J. Stuckey

Design of Cell-Permeable Inhibitors of Eukaryotic Translation Initiation Factor 4E (eIF4E) for Inhibiting Aberrant Cap-Dependent Translation in Cancer
202312 citationsauthor #5
Discovery of a Potent and Selective STAT5 PROTAC Degrader with Strong Antitumor Activity In Vivo in Acute Myeloid Leukemia.
202331 citationsauthor #10
Precise Conformational Control Yielding Highly Potent and Exceptionally Selective BRD4 Degraders with Strong Antitumor Activity.
202322 citationsauthor #7
Correction to "Profiling the Binding Activities of Peptides and Inhibitors to the U2 Auxiliary Factor Homology Motif (UHM) Domains".
20230 citationsauthor #5
Profiling the Binding Activities of Peptides and Inhibitors to the U2 Auxiliary Factor Homology Motif (UHM) Domains.
20236 citationsauthor #5
A selective small-molecule STAT5 PROTAC degrader capable of achieving tumor regression in vivo
202344 citationsauthor #16
Development of Novel Small-Molecule Activators of Pyruvate Kinase Muscle Isozyme 2, PKM2, to Reduce Photoreceptor Apoptosis
20237 citationsauthor #4
Prophylactic Mitigation of Acute Graft versus Host Disease by Novel 2-(Pyrrolidin-1-ylmethyl)pyrrole-Based Stimulation-2 (ST2) Inhibitors.
20233 citationsauthor #13
Structure-Activity relationship of 1-(Furan-2ylmethyl)Pyrrolidine-Based Stimulation-2 (ST2) inhibitors for treating graft versus host disease.
20224 citationsauthor #11
Novel Chemical Series of Anti-ST2 Small Molecules Suppress Allogeneic T Cells Proliferation While Increasing Treg Cells and Improve Gvhd and Survival In Vivo
20220 citationsauthor #12
Computational Cosolvent Mapping Analysis Leads to Identify Salicylic Acid Analogs as Weak Inhibitors of ST2 and IL33 Binding.
20223 citationsauthor #3
Lisaftoclax (APG-2575) is a Novel BCL-2 Inhibitor with Robust Antitumor Activity in Preclinical Models of Hematologic Malignancy.
202237 citationsauthor #23
Discovery of EEDi-5273 as an Exceptionally Potent and Orally Efficacious EED Inhibitor Capable of Achieving Complete and Persistent Tumor Regression.
202119 citationsauthor #14
Open Reading Frame 1 Protein of the Human Long Interspersed Nuclear Element 1 Retrotransposon Binds Multiple Equivalents of Lead.
20213 citationsauthor #3
Discovery of M-1121 as an Orally Active Covalent Inhibitor of Menin-MLL Interaction Capable of Achieving Complete and Long-Lasting Tumor Regression.
202120 citationsauthor #16
Structure of Malaysian Banana Lectin F84T
20210 citationsauthor #2
Engineering a therapeutic lectin by uncoupling mitogenicity from activity
20210 citationsauthor #23
Targeted disruption of pi–pi stacking in Malaysian banana lectin reduces mitogenicity while preserving antiviral activity
20210 citationsauthor #14
Selective inhibition of cullin 3 neddylation through covalent targeting DCN1 protects mice from acetaminophen-induced liver toxicity
202136 citationsauthor #4
Structure of WT Malaysian Banana Lectin
20211 citationsauthor #2
SD-91 as A Potent and Selective STAT3 Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression.
202134 citationsauthor #12
Targeted disruption of pi–pi stacking in Malaysian banana lectin reduces mitogenicity while preserving antiviral activity
202119 citationsauthor #14
EEDi-5285: An Exceptionally Potent, Efficacious, and Orally Active Small-Molecule Inhibitor of Embryonic Ectoderm Development.
202022 citationsauthor #15
Menin bound to inhibitor M-808
20200 citationsauthor #1
Crystal Structure of a Trigonal Pyramidal Pb(II)S3 Complex in a Three-stranded Coiled coil Peptide
20200 citationsauthor #2
Mcl-1 bound to compound 17
20200 citationsauthor #1
Mcl-1 bound to compound 24
20200 citationsauthor #1
The crystal structure of anti-apoptotic Mcl-1 protein in complex with 2, 5-substituted benzoic acid inhibitor 21
20200 citationsauthor #2
Structure of EED bound to inhibitor 5285
20200 citationsauthor #2
Discovery and Characterization of 2,5-Substituted Benzoic Acid Dual Inhibitors of the Anti-Apoptotic Mcl-1 and Bfl-1 Proteins.
