W. Benedict

PROFILE

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Aliases
William F Benedict, William Benedict, Williams F. Benedict, William F. Benedict, W. F. Benedict, W. Benedict, W F Benedict
Publication record
193 papers · 13,942 citations · H-index 58

PAPERS

Deglycosylation Does Not Affect the Cytotoxic Action of Adenoviral Interferon α‐Induced Bystander Proteins
20220 citationsauthor #3
MTAP deficiency creates an exploitable target for antifolate therapy in 9p21-loss cancers
202250 citationsauthor #19
Abstract 385: MTAP gene deficiency creates vulnerability to anti-folate therapy in urothelial bladder carcinoma
20190 citationsauthor #20
72. A Phase l Study of RB94 in Genitourinary Cancers Using a Tumor-Targeted Systemic Nanodelivery System
20160 citationsauthor #8
Abstract CT059: Systemic administration using targeted gene delivery with SGT-RB94 shows evidence of tumor targeting and anticancer activity: a phase I first-in-man trial
20160 citationsauthor #8
A phase I study of intravesical Ad-IFN in superficial bladder cancer patients.
20161 citationsauthor #2
A Phase l Study of a Tumor-targeted Systemic Nanodelivery System, SGT-94, in Genitourinary Cancers.
201651 citationsauthor #12
Use of monitoring levels of soluble forms of cytokeratin 18 in the urine of patients with superficial bladder cancer following intravesical Ad-IFNα/Syn3 treatment in a Phase l study
201413 citationsauthor #1
Low molecular weight cyclin E is associated with p27-resistant, high-grade, high-stage and invasive bladder cancer
201225 citationsauthor #6
Detection of Bladder Cancer Using Proteomic Profiling of Urine Sediments
201211 citationsauthor #6
Autophagy is induced by adenoviral-mediated interferon α treatment in interferon resistant bladder cancer and normal urothelial cells as a cell death protective mechanism but not by the bystander factors produced
201017 citationsauthor #3
Abstract 1502: Adenoviral-mediated interferon α induces endoplasmic reticulum stress related cytotoxicity in human cancer but not normal cells
20100 citationsauthor #2
Effects of IFN-α plus bortezomib in bladder cancer
20090 citationsauthor #3
Early RB94-produced cytotoxicity in cancer cells is independent of caspase activation or 50 kb DNA fragmentation
200910 citationsauthor #7
PRELIMINARY RESULTS OF A PHASE I STUDY WITH INTRAVESICAL ADMINISTRATION OF ADENOVIRAL-MEDIATED INTERFERON-α FOR PATIENTS WITH BCG REFRACTORY TRANSITIONAL CELL CARCINOMA OF THE BLADDER
20092 citationsauthor #2
Understanding the development of human bladder cancer by using a whole-organ genomic mapping strategy
200870 citationsauthor #31
Phosphorylation of Thr18 and Ser20 of p53 in Ad-p53-induced apoptosis.
200837 citationsauthor #11
Tumor-Targeting Nanocomplex Delivery of Novel Tumor Suppressor RB94 Chemosensitizes Bladder Carcinoma Cells In vitro and In vivo
200848 citationsauthor #7
Role of ER stress and caspase 4 activation in bladder cancer cell death following exposure to Ad-IFNα
20081 citationsauthor #2
A Phase I Clinical Trial of Single-Dose Intrapleural IFN-β Gene Transfer for Malignant Pleural Mesothelioma and Metastatic Pleural Effusions: High Rate of Antitumor Immune Responses
2007147 citationsauthor #16
Enhancement of intravesical delivery with Syn3 potentiates interferon-alpha2b gene therapy for superficial bladder cancer.
200726 citationsauthor #3
Single-Dose Intrapleural IFN-B GeneTransfer forMalignant PleuralMesotheliomaandMetastatic Pleural Effusions : HighRate ofAntitumor ImmuneResponses
20070 citationsauthor #16
Conditioned medium from adenoviral-mediated interferon treated cells is cytotoxic to cancer cells resistant to the interferon protein: Further evidence for a strong bystander effect
20070 citationsauthor #3
Adenoviral mediated interferon-alpha 2b gene therapy suppresses the pro-angiogenic effect of vascular endothelial growth factor in superficial bladder cancer.
200721 citationsauthor #7
