R. Kriwacki

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Aliases
Richard W Kriwacki, Richard Kriwacki, R. W. Kriwacki, R W Kriwacki, R. Kriwacki, Richard W. Kriwacki
Publication record
222 papers · 23,412 citations · H-index 69

PAPERS

HTS Identifies NUP98-KDM5A-PHD3 Domain Ligands with Novel Scaffolds.
20250 citationsauthor #12
A gated hydrophobic funnel within BAX binds long-chain alkenals to potentiate pro-apoptotic function
20241 citationsauthor #11
Intrinsic disorder: A term to define the specific physicochemical characteristic of protein conformational heterogeneity.
202411 citationsauthor #3
Uncovering the leukemogenic mechanism of non-canonical NUP98 fusion oncoproteins.
20230 citationsauthor #7
Biomolecular condensates form spatially inhomogeneous network fluids
202325 citationsauthor #9
Phase Separation in Biology and Disease; Current Perspectives and Open Questions.
202358 citationsauthor #22
Elucidating the role of nucleophosmin in protein quality control mechanisms inside the nucleolus.
20230 citationsauthor #5
Defining the condensate landscape of fusion oncoproteins.
202327 citationsauthor #6
Dissolving Fusion Oncoprotein Condensates to Reverse Aberrant Gene Expression.
20233 citationsauthor #3
Clinical and functional analysis of the germline TP53 p.K164E acetylation site variant
20230 citationsauthor #5
The Role of Phase-Separated Condensates in Fusion Oncoprotein–Driven Cancers
202330 citationsauthor #3
Defining the condensate landscape of fusion oncoproteins
202345 citationsauthor #27
Dissecting the biophysics and biology of intrinsically disordered proteins.
202316 citationsauthor #3
Understanding condensate formation by fusion oncoprotein-derived intrinsically disordered regions.
20230 citationsauthor #14
Viscoelasticity and advective flow of RNA underlies nucleolar form and function
202367 citationsauthor #15
An Image Analysis Pipeline for Quantifying the Features of Fluorescently-Labeled Biomolecular Condensates in Cells
202213 citationsauthor #8
AML-158 Phase Separation Mediates NUP98 Fusion Oncoprotein Leukemic Transformation.
202234 citationsauthor #27
Understanding the mechanism of TCF3-HLF fusion oncoprotein-driven leukemogenesis
20220 citationsauthor #8
Investigating the molecular basis of ARF tumor suppressor function in the nucleolus: how ARF disrupts ribosome biogenesis and function
20220 citationsauthor #6
Charting the human disease condensate dysregulome.
20221 citationsauthor #2
LAG3 associates with TCR–CD3 complexes and suppresses signaling by driving co-receptor–Lck dissociation
2022144 citationsauthor #8
The role of phase separation by NUP98 fusion oncoproteins in leukemia
20220 citationsauthor #13
Are fusion oncoproteins a source of disease-relevant, phase separation-prone protein regions?
20220 citationsauthor #14
Competing interactions regulate the granularity of the nucleolus
20220 citationsauthor #5
The role of phase separation in oncogenesis by fusion oncoproteins
20220 citationsauthor #1
Chromatin localization of nucleophosmin organizes ribosome biogenesis
202218 citationsauthor #9
Phase Separation in Biology & Disease: The Next Chapter.
20213 citationsauthor #2
Clinical and Functional Significance of TP53 Exon 4–Intron 4 Splice Junction Variants
202113 citationsauthor #10
Small molecule sequestration of the intrinsically disordered protein, p27Kip1, within soluble oligomers.
202128 citationsauthor #6
Phase Separation Mediates NUP98 Fusion Oncoprotein Leukemic Transformation
202183 citationsauthor #29
Composition-dependent thermodynamics of intracellular phase separation
202032 citationsauthor #8
A Rare TP53 Mutation Predominant in Ashkenazi Jews Confers Risk of Multiple Cancers
202019 citationsauthor #32
NPM1 Exhibits Structural and Dynamic Heterogeneity Upon Phase Separation with the Tumor Suppressor ARF
20202 citationsauthor #5
Intrinsic protein disorder and protein modifications in the processing of biological signals.
202018 citationsauthor #2
Converting Stochastic Assembly into an Assembly Line: Non-Equilibrium Droplet Dynamics Assist Ribosome Formation
20200 citationsauthor #3
