J. Fozard

The identification of 7-[(R)-2-((1S,2S)-2-benzyloxycyclopentylamino)-1-hydroxyethyl]-4-hydroxybenzothiazolone as an inhaled long-acting β2-adrenoceptor agonist.
20142 citationsauthor #9
Sphingosine-1-Phosphate-Induced Airway Hyper-Reactivity in Rodents Is Mediated by the Sphingosine-1-Phosphate Type 3 Receptor
201233 citationsauthor #2
An investigation into the structure-activity relationships associated with the systematic modification of the β(2)-adrenoceptor agonist indacaterol.
201231 citationsauthor #9
Solubility-driven optimization of phosphodiesterase-4 inhibitors leading to a clinical candidate.
201227 citationsauthor #23
A role for sensory nerves in the late asthmatic response
2011115 citationsauthor #7
Progress towards novel adenosine receptor therapeutics gleaned from the recent patent literature
201013 citationsauthor #2
From Hypertension (+) to Asthma: Interactions with the Adenosine A 3 Receptor from a Personal Perspective
20108 citationsauthor #1
Synthesis and evaluation of two series of 4'-aza-carbocyclic nucleosides as adenosine A2A receptor agonists.
201010 citationsauthor #7
A3 Adenosine Receptor Regulation of Cells of the Immune System and Modulation of Inflammation
20104 citationsauthor #4
The identification of indacaterol as an ultralong-acting inhaled beta2-adrenoceptor agonist.
201093 citationsauthor #14
Role of sphingosine-1-phosphate (S1P) and the S1P2 receptor in allergen-induced, mast cell-dependent contraction of rat lung parenchymal strips
200913 citationsauthor #3
In vivo pharmacological evaluation of compound 48/80‐induced airways oedema by MRI
200812 citationsauthor #5
Discovery of long acting inhaled muscarinic M3 receptor antagonists
20070 citationsauthor #10
Capsaicin‐induced mucus secretion in rat airways assessed in vivo and non‐invasively by magnetic resonance imaging
200736 citationsauthor #5
ANXIOGENIC AGENTS INCREASE TRIBULIN CONCENTRATIONS IN RAT BRAIN AND HEART
20071 citationsauthor #6
Bleomycin‐induced lung injury assessed noninvasively and in spontaneously breathing rats by proton MRI
200748 citationsauthor #5
Lung inflammation and vascular remodeling after repeated allergen challenge detected noninvasively by MRI.
200743 citationsauthor #7
In Vitro and in Vivo Pharmacological Characterization of 5-[(R)-2-(5,6-Diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-hydroxy-1H-quinolin-2-one (Indacaterol), a Novel Inhaled β2 Adrenoceptor Agonist with a 24-h Duration of Action
2006161 citationsauthor #7
Lung MRI in Small Rodents as a Tool for the Evaluation of Drugs in Models of Airways Diseases
20066 citationsauthor #5
Evidence for trypta mine receptors on cardiac sympathetic nerves
20060 citationsauthor #1
Proton MRI as a noninvasive tool to assess elastase‐induced lung damage in spontaneously breathing rats
200635 citationsauthor #5
Identification with MRI of the pleura as a major site of the acute inflammatory effects induced by ovalbumin and endotoxin challenge in the airways of the rat.
200625 citationsauthor #8
Magnetic Resonance Imaging (MRI) of the Lung as a Tool for the Non-Invasive Evaluation of Drugs in Rat Models of Airways Diseases
20051 citationsauthor #7
Effects of endotoxin and allergen alone and in combination on the sensitivity of the rat airways to adenosine.
20052 citationsauthor #3
A new orally bioavailable dual adenosine A2B/A3 receptor antagonist with therapeutic potential.
200531 citationsauthor #18
A useful muscarinic parameter and the differential recording of atrial and ventricular tension in the perfused rabbit heart
200511 citationsauthor #1
The receptor mechanism mediating the contractile response to adenosine on lung parenchymal strips from actively sensitised, allergen-challenged Brown Norway rats
200520 citationsauthor #2
Suppression of histamine-induced tachypnoea in the rhesus monkey by sibenadet: no role for dopamine D2 receptors.
20042 citationsauthor #1
A locally active antiinflammatory macrolide (MLD987) for inhalation therapy of asthma.
200414 citationsauthor #15
Synthesis and biological properties of novel glucocorticoid androstene C-17 furoate esters.
200416 citationsauthor #11
New highly potent and selective adenosine A(3) receptor antagonists.
