G. Feng

Identification of CD133+ intercellsomes in intercellular communication to offset intracellular signal deficit
20232 citationsauthor #7
Osr1 Is a Critical Regulator of Macrophage Polarization in NASH Progression
20231 citationsauthor #2
Shp2 Deficiency in Kupffer Cells and Hepatocytes Aggravates Hepatocarcinogenesis by Recruiting Non-Kupffer Macrophages
20236 citationsauthor #7
Intercellular Communication Compensates Intracellular Proliferative Signal Deficit during Liver Regeneration
20230 citationsauthor #6
Unfavorable tumor responses to immunotherapy in the liver: Lessons learned from clinical and preclinical studies
20230 citationsauthor #2
CD133 + Intercellsome Mediates Direct Cell-Cell Communication to Offset Intracellular Signal Deficit
20220 citationsauthor #5
Pharmaceutical SH2 domain–containing protein tyrosine phosphatase 2 inhibition suppresses primary and metastasized liver tumors by provoking hepatic innate immunity
20228 citationsauthor #6
Single-cell transcriptomics reveals opposing roles of Shp2 in Myc-driven liver tumor cells and microenvironment.
202140 citationsauthor #8
Targeting chondrocytes for arresting bony fusion in ankylosing spondylitis
202140 citationsauthor #9
Temporal Analyses of Postnatal Liver Development and Maturation by Single Cell Transcriptomics
202181 citationsauthor #7
Androgen receptor, neovascularization and liver cancer metastasis.
20215 citationsauthor #3
Concurrent Disruption of Ras/MAPK and NF-κB Pathways Induces Circadian Deregulation and Hepatocarcinogenesis.
20219 citationsauthor #8
Enhancing the therapeutic efficacy of programmed death ligand 1 antibody for metastasized liver cancer by overcoming hepatic immunotolerance in mice
202121 citationsauthor #7
Human‐specific polymorphic pseudogenization of SIGLEC12 protects against advanced cancer progression
202019 citationsauthor #12
SHP-2 tyrosine phosphatase inhibits p73-dependent apoptosis and expression of a subset of p53-target genes induced by the green tea polyphenol EGCG
20200 citationsauthor #4
Improving the Efficacy of Liver Cancer Immunotherapy: The Power of Combined Preclinical and Clinical Studies
202055 citationsauthor #1
Disrupting phosphatase SHP2 in macrophages protects mice from high-fat diet-induced hepatic steatosis and insulin resistance by elevating IL-18 levels
202022 citationsauthor #12
Inhibition of SHP2 ameliorates psoriasis by decreasing TLR7 endosome localization
20201 citationsauthor #13
TCF1 and LEF1 Control Treg Competitive Survival and Tfr Development to Prevent Autoimmune Diseases
201991 citationsauthor #10
A tumorigenic index for quantitative analysis of liver cancer initiation and progression
201912 citationsauthor #7
Hepatic Autophagy Deficiency Compromises Farnesoid X Receptor Functionality and Causes Cholestatic Injury
201951 citationsauthor #13
Hepatic Autophagy Deficiency Compromises FXR Functionality and Causes Cholestatic Injury
20191 citationsauthor #13
An Efficient Combination Immunotherapy for Primary Liver Cancer by Harmonized Activation of Innate and Adaptive Immunity in Mice
201950 citationsauthor #9
Stress Conditions Induced by Locoregional Therapies Stimulate Enrichment and Proliferation of Liver Cancer Stem Cells.
201910 citationsauthor #4
Tumor immunology and immunotherapy: a journey I started from Hangzhou
20191 citationsauthor #1
The role of tyrosine phosphatase Shp2 in spermatogonial differentiation and spermatocyte meiosis
201917 citationsauthor #8
Lens differentiation is controlled by the balance between PDGF and FGF signaling
201938 citationsauthor #7
β‐catenin deficiency in hepatocytes aggravates hepatocarcinogenesis driven by oncogenic β‐catenin and MET
201835 citationsauthor #11
Crk proteins transduce FGF signaling to promote lens fiber cell elongation
201842 citationsauthor #6
High-fat Feeding Reprograms Maternal Energy Metabolism and Induces Long-term Postpartum Obesity in Mice
201820 citationsauthor #6
β‐Catenin Deficiency in Hepatocytes Aggravates Hepatocarcinogenesis Driven by Oncogenic β‐Catenin and MET
20181 citationsauthor #11
Shp2 deletion in hepatocytes suppresses hepatocarcinogenesis driven by oncogenic β-Catenin, PIK3CA and MET.
201846 citationsauthor #10
A New Preventive Therapeutic Strategy for Liver Cancer
20180 citationsauthor #2
Preventive Inhibition of Liver Tumorigenesis by Systemic Activation of Innate Immune Functions.
