Honglin Li

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Honglin Li, Hongling Li
Publication record
176 papers · 7,217 citations · H-index 41

PAPERS

Macrocyclization of linear molecules by deep learning to facilitate macrocyclic drug candidates discovery
202336 citationsauthor #16
A simple monoselective C-H oxygenation approach for the synthesis of ursane triterpenoids.
20230 citationsauthor #9
Multi-valent mRNA vaccines against monkeypox enveloped or mature viron surface antigens demonstrate robust immune response and neutralizing activity
202342 citationsauthor #13
Discovery and Optimization of Quinoline Analogues as Novel Potent Antivirals against Enterovirus D68
202210 citationsauthor #10
Discovery and optimization of 4-anilinoquinazoline derivatives spanning ATP binding site and allosteric site as effective EGFR-C797S inhibitors.
202220 citationsauthor #25
Design, synthesis and SAR study of 2-aminopyridine derivatives as potent and selective JAK2 inhibitors
20225 citationsauthor #6
Efficacy of WWQ-131, a highly selective JAK2 inhibitor, in mouse models of myeloproliferative neoplasms.
20226 citationsauthor #8
Molecular Docking for Ligand-Receptor Binding Process Based on Heterogeneous Computing
202210 citationsauthor #6
RELATION: A Deep Generative Model for Structure-Based De Novo Drug Design.
202280 citationsauthor #9
Design, synthesis and biological evaluation of potent and selective S1PR1 agonists for the treatment of Ulcerative Colitis
20225 citationsauthor #12
Discovery of pyrrolo[1,2-a]quinoxalin-4(5H)-one derivatives as novel non-covalent Bruton's tyrosine kinase (BTK) inhibitors.
20225 citationsauthor #9
Discovery and optimization of novel plant activators through structure-based virtual screening
20211 citationsauthor #8
Antiallergic drug Mebhydrolin ameliorates glucose homeostasis in type 2 diabetic mice by functioning as a selective FXR antagonist.
202134 citationsauthor #10
Discovery of pyrido[3,4-b]indol-1-one derivatives as novel non-covalent Bruton's tyrosine kinase (BTK) inhibitors.
20214 citationsauthor #8
Design, Synthesis, and Structure–Activity Relationship Study of Potent MAPK11 Inhibitors
20215 citationsauthor #6
A fast protein binding site comparison algorithm for proteome‐wide protein function prediction and drug repurposing
202111 citationsauthor #5
ProfKin: A comprehensive web server for structure-based kinase profiling.
202110 citationsauthor #10
Correction to: Ponatinib efficiently kills imatinib-resistant chronic eosinophilic leukemia cells harboring gatekeeper mutant T674I FIP1L1-PDGFRα: roles of Mcl-1 and β-catenin
20210 citationsauthor #3
Guanosine ameliorates positive symptoms of schizophrenia via modulating 5-HT1A and 5-HT2A receptors.
20212 citationsauthor #9
Comprehensive assessment of deep generative architectures for de novo drug design
20217 citationsauthor #7
ePharmer: An integrated and graphical software for pharmacophore‐based virtual screening
20210 citationsauthor #6
Design, synthesis, molecular modeling, and biological evaluation of acrylamide derivatives as potent inhibitors of human dihydroorotate dehydrogenase for the treatment of rheumatoid arthritis
202020 citationsauthor #11
Design, Synthesis and SAR Studies of Novel and Potent Dipeptidyl Peptidase 4 Inhibitors
20204 citationsauthor #6
Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2
2020162 citationsauthor #24
Correction to: Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2
20203 citationsauthor #24
Computational Insight into the Allosteric Activation Mechanism of Farnesoid X Receptor
20208 citationsauthor #5
Correction to: Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2
20201 citationsauthor #24