200420 citationsauthor #12
Effect of the K+(ATP) channel opener, KCO912, on baseline and allergen induced airway hyperresponsiveness in allergic rabbits.
20048 citationsauthor #3
Interaction between adenosine and allergen or compound 48/80 on lung parenchymal strips from actively sensitized Brown Norway rats.
200411 citationsauthor #3
Blockade of the flare response to intradermal 5-hydroxytryptamine in man by MDL 72.222, a selective antagonist at neuronal 5-hydroxytryptamine receptors
200414 citationsauthor #2
The airways pharmacology of DNK333, a potent, selective, non‐peptide dual NK1/NK2 receptor antagonist
20044 citationsauthor #8
Airway hyperresponsiveness to bradykinin induced by allergen challenge in actively sensitised Brown Norway rats
200421 citationsauthor #4
The case for a role for adenosine in asthma: almost convincing?
200357 citationsauthor #1
Resolution of the oedema associated with allergic pulmonary inflammation in rats assessed noninvasively by magnetic resonance imaging
200345 citationsauthor #6
Controversies in respiratory diseases and their management.
20030 citationsauthor #1
Dual and selective antagonism of neurokinin NK1 and NK2 receptor-mediated responses in human colon mucosa
200323 citationsauthor #3
Effects of immunomodulators on airways hyperresponsiveness to adenosine induced in actively sensitised Brown Norway rats by exposure to allergen
200315 citationsauthor #5
Effects of a mitogen-activated protein kinase inhibitor on allergic airways inflammation in the rat studied by magnetic resonance imaging.
200317 citationsauthor #6
Modeling the response of the asthmatic airways to adenosine: Mechanisms and receptors
20036 citationsauthor #1
Antagonist pharmacology of adenosine A2B receptors from rat, guinea pig and dog.
200339 citationsauthor #1
Techniques: magnetic resonance imaging of the lung provides potential for non-invasive preclinical evaluation of drugs.
200330 citationsauthor #4
Stereoselective preparation of N-[(R,R)-(E)-1-(3,4-dichlorobenzyl)-3- (2-oxoazepan-3-yl)carbamoyl]allyl-N-methyl-3,5-bis(trifluoromethyl)benzamide, a potent and orally active dual neurokinin NK(1)/NK(2) receptor antagonist.
20039 citationsauthor #7
Role of endogenous adenosine in the acute and late response to allergen challenge in actively sensitized Brown Norway rats
20039 citationsauthor #3
Effects of CGS 21680, a selective adenosine A2A receptor agonist, on allergic airways inflammation in the rat.
2002119 citationsauthor #1
A randomised, single blind study to evaluate the effects of action potential simulator therapy compared with placebo in patients with chronic back pain
20027 citationsauthor #2
Pulmonary inflammation monitored noninvasively by MRI in freely breathing rats.
200258 citationsauthor #5
Evidence for an atypical receptor mediating the augmented bronchoconstrictor response to adenosine induced by allergen challenge in actively sensitized Brown Norway rats
200227 citationsauthor #7
Noninvasive detection of endotoxin-induced mucus hypersecretion in rat lung by MRI.
200252 citationsauthor #7
KCO912: a potent and selective opener of ATP-dependent potassium (KATP) channels which suppresses airways hyperreactivity at doses devoid of cardiovascular effects
200218 citationsauthor #6
Airway hyperresponsiveness to adenosine induced by lipopolysaccharide in Brown Norway rats
200214 citationsauthor #5
Species differences in bradykinin receptor-mediated responses of the airways.
200228 citationsauthor #2
Suppression of Adenosine A3 Receptor-Mediated Hypotension and Mast Cell Degranulation in the Rat by Dexamethasone
200210 citationsauthor #4
Adenosine receptor ligands as potential therapeutics in asthma.
200242 citationsauthor #1
Identification of human serum cholinesterase variants using the polyrnerase chain reaction amplification technique
20020 citationsauthor #1
human adenosine A 2B receptor gene: prevalence
20020 citationsauthor #4
Airways pharmacology of DNK333A, a dual NK1/NK2 neurokinin receptor antagonist
20021 citationsauthor #7
Single nucleotide polymorphism analysis of the human adenosine A2B receptor gene: Prevalence of SNPs in asthmatics and normal subjects
20023 citationsauthor #4
Anti‐bronchoconstrictor activities and side effect potential of inhaled formoterol and (S,R)‐epiformoterol in the rhesus monkey
20022 citationsauthor #1
Mechanism of airway hyperresponsiveness to adenosine induced by allergen challenge in actively sensitized Brown Norway rats
200166 citationsauthor #5
Pulmonary edema induced by allergen challenge in the rat: Noninvasive assessment by magnetic resonance imaging
200195 citationsauthor #6
MRI of lung parenchyma in rats and mice using a gradient‐echo sequence
200169 citationsauthor #4
Inhibition by viozan of extravasation induced in rat trachea by capsaicin is mediated exclusively by β2-adrenoceptors
200110 citationsauthor #1
Comparison of the anti-bronchoconstrictor activities of inhaled formoterol, its (R,R)- and (S,S)-enantiomers and salmeterol in the rhesus monkey.
