T. Bottiglieri

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Aliases
Teodoro G. Bottiglieri, Teodoro Bottiglieri, Teodoror Bottiglieri, T Bottiglieri, T. Bottiglieri
Publication record
304 papers · 14,824 citations · H-index 68

PAPERS

Maternal dietary deficiencies in folic acid or choline worsen stroke outcomes in adult male and female mouse offspring
20239 citationsauthor #9
P27-015-23 Ischemic Outcome in Young and Adult Male and Female Offspring After Maternal Deficiencies in One-Carbon Metabolites During Pregnancy and Lactation
20230 citationsauthor #12
Targeted metabolomic analysis in Parkinson’s disease brain frontal cortex and putamen with relation to cognitive impairment
202327 citationsauthor #2
Methylenetetrahydrofolate reductase deficiency and high dose FA supplementation disrupt embryonic development of energy balance and metabolic homeostasis in zebrafish.
20236 citationsauthor #10
Abstract WP246: Ischemic Outcome In Young And Adult Offspring After Maternal Dietary Deficiencies In One-carbon Metabolites During Pregnancy And Lactation
20230 citationsauthor #10
P11-003-23 Diet-Induced Severe Hyperhomocysteinemia Favors Experimental Atherosclerosis Progression and Modifies the Plasma Metabolome
20230 citationsauthor #4
Atorvastatin rescues hyperhomocysteinemia-induced cognitive deficits and neuroinflammatory gene changes
20238 citationsauthor #8
Revisiting One-Carbon Metabolites in Human Breast Milk: Focus on S-Adenosylmethionine
20231 citationsauthor #8
Micronutrients in High-Fat Diet Modify Insulin Resistance and Its Regulatory Genes in Adult Male Mice.
202311 citationsauthor #6
Ischemic Stroke and Dietary Vitamin B12 Deficiency in Old-Aged Females: Impaired Motor Function, Increased Ischemic Damage Size, and Changed Metabolite Profiles in Brain and Cecum Tissue
20229 citationsauthor #8
Evaluation of pathologies associated with hyperhomocysteinemia in human autopsy brain tissue
20221 citationsauthor #9
Maternal dietary deficiencies in folates or choline during pregnancy and lactation worsen stroke outcome in 3-month-old male and female mouse offspring
20224 citationsauthor #9
One-Carbon Metabolism in Alzheimer’s Disease and Parkinson’s Disease Brain Tissue
202227 citationsauthor #3
Quantitation of 5-Methyltetrahydrofolate in Cerebrospinal Fluid Using Liquid Chromatography-Electrospray-Tandem Mass Spectrometry.
20220 citationsauthor #3
Reduced stroke outcome in old-aged female mice maintained on a dietary vitamin B12 deficiency
20223 citationsauthor #8
Quantification of Plasma S-adenosylmethionine and S-adenosylhomocysteine Using Liquid Chromatography-Electrospray-Tandem Mass Spectrometry.
20222 citationsauthor #3
Targeted Metabolomic Analysis in Alzheimer’s Disease Plasma and Brain Tissue in Non-Hispanic Whites
202238 citationsauthor #4
Apolipoprotein E ε4/4 genotype limits response to dietary induction of hyperhomocysteinemia and resulting inflammatory signaling
202217 citationsauthor #8
Genetic expression changes and pathologic findings associated with hyperhomocysteinemia in human autopsy brain tissue
20227 citationsauthor #12
Quantitation of γ-Aminobutyric Acid in Cerebrospinal Fluid Using Liquid Chromatography-Electrospray-Tandem Mass Spectrometry.
20226 citationsauthor #3
One-carbon metabolism in children with marasmus and kwashiorkor
202213 citationsauthor #10
Alirocumab and Lipid Levels, Inflammatory Biomarkers, Metabolomics, and Safety in Patients Receiving Maintenance Dialysis: The ALIrocumab in DIALysis Study (A Phase 3 Trial to Evaluate the Efficacy and Safety of Biweekly Alirocumab in Patients on a Stable Dialysis Regimen)
202211 citationsauthor #6
Absorption and Tissue Distribution of Folate Forms in Rats: Indications for Specific Folate Form Supplementation during Pregnancy
202213 citationsauthor #4
The 677C > T variant in methylenetetrahydrofolate reductase causes morphological and functional cerebrovascular deficits in mice
202114 citationsauthor #9
