G. Chuang

A multidonor class of highly glycan-dependent HIV-1 gp120-gp41 interface-targeting broadly neutralizing antibodies.
20244 citationsauthor #9
Design of soluble HIV-1 envelope trimers free of covalent gp120-gp41 bonds with prevalent native-like conformation
20248 citationsauthor #13
Cholesterol reduction by immunization with a PCSK9 mimic
20244 citationsauthor #2
Antibody-directed evolution reveals a mechanism for enhanced neutralization at the HIV-1 fusion peptide site
202311 citationsauthor #23
Diverse Murine Vaccinations Reveal Distinct Antibody Classes to Target Fusion Peptide and Variation in Peptide Length to Improve HIV Neutralization
202311 citationsauthor #5
A monkeypox mRNA-lipid nanoparticle vaccine targeting virus binding, entry, and transmission drives protection against lethal orthopoxviral challenge
202215 citationsauthor #5
C3-Symmetric Aromatic Core of Griffithsin Is Essential for Potent Anti-HIV Activity.
20222 citationsauthor #7
Bivalent SARS-CoV-2 mRNA vaccines increase breadth of neutralization and protect against the BA.5 Omicron variant
202222 citationsauthor #14
Antigenic analysis of the HIV-1 envelope trimer implies small differences between structural states 1 and 2
202210 citationsauthor #9
mRNA-1273 or mRNA-Omicron boost in vaccinated macaques elicits similar B cell expansion, neutralizing responses, and protection from Omicron
2022156 citationsauthor #57
Structure of an influenza group 2-neutralizing antibody targeting the hemagglutinin stem supersite.
20227 citationsauthor #16
Bivalent SARS-CoV-2 mRNA vaccines increase breadth of neutralization and protect against the BA.5 Omicron variant in mice
2022145 citationsauthor #15
Potent SARS-CoV-2 neutralizing antibodies directed against spike N-terminal domain target a single supersite
2021521 citationsauthor #18
Blocking α4β7 integrin delays viral rebound in SHIVSF162P3-infected macaques treated with anti-HIV broadly neutralizing antibodies
202111 citationsauthor #10
GLYCO: a tool to quantify glycan shielding of glycosylated proteins
20212 citationsauthor #5
Sequence-Signature Optimization Enables Improved Identification of Human HV6-1-Derived Class Antibodies That Neutralize Diverse Influenza A Viruses
20216 citationsauthor #1
Vaccination in a humanized mouse model elicits highly protective PfCSP-targeting anti-malarial antibodies.
202133 citationsauthor #9
Extended antibody-framework-to-antigen distance observed exclusively with broad HIV-1-neutralizing antibodies recognizing glycan-dense surfaces
20217 citationsauthor #14
Design of Alphavirus Virus-Like Particles Presenting Circumsporozoite Junctional Epitopes That Elicit Protection against Malaria
202118 citationsauthor #3
N-terminal transmembrane-helix epitope tag for x-ray crystallography and electron microscopy of small membrane proteins.
202122 citationsauthor #7
Nanobodies from camelid mice and llamas neutralize SARS-CoV-2 variants
2021195 citationsauthor #18
Structural basis of glycan276-dependent recognition by HIV-1 broadly neutralizing antibodies
20219 citationsauthor #6
Mutational fitness landscapes reveal genetic and structural improvement pathways for a vaccine-elicited HIV-1 broadly neutralizing antibody
202119 citationsauthor #7
Structural basis of LAIR1 targeting by polymorphic Plasmodium RIFINs
20216 citationsauthor #15
Multimeric nanobodies from camelid engineered mice and llamas potently neutralize SARS-CoV-2 variants
202113 citationsauthor #12
Newcastle Disease Virus-Like Particles Displaying Prefusion-Stabilized SARS-CoV-2 Spikes Elicit Potent Neutralizing Responses
202134 citationsauthor #21
Interprotomer disulfide-stabilized variants of the human metapneumovirus fusion glycoprotein induce high titer-neutralizing responses
202125 citationsauthor #8
Vaccination induces maturation in a mouse model of diverse unmutated VRC01-class precursors to HIV-neutralizing antibodies with >50% breadth.
202151 citationsauthor #6
Development of a 3Mut-Apex-Stabilized Envelope Trimer That Expands HIV-1 Neutralization Breadth When Used To Boost Fusion Peptide-Directed Vaccine-Elicited Responses
202024 citationsauthor #1
Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth
202074 citationsauthor #37
Removal of variable domain N-linked glycosylation as a means to improve the homogeneity of HIV-1 broadly neutralizing antibodies
20208 citationsauthor #1
Glycan Positioning Impacts HIV-1 Env Glycan-Shield Density, Function, and Recognition by Antibodies
202010 citationsauthor #14
Immune Monitoring Reveals Fusion Peptide Priming to Imprint Cross-Clade HIV-Neutralizing Responses with a Characteristic Early B Cell Signature
202024 citationsauthor #4
Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains
2020317 citationsauthor #6
VRC34-Antibody Lineage Development Reveals How a Required Rare Mutation Shapes the Maturation of a Broad HIV-Neutralizing Lineage.
