T. Sosnick

BPS2026 – The trouble with tryptophan: Effects on disordered protein conformational ensembles and intermolecular interactions
20260 citationsauthor #4
Design and Use of AsLOV2-Based Optogenetic Tools for Actin Imaging.
20250 citationsauthor #2
Monte Carlo Tree Diffusion with Multiple Experts for Protein Design
20250 citationsauthor #7
BPS2025 - Effects of hydrophobic sequence patterns on the disordered conformational ensembles of foldable proteins
20250 citationsauthor #3
BPS2025 - Intrinsically disordered regions are crucial for myosin 10 cargo binding as revealed by HDX/XL-MS and DNA-PAINT
20250 citationsauthor #7
Direct observation of protein-peptide folding and binding in the formation of ribonuclease S
20240 citationsauthor #6
Correction to "Trifluoroethanol Promotes Helix Formation by Destabilizing Backbone Exposure: Desolvation Rather than Native Hydrogen Bonding Defines the Kinetic Pathway of Dimeric Coiled Coil Folding".
20240 citationsauthor #2
Tuning prestin’s areal expansion through transmembrane helix stability as measured by HDX-MS
20240 citationsauthor #5
Collapse and Protein Folding: Should We Be Surprised that Biothermodynamics Works So Well?
20243 citationsauthor #1
Effects of hydrophobic sequence patterns on disordered protein conformational ensembles
20240 citationsauthor #3
Correction to Gaffney et al., Lipid bilayer induces contraction of the denatured state ensemble of a helical-bundle membrane protein
20240 citationsauthor #15
Using HDX-MS to probe the dynamics and free energy surface of GlpG, a helical membrane protein
20240 citationsauthor #4
Folding stability at the anion-binding site distinguishes prestin from other SLC26 transporters as revealed by HDX-MS.
20230 citationsauthor #6
Coarse-grained RNA simulations with concerted c2'/c3'-endo sugar pucker transitions.
20230 citationsauthor #5
Investigating the sequence properties that govern disorder and secretion of bacterial virulence proteins.
20230 citationsauthor #3
The functional and molecular determinants of stress-induced mRNA condensation.
20230 citationsauthor #4
An adaptive biomolecular condensation response is conserved across environmentally divergent species
202315 citationsauthor #7
Using HDX-MS to probe the dynamics and denatured state of GlpG, a helical membrane protein.
20230 citationsauthor #4
The factors that determine the force needed to unfold a membrane protein in silico depend on the pulling direction.
20230 citationsauthor #3
AlphaFold developers Demis Hassabis and John Jumper share the 2023 Albert Lasker Basic Medical Research Award
20230 citationsauthor #1
Factors That Control the Force Needed to Unfold a Membrane Protein in Silico Depend on the Mode of Denaturation
20231 citationsauthor #3
Development of in vivo HDX‐MS with applications to a TonB‐dependent transporter and other proteins
202210 citationsauthor #5
HDX-MS performed on BtuB in E. coli outer membranes delineates the luminal domain’s allostery and unfolding upon B12 and TonB binding
202223 citationsauthor #4
Conformational diversity and contraction of the denatured state ensemble of a helical membrane protein
20220 citationsauthor #1
Characterizing the sequence determinants of protein disorder and its impact on virulence protein secretion
20220 citationsauthor #4
The functional and molecular determinants of stress-induced mRNA condensation
20220 citationsauthor #3
Challenges and Advantages of Accounting for Backbone Flexibility in Prediction of Protein-Protein Complexes.
20225 citationsauthor #5
Sequential Activation and Local Unfolding Control Poly(A)-Binding Protein Condensation
20222 citationsauthor #7
Quantification of allosterically-driven unfolding in a TonB-dependent transporter using HDX-ms in outer membranes
20220 citationsauthor #4
The downside and upside of including backbone flexibility for predicting protein and antibody binding
20220 citationsauthor #4
Molecular basis of stress-triggered phase separation of Pab1 mediated by folded domains rather than disordered regions
20221 citationsauthor #6
Potassium channel folding assessed by hydrogen exchange mass spectrometry and tryptophan fluorescence identifies pore helix and selectivity filter folding events
20220 citationsauthor #7
LILAC: Enhanced actin imaging with an optogenetic Lifeact
20224 citationsauthor #3
Folding and misfolding of potassium channel monomers during assembly and tetramerization
20214 citationsauthor #7
Lipid bilayer induces contraction of the denatured state ensemble of a helical-bundle membrane protein
202117 citationsauthor #15
Engineered Metal-Binding Sites to Probe Protein Folding Transition States: Psi Analysis.
