The Ins and Outs of RAS Effector Complexes
202148 citationsauthor #3
A Chemo-Genomic Approach Identifies Diverse Epigenetic Therapeutic Vulnerabilities in MYCN-Amplified Neuroblastoma
20217 citationsauthor #6
Hidden Targets in RAF Signalling Pathways to Block Oncogenic RAS Signalling
202125 citationsauthor #3
KBoost: a new method to infer gene regulatory networks from gene expression data
202125 citationsauthor #3
P31: Use of omics technology for the identification of critical mediators and pathways in patients with hidradenitis suppurativa
20210 citationsauthor #14
P30: Prevalence and treatment patterns of adult atopic dermatitis in the UK Clinical Practice Research Datalink
20210 citationsauthor #14
Abstract 658: CRABP2 - a novel biomarker for high risk endometrial cancer
20210 citationsauthor #6
A systematic analysis of signaling reactivation and drug resistance
202128 citationsauthor #3
Emerging RAS-directed therapies for cancer
202113 citationsauthor #3
P29: Routine screening with early‐morning cortisol facilitates identification and improves management of adrenal insufficiency in glucocorticoid‐treated dermatology patients
20210 citationsauthor #10
Transcriptional profiling of early differentiation of primary human mesenchymal stem cells into chondrocytes
20217 citationsauthor #8
RASSF1A Tumour Suppressor: Target the Network for Effective Cancer Therapy
202053 citationsauthor #3
Characterisation of HRas local signal transduction networks using engineered site-specific exchange factors
202011 citationsauthor #8
Role of raf and myc Oncogenes in Signal Transduction
20200 citationsauthor #5
Precision therapy in RAS mutant colorectal cancer.
202057 citationsauthor #10
Periodic propagating waves coordinate RhoGTPase network dynamics at the leading and trailing edges during cell migration
202050 citationsauthor #7
The future of genomics in Ireland – focus on genomics for health
20202 citationsauthor #18
Author response: Periodic propagating waves coordinate RhoGTPase network dynamics at the leading and trailing edges during cell migration
20201 citationsauthor #7
Systems biology approaches to macromolecules: the role of dynamic protein assemblies in information processing.
20203 citationsauthor #3
Targeting MAPK Signaling in Cancer: Mechanisms of Drug Resistance and Sensitivity
2020663 citationsauthor #3
Signaling Dynamics Regulating Crosstalks between T-Cell Activation and Immune Checkpoints.
202028 citationsauthor #5
Loss of RAF kinase inhibitor protein is involved in myelomonocytic differentiation and aggravates RAS-driven myeloid leukemogenesis
201916 citationsauthor #15
An Integrated Global Analysis of Compartmentalized HRAS Signaling.
201937 citationsauthor #14
An integrative computational approach for a prioritization of key transcription regulators associated with nanomaterial-induced toxicity.
20199 citationsauthor #7
All over the place: deciphering HRAS signaling from different subcellular compartments
20190 citationsauthor #1
Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer
201934 citationsauthor #28
Accurate prediction of kinase-substrate networks using knowledge graphs
201921 citationsauthor #13
121 Mass Spectrometry-based Proteome Analysis of Skin Microdialysates
20190 citationsauthor #8
SP-0220 Precision medicine and systems biology - transforming cancer research in the 21st century
20190 citationsauthor #1
Transcriptional and metabolic rewiring of colorectal cancer cells expressing the oncogenic KRASG13D mutation
201947 citationsauthor #16
Introduction into the Concept of Systems Medicine
20180 citationsauthor #2
PO-461 Mitochondria-mediated anticancer effect of diphenyleneiodonium chloride (DPI) in aggressive neuroblastoma is regulated by MYCN
20180 citationsauthor #7
From oncogenic mutation to dynamic code
20184 citationsauthor #1
Essays In Biochemistry: 62 (4)
20180 citationsauthor #1
PO-311 Characterisation of colorectal tumour endothelial cells
20180 citationsauthor #7
Adaptive rewiring of protein-protein interactions and signal flow in the EGFR signaling network by mutant RAS
20180 citationsauthor #4
Transcriptional regulatory mechanisms of fibrosis development in mouse lung tissue exposed to carbon nanotubes
20181 citationsauthor #7
Dissecting RAF Inhibitor Resistance by Structure-based Modeling Reveals Ways to Overcome Oncogenic RAS Signaling.
201864 citationsauthor #15
Systems biology: old news or new stimulus for biochemistry.
