L. Wojnowski

Transcriptional Response to Standard AML Drugs Identifies Synergistic Combinations
20232 citationsauthor #7
A year in pharmacology: new drugs approved by the US Food and Drug Administration in 2022
20239 citationsauthor #3
Correction to: A year in pharmacology: new drugs approved by the US Food and Drug Administration in 2021
20220 citationsauthor #3
A year in pharmacology: new drugs approved by the US Food and Drug Administration in 2021
202219 citationsauthor #3
AB1299-HPR THE RHEUMA-VOR APP: OPTIMIZING THE EARLY DIAGNOSIS OF RHEUMATIC DISEASES
20200 citationsauthor #2
Doxorubicin induces cardiotoxicity in a pluripotent stem cell model of aggressive B cell lymphoma cancer patients
202021 citationsauthor #15
Drivers of topoisomerase II poisoning mimic and complement cytotoxicity in AML cells
20192 citationsauthor #7
Health-Relevant Phenotypes in the Offspring of Mice Given CAR Activators Prior to Pregnancy
20185 citationsauthor #12
TAF-ChIP: an ultra-low input approach for genome-wide chromatin immunoprecipitation assay
201812 citationsauthor #7
Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry
201820 citationsauthor #1974
Key Learning Outcomes for Clinical Pharmacology and Therapeutics Education in Europe: A Modified Delphi Study
201867 citationsauthor #48
The SGLT2 inhibitor empagliflozin improves the primary diabetic complications in ZDF rats
2017259 citationsauthor #14
Association of NADPH oxidase polymorphisms with anthracycline-induced cardiotoxicity in the RICOVER-60 trial of patients with aggressive CD20(+) B-cell lymphoma.
201551 citationsauthor #14
The catalytic topoisomerase II inhibitor dexrazoxane induces DNA breaks, ATF3 and the DNA damage response in cancer cells
201542 citationsauthor #8
Dexrazoxane may prevent doxorubicin-induced DNA damage via depleting both Topoisomerase II isoforms
2014158 citationsauthor #7
Accuracy and Completeness of Drug Information in Wikipedia: A Comparison with Standard Textbooks of Pharmacology
201493 citationsauthor #6
Report on the International Colloquium on Cardio-Oncology (Rome, 12–14 March 2014)
201419 citationsauthor #6
Dexrazoxane may prevent doxorubicin-induced DNA damage via depleting both Topoisomerase II isoforms
20141 citationsauthor #7
Role of nitric oxide synthase isoforms for ophthalmic artery reactivity in mice.
201421 citationsauthor #6
A role for cutaneous CYP3A in vitamin D homeostasis
20140 citationsauthor #5
Structural and Functional Similarity of Amphibian Constitutive Androstane Receptor with Mammalian Pregnane X Receptor
20145 citationsauthor #5
Correction: Structural and Functional Similarity of Amphibian Constitutive Androstane Receptor with Mammalian Pregnane X Receptor
20140 citationsauthor #6
Reduction of nevirapine-driven HIV mutations by carbamazepine is modulated by CYP3A activity.
20143 citationsauthor #10
Inactivation of Patched1 in mice leads to development of gastrointestinal stromal-like tumors that express Pdgfrα but not kit.
201338 citationsauthor #14
Contribution of nitric oxide synthase isoforms to cholinergic vasodilation in murine retinal arterioles.
201327 citationsauthor #5
Lineage-Specific Duplications of MuroideaFaim and Spag6 Genes and Atypical Accelerated Evolution of the Parental Spag6 Gene
201315 citationsauthor #4
PI3K Inhibition Enhances Doxorubicin-Induced Apoptosis in Sarcoma Cells
201227 citationsauthor #10
Nitric Oxide Production and Endothelium-Dependent Vasorelaxation Ameliorated by N 1-Methylnicotinamide in Human Blood Vessels
201237 citationsauthor #9
Evolutionary history and functional characterization of the amphibian xenosensor CAR.
201234 citationsauthor #11
Pregnane X Receptor and Yin Yang 1 Contribute to the Differential Tissue Expression and Induction of CYP3A5 and CYP3A4
201210 citationsauthor #6
Functional characterization of protein variants of the human multidrug transporter ABCC2 by a novel targeted expression system in fibrosarcoma cells
201220 citationsauthor #7
N1-methylnicotinamide improves endothelial dysfunction in human blood vessels: Direct evidence at a single cell level
20120 citationsauthor #9
The unique complexity of the CYP3A4 upstream region suggests a nongenetic explanation of its expression variability
201023 citationsauthor #10
A functional polymorphism in the NAD(P)H oxidase subunit CYBA is related to gene expression, enzyme activity, and outcome in non-Hodgkin lymphoma.