202029 citationsauthor #15
Abstract LB-226: Discovery of small molecule Mcl-1 and Bfl-1 inhibitors
20200 citationsauthor #15
Crystal Structure of tris-thiolate Pb(II) complex with adjacent water in a de novo Three Stranded Coiled Coil Peptide
20200 citationsauthor #3
Abstract 1036: Discovery of a highly potent, efficacious and orally active small-molecule inhibitor of embryonic ectoderm development (EED)
20200 citationsauthor #8
Structure of EED bound to inhibitor 1056
20200 citationsauthor #2
Discovery of Potent Small-Molecule Inhibitors of MLL Methyltransferase.
202013 citationsauthor #4
Discovery of CJ-2360 as a Potent and Orally Active Inhibitor of Anaplastic Lymphoma Kinase Capable of Achieving Complete Tumor Regression.
202013 citationsauthor #9
Discovery of M-808 as a Highly Potent, Covalent, Small-Molecule Inhibitor of the Menin-MLL Interaction with Strong In Vivo Antitumor Activity.
202027 citationsauthor #12
Heteromeric three-stranded coiled coils designed using a Pb(ii)(Cys)3 template mediated strategy
202033 citationsauthor #7
Lipid-based vaccine nanoparticles for induction of humoral immune responses against HIV-1 and SARS-CoV-2
202036 citationsauthor #7
Structure-Based Design of N-(5-Phenylthiazol-2-yl)acrylamides as Novel and Potent Glutathione S-Transferase Omega 1 Inhibitors.
201920 citationsauthor #5
Stat3 Core in complex with compound SI109
20190 citationsauthor #2
Crystal Structure of a de Novo Three-stranded Coiled Coil Peptide Containing an Ala Residue in the Second Coordination Sphere of the Hg(II)S3 Binding Site
20190 citationsauthor #2
Discovery of ARD-69 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor (AR) for the Treatment of Prostate Cancer.
2019297 citationsauthor #12
Crystal Structure of a de novo Three-stranded Coiled Coil Peptide Containing D-Leu in a d-site Position of a Tris-thiolate Binding Site
20190 citationsauthor #2
Crucial Role of the SH2B1 PH Domain for the Control of Energy Balance
201917 citationsauthor #16
Changing the Apoptosis Pathway through Evolutionary Protein Design.
201921 citationsauthor #15
Changing the Ap through Evolutio
20190 citationsauthor #15
Glutathione S-Transferase Omega 1 bound to covalent inhibitor 44
20190 citationsauthor #2
How Outer Coordination Sphere Modifications Can Impact Metal Structures in Proteins: A Crystallographic Evaluation.
201910 citationsauthor #2
BRD4 bromodomain 1 in complex with HYB157
20190 citationsauthor #2
V308E mutant of cytochrome P450 2D6 complexed with prinomastat
20190 citationsauthor #7
Crystal Structure of a Three-stranded Coiled Coil Peptide Containing a Trigonal Planar Hg(II)S3 Site Modified by D-Leu in the Second Coordination Sphere
20190 citationsauthor #2
Glutathione S-Transferase Omega 1 bound to covalent inhibitor 37
20190 citationsauthor #5
Structure of the zinc-finger antiviral protein in complex with RNA reveals a mechanism for selective targeting of CG-rich viral sequences
2019121 citationsauthor #9
A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo.
2019479 citationsauthor #17
Discovery of ERD-308 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Estrogen Receptor (ER).
2019209 citationsauthor #12
V308E mutant of cytochrome P450 2D6 complexed with thioridazine
20190 citationsauthor #7
Crystal Structure of a de Novo Three-stranded Coiled Coil Peptide Containing a D-Leu in the Second Coordination Sphere of a Non-metalated Tris-thiolate Binding Site
20190 citationsauthor #2
Structure-Based Discovery of SD-36 as a Potent, Selective and Efficacious PROTAC Degrader of STAT3 Protein.
2019164 citationsauthor #18
Menin bound to M-89
20190 citationsauthor #1
Changing the Ap Evolutionary Pro
20190 citationsauthor #16
Discovery of Highly Potent and Efficient PROTAC Degraders of Androgen Receptor (AR) by Employing Weak Binding Affinity VHL E3 Ligase Ligands.
2019162 citationsauthor #10
Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein-Protein Interaction.
201854 citationsauthor #6