Deep Learning Based Drug Metabolites Prediction
202031 citationsauthor #7
Correction to: Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2
20200 citationsauthor #24
Discovery of a natural fluorescent probe targeting the Plasmodium falciparum cysteine protease falcipain-2
20205 citationsauthor #11
A Small-Scale Medication of Leflunomide as a Treatment of COVID-19 in an Open-Label Blank-Controlled Clinical Trial
202048 citationsauthor #10
Novel and potent inhibitors targeting DHODH, a rate-limiting enzyme in de novo pyrimidine biosynthesis, are broad-spectrum antiviral against RNA viruses including newly emerged coronavirus SARS-CoV-2
202047 citationsauthor #24
Design, synthesis and biological evaluation of potent EGFR kinase inhibitors against 19D/T790M/C797S mutation.
202019 citationsauthor #9
Discovery and optimization of 2-aminopyridine derivatives as novel and selective JAK2 inhibitors.
20207 citationsauthor #7
Jie Du Tong Ye San Prevents N-Nitrosomethylbenzylamine-Induced Esophageal Carcinogenesis via Inhibition of Inflammation and Proliferation
20193 citationsauthor #9
Correction to Discovery of a Natural-Product-Derived Preclinical Candidate for Once-Weekly Treatment of Type 2 Diabetes.
20191 citationsauthor #19
Development of drug design in China: 40 years of achievements
20190 citationsauthor #10
Discovery and Biological evaluation of pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione derivatives as potent Bruton's tyrosine kinase inhibitors.
20193 citationsauthor #12
Discovery of Potent and Noncovalent Reversible EGFR Kinase Inhibitors of EGFRL858R/T790M/C797S.
201950 citationsauthor #14
A diversity-oriented rhodamine library for wide-spectrum bactericidal agents with low inducible resistance against resistant pathogens
201970 citationsauthor #14
Drug Design of “Undruggable” Targets
20199 citationsauthor #3
Design and Synthesis of a Series of Novel Macrocycle Janus Kinase 2 Inhibitors
20193 citationsauthor #11
Discovery of a Natural-Product-Derived Preclinical Candidate for Once-Weekly Treatment of Type 2 Diabetes.
201922 citationsauthor #19
Design, synthesis and structure-activity relationship study of aminopyridine derivatives as novel inhibitors of Janus kinase 2.
201915 citationsauthor #16
eSHAFTS: Integrated and graphical drug design software based on 3D molecular similarity
20199 citationsauthor #6
Quercetin‐3‐methyl ether inhibits esophageal carcinogenesis by targeting the AKT/mTOR/p70S6K and MAPK pathways
201839 citationsauthor #4
Pharmacodynamics simulation of HOEC by a computational model of arachidonic acid metabolic network
20183 citationsauthor #7
Synthesis and biological evaluation of a novel β-D-2'-deoxy-2'-α-fluoro-2'-β-C-(fluoromethyl)uridine phosphoramidate prodrug for the treatment of hepatitis C virus infection.
20187 citationsauthor #10
Multi-Body Interactions in Molecular Docking Program Devised with Key Water Molecules in Protein Binding Sites
201839 citationsauthor #5
Novel benzoyl thioureido benzene sulfonamides as highly potent and selective inhibitors of carbonic anhydrase IX: optimization and bioactive studies.
20185 citationsauthor #5
Design, Synthesis, and Biological Evaluation of Pyrimido[4,5- d]pyrimidine-2,4(1 H,3 H)-diones as Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors against L858R/T790M Resistance Mutation.
201829 citationsauthor #14
Discovery and biological evaluation of N5-substituted 6,7-dioxo-6,7-dihydropteridine derivatives as potent Bruton's tyrosine kinase inhibitors.
20183 citationsauthor #11
LOX inhibitor HOEC interfered arachidonic acid metabolic flux in collagen-induced arthritis rats.
201813 citationsauthor #4
Structural and genetic analysis of START superfamily protein MSMEG_0129 from Mycobacterium smegmatis
