H. Schut

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Aliases
Herman A Schut, Herman A.j. Schut, Herman A J Schut, H A Schut, Herman A. J. Schut, H. A.j. Schut, H.a.j Schut, H. Schut, H.a.j. Schut, H. A. J. Schut, H A J Schut
Publication record
114 papers · 3,807 citations · H-index 35

PAPERS

Biotransformation of Occupational Carcinogens
20200 citationsauthor #1
Activation of aminoimidazole carcinogens by nitrosation: mutagenicity and nucleotide adducts.
200916 citationsauthor #3
Deficiency in N-acetylgalactosamine-6-sulfate sulfatase results in collagen perturbations in cartilage of Morquio syndrome A patients.
200936 citationsauthor #6
Novel LC-ESI/MS/MS(n) method for the characterization and quantification of 2'-deoxyguanosine adducts of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by 2-D linear quadrupole ion trap mass spectrometry.
200778 citationsauthor #2
Stability and reactivity of 2-nitrosoamino-3,8-dimethylimidazo[4,5-f]quinoxaline.
200610 citationsauthor #3
Metabolic Activation and Genotoxicity of Heterocyclic Arylamines1
20060 citationsauthor #3
Comparative Carcinogenicity in A/J Mice and Metabolism by Cultured Mouse Peripheral Lung of AT-Nitrosonornicotine, and Their Analogues1
20060 citationsauthor #7
Role of nucleotide excision repair deficiency in intestinal tumorigenesis in multiple intestinal neoplasia (Min) mice.
20067 citationsauthor #2
P-Postlabeling analysis of IQ , MelQx and PhIP adducts formed in vitro in DNA and polynucleotides and found in vivo in hepatic DNA from IQ-, MelQx-and PhlP-treated monkeys
20051 citationsauthor #5
Age at exposure and Apc status influence the levels of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-DNA adducts in mouse intestine and liver.
20056 citationsauthor #2
2-Nitrosoamino-3-methylimidazo[4,5-f]quinoline activated by the inflammatory response forms nucleotide adducts.
200515 citationsauthor #2
Susceptibility of rats to mammary gland carcinogenesis by the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) varies with age and is associated with the induction of differential gene expression.
200430 citationsauthor #3
457 Different levels of PhlP-DNA adducts in mice depending on exposure time point and APC status could not be explained by differences in cell proliferation
20030 citationsauthor #2
Mutagenesis and DNA adduct formation in the mouse mammary gland exposed to 2-hydroxyamino-1-methyl-6-phenylimidazo-[4,5-b]pyridine in whole organ culture.
20031 citationsauthor #5
Chemoprevention of oral cancer by black raspberries.
2002129 citationsauthor #6
Mutagenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the mammary gland of Big Blue rats on high-and low-fat diets.
200216 citationsauthor #5
Effect of CYP1A2 deficiency on heterocyclic amine DNA adduct levels in mice.
200240 citationsauthor #3
Lobe-specific increases in malondialdehyde DNA adduct formation in the livers of mice following infection with Helicobacter hepaticus.
200148 citationsauthor #7
Intestinal tumorigenesis in multiple intestinal neoplasia mice induced by the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine: perinatal susceptibility, regional variation, and correlation with DNA adducts.
200132 citationsauthor #2
Indole-3-carbinol as a chemopreventive agent in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) carcinogenesis: inhibition of PhIP-DNA adduct formation, acceleration of PhIP metabolism, and induction of cytochrome P450 in female F344 rats.
200062 citationsauthor #4
Age-related alterations in 32P-postlabeled DNA adducts in livers of mice infected with the tumorigenic bacterial pathogen, Helicobacter hepaticus.
20005 citationsauthor #2
Tea as a Potential Chemopreventive Agent in PhIP Carcinogenesis: Effects of Green Tea and Black Tea on PhIP-DNA Adduct Formation in Female F-344 Rats
200045 citationsauthor #1
Inhibition of DNA adduct formation of 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine and 2‐amino‐3‐methylimidazo[4,5‐f]quinoline by dietary indole‐3‐carbinol in female rats
199916 citationsauthor #2
N-Acetyltransferase expression and DNA binding of N-hydroxyheterocyclic amines in human prostate epithelium.
199969 citationsauthor #3
