S. Labeit

Small-Molecule Inhibition of MuRF1 Prevents Early Disuse-Induced Diaphragmatic Dysfunction and Atrophy
202313 citationsauthor #5
Immunological and Structural Characterization of Titin Main Immunogenic Region; I110 Domain Is the Target of Titin Antibodies in Myasthenia Gravis
20235 citationsauthor #12
Truncated titin is integrated into the human dilated cardiomyopathic sarcomere
20230 citationsauthor #10
Molecular Mechanisms behind Persistent Presence of Parvovirus B19 in Human Dilated Myocardium.
20224 citationsauthor #9
Removal of MuRF1 Increases Muscle Mass in Nemaline Myopathy Models, but Does Not Provide Functional Benefits
20225 citationsauthor #6
The Effect of Heat Shock on Myogenic Differentiation of Human Skeletal-Muscle-Derived Mesenchymal Stem/Stromal Cells
20223 citationsauthor #2
Targeting MuRF1 by small molecules in a HFpEF rat model improves myocardial diastolic function and skeletal muscle contractility
202243 citationsauthor #14
Empagliflozin Preserves Skeletal Muscle Function in a HFpEF Rat Model
202224 citationsauthor #9
Identification of Bovine miRNAs with the Potential to Affect Human Gene Expression
202213 citationsauthor #2
The skeletal muscle circadian clock regulates titin splicing through RBM20
202213 citationsauthor #10
miR-29c Increases Protein Synthesis in Skeletal Muscle Independently of AKT/mTOR
20228 citationsauthor #4
Regulation of Glucose Metabolism by MuRF1 and Treatment of Myopathy in Diabetic Mice with Small Molecules Targeting MuRF1
202117 citationsauthor #1
Muscle ankyrin repeat protein 1 (MARP1) locks titin to the sarcomeric thin filament and is a passive force regulator
202126 citationsauthor #9
CHARACTERISTICS OF miRNA INTERACTION WITH mRNA OF ISCHEMIC HEART DISEASE CANDIDATE GENES
20210 citationsauthor #2
MuRF1 deficiency prevents age‐related fat weight gain, possibly through accumulation of PDK4 in skeletal muscle mitochondria in older mice
20218 citationsauthor #7
Titin kinase ubiquitination aligns autophagy receptors with mechanical signals in the sarcomere
202131 citationsauthor #11
The skeletal muscle circadian clock regulates sarcomere length homeostasis through titin splicing
20210 citationsauthor #8
Cardiomyogenic Differentiation Potential of Human Dilated Myocardium-Derived Mesenchymal Stem/Stromal Cells: The Impact of HDAC Inhibitor SAHA and Biomimetic Matrices
20218 citationsauthor #11
Emerging Strategies Targeting Catabolic Muscle Stress Relief
202014 citationsauthor #3
Skeletal Muscle Anti-Atrophic Effects of Leucine Involve Myostatin Inhibition
202011 citationsauthor #7
Expression of MuRF1 or MuRF2 is essential for the induction of skeletal muscle atrophy and dysfunction in a murine pulmonary hypertension model
20205 citationsauthor #7
Abstract 15172: Murf1 Inhibitor Embl205 is a New Approach for Treatment of Heart Failure With Preserved Ejection Fraction in an Animal Model
20200 citationsauthor #7
ZSF1 rat as animal model for HFpEF: Development of reduced diastolic function and skeletal muscle dysfunction
202053 citationsauthor #11
Leucine Supplementation Decreases HDAC4 Expression and Nuclear Localization in Skeletal Muscle Fiber of Rats Submitted to Hindlimb Immobilization
20206 citationsauthor #4
Histone Deacetylase Inhibitor Suberoylanilide Hydroxamic Acid Improves Energetic Status and Cardiomyogenic Differentiation of Human Dilated Myocardium-Derived Primary Mesenchymal Cells
202010 citationsauthor #4
Features of miRNAs binding sites within the C2H2 ZNF family: а Bos taurus, Eqqus caballus, and Ovies aries comparative approach
20200 citationsauthor #2
Expression of MuRF1 or MuRF2 is essential for the induction of skeletal muscle atrophy and dysfunction in a murine pulmonary hypertension model
202031 citationsauthor #7
Evaluation of Redox Activity of Human Myocardium‐derived Mesenchymal Stem Cells by Scanning Electrochemical Microscopy
202013 citationsauthor #11
Small-Molecule Chemical Knockdown of MuRF1 in Melanoma Bearing Mice Attenuates Tumor Cachexia Associated Myopathy
202026 citationsauthor #7
In silico Prediction of miRNA Interactions With Candidate Atherosclerosis Gene mRNAs
202014 citationsauthor #5
ASSOCIATIONS OF miRNA WITH mRNA OF ATHEROSCLEROSIS CANDIDATE GENES
20200 citationsauthor #2
Perturbation of the titin/MURF1 signaling complex is associated with hypertrophic cardiomyopathy in a fish model and in human patients
201917 citationsauthor #13
Small‐molecule‐mediated chemical knock‐down of MuRF1/MuRF2 and attenuation of diaphragm dysfunction in chronic heart failure
201946 citationsauthor #18
[The Interaction of miRNA-5p and miRNA-3p with the mRNAs of Orthologous Genes].