20187 citationsauthor #7
Synthesis, Design, and Structure–Activity Relationship of the Pyrimidone Derivatives as Novel Selective Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase
201814 citationsauthor #5
Discovery of Natural Products as Novel and Potent FXR Antagonists by Virtual Screening
201813 citationsauthor #8
RD-Metabolizer: an integrated and reaction types extensive approach to predict metabolic sites and metabolites of drug-like molecules
20179 citationsauthor #5
Structure-Guided Design of C4-alkyl-1,4-dihydro-2H-pyrimido[4,5-d][1,3]oxazin-2-ones as Potent and Mutant-Selective Epidermal Growth Factor Receptor (EGFR) L858R/T790M Inhibitors
201712 citationsauthor #10
Structural analysis of recombinant human ubiquitin-conjugating enzyme UbcH5c
20179 citationsauthor #3
The discovery of new scaffold of plant activators: From salicylic acid to benzotriazole
201713 citationsauthor #8
Functional Metabolomics Characterizes a Key Role for N-Acetylneuraminic Acid in Coronary Artery Diseases
2017157 citationsauthor #12
The gene expression profiles in response to 102 traditional Chinese medicine (TCM) components: a general template for research on TCMs
201789 citationsauthor #9
Veratramine modulates AP-1-dependent gene transcription by directly binding to programmable DNA
201726 citationsauthor #13
Statistical Analysis, Investigation, and Prediction of the Water Positions in the Binding Sites of Proteins
20178 citationsauthor #5
Structure-Guided Design of C4-alkyl-1,4-dihydro-2H-pyrimido[4,5-d][1,3]oxazin-2-ones as Potent and Mutant-Selective Epidermal Growth Factor Receptor (EGFR) L858R/T790M Inhibitors
20170 citationsauthor #10
Novel Drugs Targeting the Epigenome
20170 citationsauthor #2
Synthesis, structure-activity relationship and binding mode analysis of 4-thiazolidinone derivatives as novel inhibitors of human dihydroorotate dehydrogenase.
20176 citationsauthor #5
Britanin Ameliorates Cerebral Ischemia–Reperfusion Injury by Inducing the Nrf2 Protective Pathway
201780 citationsauthor #11
Novel Drugs Targeting the Epigenome
20173 citationsauthor #2
PharmMapper 2017 update: a web server for potential drug target identification with a comprehensive target pharmacophore database
20171,220 citationsauthor #9
Biological evaluation of quinoline derivatives as inhibitors of human dihydroorotate dehydrogenase
20162 citationsauthor #6
Structure-based design of potent human dihydroorotate dehydrogenase inhibitors as anticancer agents
201610 citationsauthor #11
Are Topological Properties of Drug Targets Based on Protein-Protein Interaction Network Ready to Predict Potential Drug Targets?
20162 citationsauthor #6
Design, Synthesis, and Biological Evaluation of Novel Tetrahydroprotoberberine Derivatives (THPBs) as Selective α1A-Adrenoceptor Antagonists.
201627 citationsauthor #9
Design , Synthesis , and Biological Evaluation of Novel Tetrahydroprotoberberine Derivatives ( THPBs ) as Selective α 1 A-Adrenoceptor Antagonists
20161 citationsauthor #9
The characteristics of astrocyte on Aβ clearance altered in Alzheimer's disease were reversed by anti-inflammatory agent (+)-2-(1-hydroxyl-4-oxocyclohexyl) ethyl caffeate.
201610 citationsauthor #4
Discovery and Rational Design of Pteridin-7(8H)-one-Based Inhibitors Targeting FMS-like Tyrosine Kinase 3 (FLT3) and Its Mutants.
201626 citationsauthor #9
Discovery and Structural Optimization of N5-Substituted 6,7-Dioxo-6,7-dihydropteridines as Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors against L858R/T790M Resistance Mutation.
201624 citationsauthor #15
Enhancing the Enrichment of Pharmacophore-Based Target Prediction for the Polypharmacological Profiles of Drugs