DNA adducts of heterocyclic amine food mutagens: implications for mutagenesis and carcinogenesis.
1999345 citationsauthor #1
Dietary omega-3 fatty acids as potential inhibitors of carcinogenesis: effect on DNA adduct formation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in mice and rats.
199918 citationsauthor #2
Inhibition of cell death in human mammary epithelial cells by the cooked meat-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4, 5-b]pyridine.
199910 citationsauthor #4
In vivo mutagenicity and hepatocarcinogenicity of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in bitransgenic c-myc/lambda lacZ mice.
199918 citationsauthor #4
Prevention by aspirin and its combination with alpha-difluoromethylornithine of azoxymethane-induced tumors, aberrant crypt foci and prostaglandin E2 levels in rat colon.
1999102 citationsauthor #2
Effects of dietary conjugated linoleic acid on DNA adduct formation of PhIP and IQ after bolus administration to female F344 rats.
199822 citationsauthor #2
Formation of DNA adducts of the food-derived mutagen 2-amino-9H-pyrido-[2,3-b]indole (A(alpha)C) and bioassay of mammary gland carcinogenicity in Sprague-Dawley rats.
199817 citationsauthor #4
Inhibition of DNA adduct formation of PhIP in female F344 rats by dietary conjugated linoleic acid.
199829 citationsauthor #4
Proliferation, development and DNA adduct levels in the mammary gland of rats given 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and a high fat diet.
199829 citationsauthor #3
DNA adducts of heterocyclic amines: formation, removal and inhibition by dietary components.
199749 citationsauthor #1
Inhibition of 2-amino-3-methylimidazo[4,5-f]quinoline-DNA adducts by indole-3-carbinol: dose-response studies in the rat colon.
199735 citationsauthor #2
Chemopreventive properties of Indole‐3‐Carbinol (I3C): Inhibition of DNA adduct formation of the dietary carcinogen, 2‐Amino‐1‐Methyl‐6‐Phenylimidazo [4,5‐b]Pyridine (PhIP), in female F344 rats
199733 citationsauthor #3
Metabolism of food-derived heterocyclic amines in nonhuman primates.
199756 citationsauthor #6
Formation and persistence of DNA adducts of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in CDF1 mice fed a high omega-3 fatty acid diet.
199719 citationsauthor #1
In vivo mutagenicity and DNA adduct levels of heterocyclic amines in Muta mice and c-myc/lacZ double transgenic mice.
199637 citationsauthor #3
O6-methylguanine levels and histopathological changes in the rat esophagus and liver following single and repeated administration of N-nitrosomethylbenzylamine.
19967 citationsauthor #3
Loss of heterozygosity on chromosomes 1, 11, 12, and 14 in hybrid mouse lung adenocarcinomas
199619 citationsauthor #4
O6-Methyguanine levels and histopathological changes in the rat esophagus and liver following single and repeated administration of N-nitrosomethylbenzylamin
199613 citationsauthor #3
Validation in rats of two biomarkers of exposure to the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP): PhIP-DNA adducts and urinary PhIP.
199624 citationsauthor #6
MOLECULAR EPIDEMIOLOGY AND CANCER PREVENTION: Protection by green tea, black tea, and indole-3-carbinol against 2-amino-3-methylimidazo[4,5-f]quinoline-induced DNA adducts and colonic aberrant crypts in the F344 rat
1996152 citationsauthor #5
Distribution of the DNA adducts of 2‐amino‐3–methylimidazo[4,5–f]quinoline and 2–amino‐1–methyl‐6–phenylimidazo[4,5–b]pyridine in the supF gene as determined by polymerase arrest assay
19958 citationsauthor #2
Protection of conjugated linoleic acids against 2-amino-3- methylimidazo[4,5-f]quinoline-induced colon carcinogenesis in the F344 rat: a study of inhibitory mechanisms.
1995294 citationsauthor #2
Inhibition of DNA Adduct Formation of 2‐Amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine (PhIP) by Dietary Indole‐3‐carbinol (I3C) in the Mammary Gland, Colon, and Liver of the Female F‐344 Rat
199513 citationsauthor #1
Cytotoxicity, DNA adduct formation and DNA repair induced by 2-hydroxyamino-3-methylimidazo[4,5-f]quinoline and 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine in cultured human mammary epithelial cells.
199537 citationsauthor #2