201920 citationsauthor #5
MuRF1 and MuRF2 are key players in skeletal muscle regeneration involving myogenic deficit and deregulation of the chromatin‐remodeling complex
201911 citationsauthor #8
Moderated Posters Session 3
20190 citationsauthor #7
The E3 ligase MuRF2 plays a key role in the functional capacity of skeletal muscle fibroblasts
20196 citationsauthor #7
miR‐29c improves skeletal muscle mass and function throughout myocyte proliferation and differentiation and by repressing atrophy‐related genes
201946 citationsauthor #5
MuRF1 and MuRF2 independently act to mediate muscle wasting in mice with cardiac cachexia
20180 citationsauthor #4
Titin‐based mechanosensing modulates muscle hypertrophy
201848 citationsauthor #5
Titin Gene (TTN): Description of the Gene Coding for Titin, a Giant Protein of Critical Importance for Myofibrillar Integrity and Elasticity in Vertebrate Striated Muscle
20181 citationsauthor #1
Characteristics of miRNA binding sites in mRNAS of human and mouse titin gene
20170 citationsauthor #2
The giant protein titin regulates the length of the striated muscle thick filament
201787 citationsauthor #7
The Binding Sites of miR-619-5p in the mRNAs of Human and Orthologous Genes
201737 citationsauthor #7
The Binding Sites of miR-619-5p in the mRNAs of Human and Orthologous Genes
20170 citationsauthor #7
Small‐molecule inhibition of MuRF1 attenuates skeletal muscle atrophy and dysfunction in cardiac cachexia
201793 citationsauthor #13
FoxO3a suppression and VPS34 activity are essential to anti-atrophic effects of leucine in skeletal muscle
201717 citationsauthor #4
Dysregulated IER3 Expression is Associated with Enhanced Apoptosis in Titin-Based Dilated Cardiomyopathy
201718 citationsauthor #5
Inhibition of miR-208b improves cardiac function in titin-based dilated cardiomyopathy.
201745 citationsauthor #9
PT105 The Mechanism of Parvovirus B19-Induced Dilated Cardiomyopathy in Mice
20160 citationsauthor #9
Mutations in the nebulin gene as recessive nemaline myopathy
20160 citationsauthor #13
Screening for anti-titin antibodies in patients with various paraneoplastic neurological syndromes.
201611 citationsauthor #3
Sympathetic innervation controls homeostasis of neuromuscular junctions in health and disease
2016146 citationsauthor #12
PNAS-2016-Khan-1524272113
20160 citationsauthor #12
Exploration of pathomechanisms triggered by a single-nucleotide polymorphism in titin's I-band: the cardiomyopathy-linked mutation T2580I
201621 citationsauthor #13
Cardiac specific titin N2B exon is a novel sensitive serological marker for cardiac injury.
201614 citationsauthor #8
A Novel Murine Model of Parvovirus Associated Dilated Cardiomyopathy Induced by Immunization with VP1-Unique Region of Parvovirus B19
201612 citationsauthor #13
Crystal structure of I81 from titin
20160 citationsauthor #4
CARP interacts with titin at a unique helical N2A sequence and at the domain Ig81 to form a structured complex
201623 citationsauthor #7
Diaphragm muscle fiber weakness and ubiquitin-proteasome activation in critically ill patients.
2015173 citationsauthor #13
Phosphorylating Titin's Cardiac N2B Element by ERK2 or CaMKIIδ Lowers the Single Molecule and Cardiac Muscle Force.