Composition-dependent thermodynamics of intracellular phase separation
2020571 citationsauthor #8
LAG3 mediates its inhibitory function by associating with the TCR:CD3 complex and inducing co-receptor:p56lck dissociation
20200 citationsauthor #9
NPM1 exhibits structural and dynamic heterogeneity upon phase separation with the p14ARF tumor suppressor.
201928 citationsauthor #5
From uncertainty to pathogenicity: clinical and functional interrogation of a rare TP53 in-frame deletion
20198 citationsauthor #9
Exploring Relationships between the Density of Charged Tracts within Disordered Regions and Phase Separation
20199 citationsauthor #3
Altered Nucleolar Phase Separation by NPM1 in ALS
20190 citationsauthor #10
The Ins and Outs of Phase Separation in Nucleolar Biology
20192 citationsauthor #1
Composition dependent phase separation underlies directional flux through the nucleolus
201910 citationsauthor #8
C9orf72 Poly(PR) Dipeptide Repeats Disturb Biomolecular Phase Separation and Disrupt Nucleolar Function.
2019153 citationsauthor #10
Molecular Insights into the Role of RNA Structure in the Phase Separated Nucleolus
20190 citationsauthor #6
Internal Structure of Network Fluid Condensates Formed by Liquid-Liquid Phase Separation of a Multivalent Oligomeric Protein and a Disordered Linear Peptide
20193 citationsauthor #6
Intrinsically Disordered Proteins: Structure, Function and Therapeutics.
201839 citationsauthor #2
Linker histones as liquid-like glue for chromatin
201833 citationsauthor #2
CDK2 inhibitors as candidate therapeutics for cisplatin- and noise-induced hearing loss
201892 citationsauthor #18
Ion Mobility Mass Spectrometry Uncovers the Impact of the Patterning of Oppositely Charged Residues on the Conformational Distributions of Intrinsically Disordered Proteins
201875 citationsauthor #5
Ion Mobility Mass Spectrometry Measures the Conformational Landscape of p27 and its Domains and how this is Modulated upon Interaction with Cdk2/cyclin A.
201813 citationsauthor #3
Dynamic anticipation by Cdk2/Cyclin A-bound p27 mediates signal integration in cell cycle regulation
201880 citationsauthor #15
Methods for Physical Characterization of Phase-Separated Bodies and Membrane-less Organelles.
2018138 citationsauthor #7
Mapping Interactions between p27 and RhoA that Stimulate Cell Migration.
201818 citationsauthor #5
Compositional adaptability in NPM1-SURF6 scaffolding networks enabled by dynamic switching of phase separation mechanisms
201897 citationsauthor #5
Compositional adaptability in NPM1-SURF6 scaffolding networks enabled by dynamic switching of phase separation mechanisms
201897 citationsauthor #4
Regulation of apoptosis by an intrinsically disordered region of Bcl-xL
201844 citationsauthor #9
On the relationship status for Arf and NPM1 – it's complicated
201816 citationsauthor #2
Self-interaction of NPM1 modulates multiple mechanisms of liquid–liquid phase separation
2018348 citationsauthor #10
Phase Separation in Biology and Disease.
201868 citationsauthor #2
An unexpected protein interaction promotes drug resistance in leukemia
201724 citationsauthor #14
A Small Molecule Causes a Population Shift in the Conformational Landscape of an Intrinsically Disordered Protein.
201744 citationsauthor #5
An unexpected protein interaction promotes drug resistance in leukemia
20170 citationsauthor #14
Two Decades of IDPs; What have we Learned?
20171 citationsauthor #1
Real-Time Analysis of Folding upon Binding of a Disordered Protein by Using Dissolution DNP NMR Spectroscopy.
201731 citationsauthor #4
Combining Ion Mobility Mass Spectrometry and Molecular Dynamics - a look at the conformational behaviour during water droplet evaporation
20170 citationsauthor #4
MULTIVALENT ELECTROSTATIC INTERACTIONS AND AUTOINHIBITION UNDERLIE PHASE SEPARATION OF NPM 1 WITH R-RICH NUCLEOLAR PROTEIN SURF 6
20170 citationsauthor #3
Solution structure of a Bcl-xL S62E mutant
20170 citationsauthor #2
The whole-genome landscape of medulloblastoma subtypes
2017924 citationsauthor #75
Real-time Analysis of Folding Upon Binding of a Disordered Protein using Dissolution DNP NMR
20170 citationsauthor #4
