Y. Mizushima

United States Patent ( 19 ) Mizushima ( 54 ) MODIFIED BIOLOGICALLY ACTIVE PROTEIN
20170 citationsauthor #2
The Antistatic Control by Surfactant
20170 citationsauthor #1
Treatment of Inflammatory Diseases By Newly Innovated Drug Delivery System
20140 citationsauthor #1
Evasion of the accelerated blood clearance phenomenon by coating of nanoparticles with various hydrophilic polymers.
2010147 citationsauthor #8
Therapeutic effect of lecithinized superoxide dismutase on bleomycin-induced pulmonary fibrosis.
201065 citationsauthor #12
Preparation and characterization of a nanoparticulate formulation composed of PEG-PLA and PLA as anti-inflammatory agents.
201043 citationsauthor #4
Synthesis of Prostaglandin E1 Phosphate Derivatives and Their Encapsulation in Biodegradable Nanoparticles
200912 citationsauthor #17
Intracellular delivery of siRNA by cell-penetrating peptides modified with cationic oligopeptides
200927 citationsauthor #6
Therapeutic Effect of Lecithinized Superoxide Dismutase against Colitis
200995 citationsauthor #12
Accelerated Blood Clearance Phenomenon Upon Repeated Injection of PEG-modified PLA-nanoparticles
2009197 citationsauthor #17
Efficient entrapment of poorly water-soluble pharmaceuticals in hybrid nanoparticles.
200918 citationsauthor #5
Therapeutic effect of lecithinized superoxide dismutase ( PC-SOD ) on bleomycin-induced pulmonary fibrosis
20091 citationsauthor #12
Efficient encapsulation of a water-soluble corticosteroid in biodegradable nanoparticles.
200947 citationsauthor #4
JPET # 144451-1-Therapeutic effect of lecithinized superoxide dismutase ( PC-SOD ) against colitis
20080 citationsauthor #15
The pharmacokinetics and effects of a long-acting preparation of superoxide dismutase (PC-SOD) in man.
200826 citationsauthor #7
Pharmacokinetics of PC‐SOD, a Lecithinized Recombinant Superoxide Dismutase, After Single‐ and Multiple‐Dose Administration to Healthy Japanese and Caucasian Volunteers
200820 citationsauthor #6
Prolonging the In Vivo Residence Time of Prostaglandin E1 with Biodegradable Nanoparticles
200833 citationsauthor #6
Efﬁ cacy and safety of iguratimod compared with placebo and salazosulfapyridine in active rheumatoid arthritis: a controlled, multicenter, double-blind, parallel-group study
20074 citationsauthor #4
Long-term safety study of iguratimod in patients with rheumatoid arthritis
200741 citationsauthor #4
Detection of primary and metastatic lesions by [18F]fluoro‐2‐deoxy‐D‐glucose PET in a patient with thymic carcinoid
200710 citationsauthor #8
A Case of Somatoform Autonomic Dysfunction Whose Chief Complaint of Chest Oppression was Successfully Treated with Shimbuto
20070 citationsauthor #2
Efficacy and safety of iguratimod compared with placebo and salazosulfapyridine in active rheumatoid arthritis: a controlled, multicenter, double-blind, parallel-group study
200787 citationsauthor #4
Drug-supported microparticles of calcium carbonate nanocrystals and its covering with hydroxyapatite.
200735 citationsauthor #6
Dioxin immunosensor using anti-2,3,7,8-TCDD antibody which was produced with mono 6-(2,3,6,7-tetrachloroxanthene-9-ylidene) hexyl succinate as a hapten.
200618 citationsauthor #7
Polymyositis associated with infliximab treatment for rheumatoid arthritis
200651 citationsauthor #5
Primary Hyperp Immobilization Case arathyroidism Masquerading Hypercalcemia : Report of an as Illustrative
20060 citationsauthor #3
Transdermal Delivery of CaCO3-Nanoparticles Containing Insulin
200651 citationsauthor #8
Drusen, choroidal neovascularization, and retinal pigment epithelium dysfunction in SOD1-deficient mice: a model of age-related macular degeneration.
2006427 citationsauthor #8
Relation of age and smoking to serum levels of total testosterone and dehydroepiandrosterone sulfate in aged men
20060 citationsauthor #1
Administration of Optimum Sustained-Insulin Release PLGA Microcapsules to Spontaneous Diabetes-Prone BB/WorTky Rats
20069 citationsauthor #6
Treatment of experimental autoimmune uveoretinitis with poly(lactic acid) nanoparticles encapsulating betamethasone phosphate.