20212 citationsauthor #2
Molecular dynamics study of water channels in natural and synthetic amyloid-β fibrils.
20212 citationsauthor #4
Direct Observation of the Contraction of an Unfolded Protein with Temperature
20210 citationsauthor #8
Prediction and Validation of a Protein’s Free Energy Surface Using Hydrogen Exchange and (Importantly) Its Denaturant Dependence
202117 citationsauthor #11
Prediction of a Protein‘s Free Energy Surface and Validation with Hd Exchange
20210 citationsauthor #8
Properties of protein unfolded states suggest broad selection for expanded conformational ensembles
202047 citationsauthor #6
Upside: Protein Folding in CPU-Hours with Applications to Force-Unfolding of Membrane Proteins
20200 citationsauthor #1
Water as a good solvent for unfolded proteins: Folding and collapse are fundamentally different.
202033 citationsauthor #3
Membrane Induces Contraction but not Collapse of the Denatured State of a Helical Membrane Protein
20200 citationsauthor #6
Water Dynamics and Interactions Inside Amyloid-Beta Fibrils
20200 citationsauthor #4
Molecular Factors Underlying Stress-Triggered Phase-Separation of Pab1
20190 citationsauthor #6
On the Interpretation of Force-Induced Unfolding Studies of Membrane Proteins Using Fast Simulations.
201911 citationsauthor #4
Fast, Atomic-Level AFM and Magnetic Tweezers Simulations of the Unfolding of Membrane Proteins using a New Membrane Burial Potential with H-Bonding
20190 citationsauthor #4
Controlling the Folding and Misfolding of Potassium Channels
20190 citationsauthor #5
Structural Dynamics of Potassium Channel Monomer in a Membrane Environment and Tetrameric Assembly
20190 citationsauthor #5
Structural basis for adhesion G protein-coupled receptor Gpr126 function
201957 citationsauthor #6
Helical Contributions Mediate Light-Activated Conformational Change in the LOV2 Domain of Avena sativa Phototropin 1
201922 citationsauthor #3
The importance of measuring the solvent quality of unfolded proteins
20190 citationsauthor #1
Accurate calculation of side chain packing and free energy with applications to protein molecular dynamics
201833 citationsauthor #4
A Membrane Burial Potential with H-Bonds and Applications to Curved Membranes and Fast Simulations.
20187 citationsauthor #5
Commonly used FRET fluorophores promote collapse of an otherwise disordered protein
201864 citationsauthor #6
Saxs Confirms that FRET Dyes Promote Collapse of an Otherwise Fully Disordered Protein
20181 citationsauthor #6
Trajectory-based training enables protein simulations with accurate folding and Boltzmann ensembles in cpu-hours
201837 citationsauthor #4
Response to Comment on “Innovative scattering analysis shows that hydrophobic disordered proteins are expanded in water”
201832 citationsauthor #9
Measuring the solvent quality of water for disordered proteins from a single SAXS measurement
20180 citationsauthor #10
Aβ Fibrils Can Act as Aqueous Pores: a Molecular Dynamics Study
20181 citationsauthor #4
Trajectory-Based Parameterization of a Coarse-Grained Forcefield for High-Thoughput Protein Simulation
20174 citationsauthor #3
Data from: Stress-triggered phase separation is an adaptive, evolutionarily tuned response
20171 citationsauthor #6
Investigations of human myosin VI targeting using optogenetically controlled cargo loading
201719 citationsauthor #2
Visualizing Structural Details of Disordered Domain Phase Separation Associated with ALS and Cancers
20170 citationsauthor #5
Conserved salt-bridge competition triggered by phosphorylation regulates the protein interactome
201738 citationsauthor #12
Perplexing cooperative folding and stability of a low-sequence complexity, polyproline 2 protein lacking a hydrophobic core
201733 citationsauthor #8
A Phospho-Induced Theft of a Salt Bridge in RKIP Links Map Kinase and G Protein-Mediated Signaling
20170 citationsauthor #1
Aromatic claw: A new fold with high aromatic content that evades structural prediction
20170 citationsauthor #8
Stress-Triggered Phase Separation Is an Adaptive, Evolutionarily Tuned Response.