201725 citationsauthor #10
Alx4 relays sequential FGF signaling to induce lacrimal gland morphogenesis
201728 citationsauthor #4
Gel-seq: whole-genome and transcriptome sequencing by simultaneous low-input DNA and RNA library preparation using semi-permeable hydrogel barriers.
20173 citationsauthor #6
Nuclear Shp2 directs normal embryo implantation via facilitating the ERα tyrosine phosphorylation by the Src kinase
201735 citationsauthor #10
Gab2 mediates hepatocellular carcinogenesis by integrating multiple signaling pathways
201723 citationsauthor #12
Tyrosine phosphatase SHP2 negatively regulates NLRP3 inflammasome activation via ANT1-dependent mitochondrial homeostasis
20170 citationsauthor #9
Tyrosine phosphatase SHP2 negatively regulates NLRP3 inflammasome activation via ANT1-dependent mitochondrial homeostasis
2017126 citationsauthor #9
Deletion of Gab2 in mice protects against hepatic steatosis and steatohepatitis: a novel therapeutic target for fatty liver disease.
201622 citationsauthor #13
Dual Shp2 and Pten Deficiencies Promote Non-alcoholic Steatohepatitis and Genesis of Liver Tumor-Initiating Cells.
201642 citationsauthor #15
Treating leukemia at the risk of inducing severe anemia.
20163 citationsauthor #3
Targeting of Ras-mediated FGF signaling suppresses Pten-deficient skin tumor
201613 citationsauthor #5
Metavir and FIB-4 scores are associated with patient prognosis after curative hepatectomy in hepatitis B virus-related hepatocellular carcinoma: a retrospective cohort study at two centers in China
201620 citationsauthor #8
SHP‐2 Phosphatase Prevents Colonic Inflammation by Controlling Secretory Cell Differentiation and Maintaining Host‐Microbiota Homeostasis
201623 citationsauthor #8
Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting
2016746 citationsauthor #11
SHP-2 phosphatase contributes to KRAS-driven intestinal oncogenesis but prevents colitis-associated cancer development
201617 citationsauthor #7
Abnormal PTPN11 enhancer methylation promotes rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and joint inflammation.
201647 citationsauthor #10
A new VETC in hepatocellular carcinoma metastasis
201510 citationsauthor #2
Shp2 and Pten have antagonistic roles in myeloproliferation but cooperate to promote erythropoiesis in mammals
201510 citationsauthor #13
PTPN11/Shp2 overexpression enhances liver cancer progression and predicts poor prognosis of patients.
2015134 citationsauthor #15
SHP-2 Mediates C-type Lectin Receptors-induced Syk Activation and Anti-fungal TH17 Responses
201538 citationsauthor #22
SHP2‐Deficiency in Chondrocytes Deforms Orofacial Cartilage and Ciliogenesis in Mice
201516 citationsauthor #5
Deletion of the tyrosine phosphatase Shp2 in Sertoli cells causes infertility in mice
201549 citationsauthor #11
Tyrosine phosphatase SHP-2 mediates C-type lectin receptor–induced activation of the kinase Syk and anti-fungal TH17 responses
201584 citationsauthor #22
Giα proteins exhibit functional differences in the activation of ERK1/2, Akt and mTORC1 by growth factors in normal and breast cancer cells
20140 citationsauthor #7
Targeted Disruption of Shp2 in Chondrocytes Leads to Metachondromatosis With Multiple Cartilaginous Protrusions
201451 citationsauthor #2
The Transition from Stem Cell to Progenitor Spermatogonia and Male Fertility Requires the SHP2 Protein Tyrosine Phosphatase
201444 citationsauthor #8
Grb2-associated binder 1 is essential for cardioprotection against ischemia/reperfusion injury
201423 citationsauthor #14
C/EBPα regulates macrophage activation and systemic metabolism.
201451 citationsauthor #8
SHP-2 deletion in postmigratory neural crest cells results in impaired cardiac sympathetic innervation
201419 citationsauthor #4
EBP regulates macrophage activation and systemic metabolism
20144 citationsauthor #8
Protein-tyrosine Phosphatase Shp2 Positively Regulates Macrophage Oxidative Burst*
201440 citationsauthor #9
Miceagainst Intestinal Inflammation in Epithelial Tyrosine Phosphatase SHP-2
20140 citationsauthor #1
Frs2&agr; and Shp2 signal independently of Gab to mediate FGF signaling in lens development
201439 citationsauthor #7
Computation-guided discovery of influenza endonuclease inhibitors.