Forerunner genes contiguous to RB1 contribute to the development of in situ neoplasia
200750 citationsauthor #21
838: Adenoviral-Mediated IFNα2B Expression Suppresses Proangiogenic Factors in Bladder Cancer
20062 citationsauthor #5
Oncogenic Transformation of C 3 H / 10 T 1 / 2 Clone 8 Mouse Embryo Cells by Halogenated Pyrimidine Nucleosides 1
20063 citationsauthor #2
Chromosome 13 Human Cancer Cell Types by Microcell Transfer of Reconstitution of Retinoblastoma Gene Function in Various Changes in Growth and Tumorigenicity following Updated
20060 citationsauthor #7
Evidence for alternative candidate genes near RB1 involved in clonal expansion of in situ urothelial neoplasia
200624 citationsauthor #17
Characterization of a panel of cell lines derived from urothelial neoplasms: genetic alterations, growth in vivo and the relationship of adenoviral mediated gene transfer to coxsackie adenovirus receptor expression.
200642 citationsauthor #8
Loss of Heterozygosity on Chromosome 13 Is Common Only in the Biologically More Aggressive Subtypes of Ovarian Epithelial Tumors and Is Associated with Normal Retinoblastoma Gene Expression 1
20060 citationsauthor #2
Cell Cycle-specific Oncogenic Transformation of C3H/10T/2 Clone 8 Mouse Embryo Cells by 1-ÃŸ-D-Arabinofuranosylcytosme1
20060 citationsauthor #4
Advances in Brief Absence of Retinoblastoma Protein Expression in Primary Non-Small Cell Lung Carcinomas 1
20060 citationsauthor #5
Efficacy of a single intravesical treatment with Ad-IFN/Syn 3 is dependent on dose and urine IFN concentration obtained: implications for clinical investigation
200652 citationsauthor #7
Combination therapy with IFN-α plus bortezomib induces apoptosis and inhibits angiogenesis in human bladder cancer cells
200634 citationsauthor #3
p 53 Bladder Cancer Progression and Has Cooperative Effects with Elevated and Absent pRb Expression Is Associated with Updated
20060 citationsauthor #12
753: Intravesical Adenoviral-Mediated α-Interferon in the Presence of Syn3 Causes Marked Regression of Human Bladder Cancer Growing Orthotopically in Nude Mice: Correlation with Dose and Urine α-Interferon Concentrations
20052 citationsauthor #5
A modified p53 adenoviral vector is more potent than wild-type p53 in bladder cancer cells
20040 citationsauthor #1
Adenovirus-mediated IFNa-2b gene expression is a potent suppressor of proangiogenic factors in bladder cancer cells
20040 citationsauthor #5
Correlation of metastasis related gene expression and relapse-free survival in patients with locally advanced bladder cancer treated with cystectomy and chemotherapy.
200482 citationsauthor #8
Focus on bladder cancer.
2004308 citationsauthor #12
p53, p21, pRB, and p16 expression predict clinical outcome in cystectomy with bladder cancer.
2004314 citationsauthor #6
Role of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand in Interferon-Induced Apoptosis in Human Bladder Cancer Cells
200485 citationsauthor #5
Intravesical Ad-IFNalpha causes marked regression of human bladder cancer growing orthotopically in nude mice and overcomes resistance to IFN-alpha protein.
200445 citationsauthor #1
Intravesical Ad-IFNα Causes Marked Regression of Human Bladder Cancer Growing Orthotopically in Nude Mice and Overcomes Resistance to IFN-α Protein
200481 citationsauthor #1
Noninvasive detection of bladder cancer in an orthotopic murine model with green fluorescence protein cytology.
200323 citationsauthor #6
Correlation of cyclooxygenase-2 expression with molecular markers, pathological features and clinical outcome of transitional cell carcinoma of the bladder.
200370 citationsauthor #7
Efficient therapeutic gene delivery after systemic administration of a novel polyethylenimine/DNA vector in an orthotopic bladder cancer model.
200324 citationsauthor #6
Adenoviral-mediated retinoblastoma 94 produces rapid telomere erosion, chromosomal crisis, and caspase-dependent apoptosis in bladder cancer and immortalized human urothelial cells but not in normal urothelial cells.