Analysis of differential neonatal lethality in cystathionine β‐synthase deficient mouse models using metabolic profiling
20214 citationsauthor #7
High Intakes of [6S]-5-Methyltetrahydrofolic Acid Compared with Folic Acid during Pregnancy Programs Central and Peripheral Mechanisms Favouring Increased Food Intake and Body Weight of Mature Female Offspring
202110 citationsauthor #8
Development of a Zebrafish Model for Studies of the Interaction of Methylenetetrahydrofolate Reductase Deficiency and Dietary Folates on Metabolic Regulation
20210 citationsauthor #7
Abstract P807: Vitamin B12 Deficiency Impairs Balance and Coordination After Photothrombotic Damage to the Sensorimotor Cortex in Adult Male and Female Mice After Ischemic Stroke
20210 citationsauthor #2
Metabolomic Profiling of Adults with Congenital Heart Disease
202116 citationsauthor #4
Increasing breast milk betaine modulates Akkermansia abundance in mammalian neonates and improves long-term metabolic health
202142 citationsauthor #20
Urinary Cell-Cycle Arrest Biomarkers as Early Predictors of Acute Kidney Injury After Ventricular Assist Device Implantation or Cardiac Transplantation.
20214 citationsauthor #5
Longitudinal profiling of plasma and urine metabolites during liver regeneration in living liver donors
20213 citationsauthor #1
Pharmacodynamics of cerebrospinal fluid asparagine after asparaginase
20218 citationsauthor #3
Moderate Folic Acid Supplementation in Pregnant Mice Results in Altered Methyl Metabolism and in Sex-specific Placental Transcription Changes.
202116 citationsauthor #6
Dietary vitamin B12 deficiency impairs motor function and changes neuronal survival and choline metabolism after ischemic stroke in middle aged male and female mice
20217 citationsauthor #3
Choline and Folic Acid in Diets Consumed during Pregnancy Interact to Program Food Intake and Metabolic Regulation of Male Wistar Rat Offspring.
202117 citationsauthor #5
Apolipoprotein E genotypes modulate neuroinflammatory and vascular pathology in hyperhomocysteinemia‐induced VCID
20210 citationsauthor #4
Relationship of Cerebrospinal Fluid Vitamin B12 Status Markers With Parkinson's Disease Progression
202024 citationsauthor #5
Post-mortem tissue analyses in a patient with succinic semialdehyde dehydrogenase deficiency (SSADHD). I. Metabolomic outcomes
202021 citationsauthor #10
Preferential accumulation of the active S-(+) isomer in murine retina highlights novel mechanisms of vigabatrin-associated retinal toxicity.
20204 citationsauthor #6
The Zebrafish (Danio Rerio) as a Novel Model to Study Folate-mthfr Interactions During Embryonic Development and Effect(s) on Long-Term Health
20200 citationsauthor #7
Correction to: Post-mortem tissue analyses in a patient with succinic semialdehyde dehydrogenase deficiency (SSADHD). I. Metabolomic outcomes
20200 citationsauthor #10
[6S]-5-Methyltetrahydrofolic Acid and Folic Acid Pregnancy Diets Differentially Program Metabolic Phenotype and Hypothalamic Gene Expression of Wistar Rat Dams Post-Birth
20208 citationsauthor #7
The Role of One-Carbon Metabolism After Ischemic Stroke in an Aged Mouse Model
20200 citationsauthor #9
Betaine restores epigenetic control and supports neuronal mitochondria in the cuprizone mouse model of multiple sclerosis
202031 citationsauthor #10
High 5MTHF, but Not Folic Acid During Pregnancy, Alters Hypothalamic Regulatory Pathways and Associates with Post-Partum Weight-Gain in Wistar Rat Mothers
20200 citationsauthor #7
Cellular and molecular outcomes of glutamine supplementation in the brain of succinic semialdehyde dehydrogenase‐deficient mice
20203 citationsauthor #6
Impact of the MTHFR C677T polymorphism on one-carbon metabolites: Evidence from a randomised trial of riboflavin supplementation.
202025 citationsauthor #2
A Ketogenic Diet Is Protective Against Atherosclerosis in Apolipoprotein E Knockout Mice
20202 citationsauthor #4
