N. Simpkins

Azobisisobutyronitrile (AIBN)
20210 citationsauthor #1
Unusually high α-proton acidity of prolyl residues in cyclic peptides†
20204 citationsauthor #6
Tetrabutylammonium Difluorotriphenylsilicate (TBAT)
20200 citationsauthor #1
2,7-Diazabicyclo[2.2.1]heptanes: novel asymmetric access and controlled bridge-opening.
20192 citationsauthor #4
Towards the Development of Small‐Molecule MO25 Binders as Potential Indirect SPAK/OSR1 Kinase Inhibitors
201711 citationsauthor #5
First total synthesis of concavine
20174 citationsauthor #2
University of Birmingham Towards the Development of Small-Molecule MO25Binders as Potential Indirect SPAK/OSR1 Kinase Inhibitors
20170 citationsauthor #5
An Asymmetric Organocatalysis Approach to the Prenylated Alkaloid Family.
20177 citationsauthor #2
First total synthe
20170 citationsauthor #2
University of Birmingham Total Synthesis and Structural Revision of a Mangrove Alkaloid
20173 citationsauthor #5
Rafoxanide and Closantel Inhibit SPAK and OSR1 Kinases by Binding to a Highly Conserved Allosteric Site on Their C‐terminal Domains
201740 citationsauthor #4
Cover Picture: Towards the Development of Small‐Molecule MO25 Binders as Potential Indirect SPAK/OSR1 Kinase Inhibitors (ChemBioChem 5/2017)
20170 citationsauthor #5
Organocatalytic Stereoconvergent Synthesis of α-CF3 Amides: Triketopiperazines and Their Heterocyclic Metamorphosis.
201715 citationsauthor #3
Highly enantioselective access to diketopiperazines via cinchona alkaloid catalyzed Michael additions
201417 citationsauthor #4
Asymmetric Transformations by Deprotonation Using Chiral Lithium Amides
20134 citationsauthor #1
The cascade radical cyclisation approach to prenylated alkaloids: synthesis of stephacidin A and notoamide B.
201325 citationsauthor #1
Synthesis of fumaramide derived [3]rotaxanes as potential precursors for molecular boxes.
201311 citationsauthor #1
Bridgehead enolate or bridgehead organolithium? DFT calculations provide insights into a difficult bridgehead substitution reaction in the synthesis of the polycyclic polyprenylated acylphloroglucinol (PPAP) nemorosone.
20139 citationsauthor #2
Adventures in bridgehead substitution chemistry: synthesis of polycyclic polyprenylated acylphloroglucinols (PPAPs).
201328 citationsauthor #1
The Cascade Radical Cyclization Approach to Prenylated Alkaloids: Synthesis of Stephacidin A (I) and Notoamide B (II).
20130 citationsauthor #1
Chiral bases as useful probes of lithium amide reactivity.
20129 citationsauthor #2
Rapid access to polycyclic indolines related to the stephacidin alkaloids using a radical cascade.
201225 citationsauthor #1
Comparison of the cytotoxic effects of enantiopure PPAPs, including nemorosone and clusianone.
201221 citationsauthor #1
Synthesis of the asperparaline core by a radical cascade.
201132 citationsauthor #2
Kinetic Resolution of a β-Lactam Using Homochiral Lithium Amide Chemistry.
20100 citationsauthor #2
Expedient synthesis of ialibinones A and B by manganese(III)-mediated oxidative free radical cyclisation
201022 citationsauthor #1
A Concise Synthesis of Fumagillol
201010 citationsauthor #3
Application of Homochiral Lithium Amide Base Chemistry to a Thiane Oxide System
201016 citationsauthor #3
Asymmetric Deprotonations Using Chiral Lithium Amide Bases
201017 citationsauthor #1
Episulfone Substitution and Ring-Opening Reactions via α- Sulfonyl Carbanion Intermediates.
20100 citationsauthor #1
Recent Advances in Asymmetric Synthesis Using Chiral Lithium Amide Bases
20100 citationsauthor #1
A cationic cyclisation route to prenylated indole alkaloids: synthesis of malbrancheamide B and brevianamide B, and progress towards stephacidin A
201047 citationsauthor #2
The Diastereoselective and Enantioselective Substitution Reactions of an Isoindoline—Borane Complex.
20100 citationsauthor #5
Synthesis of Nemorosone viaa Difficult Bridgehead Substitution Reaction
201034 citationsauthor #1
New approaches for the synthesis of erythrinan alkaloids.
200960 citationsauthor #2
Bridgehead lithiation-substitution of bridged ketones, lactones, lactams, and imides: experimental observations and computational insights.