201541 citationsauthor #9
Exploration of the pathological potential of isolated mSNPs in titin: the cardiomyopathy-linked mutation T2580I
20150 citationsauthor #2
Antisense-mediated exon skipping: a therapeutic strategy for titin-based dilated cardiomyopathy
2015118 citationsauthor #15
Induction of Ankrd1 in Dilated Cardiomyopathy Correlates with the Heart Failure Progression
201534 citationsauthor #11
Molecular mechanisms behind progressing chronic inflammatory dilated cardiomyopathy
201521 citationsauthor #9
Role of autophagy, SQSTM1, SH3GLB1, and TRIM63 in the turnover of nicotinic acetylcholine receptors
201498 citationsauthor #11
Determining the Molecular Mechanisms that Link a Titin Mutation to Cardiomyopathy
20140 citationsauthor #3
Molecular basis for the fold organization and sarcomeric targeting of the muscle atrogin MuRF1
201421 citationsauthor #13
Titin kinase is an inactive pseudokinase scaffold that supports MuRF1 recruitment to the sarcomeric M-line
201462 citationsauthor #5
Dynamics of myosin degradation in intensive care unit-acquired weakness during severe critical illness
2014126 citationsauthor #12
Removal of immunoglobulin-like domains from titin’s spring segment alters titin splicing in mouse skeletal muscle and causes myopathy
201435 citationsauthor #6
Mechanism of Fibrosis in Inflammatory Dilated Cardiomyopathy
20140 citationsauthor #8
Bacterially expressed Titin Kinase
20140 citationsauthor #2
Inflammation-Induced Acute Phase Response in Skeletal Muscle and Critical Illness Myopathy
201492 citationsauthor #13
Degeneration of Neuromuscular Junction in Age and Dystrophy
2014176 citationsauthor #3
Shortening of Titin’s Elastic Tandem Ig Segment Leads to Diastolic Dysfunction
20131 citationsauthor #8
A Novel Mouse Model of Nebulin-Based Nemaline Myopathy
20130 citationsauthor #7
Alterations of cAMP-dependent signaling in dystrophic skeletal muscle
201320 citationsauthor #4
Single Molecule Force Spectroscopy on Titin Implicates Immunoglobulin Domain Stability as a Cardiac Disease Mechanism*
201340 citationsauthor #3
Shortening of Titin's Elastic Tandem Ig Segment Leads to Cardiac Hypertrophy and Diastolic Dysfunction
20130 citationsauthor #8
Fast Skeletal Muscle Troponin Activation Increases Force of Mouse Fast Skeletal Muscle and Ameliorates Weakness Due to Nebulin-Deficiency
201335 citationsauthor #6
The multifunctional Ca(2+)/calmodulin-dependent protein kinase II delta (CaMKIIδ) phosphorylates cardiac titin's spring elements.
201384 citationsauthor #7
P.9.10 Deleting exon 55 from the nebulin gene induces severe muscle weakness in a mouse model for nemaline myopathy
201366 citationsauthor #12
In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype.
201326 citationsauthor #23
Shortening of the Elastic Tandem Immunoglobulin Segment of Titin Leads to Diastolic Dysfunction
201397 citationsauthor #8
Single Molecule Force Spectroscopy on Titin Implicates Immunoglobulin Domain Stability as a Cardiac
20130 citationsauthor #3
Regulation of nicotinic acetylcholine receptor turnover by MuRF1 connects muscle activity to endo/lysosomal and atrophy pathways
20121 citationsauthor #11
The Multifunctional Calcium/Calmodulin-Dependent Protein Kinase II Delta (CaMKIIδ) Phosphorylates Titin N2B and PEVK Spring Elements
20124 citationsauthor #6
Single Molecule Studies of a Titin Mutation Linked to Cardiac Disease
20120 citationsauthor #3
Identification of an N-terminal inhibitory extension as the primary mechanosensory regulator of twitchin kinase
201228 citationsauthor #9
Molecular basis for clinical heterogeneity in inherited cardiomyopathies due to myopalladin mutations.
2012102 citationsauthor #17
Stretching of Twitchin Kinase
20120 citationsauthor #9
MuRFs: specialized members of the TRIM/RBCC family with roles in the regulation of the trophic state of muscle and its metabolism.
201218 citationsauthor #2
Regulation of nicotinic acetylcholine receptor turnover by MuRF1 connects muscle activity to endo/lysosomal and atrophy pathways
201265 citationsauthor #11
The Sarcomeric Protein Nebulin: Another Multifunctional Giant in Charge of Muscle Strength Optimization
201254 citationsauthor #3
Titin Gene (TTN)
20110 citationsauthor #1
Genetic Variation in Titin in Arrhythmogenic Right Ventricular Cardiomyopathy–Overlap Syndromes
2011300 citationsauthor #14
Mechanics on myocardium deficient in the N2B region of titin: the cardiac-unique spring element improves efficiency of the cardiac cycle.
201133 citationsauthor #2
Comparison of Human and Mouse Recombinant Titin N2B Fragment as a Substrate for PKA and PKG
20110 citationsauthor #5
Nebulin, a major player in muscle health and disease
201177 citationsauthor #1

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