20180 citationsauthor #1
Identification of a MYCN and Wnt-related VANGL2-ITLN1 fusion gene in neuroblastoma
20183 citationsauthor #6
ALIX Regulates Tumor-Mediated Immunosuppression by Controlling EGFR Activity and PD-L1 Presentation
2018128 citationsauthor #23
PO-136 Studying pathway interactions and dynamics to predict cell responses to chemotherapeutic treatment in breast cancer cells
20180 citationsauthor #3
Title Inferring Signaling Pathway Topologies from MultiplePerturbation Measurements of Specific Biochemical Species
20180 citationsauthor #11
Retinoic acid and TGF-β signalling cooperate to overcome MYCN-induced retinoid resistance
20170 citationsauthor #8
Retracted: Mice lacking the Raf‐1 kinase inhibitor protein exhibit exaggerated hypoxia‐induced pulmonary hypertension, by I Morecroft, B Doyle, M Nilsen, W Kolch, K Mair and MR MacLean. British Journal of Pharmacology, volume 163(5): 948–963, published in June 2011; DOI 10.1111/j.1476‐5381.2011.0130
20171 citationsauthor #4
A Brain-Derived Neurotrophic Factor Mimetic Is Sufficient to Restore Cone Photoreceptor Visual Function in an Inherited Blindness Model
201735 citationsauthor #9
Title Functional Roles of Multiple Feedback Loops in Extracellular Signal-Regulated Kinase and Wnt Signaling Pathways That Regulate Epithelial-Mesenchymal Transition
20170 citationsauthor #5
Signalling ballet in four dimensions
20170 citationsauthor #3
A novel RNA sequencing data analysis method for cell line authentication
201725 citationsauthor #6
Running title : A framework for pathway inference and modelling Character count : 48856
20170 citationsauthor #3
Lapatinib potentiates cytotoxicity of YM155 in neuroblastoma via inhibition of the ABCB1 efflux transporter
201732 citationsauthor #8
c-Myc regulates A-Raf kinase splicing and ERK path- way activation
20170 citationsauthor #7
Title Mutant KRas Activation of the Proapoptotic MST 2 Pathway
20170 citationsauthor #4
Viva Europa, a Land of Excellence in Research and Innovation for Health and Wellbeing
20178 citationsauthor #53
Retinoic acid and TGF-β signalling cooperate to overcome MYCN-induced retinoid resistance
201737 citationsauthor #8
Title PI 3 K / Akt-sensitive MEK-independent compensatory circuit of ERK activation in ER-positive PI 3 K-mutant T 47 D breast cancer cells
20170 citationsauthor #3
Next Generation RNA Sequencing Analysis Reveals Expression of a Transient EMT Profile During Early Organization of MCF10A Cells in 3D.
20171 citationsauthor #4
Metabolic stress regulates ERK activity by controlling KSR‐RAF heterodimerization
201713 citationsauthor #11
Personalized Computational Models as Biomarkers
201714 citationsauthor #1
Identification of potential new treatment response markers and therapeutic targets using a Gaussian process-based method in lapatinib insensitive breast cancer models
20173 citationsauthor #7
- 1-c-Myc regulates ARaf kinase splicing and ERK pathway activation
20170 citationsauthor #7
Title Functional proteomics to dissect tyrosine kinase signallingpathways in cancer
20170 citationsauthor #1
Spatial regulation of ARAF controls the MST2-Hippo pathway
201710 citationsauthor #2
05.02 Differentiating patient responses in rheumatoid arthritis – systems analysis of key molecular networks
20170 citationsauthor #2
Proteomics analysis of bladder cancer invasion: Targeting EIF3D for therapeutic intervention
201733 citationsauthor #12
VEGF promotes assembly of the p 130 Cas interactome to drive endothelial chemotactic signalling and angiogenesis
20160 citationsauthor #9
Integrating network reconstruction with mechanistic modeling to predict cancer therapies
201657 citationsauthor #3
BGRMI: A method for inferring gene regulatory networks from time-course gene expression data and its application in breast cancer research
201637 citationsauthor #2
MAPK kinase signalling dynamics regulate cell fate decisions and drug resistance.
201678 citationsauthor #3
Stabilization of C-RAF:KSR1 complex by DiRas3 reduces availability of C-RAF for dimerization with B-RAF.
20166 citationsauthor #5
Comparison of different statistical approaches for urinary peptide biomarker detection in the context of coronary artery disease
20166 citationsauthor #5
TBP-1 subunit of the 19S proteasome cooperates with an ERK-regulated degron to regulate turnover of the Fra-1/AP-1 transcription factor
20160 citationsauthor #6
KSR proteins link metabolic changes to the MAPK/ERK pathway
20160 citationsauthor #8
Vascular Endothelial Growth Factor (VEGF) Promotes Assembly of the p130Cas Interactome to Drive Endothelial Chemotactic Signaling and Angiogenesis*
201624 citationsauthor #9
The spatiotemporal regulation of RAS signalling.
201618 citationsauthor #3
Autophosphorylation on S614 inhibits the activity and the transforming potential of BRAF.
20165 citationsauthor #11
Wnt signalling is a bi-directional vulnerability of cancer cells
201628 citationsauthor #16
MST2-RASSF protein-protein interactions through SARAH domains
201613 citationsauthor #6
A microfluidic dual gradient generator for conducting cell-based drug combination assays.
201624 citationsauthor #9

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