201027 citationsauthor #6
Topoisomerase IIα-dependent and -independent apoptotic effects of dexrazoxane and doxorubicin
200941 citationsauthor #6
Resveratrol reduces endothelial oxidative stress by modulating the gene expression of superoxide dismutase 1 (SOD1), glutathione peroxidase 1 (GPx1) and NADPH oxidase subunit (Nox4).
2009300 citationsauthor #6
Armillaria root rot dynamics in the experimental plantation with Scots pine (Pinus sylvestris L.) seedlings non-mycorrhized and mycorrhized with the fungi Hebeloma crustuliniforme and Laccaria bicolor.
20092 citationsauthor #2
Antitumor effects of a combined 5-aza-2'deoxycytidine and valproic acid treatment on rhabdomyosarcoma and medulloblastoma in Ptch mutant mice.
2009119 citationsauthor #13
Time-point and dosage of gene inactivation determine the tumor spectrum in conditional Ptch knockouts.
200949 citationsauthor #8
Differential roles of nitric oxide synthase isozymes in cardiotoxicity and mortality following chronic doxorubicin treatment in mice
200935 citationsauthor #9
Ligand Diversity of Human and Chimpanzee CYP3A4: Activation of Human CYP3A4 by Lithocholic Acid Results from Positive Selection
20097 citationsauthor #6
Accounting for haplotype phase uncertainty in linkage disequilibrium estimation
200811 citationsauthor #5
Carbonyl Reductase 1 Is a Predominant Doxorubicin Reductase in the Human Liver
2008186 citationsauthor #11
ALDH-2 deficiency increases cardiovascular oxidative stress--evidence for indirect antioxidative properties.
200884 citationsauthor #9
GSEA-SNP: applying gene set enrichment analysis to SNP data from genome-wide association studies
2008190 citationsauthor #3
CYP3 phylogenomics: evidence for positive selection of CYP3A4 and CYP3A7
200849 citationsauthor #10
B‐Raf‐mediated signaling pathway regulates T cell development
200819 citationsauthor #5
6‐mercaptopurine and 9‐(2‐phosphonyl‐methoxyethyl) adenine (PMEA) transport altered by two missense mutations in the drug transporter gene ABCC4
200858 citationsauthor #14
is a predominant doxorubicin reductase in the human liver
20082 citationsauthor #11
[Chemotherapeutics-induced heart failure].
20076 citationsauthor #2
Gp91phox-containing NAD(P)H oxidase increases superoxide formation by doxorubicin and NADPH.
2007110 citationsauthor #6
Genotyping the risk of anthracycline-induced cardiotoxicity
200787 citationsauthor #2
Sex-dependent genetic markers of CYP3A4 expression and activity in human liver microsomes.
200769 citationsauthor #8
The interleukin-10 gene promoter polymorphism −1087AG does not correlate with clinical outcome in non-Hodgkin's lymphoma
200726 citationsauthor #7
Variability in PXR-mediated induction of CYP3A4 by commercial preparations and dry extracts of St. John’s wort
200756 citationsauthor #5
Dystrophin‐deficiency increases the susceptibility to doxorubicin‐induced cardiotoxicity
200723 citationsauthor #6
Clinical implications of CYP3A polymorphisms
2006115 citationsauthor #1
Topoisomerase II beta expression level correlates with doxorubicin-induced apoptosis in peripheral blood cells
200625 citationsauthor #7
Dominant contribution of P450 3A4 to the hepatic carcinogenic activation of aflatoxin B1.
2006153 citationsauthor #5
ADHD drugs and cardiovascular risk.
20062 citationsauthor #1
Genetic signature consistent with selection against the CYP3A4*1B allele in non-African populations
200650 citationsauthor #10
Association of genetic polymorphism in ABCC2 with hepatic multidrug resistance-associated protein 2 expression and pravastatin pharmacokinetics
2006109 citationsauthor #6
A model for PTCH1/Ptch1-associated tumors comprising mutational inactivation and gene silencing.