200684 citationsauthor #7
DDS for anti-aging and regenerative medicine (review)
20061 citationsauthor #1
Prevention of Fatal Infections by Recombinant Human Inier leukin la in Normal and Anticancer Drug-treated Mice
20063 citationsauthor #3
Negative and Positive Immunobiological Responses in Mice Pretreated with Bacillus Calmette-Guerin Cell Wall1
20060 citationsauthor #1
[Corticosteroid-loading PLA/PLGA-nanospheres].
20062 citationsauthor #3
Injectable porous hydroxyapatite microparticles as a new carrier for protein and lipophilic drugs.
2006180 citationsauthor #1
Gene analysis of K-, H-ras, p53, and retinoblastoma susceptibility genes in human lung cancer cell lines by the polymerase chain reaction/single-strand conformation polymorphism method
200518 citationsauthor #2
Ear Involvement in Patients with Rheumatoid Arthritis
200580 citationsauthor #4
Role of zinc in formulation of PLGA/PLA nanoparticles encapsulating betamethasone phosphate and its release profile.
200569 citationsauthor #8
Brain-derived neurotrophic factor bound with lecithin derivative showed a markedly enhanced pharmacological potency due to its potent cell membrane affinity followed by prolonged MAPK activation.
20051 citationsauthor #13
Successful treatment of photo-damaged skin of nano-scale atRA particles using a novel transdermal delivery.
200577 citationsauthor #7
Drug Delivery to the Cochlea Using PLGA Nanoparticles
2005130 citationsauthor #7
Swallowing and cough reflexes in patients with dementia
20053 citationsauthor #1
Effect of betamethasone phosphate–loaded polyactide nanoparticles on experimental autoimmune uveoretinitis
20042 citationsauthor #6
Microparticule a liberation prolongee contenant un medicament, procede de production correspondant et preparation contenant ladite microparticule
20040 citationsauthor #1
To the memory of Dr. Shozo Kotani
20040 citationsauthor #1
Sustained release composition it is containing zinc, their preparation and process for producing the same.
20040 citationsauthor #3
Optimum formulation for sustained-release insulin.
200436 citationsauthor #6
Extragonadal germ cell tumors.
20043 citationsauthor #1
Preparation of nanoparticles covered with inorganic compound as a drug carrier.
20040 citationsauthor #4
zinc-containing formulations with delayed release, and preparation thereof
20040 citationsauthor #3
Effects of prolonged delivery of brain-derived neurotrophic factor on the fate of neural stem cells transplanted into the developing rat retina.
200324 citationsauthor #6
Effect of Choto‐san, a Kampo medicine, on impairment of passive avoidance performance in senescence accelerated mouse (SAM)
200318 citationsauthor #1
Prevention of mucosally induced uveitis with a HSP60‐derived peptide linked to cholera toxin B subunit
200380 citationsauthor #8
Pulse Wave Velocity in Persons with Vascular Dementia
200321 citationsauthor #1
Efficacy of Rebamipide as Adjunctive Therapy in the Treatment of Recurrent Oral Aphthous Ulcers in Patients with Behçet’s Disease
200397 citationsauthor #10
Immunopathogenesis and prevention of uveitis with the Behçet's disease-specific peptide linked to cholera toxin B.
20036 citationsauthor #9
Soluble Fas ligand levels in cerebrospinal fluid in neuro-Behçet's disease.
20030 citationsauthor #10
Response to Donna Lenhoff's Letter on Mental Health Care in Nursing Homes, Nurse Staffing Studies
20030 citationsauthor #1
Insulin-loaded biodegradable PLGA microcapsules: initial burst release controlled by hydrophilic additives.
2002149 citationsauthor #5
[Prolonged release microcapsules of insulin for complement of the basal secretion].
20020 citationsauthor #5
Composition a base d'aggregats pour preparation a liberation prolongee, procede de production afferent, et preparation a liberation prolongee contenant ladite composition
20020 citationsauthor #3
Drug delivery system to control infectious diseases.
20027 citationsauthor #3
A novel sustained-release formulation of insulin with dramatic reduction in initial rapid release.