200923 citationsauthor #2
Synthesis of ent-Malbrancheamide B
20090 citationsauthor #2
Singlet oxygen conversion of indoles into α,β-unsaturated oxindoles in model compounds related to the welwitindolinone alkaloids
200931 citationsauthor #2
Bridgehead enolates and bridgehead alkenes in a welwistatin model series.
200923 citationsauthor #2
Concise Enantioselective Synthesis of ent-Malbrancheamide B (I).
20092 citationsauthor #2
tert‐Butyl Hypoiodate
20090 citationsauthor #1
Concise enantioselective synthesis of ent-malbrancheamide B.
200937 citationsauthor #2
Studies Towards Complex Bridged Alkaloids: Regio‐ and Stereocontrolled Enolate Chemistry of 2,5‐Diketopiperazines.
20080 citationsauthor #2
1(S),2(S)‐Diphenyl‐N,N′‐bis‐[1(R)‐phenylethyl]‐ethane‐1,2‐diamine‐dilithium Salt
20080 citationsauthor #1
A concise approach to a gelsemine core structure using an oxygen to carbon bridge swapping strategy.
200815 citationsauthor #2
Enantioselective synthesis of cyclopropylcarboxamides using s-BuLi-sparteine-mediated metallation.
200817 citationsauthor #2
Hydroamination of Cinnamyl Alcohol Using Lithium Amides.
20080 citationsauthor #2
Studies towards complex bridged alkaloids: regio-and stereocontrolled enolate chemistry of 2,5-diketopiperazines
200829 citationsauthor #2
Michael addition–electrophilic quenching chemistry of maleimides using dialkylzinc reagents
20076 citationsauthor #3
An enantiospecific synthesis of (+ ) -demethoxyerythratidinone from (S)-malic acid : key observations concerning the diastereocontrol in malic acid-derived N-acyliminium ion cyclisations
200728 citationsauthor #2
Michael Addition—Electrophilic Quenching Chemistry of Maleimides Using Dialkylzinc Reagents.
20071 citationsauthor #3
Synthesis Towards Complex Bridged Alkaloids Derived from Diketopiperazines: A Cationic Cascade Approach to Stephacidins, Paraherquamides and Related Systems.
20071 citationsauthor #2
An Enantiospecific Synthesis of (+)‐Demethoxyerythratidinone from (S)‐Malic Acid: Key Observations Concerning the Diastereocontrol in Malic Acid Derived N‐Acyliminium Ion Cyclizations.
20073 citationsauthor #2
Synthesis of (±)-Clusianone
20070 citationsauthor #3
Synthesis of polyprenylated acylphloroglucinols using bridgehead lithiation: the total synthesis of racemic clusianone and a formal synthesis of racemic garsubellin A.
200770 citationsauthor #3
Hydroamination of cinnamyl alcohol using lithium amides
20077 citationsauthor #2
Kinetic resolution in a bridgehead lithiation mediated by a chiral bis-lithium amide: assignment of the absolute configuration of clusianone.
200752 citationsauthor #2
Chiral Lithium Amide Base Desymmetrization of a Ring Fused Imide: Formation of (3aS, 7aS)‐2‐[2‐(3,4‐Dimethoxyphenyl)‐Ethyl]‐1,3‐Dioxo‐Octahydro‐Isoindole‐3a‐Carboxylic Acid Methyl Ester
20070 citationsauthor #2
t‐Butyl Hypochlorite
20060 citationsauthor #1
An Asymmetric Synthesis of (+)‐Erysotramidine.
20060 citationsauthor #4
Synthesis towards complex bridged alkaloids derived from diketopiperazines: a cationic cascade approach to stephacidins, paraherquamides and related systems
20064 citationsauthor #2
Chiral base mediated transformation of cyclic 1,3-diketones.
200620 citationsauthor #3
Synthesis of (+/-)-clusianone: high-yielding bridgehead and diketone substitutions by regioselective lithiation of enol ether derivatives of bicyclo[3.3.1]nonane-2,4,9-triones.
200651 citationsauthor #3
An asymmetric synthesis of (+)-erysotramidine
20052 citationsauthor #4
A Chiral Base Desymmetrization—Ring-Closing Metathesis Route to Chiral Azaspirocycles: Synthesis of Core Structures Related to Pinnaic Acid and Halichlorine.
20050 citationsauthor #2
The synthesis of bioactive indolocarbazoles related to K-252a.
200515 citationsauthor #4
Rapid access to the Welwitindolinone alkaloid skeleton by cyclization of indolecarboxaldehyde substituted cyclohexanones.