201427 citationsauthor #5
Macrophage Depletion Disrupts Immune Balance and Energy Homeostasis
201427 citationsauthor #4
IN THE SPOTLIGHT VEGFA Genomic Amplifi cation Tailors Treatment of HCCs with Sorafenib
20140 citationsauthor #2
Giα proteins exhibit functional differences in the activation of ERK1/2, Akt and mTORC1 by growth factors in normal and breast cancer cells
201417 citationsauthor #7
NCOA5, a molecular link between type 2 diabetes and liver cancer.
201412 citationsauthor #2
Bridging cell surface receptor with nuclear receptors in control of bile acid homeostasis
20146 citationsauthor #3
Intermittent Cold Exposure Enhances Fat Accumulation in Mice
201446 citationsauthor #6
Tyrosine Phosphatase Shp2 Mediates the Estrogen Biological Action in Breast Cancer via Interaction with the Estrogen Extranuclear Receptor
201426 citationsauthor #9
Macrophage NADPH Oxidase Activation and ROS Production Is Positively Regulated By Shp2 Phosphatase Function
20140 citationsauthor #11
Adiponectin reduces thermogenesis by inhibiting brown adipose tissue activation in mice
201475 citationsauthor #5
Functional and Mechanistic Contribution of Shp 2 to Oxidative Burst 1 Protein Tyrosine Phosphatase , Shp 2 , Positively Regulates Macrophage Oxidative Burst
20140 citationsauthor #9
VEGFA genomic amplification tailors treatment of HCCs with sorafenib.
201412 citationsauthor #2
Protein Tyrosine Phosphatase, Shp2, Positively Regulates Macrophage Oxidative Burst
20140 citationsauthor #10
Role of SH2-containing tyrosine phosphatase Shp2 in mouse corneal epithelial stratification.
201313 citationsauthor #5
Hematopoietic Colony Formation from Human Growth Factor-Dependent TF1 Cells and Human Cord Blood Myeloid Progenitor Cells Depends on SHP2 Phosphatase Function
201312 citationsauthor #7
Induction of SHP2 Deficiency in Chondrocytes Causes Severe Scoliosis and Kyphosis in Mice
201343 citationsauthor #5
Deletion of SHP-2 in mesenchymal stem cells causes growth retardation, limb and chest deformity, and calvarial defects in mice
201343 citationsauthor #3
of SHP2 as a druggable target in diseases involving oncogenic KIT Role of SHP2 phosphatase in KIT-induced transformation: identification
20130 citationsauthor #7
Cyclin G1 Expands Liver Tumor-Initiating Cells by Sox2 Induction via Akt/mTOR Signaling
201343 citationsauthor #11
Epithelial Tyrosine Phosphatase SHP-2 Protects against Intestinal Inflammation in Mice
201338 citationsauthor #7
Metabolic Effects of Neural and Pancreatic Shp2
20130 citationsauthor #4
stem cell differentiation and hematopoiesis A definitive role of Shp-2 tyrosine phosphatase in mediating embryonic
20130 citationsauthor #5
S-nitrosylated SHP-2 contributes to NMDA receptor-mediated excitotoxicity in acute ischemic stroke
201359 citationsauthor #5
UNIVERSITY OF CALIFORNIA, SAN DIEGO The Role of SRSF2 Splicing Factor in Hematopoiesis A Thesis submitted in satisfaction of the requirements for the degree Master of Science in Biology by Leo I. Lin Committee in charge: Dong-Er Zhang, Chair
20130 citationsauthor #1
Deficient FGF signaling causes optic nerve dysgenesis and ocular coloboma
201359 citationsauthor #6
Control of body weight versus tumorigenesis by concerted action of leptin and estrogen
20132 citationsauthor #2
Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT.
201260 citationsauthor #17
SUMO1 modification of PTEN regulates tumorigenesis by controlling its association with the plasma membrane
2012195 citationsauthor #12
Conflicting roles of molecules in hepatocarcinogenesis: paradigm or paradox.
2012112 citationsauthor #1
Shp2 Controls Female Body Weight and Energy Balance by Integrating Leptin and Estrogen Signals
201261 citationsauthor #12
Nonreceptor tyrosine phosphatase Shp2 promotes adipogenesis through inhibition of p38 MAP kinase
201257 citationsauthor #14
The Unique Cysteine Knot Regulates the Pleotropic Hormone Leptin
201249 citationsauthor #4
Cyclin G1–mediated epithelial‐mesenchymal transition via phosphoinositide 3‐kinase/Akt signaling facilitates liver cancer progression
2012105 citationsauthor #13
A Src family kinase-Shp2 axis controls RUNX1 activity in megakaryocyte and T-lymphocyte differentiation.
201263 citationsauthor #7

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