D. Sabatini

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Aliases
David M Sabatini, D. M. Sabatini, David M. Sabatini, D M Sabatini, David Sabatini, Davidm. Sabatini
Publication record
376 papers · 134,873 citations · H-index 144

PAPERS

An evolutionary mechanism to assimilate new nutrient sensors into the mTORC1 pathway
20239 citationsauthor #5
Organelle proteomic profiling reveals lysosomal heterogeneity in association with longevity
202214 citationsauthor #9
Author Correction: NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis
20228 citationsauthor #7
Author Correction: Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila
20223 citationsauthor #11
Zonated leucine sensing by Sestrin-mTORC1 in the liver controls the response to dietary leucine
202251 citationsauthor #14
Structure of the nutrient-sensing hub GATOR2
202261 citationsauthor #10
CLN3 is required for the clearance of glycerophosphodiesters from lysosomes
202299 citationsauthor #15
Collateral deletion of the mitochondrial AAA+ ATPase ATAD1 sensitizes cancer cells to proteasome dysfunction
202215 citationsauthor #15
Author Correction: Histidine catabolism is a major determinant of methotrexate sensitivity
20223 citationsauthor #10
Author Correction: Histidine catabolism is a major determinant of methotrexate sensitivity
20220 citationsauthor #10
Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila
202245 citationsauthor #11
GCN2 adapts protein synthesis to scavenging-dependent growth.
202126 citationsauthor #12
APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia
2021259 citationsauthor #16
Fumarate is a terminal electron acceptor in the mammalian electron transport chain
2021168 citationsauthor #14
mTOR-activating mutations in RRAGD cause kidney tubulopathy and cardiomyopathy (KICA) syndrome
20211 citationsauthor #31
Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling
202126 citationsauthor #18
Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling
20210 citationsauthor #18
DDRE-22. TARGETING SERINE SYNTHESIS IN BRAIN METASTASIS
20210 citationsauthor #22
mTOR-Activating Mutations in RRAGD Are Causative for Kidney Tubulopathy and Cardiomyopathy
202136 citationsauthor #31
Co-deletion of ATAD1 with PTEN primes cells for BIM-mediated apoptosis
20214 citationsauthor #12
MFSD12 mediates the import of cysteine into melanosomes and lysosomes
20202 citationsauthor #8
Author Correction: Tumours with PI3K activation are resistant to dietary restriction
20204 citationsauthor #2
Author Correction: Cooperative nutrient accumulation sustains growth of mammalian cells
20201 citationsauthor #9
Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction
2020100 citationsauthor #8
Increased lysosomal biomass is responsible for the resistance of triple-negative breast cancers to CDK4/6 inhibition
202045 citationsauthor #25
ATRAID regulates the action of nitrogen-containing bisphosphonates on bone
202019 citationsauthor #36
Abstract PR02: Structural and functional analyses of GATOR1, a negative regulator of the mTORC1 pathway
20200 citationsauthor #4
Abstract 5712: Nutrient scarcity confers breast cancer brain metastasis sensitivity to serine synthesis pathway inhibition
20200 citationsauthor #25
Limited Environmental Serine Confers Sensitivity to PHGDH Inhibition in Brain Metastasis
20202 citationsauthor #26
Correction for: Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance
20203 citationsauthor #7
CRISPR screens in physiologic medium reveal conditionally essential genes in human cells
2020113 citationsauthor #6
Abstract IA10: Structure and dynamics of Rag heterodimers in a complex with mTORC1
20200 citationsauthor #8
MCART1 is required for mitochondrial NAD transport
20200 citationsauthor #12
A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance
20200 citationsauthor #21
Increased lysosomal biomass is responsible for the resistance of triple-negative breast cancers to CDK4/6 inhibition.
202013 citationsauthor #25
Lysosomal nucleotide metabolism regulates ER proteostasis through mTOR signaling
20209 citationsauthor #9
Author Correction: A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance
20204 citationsauthor #21
Author Correction: mTOR at the nexus of nutrition, growth, ageing and disease
202043 citationsauthor #2
MCART1/SLC25A51 is required for mitochondrial NAD transport
2020156 citationsauthor #12
Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition.
2020192 citationsauthor #29
Decision letter: Translation in amino-acid-poor environments is limited by tRNAGln charging
20200 citationsauthor #1
Dihydroxyacetone phosphate signals glucose availability to mTORC1
2020182 citationsauthor #8
MFSD12 mediates the import of cysteine into melanosomes and lysosomes
202077 citationsauthor #8
Correction: An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1.
20207 citationsauthor #9
Metabolic determinants of cellular fitness dependent on mitochondrial reactive oxygen species
202044 citationsauthor #6
A Nutrient-Sensing Transition at Birth Triggers Glucose-Responsive Insulin Secretion.
2020107 citationsauthor #8
mTOR at the nexus of nutrition, growth, ageing and disease
20202,136 citationsauthor #2
Dietary modifications for enhanced cancer therapy
2020307 citationsauthor #3
Author Correction: A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance
20200 citationsauthor #21
Abstract A63: Whole-genome CRISPR/CAS9 screen using patient samples reveals JunB as a unique genetic liability
20200 citationsauthor #9
Abstract IA03: Regulation of growth by the mTOR pathway
20200 citationsauthor #1