202023 citationsauthor #25
Disulfide stabilization of human norovirus GI.1 virus-like particles focuses immune response toward blockade epitopes
20200 citationsauthor #5
Preclinical Development of a Fusion Peptide Conjugate as an HIV Vaccine Immunogen
202046 citationsauthor #3
Impact of glycan positioning on HIV-1 Env glycan shield density, function, and antibody recognition
20201 citationsauthor #14
Structure of Super-Potent Antibody CAP256-VRC26.25 in Complex with HIV-1 Envelope Reveals a Combined Mode of Trimer-Apex Recognition.
202060 citationsauthor #2
A pH-dependent switch mediates conformational masking of SARS-CoV-2 spike
202047 citationsauthor #16
Identification and Structure of a Multidonor Class of Head-Directed Influenza-Neutralizing Antibodies Reveal the Mechanism for Its Recurrent Elicitation.
202021 citationsauthor #18
Disulfide stabilization of human norovirus GI.1 virus-like particles focuses immune response toward blockade epitopes
202014 citationsauthor #5
Vaccination Induces Maturation of Diverse Unmutated VRC01-Class Precursors to HIV-1 Broadly Neutralizing Antibodies in an Ig-Humanized Mouse Model
20201 citationsauthor #6
Cryo-EM Structures Delineate a pH-Dependent Switch that Mediates Endosomal Positioning of SARS-CoV-2 Spike Receptor-Binding Domains
202021 citationsauthor #7
Automated Design by Structure-Based Stabilization and Consensus Repair to Achieve Prefusion-Closed Envelope Trimers in a Wide Variety of HIV Strains.
202034 citationsauthor #13
Cryo-EM structure of vaccine-elicited antibody 0PV-b.01 in complex with HIV-1 Env BG505 DS-SOSIP and antibodies VRC03 and PGT122
201970 citationsauthor #14
Improvement of antibody functionality by structure-guided paratope engraftment
201933 citationsauthor #10
Crystal Structure of RSV strain B18537 Prefusion-stabilized glycoprotein F Variant DS-Cav1
20190 citationsauthor #15
Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization.
201957 citationsauthor #14
Consistent elicitation of cross-clade HIV-neutralizing responses achieved in guinea pigs after fusion peptide priming by repetitive envelope trimer boosting
201943 citationsauthor #4
BCrystal: an interpretable sequence-based protein crystallization predictor
201925 citationsauthor #6
Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry
201946 citationsauthor #7
Structure of Antibody CAP256-VRC26.25 in Complex with HIV-1 Envelope Reveals a Combined Mode of Trimer-Apex Recognition
20192 citationsauthor #2
Longitudinal Analysis Reveals Early Development of Three MPER‐Directed Neutralizing Antibody Lineages from an HIV‐1‐Infected Individual
201990 citationsauthor #23
Crystal Structure and Immunogenicity of the DS-Cav1-Stabilized Fusion Glycoprotein From Respiratory Syncytial Virus Subtype B
201926 citationsauthor #15
Structural Survey of Broadly Neutralizing Antibodies Targeting the HIV-1 Env Trimer Delineates Epitope Categories and Characteristics of Recognition.
201976 citationsauthor #1
Endothelial Targeted Strategies to Combat Oxidative Stress: Improving Outcomes in Traumatic Brain Injury
201935 citationsauthor #5
Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry
201928 citationsauthor #7
Isolation and Structure of an Antibody that Fully Neutralizes Isolate SIVmac239 Reveals Functional Similarity of SIV and HIV Glycan Shields.
201914 citationsauthor #5
Accurate Prediction for Antibody Resistance of Clinical HIV-1 Isolates
201944 citationsauthor #12
Iterative screen optimization maximizes the efficiency of macromolecular crystallization
20198 citationsauthor #7
CRISPro: An Automated Pipeline for Protein Conformation Stabilization by Proline
20184 citationsauthor #4
Structural survey of HIV-1-neutralizing antibodies targeting Env trimer delineates epitope categories and suggests vaccine templates
20182 citationsauthor #1
Accurate Prediction of Antibody Resistance in Clinical HIV-1 Isolates
20180 citationsauthor #12
A human monoclonal antibody prevents malaria infection and defines a new site of vulnerability on Plasmodium falciparum circumsporozoite protein
2018190 citationsauthor #30
Interdomain Stabilization Impairs CD4 Binding and Improves Immunogenicity of the HIV-1 Envelope Trimer.
