M. D. de Leon

Genetic modifiers of APOE-ε4-associated cognitive decline.
20260 citationsauthor #131
Brain glymphatic fluid mapping in Alzheimer’s disease: a human MRI and PET study
20257 citationsauthor #14
Concordance between Centiloid Quantification and Visual Interpretation of Amyloid PET Scans across the Alzheimer Disease Continuum
20252 citationsauthor #13
Heterogeneous tau deposition patterns in the preclinical stage link to domain‐specific cognitive deficits
20252 citationsauthor #9
Human lifespan changes in the brain’s functional connectome
202557 citationsauthor #183
Voxel-wise insights into early Alzheimer’s disease pathology progression: the association with APOE and memory decline
20250 citationsauthor #120
Inter-network functional connectivity increases by beta-amyloid and may facilitate the early stage of tau accumulation.
20257 citationsauthor #3
Dynamic proportional loss of functional connectivity revealed change of left superior frontal gyrus in subjective cognitive decline: an explanatory study based on Chinese and Western cohorts
20251 citationsauthor #130
PET Imaging of Neurofluids.
20250 citationsauthor #3
Association between self-reported multimorbidity and longitudinal brain Aβ deposition in Alzheimer’s disease
20251 citationsauthor #86
Region-informed machine learning model for choroid plexus segmentation in Alzheimer’s disease
20250 citationsauthor #11
Divergent neurodegeneration associations with choroid plexus volume and degree of calcification in cognitively normal APOE ε4 carriers and non-carriers
20254 citationsauthor #20
PET Imaging of Neurofluids.
20251 citationsauthor #3
Basic Science and Pathogenesis.
20240 citationsauthor #16
Clinical Arterial Spin-Labeling MR Imaging to Screen for Typical and Atypical Neurodegenerative Disease in the New Era of Alzheimer Treatment
20244 citationsauthor #10
Remote Associations Between Tau and Cortical Amyloid-β Are Stage-Dependent
20244 citationsauthor #4
Altered Cerebral Blood Flow as a Screening Test for Neurodegenerative Disease: A Comparative Analysis of Arterial Spin Labeled Magnetic Resonance Imaging and 18F‐Fluorodeoxyglucose Positron Emission Tomography
20240 citationsauthor #7
Longitudinal trajectories of Alzheimer's disease CSF biomarkers and blood pressure in cognitively healthy subjects
20246 citationsauthor #14
Brain Fluid Clearance After Traumatic Brain Injury Measured Using Dynamic Positron Emission Tomography
20244 citationsauthor #16
Reduction in Constitutively Activated Auditory Brainstem Microglia in Aging and Alzheimer’s Disease
20242 citationsauthor #21
Diffusion Tensor Imaging Along Perivascular Spaces (DTI-ALPS) to Assess Effects of Age, Sex, and Head Size on Interstitial Fluid Dynamics in Healthy Subjects
202413 citationsauthor #11
Quantitative transport mapping of multi-delay arterial spin labeling MRI detects early blood perfusion alteration in Alzheimer’s disease
20240 citationsauthor #8
A novel spatiotemporal graph convolutional network framework for functional connectivity biomarkers identification of Alzheimer’s disease
202415 citationsauthor #134
[1-11C]-Butanol Positron Emission Tomography reveals an impaired brain to nasal turbinates pathway in aging amyloid positive subjects
20247 citationsauthor #27
Polygenic effects on the risk of Alzheimer’s disease in the Japanese population
202413 citationsauthor #87
Quantitative transport mapping of multi-delay arterial spin labeling MRI detects early blood perfusion alterations in Alzheimer’s disease
20249 citationsauthor #8
Abstract P374: Systolic blood pressure burden better predicts tau accumulation than a one-time measurement
20240 citationsauthor #8
Robust, fully-automated assessment of cerebral perivascular spaces and white matter lesions: a multicentre MRI longitudinal study of their evolution and association with risk of dementia and accelerated brain atrophy
202414 citationsauthor #119
Impact of amyloid and cardiometabolic risk factors on prognostic capacity of plasma neurofilament light chain for neurodegeneration
20241 citationsauthor #119
Sex differences in interacting genetic and functional connectivity biomarkers in Alzheimer’s disease
20243 citationsauthor #122
Remote associations between beta‐amyloid and tau are mediated by between‐network connectivity
20240 citationsauthor #3
Multiomics analysis to explore blood metabolite biomarkers in an Alzheimer’s Disease Neuroimaging Initiative cohort
202420 citationsauthor #123
Evidence of Pericyte Damage in a Cognitively Normal Cohort
20245 citationsauthor #14
Diagnostic accuracy of phosphorylated tau217 in detecting Alzheimer's disease pathology among cognitively impaired and unimpaired: A systematic review and meta‐analysis
202429 citationsauthor #17
Parenchymal CSF fraction is a measure of brain glymphatic clearance and positively associated with amyloid beta deposition on PET
202421 citationsauthor #9