Protection by chlorophyllin and indole-3-carbinol against 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced DNA adducts and colonic aberrant crypts in the F344 rat.
1995125 citationsauthor #2
DNA adducts of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in colon, bladder, and kidney of congenic mice differing in Ah responsiveness and N-acetyltransferase genotype.
199521 citationsauthor #2
Inhibitory effect of dietary 4-ipomeanol on DNA adduct formation by the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in male CDF1 mice.
199514 citationsauthor #2
Possible relationship between tissue distribution of DNA adducts and genotoxicity of food-derived heterocyclic amines.
19959 citationsauthor #3
Possible mechanisms for PhIP-DNA adduct formation in the mammary gland of female Sprague-Dawley rats.
199551 citationsauthor #3
Consequences of 3-methylcholanthrene-type induction for the metabolism of 4-aminobiphenyl in isolated rat hepatocytes.
199420 citationsauthor #3
Inhibition of Chemically Induced Carcinogenesis by Citrus Limonoids
199433 citationsauthor #4
Accumulation of DNA adducts of 2-amino-3-methylimidazo[4,5-f] quinoline (IQ) in tissues and white blood cells of the Fischer-344 rat after multiple oral dosing.
199414 citationsauthor #1
Metabolic activation of heterocyclic amine food mutagens in the mammary gland of lactating Fischer 344 rats.
199415 citationsauthor #3
Removal of DNA adducts of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the male Fischer-344 rat.
199430 citationsauthor #2
Metabolism of the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by lactating Fischer 344 rats and their nursing pups.
199416 citationsauthor #3
Adduction of the heterocyclic amine food mutagens IQ and PhIP to mitochondrial and nuclear DNA in the liver of Fischer-344 rats.
199420 citationsauthor #2
Mutagenic specificity of 2-amino-3-methylimidazo[4,5-f]quinoline and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in the supF shuttle vector system.
199443 citationsauthor #2
DNA adduct levels of 2-amino-1-methyl-6-phenylimidazo-[4,5-b]pyridine (PhIP) in tissues of cynomolgus monkeys after single or multiple dosing.
199432 citationsauthor #2
Dietary modulation of DNA adduct formation of the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline in the male Fischer 344 rat.
19946 citationsauthor #1
Effects of dietary menhaden oil on DNA adducts of the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in Fischer-344 rats.
199311 citationsauthor #1
Mutagenic activation of IQ, PhIP and MeIQx by hepatic microsomes from rat, monkey and man: low mutagenic activation of MeIQx in cynomolgus monkeys in vitro reflects low DNA adduct levels in vivo.
199359 citationsauthor #2
Quantitation of 2‐amino‐3‐methylimidazo[4,5‐f]quinoline and 2‐amino‐3,8‐dimethylimidazo[4,5‐f]quinoxaline DNA adducts in specific sequences using alkali or uvrABC excinuclease
19935 citationsauthor #3
Effect of 3-methylcholanthrene induction on the distribution and DNA adduction of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in F344 rats.
199317 citationsauthor #3
ras mutations in 2‐amino‐3‐methylimidazo‐[4,5‐f]quinoline—induced tumors in the CDF1 mouse
199312 citationsauthor #2
32P-postlabeling analysis of IQ, MeIQx and PhIP adducts formed in vitro in DNA and polynucleotides and found in vivo in hepatic DNA from IQ-, MeIQx- and PhIP-treated monkeys.
199371 citationsauthor #5
Enzymatic phase II activation of the N-hydroxylamines of IQ, MeIQx and PhIP by various organs of monkeys and rats.
199376 citationsauthor #2
Inhibition of 2-amino-3-methylimidazo[4,5-f]quinoline-DNA adduct formation in CDF1 mice by heat-altered derivatives of linoleic acid.
199246 citationsauthor #2
Formation of DNA adducts of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in male Fischer-344 rats.
199265 citationsauthor #1
Metabolic activation and genotoxicity of heterocyclic arylamines.
199235 citationsauthor #2
DNA adducts in humans as dosimeters of exposure to environmental, occupational, or dietary genotoxins 1
199237 citationsauthor #1
Similar patterns of DNA adduct formation of 2-amino-3-methylimidazo [4,5-f]quinoline in the Fischer 344 rat, CDF1 mouse, cynomolgus monkey and Salmonella typhimurium.
199127 citationsauthor #1