Sestrin-mediated leucine sensing by mTORC1 is essential for detecting and adapting to a low leucine diet in Drosophila
20200 citationsauthor #1
C7orf59/LAMTOR4 phosphorylation and structural flexibility modulate Ragulator assembly
20198 citationsauthor #9
Cryo-EM Structure of the Human FLCN-FNIP2-Rag-Ragulator Complex.
2019102 citationsauthor #6
The next decade of metabolism
20190 citationsauthor #9
Genome-wide CRISPR screen for Zika virus resistance in human neural cells
2019110 citationsauthor #10
NEK10 Loss of Function Causes a Novel Human Motile Ciliopathy
20190 citationsauthor #7
Activation of PASK by mTORC1 is required for the onset of the terminal differentiation program
201927 citationsauthor #7
Arg-78 of Nprl2 catalyzes GATOR1-stimulated GTP hydrolysis by the Rag GTPases
201954 citationsauthor #4
Nutrient mTORC1 signaling underpins regulatory T cell control of immune tolerance
201939 citationsauthor #9
Structural basis for the docking of mTORC1 on the lysosomal surface
2019173 citationsauthor #15
Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium
2019230 citationsauthor #21
Raptor-Rag-Ragulator complex
20190 citationsauthor #2
Amino acids regulate mTORC1
20190 citationsauthor #2
The next decade of metabolism
20196 citationsauthor #9
Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death
2019351 citationsauthor #15
Nutrient regulation of mTORC1 at a glance
2019266 citationsauthor #2
Architecture of human Rag GTPase heterodimers and their complex with mTORC1
2019115 citationsauthor #9
A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance
201955 citationsauthor #21
Identification and characterization of a transporter complex responsible for the cytosolic entry of nitrogen-containing-bisphosphonates
20180 citationsauthor #8
Abstract NG02: NFS1 undergoes positive selection in lung tumors and protects cells from ferroptosis
20180 citationsauthor #7
Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates
201843 citationsauthor #8
Genome-Wide CRISPR/Cas9 Screening for Identification of Cancer Genes in Cell Lines.
201818 citationsauthor #3
RAB7A phosphorylation by TBK1 promotes mitophagy via the PINK-PARKIN pathway
2018175 citationsauthor #6
Histidine catabolism is a major determinant of methotrexate sensitivity
20180 citationsauthor #10
SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism
2018194 citationsauthor #12
A mouse model of DEPDC5-related epilepsy: Neuronal loss of Depdc5 causes dysplastic and ectopic neurons, increased mTOR signaling, and seizure susceptibility.
201889 citationsauthor #7
Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs.
2018175 citationsauthor #9
Architecture of the human GATOR1 and GATOR1–Rag GTPases complexes
2018165 citationsauthor #11
Architecture of the human GATOR 1 and GATOR 1 – Rag GTPases complexes Citation
20180 citationsauthor #12
Crystal structure of the C7orf59-HBXIP dimer
20180 citationsauthor #5
Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms
2018123 citationsauthor #2
NUFIP1 is a ribosome receptor for starvation-induced ribophagy
2018305 citationsauthor #10
Architecture of the human GATOR1 and GATOR1–Rag GTPases complexes
20180 citationsauthor #12
Glyceraldehyde 3-phosphate dehydrogenase modulates nonoxidative pentose phosphate pathway to provide anabolic precursors in hypoxic tumor cells
201812 citationsauthor #5
ATRAID, a genetic factor that regulates the clinical action of nitrogen-containing bisphosphonates on bone
20183 citationsauthor #36
Cryo-EM structure of GATOR1
20180 citationsauthor #5
Author Correction: High-fat diet enhances stemness and tumorigenicity of intestinal progenitors
201842 citationsauthor #27
Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging.
2018362 citationsauthor #19
MITO-Tag Mice enable rapid isolation and multimodal profiling of mitochondria from specific cell types in vivo
201897 citationsauthor #9
Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors
201837 citationsauthor #14
DEPTOR modulates activation responses in CD4+ T cells and enhances immunoregulation following transplantation
201816 citationsauthor #6
Histidine catabolism is a major determinant of methotrexate sensitivity
2018262 citationsauthor #10
mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient.
2017394 citationsauthor #8
mTORC1 activates PASK-Wdr5 signaling to epigenetically connect the nutrient status with myogenesis
20170 citationsauthor #7
mTOR Signaling in Growth, Metabolism, and Disease.
20173,905 citationsauthor #2
Abstract IA02: Regulation of growth by the mTOR pathway
20170 citationsauthor #1
Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase.
2017496 citationsauthor #8
Abstract 4988: Genome-wide CRISPR screen and metabolite profiling reveal a new mechanism of methotrexate sensitivity
20170 citationsauthor #6
The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway.
2017475 citationsauthor #2

TIMELINE

1983 18 citations

1994 1,570 citations

1995 558 citations

1996 265 citations

1997 27 citations

1998 433 citations

1999 196 citations

2000 181 citations

2001 1,077 citations

2002 4,417 citations

2003 3,058 citations

2004 3,291 citations

2005 8,518 citations

2006 14,755 citations

2007 5,279 citations

2008 6,216 citations

2009 10,778 citations

2010 9,009 citations

2011 5,717 citations

2012 17,608 citations

2013 7,949 citations

2014 4,007 citations

2015 4,525 citations

2016 5,071 citations

2017 12,028 citations

2018 2,118 citations

2019 1,536 citations

2020 3,566 citations

2021 520 citations

2022 299 citations

2023 9 citations

Unknown 410 citations

D. Sabatini

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