Quantitative transport mapping estimated blood flow velocity is more sensitive to the perfusion change in Alzheimer's disease than the conventional cerebral blood flow, estimated from multiple delay arterial spin labeling
20240 citationsauthor #9
Local molecular and connectomic contributions of tau-related neurodegeneration
20243 citationsauthor #125
The neutrophil to lymphocyte ratio associates with markers of Alzheimer’s disease pathology in cognitively unimpaired elderly people
202416 citationsauthor #22
Complementary value of molecular, phenotypic, and functional aging biomarkers in dementia prediction
20244 citationsauthor #118
Correction: Polygenic effects on the risk of Alzheimer’s disease in the Japanese population
20240 citationsauthor #87
Glucose metabolism in posterior cingulate cortex has supplementary value to predict the progression of cognitively unimpaired to dementia due to Alzheimer’s disease: an exploratory study of ^18F-FDG-PET
202312 citationsauthor #131
Clearance of interstitial fluid (ISF) and CSF (CLIC) group‐part of Vascular Professional Interest Area (PIA), updates in 2022‐2023. Cerebrovascular disease and the failure of elimination of Amyloid‐β from the brain and retina with age and Alzheimer's disease: Opportunities for therapy
202321 citationsauthor #11
Brain tissue cerebrospinal fluid fraction increases quadratically in normal aging
20230 citationsauthor #10
Abstract 104: Assessment Of Brain Venous System In Hypertension
20230 citationsauthor #8
Thriving In and Out of the Reading Room: A Faculty Development Workshop.
20232 citationsauthor #8
Brain fog in long COVID limits function and health status, independently of hospital severity and preexisting conditions
202310 citationsauthor #7
Glymphatic clearance estimated using diffusion tensor imaging along perivascular spaces is reduced after traumatic brain injury and correlates with plasma neurofilament light, a biomarker of injury severity
202343 citationsauthor #9
Association of brain tissue cerebrospinal fluid fraction with age in healthy cognitively normal adults
202314 citationsauthor #10
Associations of NREM Slow Wave Activity and Regional in‐vivo tau PET deposition in black and white community‐dwelling cognitively normal older‐adults with normal sleep
20230 citationsauthor #11
CSF Fraction Mapping Derived from Multi‐echo MR FAST‐T2 Sequence Could be an Alternative Measure of Total Perivascular Space in the Brain Parenchyma
20230 citationsauthor #7
Peripheral immune cell imbalance is associated with cortical beta-amyloid deposition and longitudinal cognitive decline
202326 citationsauthor #7
Deep learning-based polygenic risk analysis for Alzheimer’s disease prediction
202349 citationsauthor #138
Quantitative Transport Mapping Derived Tracer Velocity for Alzheimer’s Disease
20230 citationsauthor #4
Multimodal Assessment of Brain Fluid Clearance is Associated with Amyloid-Beta Deposition in Humans.
202327 citationsauthor #8
Author Correction: Predicting Alzheimer’s disease progression using multi-modal deep learning approach
20230 citationsauthor #135
Reduced glymphatic function after traumatic brain injury measured using diffusion MRI
20221 citationsauthor #9
Quantitative Water Permeability Mapping of Blood-Brain-Barrier Dysfunction in Aging
202247 citationsauthor #5
Targeting Succinate Receptor Reduces Microglial Activation and Neuroinflammation
20220 citationsauthor #9
Comprehensive analysis of epigenetic clocks reveals associations between disproportionate biological ageing and hippocampal volume
202225 citationsauthor #129
An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer’s disease
202237 citationsauthor #138
The Brain-Nose Interface: A Potential Cerebrospinal Fluid Clearance Site in Humans
202239 citationsauthor #15
Quantifying cerebrospinal fluid dynamics: A review of human neuroimaging contributions to CSF physiology and neurodegenerative disease
202235 citationsauthor #13
Decreased CSF clearance and increased brain amyloid in Alzheimer’s disease
20221 citationsauthor #17
Neurodegeneration blood markers in largely Hispanic and non‐Hispanic Black COVID‐19 patients: from acute hospitalization to long‐term PASC with/without brain fog
20220 citationsauthor #6
Higher body mass index is associated with worse hippocampal vasoreactivity to carbon dioxide
20224 citationsauthor #13
Multimodal Imaging Analysis for Brain Clearance: PET Imaging Based Clearance Slope, FASTT2 MRI‐based Parenchyma CSF fraction, and DTI‐based ALPS‐index
20220 citationsauthor #4
Glucose metabolism patterns: A potential index to characterize brain ageing and predict high conversion risk into cognitive impairment
202212 citationsauthor #132
Dissociation of tau pathology and neuronal hypometabolism within the ATN framework of Alzheimer’s disease
202237 citationsauthor #120
Positron Emission Tomography reveals age-associated hypothalamic microglial activation in women
202210 citationsauthor #18
Association Between Systemic Amyloidosis and Intracranial Hemorrhage.