200529 citationsauthor #8
NAD(P)H Oxidase and Multidrug Resistance Protein Genetic Polymorphisms Are Associated With Doxorubicin-Induced Cardiotoxicity
2005477 citationsauthor #1
A critical function for B-Raf at multiple stages of myelopoiesis.
200533 citationsauthor #4
Genome‐wide single‐nucleotide polymorphism arrays demonstrate high fidelity of multiple displacement‐based whole‐genome amplification
200556 citationsauthor #6
Application of genomewide SNP arrays for detection of simulated susceptibility loci
20054 citationsauthor #11
Contribution of CYP3A5 to the in vitro hepatic clearance of tacrolimus.
2005220 citationsauthor #7
Three haplotypes associated with CYP2A6 phenotypes in Caucasians
2005109 citationsauthor #9
Nad(p)h oxidase and MRP genetic polymorphisms associate with doxorubicin-induced cardiotoxicity.
20040 citationsauthor #1
Limited contribution of CYP3A5 to the hepatic 6β-hydroxylation of testosterone
200422 citationsauthor #6
Cell transformation induces a cytoplasmic Ca2+ oscillator in Madin-Darby canine kidney cells
20045 citationsauthor #1
Genetics of the variable expression of CYP3A in humans.
2004135 citationsauthor #1
Single nucleotide polymorphism characterization by mRNA expression imbalance assessment.
200417 citationsauthor #1
The Induction of Cytochrome P450 3A5 (CYP3A5) in the Human Liver and Intestine Is Mediated by the Xenobiotic Sensors Pregnane X Receptor (PXR) and Constitutively Activated Receptor (CAR)*
2004196 citationsauthor #8
Increased levels of aflatoxin-albumin adducts are associated with CYP3A5 polymorphisms in The Gambia, West Africa.
200469 citationsauthor #1
Cytochrome P450 3A and their regulation
2004155 citationsauthor #2
Cytoplasmic Ca2+ determines the rate of Ca2+ entry into Mardin-Darby canine kidney-focus (MDCK-F) cells
20045 citationsauthor #1
B-Raf Acts via the ROCKII/LIMK/Cofilin Pathway To Maintain Actin Stress Fibers in Fibroblasts
2004117 citationsauthor #3
Pharmacogenomics of diuretic drugs: data on rare monogenic disorders and on polymorphisms and requirements for further research.
200325 citationsauthor #4
Interindividual variability and tissue-specificity in the expression of cytochrome P450 3A mRNA.
2002348 citationsauthor #11
Molecular Mechanisms of Polymorphic CYP3A7 Expression in Adult Human Liver and Intestine*
2002193 citationsauthor #13
Re: modification of clinical presentation of prostate tumors by a novel genetic variant in CYP3A4.
2002125 citationsauthor #1
Natural protein variants of pregnane X receptor with altered transactivation activity toward CYP3A4.
2001224 citationsauthor #10
The genetic determinants of the CYP3A5 polymorphism.
2001711 citationsauthor #16
Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene.
2001249 citationsauthor #17
Identification and functional characterization of eight CYP3A4 protein variants.
2001233 citationsauthor #14
Identification des determinants genetiques de l'expression polymorphe de cyp3a5
20010 citationsauthor #1
POLYMORPHISMS OF HUMAN hPXR gene AND THEIR USE IN DIAGNOSIS AND THERAPY
20000 citationsauthor #1
Patched Target Igf2 Is Indispensable for the Formation of Medulloblastoma and Rhabdomyosarcoma*
2000227 citationsauthor #2
The patched signaling pathway in tumorigenesis and development: lessons from animal models
1999104 citationsauthor #2
Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome
1998458 citationsauthor #2
Craf-1 protein kinase is essential for mouse development.
1998130 citationsauthor #1
Reduced activity of BRAF protein kinase in hop and hophpy mouse mutants
19985 citationsauthor #1
Use of transgenic mice to study activation of retinoic acid-responsive promoters.
19971 citationsauthor #1
Endothelial apoptosis in Braf-deficient mice
1997321 citationsauthor #1
Regulation of A-raf expression.
199620 citationsauthor #3
Oscillating activity of a Ca(2+)-sensitive K+ channel. A prerequisite for migration of transformed Madin-Darby canine kidney focus cells.
199499 citationsauthor #2
Extracellular pH determines the rate of Ca2+ entry into Madin-Darby canine kidney-focus cells
19944 citationsauthor #1
Spontaneously oscillating K+ channel activity in transformed Madin-Darby canine kidney cells.
199332 citationsauthor #3

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