2016244 citationsauthor #5
A Rapid Python-Based Methodology for Target-Focused Combinatorial Library Design.
20164 citationsauthor #4
Isoindole-1,3-dione derivatives as RSK2 inhibitors: synthesis, molecular docking simulation and SAR analysis
201610 citationsauthor #6
Crystal structures of SIRT3 reveal that the alpha 2-alpha 3 loop and alpha 3-helix affect the interaction with long-chain acyl lysine.
20167 citationsauthor #2
Additional file 7: of Accurate prediction of RNA-binding protein residues with two discriminative structural descriptors
201614 citationsauthor #6
Discovery and Rational Design of Natural-Product-Derived 2-Phenyl-3,4-dihydro-2H-benzo[f]chromen-3-amine Analogs as Novel and Potent Dipeptidyl Peptidase 4 (DPP-4) Inhibitors for the Treatment of Type 2 Diabetes.
201652 citationsauthor #24
The discovery of new plant activators and scaffolds with potential induced systemic resistance: from jasmonic acid to pyrrolidone
20169 citationsauthor #8
Accurate prediction of RNA-binding protein residues with two discriminative structural descriptors
201610 citationsauthor #6
Discovery of peptide inhibitors targeting human programmed death 1 (PD-1) receptor
201648 citationsauthor #10
Distinctive effect on nerve growth factor-induced PC12 cell neurite outgrowth by two unique neolignan enantiomers from Illicium merrillianum
20156 citationsauthor #4
Abstract LB-A13: Cellular characterization of the selective inhibition of UBA5 by organometallic, adenosine-based inhibitors
20150 citationsauthor #6
Rational Design of Benzylidenehydrazinyl-Substituted Thiazole Derivatives as Potent Inhibitors of Human Dihydroorotate Dehydrogenase with in Vivo Anti-arthritic Activity
201523 citationsauthor #15
An Accurate Metalloprotein-Specific Scoring Function and Molecular Docking Program Devised by a Dynamic Sampling and Iteration Optimization Strategy
201518 citationsauthor #6
Pterocarpans and triterpenoids from Gueldenstaedtia verna.
20157 citationsauthor #7
Antiproliferative and apoptosis-inducing activities of novel naphthalimide-cyclam conjugates through dual topoisomerase (topo) I/II inhibition.
201528 citationsauthor #11
Design, synthesis, X-ray crystallographic analysis, and biological evaluation of thiazole derivatives as potent and selective inhibitors of human dihydroorotate dehydrogenase.
201550 citationsauthor #17
Synthesis and biological evaluation of pentanedioic acid derivatives as farnesyltransferase inhibitors
201510 citationsauthor #7
Design, synthesis and evaluation of PPAR gamma binding activity of 2-thioxo-4-thiazolidinone derivatives
201519 citationsauthor #7
Ponatinib efficiently kills imatinib-resistant chronic eosinophilic leukemia cells harboring gatekeeper mutant T674I FIP1L1-PDGFRα: roles of Mcl-1 and β-catenin
201423 citationsauthor #3
A sesquiterpene lactone from a medicinal herb inhibits proinflammatory activity of TNF-α by inhibiting ubiquitin-conjugating enzyme UbcH5.
201454 citationsauthor #8
Identification of diverse natural products as falcipain-2 inhibitors through structure-based virtual screening.
201421 citationsauthor #9
iDrug: a web-accessible and interactive drug discovery and design platform
201436 citationsauthor #10

TIMELINE

2004 50 citations

2006 389 citations

2007 16 citations

2008 163 citations

2009 602 citations

2010 904 citations

2011 545 citations

2012 295 citations

2013 793 citations

2014 204 citations

2015 161 citations

2016 500 citations

2017 1,632 citations

2018 172 citations

2019 185 citations

2020 355 citations

2021 74 citations

2022 141 citations

2023 78 citations

Honglin Li

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PAPERS

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