201843 citationsauthor #18
DeepSol: a deep learning framework for sequence‐based protein solubility prediction
2018193 citationsauthor #4
Author Correction: A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite
201836 citationsauthor #32
Completeness of HIV-1 Envelope Glycan Shield at Transmission Determines Neutralization Breadth
201896 citationsauthor #13
Surface-Matrix Screening Identifies Semi-specific Interactions that Improve Potency of a Near Pan-reactive HIV-1-Neutralizing Antibody
201860 citationsauthor #2
Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1.
201813 citationsauthor #5
PaRSnIP: sequence-based protein solubility prediction using gradient boosting machine
201895 citationsauthor #6
Complete functional mapping of infection- and vaccine-elicited antibodies against the fusion peptide of HIV
201851 citationsauthor #6
A Universal Approach to Optimize the Folding and Stability of Prefusion-Closed HIV-1 Envelope Trimers.
201888 citationsauthor #10
A Neutralizing Antibody Recognizing Primarily N‐Linked Glycan Targets the Silent Face of the HIV Envelope
201873 citationsauthor #4
A human monoclonal antibody prevents malaria infection and defines a new site of vulnerability on Plasmodium falciparum circumsporozoite protein
201865 citationsauthor #30
Structure-based design of a quadrivalent fusion glycoprotein vaccine for human parainfluenza virus types 1–4
201888 citationsauthor #2
Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1
2018273 citationsauthor #5
Structure-Based Design of a Soluble Prefusion-Closed HIV-1 Env Trimer with Reduced CD4 Affinity and Improved Immunogenicity
201787 citationsauthor #1
Crystal structures of trimeric HIV Env with entry inhibitors BMS-378806 and BMS-626529
2017119 citationsauthor #9
Conformational Changes in HIV-1 Env Trimer Induced by a Single CD4 as Revealed by Cryo-EM
20170 citationsauthor #10
Hiv-1 env fusion peptide immunogens and their use
20170 citationsauthor #11
Mapping Polyclonal HIV-1 Antibody Responses via Next-Generation Neutralization Fingerprinting
201770 citationsauthor #7
Antibodyomics: bioinformatics technologies for understanding B‐cell immunity to HIV‐1
201731 citationsauthor #2
Crystal Structure of a Stabilized DS-SOSIP.6mut BG505 gp140 HIV-1 Env Trimer, Containing Mutations I201C-P433C (DS), L154M, Y177W, N300M, N302M, T320L, I420M in Complex with Human Antibodies PGT122 and 35O22 at 4.3 A
20170 citationsauthor #2
Quaternary contact in the initial interaction of CD4 with the HIV-1 envelope trimer
2017107 citationsauthor #11
Corrigendum: Quaternary contact in the initial interaction of CD4 with the HIV-1 envelope trimer
20175 citationsauthor #11
Quantification of the Impact of the HIV-1-Glycan Shield on Antibody Elicitation.
2017173 citationsauthor #5
Soluble Prefusion Closed DS-SOSIP.664-Env Trimers of Diverse HIV-1 Strains.
201761 citationsauthor #6
Crystal Structure of a Stabilized DS-SOSIP.mut4 BG505 gp140 HIV-1 Env Trimer, Containing Mutations I201C-P433C (DS), L154M, N300M, N302M, T320L in Complex with Human Antibodies PGT122 and 35O22 at 4.1 Angstrom
20170 citationsauthor #2
P-D3 Crystal structures of small-molecules HIV-1 entry ihibitor, BMS-378806 and BMS-626529, bound to BG505 SOSIP.664 HIV-1 Env trimer reveal an allosteric competitive etry inhibition mechanism
20170 citationsauthor #7
Adjuvants and the vaccine response to the DS-Cav1-stabilized fusion glycoprotein of respiratory syncytial virus
201749 citationsauthor #6
Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody
2016335 citationsauthor #15
Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G.
2016409 citationsauthor #5
Iterative structure-based improvement of a respiratory syncytial virus fusion glycoprotein vaccine
2016124 citationsauthor #5
Quantifying B cells capable of producing broadly neutralizing antibodies against influenza serves as a metric to guide the development of a universal influenza vaccine
2016305 citationsauthor #4
Iterative structure-based improvement of a respiratory syncytial virus fusion glycoprotein vaccine
201618 citationsauthor #5
Envelope residue 375 substitutions in simian–human immunodeficiency viruses enhance CD4 binding and replication in rhesus macaques
2016220 citationsauthor #14
Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody.
2016289 citationsauthor #8
Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth.
2016358 citationsauthor #12

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