200342 citationsauthor #10
Visualizing superficial human bladder cancer cell growth in vivo by green fluorescent protein expression
200231 citationsauthor #7
Syn3 provides high levels of intravesical adenoviral-mediated gene transfer for gene therapy of genetically altered urothelium and superficial bladder cancer
200276 citationsauthor #11
Inhibition of tumorigenicity and metastasis of human bladder cancer growing in athymic mice by interferon-beta gene therapy results partially from various antiangiogenic effects including endothelial cell apoptosis.
200295 citationsauthor #9
Gene therapy for superficial bladder cancer
20017 citationsauthor #2
Conference Abstracts
20010 citationsauthor #1
An improved polyethylenemine/DNA vector formulation that exhibits highly efficient in vitro and in vivo gene delivery
20010 citationsauthor #3
Susceptibility of nonpromoter CpG islands to de novo methylation in normal and neoplastic cells.
2001158 citationsauthor #8
Genetic modeling of human urinary bladder carcinogenesis
200070 citationsauthor #7
Differential retinoblastoma and p16INK4A protein expression in neuroendocrine tumors of the lung
200048 citationsauthor #8
Immunohistochemical Analysis of p16 in Bladder Cancer
20000 citationsauthor #2
TabBO: a model reflecting common molecular features of androgen-independent prostate cancer.
200035 citationsauthor #3
Pigment epithelium-derived factor: a potent inhibitor of angiogenesis.
19991,425 citationsauthor #6
LOSS OF P21/WAF1/CIP1 EXPRESSION IS AN IMPORTANT PREDICTOR OF AGGRESSIVE BEHAVIOR IN URINARY BLADDER CANCER
19990 citationsauthor #5
Level of retinoblastoma protein expression correlates with p16 (MTS-1/INK4A/CDKN2) status in bladder cancer
1999126 citationsauthor #1
ADENOVIRUS p16 INFECTION OF NORMAL UROTHELIAL CELLS INDUCES GROWTH SUPPRESSION BUT NOT SENESCENCE
19990 citationsauthor #3
Superimposed histologic and genetic mapping of chromosome 9 in progression of human urinary bladder neoplasia: implications for a genetic model of multistep urothelial carcinogenesis and early detection of urinary bladder cancer
1999140 citationsauthor #11
Low and maximally phosphorylated levels of the retinoblastoma protein confer poor prognosis in newly diagnosed acute myelogenous leukemia: a prospective study.
199819 citationsauthor #11
Altered retinoblastoma protein expression in nonsmall cell lung cancer
199797 citationsauthor #9
Differential retinoblastoma protein expression in neuroendocrine tumors of the lung. Potential diagnostic implications.
199795 citationsauthor #5
Deletion of three distinct regions on chromosome 13q in human non‐small‐cell lung cancer
199758 citationsauthor #7
Mantle cell lymphoma: correlation of clinical outcome and biologic features with three histologic variants.
1997146 citationsauthor #4
Cooperative effects of p53 and pRB alterations in primary superficial bladder tumors.
1997225 citationsauthor #9
Loss of retinoblastoma gene function and heterozygosity at the RB locus in renal cortical neoplasms.
199711 citationsauthor #2
Cytogenetic responses to G2 phase x-irradiation of cells from retinoblastoma patients.
199622 citationsauthor #5
Altered retinoblastoma and p53 protein status in non-small cell carcinoma of the lung: potential synergistic effects on prognosis.
199661 citationsauthor #5
Expression of the Retinoblastoma Protein in Low-Grade B-Cell Lymphoma: Relationship to Cyclin D1
199639 citationsauthor #2
Immunohistochemical detection of p53, bcl-2, and retinoblastoma proteins in follicular lymphoma.
199650 citationsauthor #3
DEVELOPMENT OF AN OPTIMAL PROTOCOL FOR ANTIGEN RETRIEVAL: A ‘TEST BATTERY’ APPROACH EXEMPLIFIED WITH REFERENCE TO THE STAINING OF RETINOBLASTOMA PROTEIN (pRB) IN FORMALIN‐FIXED PARAFFIN SECTIONS
199678 citationsauthor #6