200128 citationsauthor #1
Effects of wortmannin on airways inflammation induced by allergen in actively sensitised Brown Norway rats.
200131 citationsauthor #4
Potassium Channel Openers Agents for the Treatment of Airway Hyperreactivity
20019 citationsauthor #1
Adenosine-mediated mast cell degranulation in adenosine deaminase-deficient mice.
200162 citationsauthor #4
Effects of wortmannin on bronchoconstrictor responses to adenosine in actively sensitised Brown Norway rats.
200010 citationsauthor #4
Adenosine receptor ligands: potential as therapeutic agents in asthma and COPD.
199994 citationsauthor #1
KATP channel openers for the treatment of airways hyperreactivity.
199919 citationsauthor #2
Further pharmacological characterization of the adenosine receptor subtype mediating inhibition of oxidative burst in human isolated neutrophils
199833 citationsauthor #4
Two kinds of tryptamine receptor
19970 citationsauthor #3
SCA 40: studies of the relaxant effects on cryopreserved human airway and vascular smooth muscle
199719 citationsauthor #2
Adenosine receptor modulation of sympathetic neurotransmission in rat isolated kidney
19960 citationsauthor #2
Subtypes of the type 4 cAMP phosphodiesterases: structure, regulation and selective inhibition.
1996155 citationsauthor #3
5-Hydroxytryptamine (5-HT) receptors in migraine
19960 citationsauthor #1
Mast cell degranulation following adenosine A3 receptor activation in rats.
1996131 citationsauthor #1
Neurotherapeutic potential of 5-HT3 receptor antagonists
19961 citationsauthor #7
The 5-hydroxytryptamine-nitric oxide connection: the key link in the initiation of migraine?
199537 citationsauthor #1
Further analysis of the mechanisms underlying the tracheal relaxant action of SCA40
199543 citationsauthor #5
General pharmacology of SDZ WAG 994, a potent selective and orally active adenosine A1 receptor agonist
199522 citationsauthor #8
Salbutamol-induced airway hyperreactivity in guinea pigs is not due to a loss of its bronchodilator effect.
199524 citationsauthor #3
A role for mast cells in adenosine A3 receptor‐mediated hypotension in the rat
1995118 citationsauthor #1
Cardiovascular effects of cyclosporine A and OG 37-325 after chronic administration to conscious rats: role of endothelin.
19944 citationsauthor #1
International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin).
19943,158 citationsauthor #3
Carruthers and Fozard reply
19947 citationsauthor #2
BW-A522 blocks adenosine A3 receptor-mediated hypotensive responses in the rat.
199439 citationsauthor #1
5-Hydroxytryptamine (5-HT) and the initiation of migraine: new perspectives
199453 citationsauthor #1
Pre‐anaesthetic counselling
19930 citationsauthor #1
The cardiovascular effects of selective adenosine A1 and A2 receptor agonists in the pithed rat: no role for glibenclamide-sensitive potassium channels
19938 citationsauthor #1
Effect of pertussis toxin treatment on the putative adenosine A3 receptor-mediated hypotensive response in the rat.
199321 citationsauthor #2
SDZ 216-525, a selective and potent 5-HT1A receptor antagonist.
199352 citationsauthor #2
Hypotensive responses to the putative adenosine A3 receptor agonist N6‐2‐(4‐aminophenyl)‐ethyladenosine in the rat
199311 citationsauthor #2
The novel 5‐HT1A receptor antagonist, SDZ 216–525, decreases 5‐HT release in rat hippocampus in vivo
199321 citationsauthor #3
Pharmacological properties of dolasetron, a potent and selective antagonist at 5‐HT3 receptors
199378 citationsauthor #6
Adenosine A3 receptors 1 mediate hypotension in the angiotensin II‐supported circulation of the pithed rat
1993121 citationsauthor #1
Contraction of the rat isolated spleen mediated by adenosine A1 receptor activation
199329 citationsauthor #1

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