20225 citationsauthor #9
Obstructive Sleep Apnea and Hypertension with Longitudinal β-Amyloid Burden and Cognitive Changes.
202210 citationsauthor #17
Statistical Parametric Mapping in Amyloid Positron Emission Tomography
20225 citationsauthor #10
Quadratic relationship between systolic blood pressure and white matter lesions in individuals with hypertension
20222 citationsauthor #9
Tau PET following acute TBI: Off-target binding to blood products, tauopathy, or both?
20225 citationsauthor #21
Amyloid-associated increases in soluble tau relate to tau aggregation rates and cognitive decline in early Alzheimer’s disease
202293 citationsauthor #122
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients
202219 citationsauthor #83
Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum.
2022215 citationsauthor #92
Four distinct trajectories of tau deposition identified in Alzheimer’s disease
2021571 citationsauthor #125
KL-VS heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in Alzheimer’s disease
202148 citationsauthor #120
Traumatic brain injury and age at onset of cognitive decline in corticobasal degeneration, corticobasal syndrome, and progressive supranuclear palsy
20210 citationsauthor #5
Rationale, study design and implementation of the LUCINDA Trial: Leuprolide plus cholinesterase inhibition to reduce neurologic decline in Alzheimer's.
202117 citationsauthor #7
CSF biomarkers and blood pressure trajectories in normotensive individuals and subjects with controlled and uncontrolled hypertension
20210 citationsauthor #8
Traumatic brain injury accelerates Parkinson’s disease onset without altering Parkinson’s neuropathology
20212 citationsauthor #5
Association between lower body temperature and increased tau pathology in cognitively normal older adults
202110 citationsauthor #11
Interactive Associations of Neuropsychiatry Inventory-Questionnaire Assessed Sleep Disturbance and Vascular Risk on Alzheimer’s Disease Stage Progression in Clinically Normal Older Adults
20216 citationsauthor #15
Obesity and Race May Explain Differential Burden of White Matter Hyperintensity Load
202116 citationsauthor #5
Menopause impacts human brain structure, connectivity, energy metabolism, and amyloid-beta deposition
2021200 citationsauthor #15
Decreased CSF clearance and increased brain amyloid in Alzheimer’s disease
202177 citationsauthor #17
Correlation between Alzheimer’s disease and type 2 diabetes using non-negative matrix factorization
202122 citationsauthor #132
Author Correction: Spread of pathological tau proteins through communicating neurons in human Alzheimer’s disease
20216 citationsauthor #122
Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease
202184 citationsauthor #147
Periodontal dysbiosis associates with reduced CSF Aβ42 in cognitively normal elderly
202148 citationsauthor #13
Publisher Correction: Microglial activation and tau propagate jointly across Braak stages
202125 citationsauthor #16
Effects of blood pressure on white matter lesions and brain volumes in hypertensive and normotensive subjects
20211 citationsauthor #10
Cognitive dysfunction in young subjects with periodontal disease
202117 citationsauthor #5
Betahydroxybutyrate Consumption in Autopsy Brain Tissue from Alzheimer’s Disease Subjects
20215 citationsauthor #2
The trend of disruption in the functional brain network topology of Alzheimer’s disease
202136 citationsauthor #186
Heuristic scoring method utilizing FDG-PET statistical parametric mapping in the evaluation of suspected Alzheimer disease and frontotemporal lobar degeneration.
202110 citationsauthor #11
Microglial activation and tau propagate jointly across Braak stages
2021378 citationsauthor #16
The LUCINDA trial: Leuprolide + cholinesterase inhibition to reduce neurologic decline in Alzheimer's
20200 citationsauthor #6

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