C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles.
2016624 citationsauthor #20
C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles.
2016624 citationsauthor #19
Editorial Overview: Functional and Mechanistic Landscape of the Nuclear Pore Complex.
20162 citationsauthor #2
Coexisting Liquid Phases Underlie Nucleolar Subcompartments.
20161,630 citationsauthor #7
Monitoring Ligand-Induced Protein Ordering in Drug Discovery.
201623 citationsauthor #13
Monitoring Ligand-Induced Protein Ordering in Drug Discovery.
201623 citationsauthor #12
Author response: Nucleophosmin integrates within the nucleolus via multi-modal interactions with proteins displaying R-rich linear motifs and rRNA
20165 citationsauthor #9
Discoveries and controversies in BCL‐2 protein‐mediated apoptosis
2016202 citationsauthor #3
Cryptic sequence features within the disordered protein p27Kip1 regulate cell cycle signaling
2016114 citationsauthor #4
Nucleophosmin integrates within the nucleolus via multi-modal interactions with proteins displaying R-rich linear motifs and rRNA
2016416 citationsauthor #9
Asymmetric Modulation of Protein Order-Disorder Transitions by Phosphorylation and Partner Binding.
201627 citationsauthor #3
Dynamic Protein Interaction Networks and New Structural Paradigms in Signaling.
2016188 citationsauthor #3
Phase separation in biology; functional organization of a higher order
2016630 citationsauthor #2
Conformational Polymorphism in Conditionally Disordered Nucleophosmin: From Single-Molecules to Liquid Droplets
20160 citationsauthor #3
Discovery of Small Molecules that Inhibit the Disordered Protein, p27Kip1
201585 citationsauthor #8
Pin1-Induced Proline Isomerization in Cytosolic p53 Mediates BAX Activation and Apoptosis.
201596 citationsauthor #6
The activity and stability of the intrinsically disordered Cip/Kip protein family are regulated by non-receptor tyrosine kinases.
201527 citationsauthor #5
The landscape of somatic mutations in Infant MLL rearranged acute lymphoblastic leukemias
2015442 citationsauthor #12
Erratum: Protein dynamics: Tuning disorder propensity in p53
20150 citationsauthor #1
Nuclear ULK1 promotes cell death in response to oxidative stress through PARP1
201565 citationsauthor #11
Design, Synthesis and Evaluation of 2,5-Diketopiperazines as Inhibitors of the MDM2-p53 Interaction
201512 citationsauthor #5
8-Triazolylpurines: Towards Fluorescent Inhibitors of the MDM2/p53 Interaction
20158 citationsauthor #8
Solution Structure of BCL-xL in its p53-bound conformation determined with selective isotope labelling of I,L,V sidechains
20140 citationsauthor #3
Solution Structure of the Complex Between BCL-xL and the p53 Core Domain determined with PRE restraints
20140 citationsauthor #3
NPM-N (Nucleophosmin) pentamer assignment
20140 citationsauthor #11
Control of Disorder and order in Signaling by Proteins
20140 citationsauthor #1
Broadly protective protein-based pneumococcal vaccine composed of pneumolysin toxoid-CbpA peptide recombinant fusion protein.
201481 citationsauthor #10
Protein dynamics: tuning disorder propensity in p53.
20144 citationsauthor #1
Classification of Intrinsically Disordered Regions and Proteins
20141,878 citationsauthor #12
Abstract PR03: The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma
20142 citationsauthor #20

TIMELINE

1987 2 citations

1988 1 citations

1989 36 citations

1992 125 citations

1993 72 citations

1996 636 citations

1997 187 citations

1998 95 citations

1999 264 citations

2000 394 citations

2001 193 citations

2002 276 citations

2003 237 citations

2004 311 citations

2005 321 citations

2006 144 citations

2007 470 citations

2008 660 citations

2009 144 citations

2010 123 citations

2011 337 citations

2012 3,570 citations

2013 1,279 citations

2014 4,133 citations

2015 735 citations

2016 3,861 citations

2017 1,024 citations

2018 1,061 citations

2019 213 citations

2020 642 citations

2021 127 citations

2022 210 citations

2023 271 citations

2024 12 citations

2025 0 citations

Unknown 0 citations

R. Kriwacki

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