200265 citationsauthor #5
A novel insulin formulation can keep providing steady levels of insulin for much longer periods in‐vivo
200212 citationsauthor #5
Novel techniques inhibiting the immunological rejection in regeneration medicine
20020 citationsauthor #1
Efect of PGE_1 on hypoxia or hypoxia/ reoxygenation-treated human vascular endothelial cells
20020 citationsauthor #5
Clinical evaluations of TS-110 against rheumatoid arthritis
20010 citationsauthor #1
Lecithinized copper, zinc-superoxide dismutase ameliorates ischemia-induced myocardial damage.
200117 citationsauthor #6
Message to new century
20010 citationsauthor #1
Marked hypotensive and blood flow-increasing effects of a new lipo-PGE(1) (lipo-AS013) due to vascular wall targeting.
200133 citationsauthor #6
Changes in urinary levels of 8‐hydroxy‐2′‐deoxyguanosine due to aging and smoking
200114 citationsauthor #1
Osteoclast-like cells in an in vitro model of bone destruction by rheumatoid synovium.
200151 citationsauthor #9
Independence of Nation by science on basis of a patented technology
20010 citationsauthor #1
Memory of the late Prof. Tsuyoshi Sakane
20010 citationsauthor #1
Prognostic comparison between peripheral and central types of squamous cell carcinoma of the lung in patients undergoing surgical resection.
200018 citationsauthor #1
Possibility of lipid microsphere-encapsulated Y-24180 as an injectable drug and an inhaler for the treatment of bronchoconstriction
20002 citationsauthor #3
Genomic DNA Analysis of Thyrotropin with .Hereditary Hyperthyroidism Receptor in a Family
20000 citationsauthor #4
A major metabolite of aceclofenac, 4′-hydroxy aceclofenac, suppresses the production of interstitial pro-collagenase/proMMP-1 and pro-stromelysin-1/proMMP-3 by human rheumatoid synovial cells
200028 citationsauthor #3
Lecithinized copper, zinc-superoxide dismutase ameliorates prolonged hypoxia-induced injury of cardiomyocytes.
200012 citationsauthor #7
The future theme of the Japanese Inflammation Society
20000 citationsauthor #1
Genomic DNA analysis of thyrotropin receptor in a family with hereditary hyperthyroidism.
20005 citationsauthor #4
Effect of Combined Use of Lecithinized Superoxide Dismutase (PC-SOD) and Methylprednisolone (MPSL) on the Interstitial Pneumonia Model Induced by Bleomycin in Mice
20000 citationsauthor #6
Effect of a soluble pseudo-receptor on verotoxin 2-induced toxicity
20009 citationsauthor #6
A primary adrenal steroid, 11β-hydroxyandrostenedione, has an osteotropic effect and little androgenic activity
20007 citationsauthor #5
SOD activity, NOx, SH level in wobbler mice
19990 citationsauthor #7
Lecithinized ascorbic acid (PC-AS) effectively inhibits murine pulmonary metastasis.
199910 citationsauthor #4
Differential Modulatory Effects of Clarithromycin on the Production of Cytokines by a Tumor
199920 citationsauthor #2
Effect of Methylprednisolone on the Pharmacokinetics of Lecithinized SOD (PC-SOD) in Mice
19990 citationsauthor #3
Lipid microsphere preparation of a lipophilic ceramide derivative suppresses colony formation in a murine experimental pulmonary metastasis model.
19996 citationsauthor #8
Lipid microsphere preparation of a lipophilic ceramide derivative suppressed the colony formation of murine experimental metastasis.
19990 citationsauthor #6
Effect of lecithinized superoxide dismutase (PC-SOD) on experimental pulmonary metastasis in mice.
199918 citationsauthor #4
Highway institute for the development of innovative drugs.
19990 citationsauthor #1
A study of novel antiallergic agents with eosinophilic infiltration inhibiting action.
19994 citationsauthor #6
Therapeutic Effect of Clarithromycin on a Transplanted Tumor in Rats
199932 citationsauthor #2
[The trends of new drug development in the 21st century].
19990 citationsauthor #1
Synovial fibroblast proliferation and cytokines: Possible regulation by ras gene.
19990 citationsauthor #5
Therapeutic effect of a new synthetic lipid A analog (ONO-4007) on a tumor implanted at different sites in rats.
19997 citationsauthor #1
Influence of long-term low-dose methotrexate therapy on periarticular and generalized osteoporosis in rheumatoid arthritis
19991 citationsauthor #4
Prognosis for patients with pneumonectomy or lesser resections for non-small cell lung cancer based on histologic cell type.
19986 citationsauthor #1

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