Frequent methylation of p15 5′ region in leukemic and preleukemic disorders, and reduction of p15 methylation levels by 5-aza-deoxycytidine treatment is correlated with clinical remission
19960 citationsauthor #3
Expression of the retinoblastoma protein in low-grade B-cell lymphoma: relationship to cyclin D1.
199635 citationsauthor #2
p53, Rb, and cyclin D1 expression in human oral verrucous carcinomas
199673 citationsauthor #8
n D1 Expression in Human Oral mas
19960 citationsauthor #7
Genetic disparity between morphologically benign cysts contiguous to ovarian carcinomas and solitary cystadenomas.
199583 citationsauthor #2
Retinoblastoma-like Phenotype Expressed in Medulloblastomas
199515 citationsauthor #5
The loss of retinoblastoma gene in association with c-myc and transforming growth factor-beta 1 gene expression in human bladder cancer.
199523 citationsauthor #8
Frequent loss of heterozygosity at the retinoblastoma susceptibility gene (RB) locus in aggressive pituitary tumors: evidence for a chromosome 13 tumor suppressor gene other than RB.
1995224 citationsauthor #6
Growth-factor stimulation reveals two mechanisms of retinoblastoma gene inactivation in human myelogenous leukemia cells.
19956 citationsauthor #7
Loss of heterozygosity on chromosome 13 is common only in the biologically more aggressive subtypes of ovarian epithelial tumors and is associated with normal retinoblastoma gene expression.
199483 citationsauthor #2
Loss of the retinoblastoma tumor-suppressor gene in parathyroid carcinoma.
1994287 citationsauthor #7
The retinoblastoma gene is involved in malignant progression of astrocytomas
1994232 citationsauthor #7
Enhanced tumor cell growth suppression by an N-terminal truncated retinoblastoma protein.
199462 citationsauthor #5
Chromosome 13 transfer provides evidence for regulation of RBI protein expression
199410 citationsauthor #5
Levels of retinoblastoma protein expression in newly diagnosed acute myelogenous leukemia
199440 citationsauthor #9
Further characterization of retinoblastoma gene-mediated cell growth and tumor suppression in human cancer cells.
199439 citationsauthor #5
Aberrant RB gene expression in routinely processed, archival tumor tissues determined by three different anti‐RB antibodies
199470 citationsauthor #4
Gene therapy: Chemoprotection, immunoenhancement, and modification of tumor cells
19931 citationsauthor #17
Loss of RB protein expression in primary bladder cancer correlates with loss of heterozygosity at the RB locus and tumor progression
1993167 citationsauthor #5
Changes in growth and tumorigenicity following reconstitution of retinoblastoma gene function in various human cancer cell types by microcell transfer of chromosome 13.
199241 citationsauthor #7
Expression in Acute Myelogenous Leukemia
19922 citationsauthor #13
Immortalization of fibroblasts from two patients with hereditary retinoblastoma.
19927 citationsauthor #7
Intraocular tumor formation of RB reconstituted retinoblastoma cells.
199186 citationsauthor #7

TIMELINE

1969 31 citations

1970 41 citations

1971 11 citations

1972 234 citations

1973 60 citations

1974 3 citations

1975 487 citations

1976 173 citations

1977 278 citations

1978 56 citations

1979 136 citations

1980 473 citations

1981 0 citations

1982 66 citations

1983 2,518 citations

1984 603 citations

1985 222 citations

1986 285 citations

1987 788 citations

1988 318 citations

1989 108 citations

1990 155 citations

1991 471 citations

1992 50 citations

1993 168 citations

1994 823 citations

1995 351 citations

1996 358 citations

1997 632 citations

1998 19 citations

1999 1,691 citations

2000 153 citations

2001 165 citations

2002 202 citations

2003 159 citations

2004 915 citations

2005 2 citations

2006 157 citations

2007 244 citations

2008 156 citations

2009 12 citations

2010 17 citations

2012 36 citations

2014 13 citations

2016 52 citations

2019 0 citations

2022 50 citations

W. Benedict

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