Cytochrome P4501A2 constitutively expressed from transduced DNA mediates metabolic activation and DNA‐adduct formation of aromatic amine carcinogens in NIH 3T3 cells
199118 citationsauthor #2
Sex differences in the formation and persistence of DNA adducts of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in CDF1 mice.
199114 citationsauthor #2
Formation and persistence of DNA adducts of 2-amino-3-methylimidazo[4,5-f] quinoline in male Fischer-344 rats.
199113 citationsauthor #2
A mammalian cell system expressing cytochrome P450 for in situ evaluation of metabolism, genotoxicity, and mutagenicity of xenobiotics
19900 citationsauthor #3
Preferential activation and genotoxicity of food derived heterocyclic amine mutagens by recombinant cytochrome P4501A2.
19907 citationsauthor #4
Role of recombinant cytochromes P4501A1 and P4501A2 in the metabolism and genotoxicity of food derived mutagens.
19901 citationsauthor #3
DNA adduct formation of the carcinogen 2-amino-3-methylimidazo[4,5-f]-quinoline in target tissues of the F-344 rat.
198850 citationsauthor #1
Preliminary investigations of tissue specificity, species specificity, and strategies for identifying chemicals causing DNA adducts in human placenta.
198719 citationsauthor #4
DNA binding of 4,4'-methylene-bis(2-chloroaniline) (MOCA) in explant cultures of human and dog bladder.
198711 citationsauthor #3
Metabolism of 4,4′-methylene-bis(2-chloroaniline) in explant cultures of human and dog bladder and dog liver cell cultures
19871 citationsauthor #3
Metabolism of the oesophageal carcinogen N-nitrosomethylamylamine: changes with age, clearance from blood and DNA alkylation.
19872 citationsauthor #4
Ethylnitrosourea-induced transplacental carcinogenesis in the mouse: tumor response, DNA binding, and adduct formation.
198714 citationsauthor #3
Metabolism and DNA binding of 2,6-dinitrotoluene in Fischer-344 rats and A/J mice.
198618 citationsauthor #2
A comparison of covalent DNA binding of benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene in respiratory tissues from human, rat and mouse.
19867 citationsauthor #2
In vivo and in vitro metabolism of 2,4-dinitrotoluene in strain A mice.
19859 citationsauthor #1
Bioassay of Military Relevant Compounds for Carcinogenic Activity by the Strain A Mouse Lung Tumor Bioassay
19850 citationsauthor #2
A comparison of the lung adenoma response in strain A/J mice after intraperitoneal and oral administration of carcinogens.
198440 citationsauthor #3
Interindividual Variation in the DNA Binding of Chemical Genotoxins Following Metabolism by Human Bladder and Bronchus Explants
19848 citationsauthor #3
Metabolism and DNA adduct formation of 2-acetylaminofluorene by bladder explants from human, dog, monkey, hamster and rat.
198430 citationsauthor #1
Interspecies comparisons of benzo(a)pyrene metabolism and DNA-adduct formation in cultured human and animal bladder and tracheobronchial tissues.
198341 citationsauthor #2
Metabolism of tobacco-specific N-nitrosamines by cultured human tissues.
1983105 citationsauthor #3
Dna alkylation in human and animal esophageal and colonic explants. Abstr.
19830 citationsauthor #1
Comparative carcinogenicity in A/J mice and metabolism by cultured mouse peripheral lung of N'-nitrosonornicotine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, and their analogues.
1983150 citationsauthor #11
Distribution, elimination, and test for carcinogenicity of 2,4-dinitrotoluene in strain A mice.
198213 citationsauthor #1
Metabolism and DNA binding of benzo[a]pyrene in cultured human bladder and bronchus.
198251 citationsauthor #4

TIMELINE

1977 18 citations

1978 159 citations

1979 12 citations

1981 3 citations

1982 99 citations

1983 296 citations

1984 78 citations

1985 9 citations

1986 25 citations

1987 47 citations

1988 50 citations

1990 8 citations

1991 72 citations

1992 183 citations

1993 251 citations

1994 229 citations

1995 572 citations

1996 252 citations

1997 192 citations

1998 97 citations

1999 578 citations

2000 112 citations

2001 80 citations

2002 185 citations

2003 1 citations

2004 30 citations

2005 22 citations

2006 17 citations

2007 78 citations

2009 52 citations

2020 0 citations

Unknown 0 citations

H. Schut

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