2017786 citationsauthor #6
Innovative scattering analysis shows that hydrophobic disordered proteins are expanded in water
2017204 citationsauthor #10
Extending Upside, a Near-Atomic Level Model for Fast Protein Folding, for Predicting Protein-Protein Interactions
20170 citationsauthor #4
Measuring the (Good) Solvent Quality of Water for Disordered Proteins from a Single SAXS Measurement
20170 citationsauthor #10
Investigations of human myosin VI targeting using optogenetically-controlled cargo loading
20170 citationsauthor #2
Folding Membrane Proteins by Contacts Inferred from Non-Membrane Proteins and Near-Atomic Level Refinement
20170 citationsauthor #5
Molecular Determinants of Specificity in the Dpr-DIP Interaction Network
20170 citationsauthor #4
The Pentablock Amphiphilic Copolymer T1107 Prevents Aggregation of Denatured and Reduced Lysozyme.
20174 citationsauthor #2
How Evolution Tunes Stress-Triggered Protein Phase Separation to Promote Cell Fitness During Stress
20171 citationsauthor #5
Cooperative folding near the downhill limit determined with amino acid resolution by hydrogen exchange
20168 citationsauthor #5
Rapid calculation of side chain packing and free energy with applications to protein molecular dynamics
20164 citationsauthor #3
Including H-Bonding in Depth-Dependent Membrane Burial Potentials for Improving Folding Simulations
20161 citationsauthor #4
Erratum: "Ionic strength independence of charge distributions in solvation of biomolecules" [J. Chem. Phys. 141, 22D503 (2014)].
20160 citationsauthor #2
Optogenetically controlled cargo shows full length human myosin VI integrates activation signals in vivo and in vitro
20160 citationsauthor #2
Hydrophobicity of Poly(A)-Binding Protein's Intrinsically Disordered Region Determines its Conformation and Organism Thermotolerance
20160 citationsauthor #3
Introduction of a polar core into the de novo designed protein Top7
20169 citationsauthor #5
An Optogenetic Method for Controlling Full-Length Myosin VI through its Cargo Binding Domain
20160 citationsauthor #3
Dissecting the Folding Pathway of Potassium Channel Pore Domains
20160 citationsauthor #3
Upside: A New Dynamics Method Capable of Cooperative De Novo Protein Folding in CPU-Hours
20160 citationsauthor #1
Aβ Fibrils Act as Aqueous Pores: A Molecular Dynamics Study
20160 citationsauthor #3
Maximum-likelihood, self-consistent side chain free energies with applications to protein molecular dynamics
20163 citationsauthor #3
Spectroscopic Study of Full-Length Recombinant Proteoglycan 4 (rhPRG4): Self-Assembly and Interactions with Hyaluronan
20150 citationsauthor #5
Random coil negative control reproduces the discrepancy between scattering and FRET measurements of denatured protein dimensions
201550 citationsauthor #3
Even with nonnative interactions, the updated folding transition states of the homologs Proteins G & L are extensive and similar
201522 citationsauthor #8
Heat Shock Triggers Assembly of tRNA Synthetases into an Active Supercomplex
20151 citationsauthor #7
Loss of conformational entropy in protein folding calculated using realistic ensembles and its implications for NMR-based calculations
2014106 citationsauthor #5
Ionic strength independence of charge distributions in solvation of biomolecules.
20148 citationsauthor #2
Benchmarking all-atom simulations using hydrogen exchange
201470 citationsauthor #7
RNA Structure and Folding Analyzed Using Small‐Angle X‐Ray Scattering
20142 citationsauthor #3
Factors That Control the Chemistry of the LOV Domain Photocycle
2014110 citationsauthor #2
Structural Characterization of a Phospho‐Switch in the Metastasis Suppressor RKIP (LB189)
20140 citationsauthor #4

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