T. Kumai

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Aliases
T Kumai, T. Kumai, Toshio Kumai
Publication record
216 papers · 2,516 citations · H-index 30

PAPERS

A new bioinformatics approach identifies overexpression of GRB2 as a poor prognostic biomarker for prostate cancer
20217 citationsauthor #16
NF‐kB signaling in cardiomyocytes is inhibited by sevoflurane and promoted by propofol
20206 citationsauthor #7
Stress-related over-enhancement of the hypothalamic-pituitary-adrenal axis causes experimental neurolathyrism in rats.
20191 citationsauthor #5
Introduction of a cartilage calcification insufficient rat as an infertile model animal
20180 citationsauthor #9
The effect of physiological stress as a risk factor of neurolathyrism
20180 citationsauthor #2
Population Profile of Cytochrome P450 Isozymes in the Small Intestine of Japanese
20182 citationsauthor #13
A bioinformatics-to-clinic sequential approach to analysis of prostate cancer biomarkers using TCGA datasets and clinical samples: a new method for precision oncology?
20178 citationsauthor #12
A Subclassification of Basal-like Breast Cancer for Prognostic Prediction
20170 citationsauthor #6
Role of Gremlins in the Aortic Arch of Spontaneously Hypertensive and Hyperlipidemic Rats
20162 citationsauthor #7
Effects of serotonin transporter gene polymorphism on mood during the period before the competition in Japanese ballet dancers
20163 citationsauthor #2
Beyond resistance to PARP inhibition: Mechanisms and effective treatment options.
20155 citationsauthor #4
Effects of Genetic Polymorphism of CYP2B6 and UGT1A9 and Sex Differences on Pharmacokinetics of Propofol
20155 citationsauthor #5
Proteomic Analysis Reveals the Association between the Rho-GDI Signaling Pathway and Kidney Injury in Spontaneously Hypertensive and Hyperlipidemic Rats
20150 citationsauthor #7
Calcitonin Gene-related Peptide Inhibits Tumor Cell Proliferation of Hepatocellular Carcinoma Cells Through the Ras/MEK/ERK Pathway
20151 citationsauthor #6
Proteomic analysis of differential protein expression by brain metastases of gynecological malignancies
201338 citationsauthor #7
Gene expression in the vascular wall of the aortic arch in spontaneously hypertensive hyperlipidemic model rats using DNA microarray analysis.
20139 citationsauthor #2
Hepatic Gene Expression Associated With Macrophage and OxidativeStress of Simple Steatosis and Non-Alcoholic Steatohepatitis Model RatsUsing DNA Microarray Analysis Microarray Analysis
20130 citationsauthor #2
Vildagliptin Improves Glucose Tolerance and Decreases Plasma Triglycerides in Sprague-Dawley Rats
20130 citationsauthor #2
Hepatic Gene Expression Associated With Macrophage and Oxidative Stress of Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis Model Rats Using DNA Microarray Analysis
20120 citationsauthor #2
17β-estradiol prevents reduction of retinal phosphorylated 14-3-3 zeta protein levels following a neurotoxic insult.
20126 citationsauthor #4
The Rho kinase inhibitor fasudil is involved in p53-mediated apoptosis in human hepatocellular carcinoma cells
201225 citationsauthor #6
Hepatic Gene Expression Associated With Macrophage and Oxidative Stress of Simple Steatosis and Non-Alcoholic Steatohepatitis Model Rats Using DNA Microarray Analysis
20121 citationsauthor #2
Increase in Matrix Metalloproteinase-2 and 9 in the Liver of Nonalcoholic Steatohepatitis (NASH) Model Rats
20115 citationsauthor #3
Axonal protection by 17β-estradiol through thioredoxin-1 in tumor necrosis factor-induced optic neuropathy.
201130 citationsauthor #7
Polymorphism of warfarin related genes (VKORC1 and CYP2C9) analyzed by the smart amplification process method in patients with atrial fibrillation
20110 citationsauthor #3