BRD4 BD1 in complex with compound CF53
20180 citationsauthor #2
Structure-Based Discovery of CF53 as a Potent and Orally Bioavailable Bromodomain and Extra-Terminal (BET) Bromodomain Inhibitor.
201832 citationsauthor #7
High-Affinity Peptidomimetic Inhibitors of the DCN1-UBC12 Protein-Protein Interaction.
201854 citationsauthor #12
Menin bound to M-525
20180 citationsauthor #1
Structure of cytochrome P450 2B4 with an acetate ligand and an active site hydrogen bond network similar to oxyferrous P450cam.
20181 citationsauthor #5
Inhibition of Biomarker ST2 by Small Molecules Improves Survival in Allogeneic Hematopoietic Cell Transplantation
20180 citationsauthor #10
BRD4 BD2 in complex with compound CE277
20180 citationsauthor #2
Design, Synthesis, and Biological Evaluation of 4-Quinoline Carboxylic Acids as Inhibitors of Dihydroorotate Dehydrogenase.
201846 citationsauthor #6
Clarifying the Copper Coordination Environment in a de Novo Designed Red Copper Protein.
201820 citationsauthor #11
Human dihydroorotate dehydrogenase bound to napthyridine inhibitor 46
20180 citationsauthor #2
Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression.
2018210 citationsauthor #10
Differential Conformational Dynamics Encoded by the Linker between Quasi RNA Recognition Motifs of Heterogeneous Nuclear Ribonucleoprotein H
201814 citationsauthor #5
From proteomics to discovery of first-in-class ST2 inhibitors active in vivo.
201835 citationsauthor #11
Human dihydroorotate dehydrogenase bound to 4-quinoline carboxylic acid inhibitor 43
20180 citationsauthor #2
Elongated version of a de novo designed three helix bundle structure (GRa3D)
20180 citationsauthor #4
Discovery of Mcl-1 inhibitors from integrated high throughput and virtual screening
201819 citationsauthor #10
Structure of hnRNP H qRRM1,2
20182 citationsauthor #5
DCN1 bound to 38
20180 citationsauthor #1
The Tris-thiolate Zn(II)S3Cl Binding Site Engineered by D-Cysteine Ligands in de Novo Three-stranded Coiled Coil Environment
20170 citationsauthor #3
Crystal structure of RBBP4 bound to BCL11a peptide
20170 citationsauthor #2
Abstract 4495: Elucidating BCL11A’s function in triple negative breast cancer
20170 citationsauthor #6
BRD4 bromodomain 2 in complex with CD161
20170 citationsauthor #2
DCN1 bound to DI-591
20170 citationsauthor #1
Structure-Based Discovery of 4-(6-Methoxy-2-methyl-4-(quinolin-4-yl)-9H-pyrimido[4,5-b]indol-7-yl)-3,5-dimethylisoxazole (CD161) as a Potent and Orally Bioavailable BET Bromodomain Inhibitor.
201741 citationsauthor #5
De Novo Three-stranded Coiled Coil Peptide Containing a Tris-thiolate Site Engineered by D-Cysteine Ligands
20170 citationsauthor #2
A potent small-molecule inhibitor of the DCN1-UBC12 interaction that selectively blocks cullin 3 neddylation
201780 citationsauthor #9
Targeted Degradation of BET Proteins in Triple-Negative Breast Cancer.
2017155 citationsauthor #18
Probing the interaction between the histone methyltransferase/deacetylase subunit RBBP4/7 and the transcription factor BCL11A in epigenetic complexes
201751 citationsauthor #9
High-resolution crystal structures of Colocasia esculenta tarin lectin
201716 citationsauthor #7
Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction.
201785 citationsauthor #17
WDR5 bound to inhibitor MM-589
20170 citationsauthor #1
Crystallographic determination of Cys ligands upon metal binding in metalloproteins
20170 citationsauthor #3
Flavin-dependent thymidylate synthase with H2-dUMP
20170 citationsauthor #2
d-Cysteine Ligands Control Metal Geometries within De Novo Designed Three-Stranded Coiled Coils.
201712 citationsauthor #5
Crystal Structure of Tarin Lectin bound to Trimannose
20160 citationsauthor #3
Heat Shock Protein 90 Bound to CS311
20160 citationsauthor #2
Crystal Structure of a Tris-thiolate Zn(II)S3O Complex in a de Novo Three-stranded Coiled Coil Peptide
20160 citationsauthor #3

PROFILE

PAPERS

TIMELINE

COAUTHOR MAP

CONCEPT FOOTPRINT