Novel biomarkers and age-related metabolite correlations in plasma and dried blood spots from patients with succinic semialdehyde dehydrogenase deficiency
20205 citationsauthor #8
Choline Supplementation Mitigates the Adverse Effects of a High Folic Acid Maternal Diet on Food Intake Regulation in the Offspring
20200 citationsauthor #6
Memantine Protects From Exacerbation of Ischemic Stroke and Blood Brain Barrier Disruption in Mild But Not Severe Hyperhomocysteinemia
202017 citationsauthor #7
Altered Brain Metabolome Is Associated with Memory Impairment in the rTg4510 Mouse Model of Tauopathy
202012 citationsauthor #7
ARTIFICIAL INTELLIGENCE FACILITATED METABOLOMIC PROFILING IN ADULT CONGENITAL HEART DISEASE (ACHD)
20200 citationsauthor #4
Gamma-Hydroxybutyrate content in dried bloodspots facilitates newborn detection of succinic semialdehyde dehydrogenase deficiency.
20199 citationsauthor #4
Maternal glutamine supplementation in murine succinic semialdehyde dehydrogenase deficiency, a disorder of γ‐aminobutyric acid metabolism
20195 citationsauthor #9
One-carbon metabolism supplementation improves outcome after stroke in aged male MTHFR-deficient mice.
201922 citationsauthor #10
Can targeted metabolomics predict depression recovery? Results from the CO-MED trial
201936 citationsauthor #6
Metabolomic analyses of vigabatrin (VGB)‐treated mice: GABA‐transaminase inhibition significantly alters amino acid profiles in murine neural and non‐neural tissues
201918 citationsauthor #3
Choline and Folic Acid Balance in Diets During Pregnancy Programs Food Intake Regulation in Wistar Rat Offspring (FS08-05-19).
20190 citationsauthor #9
Dysregulated DNA methylation in the pathogenesis of Fabry disease
20195 citationsauthor #12
Targeted metabolomics to understand the association between arsenic metabolism and diabetes‐related outcomes: Preliminary evidence from the Strong Heart Family Study
201923 citationsauthor #8
5-Methyltetrahydrofolate in Maternal Diets Alters DNA Methylation Potential and Increases Later Life Weight Gain and Food Intake in Wistar Rat Dams and Female Offspring (P11-022-19).
20190 citationsauthor #10
Betaine attenuates pathology by stimulating lipid oxidation in liver and regulating phospholipid metabolism in brain of methionine‐choline–deficient rats
201922 citationsauthor #6
Rett syndrome (MECP2) and succinic semialdehyde dehydrogenase (ALDH5A1) deficiency in a developmentally delayed female
20191 citationsauthor #4
Cysteine/Glutathione Deficiency: A Significant and Treatable Corollary of Disease
201812 citationsauthor #10
Circulating Dkk1 and TRAIL Are Associated With Cognitive Decline in Community-Dwelling, Older Adults With Cognitive Concerns
201838 citationsauthor #4
Abstract WMP80: Cystathionine β Synthase Deficiency Exacerbates Cerebral Ischemia Reperfusion Injury Through Activation of the NMDA Receptor and Loss of Blood Brain Barrier Integrity in Mice
20181 citationsauthor #5
Alteration of lipid metabolism in chronic kidney disease, the role of novel antihyperlipidemic agents, and future directions.
201834 citationsauthor #2
Pharmacology, Formulations, and Adverse Effects
20185 citationsauthor #11
Association of urinary 11-dehydro-thromboxane B2 and F2-isoprostanes with mortality in aspirin-treated stable coronary artery disease patients
20180 citationsauthor #4
Homocysteine and Dementia: An International Consensus Statement
2018281 citationsauthor #3
Neuropathology of vitamin B12 deficiency in the Cd320−/− mouse
201824 citationsauthor #6
Dysregulation of methionine metabolism in multiple sclerosis
201831 citationsauthor #8
Priapism in a Fabry disease mouse model is associated with upregulated penile nNOS and eNOS expression
20188 citationsauthor #8
Metabolomic studies identify changes in transmethylation and polyamine metabolism in a brain-specific mouse model of tuberous sclerosis complex
201817 citationsauthor #7
Prognostic value of urinary 11‐dehydro‐thromboxane B2 for mortality: A cohort study of stable coronary artery disease patients treated with aspirin