Individual differences in pharmacokinetics and pharmacodynamics of anesthetic agent propofol with regard to CYP2B6 and UGT1A9 genotype and patient age.
201138 citationsauthor #2
Orange Juice and Its Component, Hesperidin, Decrease the Expression of Multidrug Resistance-Associated Protein 2 in Rat Small Intestine and Liver
201111 citationsauthor #4
Comparative study of culture conditions for maintaining CYP3A4 and ATP-binding cassette transporters activity in primary cultured human hepatocytes.
201116 citationsauthor #5
Comparison of the effects of omeprazole and rabeprazole on ticlopidine metabolism in vitro.
20113 citationsauthor #9
Individual metabolic capacity evaluation of cytochrome P450 2C19 by protein and activity in the small intestinal mucosa of Japanese pancreatoduodenectomy patients.
201111 citationsauthor #6
Sucrose and a high-fat diet enhance visceral fat tissue gain and lipid deposition in the aorta of spontaneously hypertensive hyperlipidemic rats
20110 citationsauthor #2
Limited effects of frequent CYP2D6*36-*10 tandem duplication allele on in vivo dextromethorphan metabolism in a Japanese population
201030 citationsauthor #3
Visceral Fat Accumulation is Associated with Oxidative Stress and Increased Matrix Metalloproteinase-9 Expression in Atherogenic Factor-overlapped Model Rats
20104 citationsauthor #3
Effects of a calcium-channel blocker (CV159) on hepatic ischemia/reperfusion injury in rats: evaluation with selective NO/pO2 electrodes and an electron paramagnetic resonance spin-trapping method.
201015 citationsauthor #9
Overexpression of heat shock protein 27 in squamous cell carcinoma of the uterine cervix: a proteomic analysis using archival formalin-fixed, paraffin-embedded tissues.
200932 citationsauthor #2
Antenatal glucocorticoid therapy increase cardiac alpha-enolase levels in fetus and neonate rats.
200922 citationsauthor #3
Inter-individual variation in flavin-containing monooxygenase 3 in livers from Japanese: correlation with hepatic transcription factors.
200929 citationsauthor #5
Potential of lansoprazole as a novel probe for cytochrome P450 3A activity by measuring lansoprazole sulfone in human liver microsomes.
20098 citationsauthor #4
Axonal and Cell Body Protection By Nicotinamide Adenine Dinucleotide in Tumor Necrosis Factor-Induced Optic Neuropathy
200930 citationsauthor #3
Identification and Expression of Cardiac Contractry Protein Troponin T by Antenatal Glucocorticoid Therapy in Fetal and Infant Rats
20083 citationsauthor #3
Axonal protection by brain-derived neurotrophic factor associated with CREB phosphorylation in tumor necrosis factor-α-induced optic nerve degeneration
200831 citationsauthor #6
Decreased Nicotinamide Adenine Dinucleotide (NAD) Level and the Effect of Exogenous NAD on Microglia Activation N TNF--Induced Optic Nerve Degeneration
20080 citationsauthor #4
Pioglitazone Modulates Plasma MMP-9 and TIMP-1 Activities in Spontaneously Hypertensive Hyperlipidemic Rats Fed a High-fat Diet Plus Sucrose Solution
20081 citationsauthor #4
Matrix metalloproteinase-9 in spontaneously hypertensive hyperlipidemic rats.
200810 citationsauthor #4
Effects of antenatal dexamethasone on antioxidant enzymes and nitric oxide synthase in the rat lung.
200816 citationsauthor #2
Alterations of Glucose-Dependent and -Independent Bladder Smooth Muscle Contraction in Spontaneously Hypertensive and Hyperlipidemic Rat
200816 citationsauthor #3
Involvement of Antioxidant Enzymes in NMDA-Induced Retinal Excitotoxicity
20070 citationsauthor #2
Pioglitazone Increases Tissue Inhibitors of Metalloproteinase-1 in Plasma in Spontaneously Hypertensive Hyperlipidemic Rats
20070 citationsauthor #5
Irinotecan activates p53 with its active metabolite, resulting in human hepatocellular carcinoma apoptosis.
200753 citationsauthor #2