200541 citationsauthor #3
Stereoselectivity in reactions of atropisomeric lactams and imides
200441 citationsauthor #6
A Novel Asymmetric Route to Succinimides and Derived Compounds: Synthesis of the Lignan Lactone (+)‐Hinokinin.
20042 citationsauthor #3
Novel features of iron-mediated radical reactions: an unusual mode of silyloxycyclopropane fission, and a new method for radical chain termination using CH2I2
20045 citationsauthor #3
A novel asymmetric route to succinimides and derived compounds: synthesis of the lignan lactone (+)-hinokinin.
200440 citationsauthor #3
Synthesis of bioactive indolocarbazoles: synthesis, nucleophilic ring-opening and chiral base desymmetrisation of a cyclic sulfate intermediate
200410 citationsauthor #2
A Chiral base desymmetrisation-ring-closing metathesis route to Chiral azaspirocycles: Synthesis of core structures related to pinnaic acid and halichlorine
20042 citationsauthor #2
Application of the chiral base desymmetrisation of imides to the synthesis of the alkaloid jamtine and the antidepressant paroxetine
200343 citationsauthor #3
Asymmetric synthesis of the erythrinan alkaloid system using a chiral lithium amide base desymmetrisation as the key step
200325 citationsauthor #3
A Novel Chiral Base Mediated Glutarimide Desymmetrization: Application to the Asymmetric Synthesis of (‐)‐Paroxetine.
20031 citationsauthor #2
Asymmetric total synthesis of the proposed structure of the medicinal alkaloid jamtine using the chiral base approach.
200338 citationsauthor #1
Bridgehead enolates: substitution and asymmetric desymmetrization of small bridged carbonyl compounds by lithium amide bases.
200326 citationsauthor #4
Organolithiums: selectivity for synthesis J. Clayden, Tetrahedron Organic Chemistry Series 23, Pergamon Press, Oxford, 2002, 384 pp., €45, $145; ISBN 0-08-043262X (hardback); €145, $45; ISBN 0-08-0432611 (paperback)
20031 citationsauthor #1
Enantioselective synthesis of phospholanes using chiral lithium amide desymmetrisation
200215 citationsauthor #4
Highly Enantioselective Synthesis of Chiral Imides and Derived Products via Chiral Base Desymmetrization.
20021 citationsauthor #5
The Enantioselective Generation of Bridgehead Enolates.
20020 citationsauthor #4
Highly enantioselective synthesis of chiral imides and derived products via chiral base desymmetrisation
200237 citationsauthor #5
A Novel Chiral Base Mediated Glutarimide Desymmetrisation: Application to the Asymmetric Synthesis of (-)-Paroxetine
20025 citationsauthor #2
Nucleophilic addition reactions of bridged triene η6-chromiumtricarbonyl complexes
20021 citationsauthor #4
Enantioselective Synthesis of Phospholanes Using Chiral Lithium Amide Desymmetrization.
20020 citationsauthor #4
Chlorotrimethylsilane-mediated Michael addition reactions of chiral benzylic anions derived from η6-chromiumtricarbonyl complexes
20025 citationsauthor #3
Bis(trimethylstannyl) Benzopinacolate
20010 citationsauthor #1
Enantioselective Protonation of Organolithiums Having the Tetrahydroisoquinoline Skeleton
20012 citationsauthor #3
t‐Butyl 4‐Benzoylperbenzoate
20010 citationsauthor #1
The highly enantioselective transformation of silylketenes into α-silylthioesters catalysed by cinchona alkaloids
200115 citationsauthor #4
The enantioselective generation of bridgehead enolates
200119 citationsauthor #4
The Highly Enantioselective Transformation of Silylketenes into α-Silylthioesters Catalyzed by Cinchona Alkaloids.
20010 citationsauthor #4
Concerning the Synthesis and Enantioselective Rearrangements of Episulfoxides.
20000 citationsauthor #4
Concerning the synthesis and enantioselective rearrangements of episulfoxides
200023 citationsauthor #4
Enantioselective Proton Transfer Chemistry: Asymmetric Synthesis with Chiral Lithium Amide Bases
20001 citationsauthor #1
A Very Rapid Stereocontrolled Entry to Highly Functionalized [5-8-5] Ring Systems Using the Saegusa Reaction.
20001 citationsauthor #4
High Stereochemical Fidelity in Reactions of an Atropisomeric N-Acyliminium Intermediate
20005 citationsauthor #2
Metalation of Benzylic Amines via Amine‐Borane Complexes.
19990 citationsauthor #2
Double Ring-Opening Reactions of Bis-Cyclopropanes Promoted by Iron Salts
19992 citationsauthor #3

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