20189 citationsauthor #4
Methylenetetrahydrofolate Reductase Deficiency Deregulates Regional Brain Amyloid-β Protein Precursor Expression and Phosphorylation Levels
201812 citationsauthor #6
Gene Environment Interactions and Predictors of Colorectal Cancer in Family-Based, Multi-Ethnic Groups
201818 citationsauthor #5
Low Dietary Folate Interacts with MTHFD1 Synthetase Deficiency in Mice, a Model for the R653Q Variant, to Increase Incidence of Developmental Delays and Defects.
201812 citationsauthor #7
Drug‐Penetration Gradients Associated with Acquired Drug Resistance in Patients with Tuberculosis
2018127 citationsauthor #8
The use of microwave irradiation for quantitative analysis of neurotransmitters in the mouse brain.
201816 citationsauthor #3
Pharmacokinetics and pharmacodynamics of PEGylated truncated human cystathionine beta‐synthase for treatment of homocystinuria
20187 citationsauthor #5
Methionine Metabolites in Patients With Sepsis
201817 citationsauthor #9
A comprehensive data mining study shows that most nuclear receptors act as newly proposed homeostasis-associated molecular pattern receptors
201731 citationsauthor #11
Urinary Metabolites in Patients Undergoing Coronary Catheterization Via the Radial Versus Femoral Artery Approach
20171 citationsauthor #7
843. Serum Metabolites as a Predictor of Antidepressant Responsiveness in the Co-Med Trial
20170 citationsauthor #3
Biochemical, physiologic, and clinical effects of L-methylfolate in schizophrenia: A randomized controlled trial
201749 citationsauthor #9
Confirmation that MAT1A p.Ala259Val mutation causes autosomal dominant hypermethioninemia
201710 citationsauthor #3
Abstract 146: Deficiency of Cystathionine beta Synthase Alters Blood Brain Barrier Integrity and Exacerbates Cerebral Ischemia Reperfusion Injury in Mice
20170 citationsauthor #4
(568) – Metabolomic Differences Between Patients with Advanced Heart Failure and Healthy Controls
20170 citationsauthor #8
Deficiency of superoxide dismutase promotes cerebral vascular hypertrophy and vascular dysfunction in hyperhomocysteinemia
201723 citationsauthor #4
Computation of a cardiac severity score with left-censored biomarkers for patients with heart failure
20171 citationsauthor #3
S-Adenosylmethionine (SAMe) for Neuropsychiatric Disorders: A Clinician-Oriented Review of Research.
2017125 citationsauthor #3
Residual thromboxane activity and oxidative stress: influence on mortality in patients with stable coronary artery disease
20178 citationsauthor #2
Corrigendum: Intestinal microbiota as a tetrahydrobiopterin exogenous source in hph-1 mice
20173 citationsauthor #4
Intestinal microbiota as a tetrahydrobiopterin exogenous source in hph-1 mice
201729 citationsauthor #4
Tetrahydrobiopterin deficiency in the pathogenesis of Fabry disease
201721 citationsauthor #15
Multicompartment analysis of protein-restricted phenylketonuric mice reveals amino acid imbalances in brain
201711 citationsauthor #3
Urinary 11-Dehydro-Thromboxane B2 and Mortality in Patients With Stable Coronary Artery Disease.
201719 citationsauthor #11

TIMELINE

1983 78 citations

1984 14 citations

1986 62 citations

1987 99 citations

1988 164 citations

1989 66 citations

1990 181 citations

1991 13 citations

1992 153 citations

1993 59 citations

1994 47 citations

1995 338 citations

1997 312 citations

1998 176 citations

1999 62 citations

2000 748 citations

2001 1,203 citations

2002 537 citations

2003 817 citations

2004 1,657 citations

2005 768 citations

2006 1,004 citations

2007 680 citations

2008 1,056 citations

2009 540 citations

2010 494 citations

2011 51 citations

2012 431 citations

2013 405 citations

2014 468 citations

2015 125 citations

2016 382 citations

2017 331 citations

2018 669 citations

2019 141 citations

2020 152 citations

2021 141 citations

2022 151 citations

2023 62 citations

T. Bottiglieri

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