Irinotecan-induced apoptosis is inhibited by increased P-glycoprotein expression and decreased p53 in human hepatocellular carcinoma cells.
200740 citationsauthor #3
Fasudil attenuates sympathetic nervous activity in the adrenal medulla of spontaneously hypertensive rats.
20079 citationsauthor #1
Calcium/calmodulin-dependent protein kinase II regulates the phosphorylation of CREB in NMDA-induced retinal neurotoxicity.
200744 citationsauthor #4
Pioglitazone Improvement of Matrix Metalloproteinase-9 Activity in Vitreous of Spontaneously Hypertensive Hyperlipidemic Rats Fed High Fat Diet and Sucrose Solution
20070 citationsauthor #4
Hypertension aggravates glomerular dysfunction with oxidative stress in a rat model of diabetic nephropathy.
200750 citationsauthor #2
Bax Activation-Mediated Apoptosis in Glutamate-Induced Neurotoxicity
20070 citationsauthor #3
Early Phosphorylation of Calcium / Calmodulin-Dependent Protein Kinase II in NMDA-Induced Retinal Damage
20070 citationsauthor #6
Development of hyperfibrinogenemia in spontaneously hypertensive and hyperlipidemic rats: a potentially useful animal model as a complication of hypertension and hyperlipidemia.
200718 citationsauthor #4
Effects of pioglitazone on increases in visceral fat accumulation and oxidative stress in spontaneously hypertensive hyperlipidemic rats fed a high-fat diet and sucrose solution.
200742 citationsauthor #4
Tnf– Production in Glutamate–Induced Apoptosis in a Differentiated Neuronal Cell Line
20060 citationsauthor #3
Involvement of TNF-alpha in glutamate-induced apoptosis in a differentiated neuronal cell line.
200614 citationsauthor #3
Questionnaire on the Human Tissue Bank for Medical Research on Patients and Medical Staff
20061 citationsauthor #3
Enhanced Expression of Activator Protein–1 (AP–1) in N–Methyl–D–Aspartate (NMDA)–Induced Apoptotic Cell Death
20060 citationsauthor #4
Dosage quantity, plasma risperidone concentration and relationship with clinical effect: contribution of 9-OH-RIS
20060 citationsauthor #3
The elucidation of the mechanism of weight gain and glucose tolerance abnormalities induced by chlorpromazine.
200621 citationsauthor #2
Liver-type fatty acid-binding protein attenuates renal injury induced by unilateral ureteral obstruction.
200685 citationsauthor #7
Effect of genetic polymorphism of CYP2D6 and plasma 9-OH-RIS concentration on clinical effect
20060 citationsauthor #3
Relationship between efficacy of risperidone and genetic polymorphism in schizophrenia treatment
20060 citationsauthor #3
Pro‐apoptotic role of c‐Jun in NMDA‐induced neurotoxicity in the rat retina
200630 citationsauthor #4
Orange juice increased the bioavailability of pravastatin, 3-hydroxy-3-methylglutaryl CoA reductase inhibitor, in rats and healthy human subjects.
200640 citationsauthor #2
Neuroprotective effect of atrial natriuretic peptide against NMDA-induced neurotoxicity in the rat retina.
200630 citationsauthor #3
Involvement of TNF-α in glutamate-induced apoptosis in a differentiated neuronal cell line
200623 citationsauthor #3
Pioglitazone Improves Matrix Metalloproteinase–9 Activity in Plasma and Vitreous in Spontaneously Hypertensive Hyperlipidemic Rats
20060 citationsauthor #6
L-NAME Inhibits Colon Cancer Cell-induced Angiogenesis and VEGF Production
20050 citationsauthor #2
TNF– Production in Glutamate–induced Apoptotic Neuronal Cell Death
20050 citationsauthor #3
Problems and Their Solutions in University Hospitals Providing Tissue to the Public Human Tissue Bank for Research Use
20051 citationsauthor #3
The Improving Mechanism of Atrial Natriuretic Polypeptide on NMDA–Induced Neurotoxicity of Rat Retina
20051 citationsauthor #2
Increase in Matrix Metalloproteinase–9 Activities in Spontaneously Hypertensive Hyperlipidemic Rats
20050 citationsauthor #8
Construction of research utilization system of the human tissues and research application. 3. Present states of human tissue offering medical institution.
20050 citationsauthor #1
Pleiotropic effects of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors: candidate mechanisms for anti-lipid deposition in blood vessels.
200516 citationsauthor #1
Enhancement of the coagulation system in spontaneously hypertensive and hyperlipidemic rats.
200524 citationsauthor #4
Contribution of mitogen-activated protein kinases to NMDA-induced neurotoxicity in the rat retina.
200549 citationsauthor #8
Utilization of human liver microsomes to explain individual differences in paclitaxel metabolism by CYP2C8 and CYP3A4.
200555 citationsauthor #2
Attempting to predict the efficacy of olanzapine by genotype
20050 citationsauthor #3
Examination about Vascular Wall Lipid Deposition and Alteration of Fat Metabolism Aberration-related Protein out of Spontaneously Hypertensive Hyperlipidemic Rats(Atherosclerosis, Basic 5 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
20050 citationsauthor #2
Expression of c–Jun in NMDA–induced Apoptosis Pathway in the Rat Retina
20050 citationsauthor #4
Polymorphism of serotonin and histamine receptors and clinical efficacy of olanzapine
20040 citationsauthor #3
Involvement of RhoA and possible neuroprotective effect of fasudil, a Rho kinase inhibitor, in NMDA-induced neurotoxicity in the rat retina.
2004100 citationsauthor #3
N-methyl-D-aspartate induces phosphorylation of cAMP response element (CRE)-binding protein and increases DNA-binding activity of CRE in rat retina.
200410 citationsauthor #2
Plasma concentration of olanzapine and its clinical efficacy
20040 citationsauthor #3
Activation CaMKII and CREB following NMDA–induce neurotoxicity in rat retina
20040 citationsauthor #2
Anti-lipid deposition effect of HMG-CoA reductase inhibitor, pitavastatin, in a rat model of hypertension and hypercholesterolemia.
200420 citationsauthor #1
Expression of CYP3A4 mRNA is correlated with CYP3A4 protein level and metabolic activity in human liver.
200443 citationsauthor #2
Atrial natriuretic peptide recovered NMDA–induced reduction of catecholamine synthetic pathway in retina of rats
20041 citationsauthor #3
The effect of orange juice on the pharmacokinetics of the 3‐hydroxy‐3‐methylglutaryl COA (HMG‐COA) reductase inhibitor pravastatin
20040 citationsauthor #2
Modulation of retinal dopaminergic cells by nitric oxide. A protective effect on NMDA-induced retinal injury.
200411 citationsauthor #2
Apoptosis in anti‐tumor effect of irinotecan is mediated by p53 in human hepatocellular carcinoma cell line
20040 citationsauthor #2
Dispositif de traitement d'information
20040 citationsauthor #2
The effect of polymorphism on serotonin and histamine reseptor in antipsychotic action of olanzapine
20040 citationsauthor #3
P–JNK expression of the rat retina in NMDA–induced neurotoxicity.
20041 citationsauthor #7
Nuclear factor-kappa B p65 in NMDA-induced retinal neurotoxicity.
200437 citationsauthor #2

TIMELINE

1981 1 citations

1982 79 citations

1983 0 citations

1984 3 citations

1985 2 citations

1986 3 citations

1987 1 citations

1988 1 citations

1989 1 citations

1990 3 citations

1991 6 citations

1992 5 citations

1993 0 citations

1994 74 citations

1995 50 citations

1996 40 citations

1997 232 citations

1998 92 citations

1999 196 citations

2000 106 citations

2001 102 citations

2002 79 citations

2003 85 citations

2004 231 citations

2005 146 citations

2006 244 citations

2007 256 citations

2008 77 citations

2009 121 citations

2010 49 citations

2011 114 citations

2012 32 citations

2013 47 citations

2015 11 citations

2016 5 citations

2017 8 citations

2018 2 citations

2019 1 citations

2020 6 citations

2021 7 citations

T. Kumai

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