L. Shultz

Simultaneous evaluation of treatment efficacy and toxicity for bispecific T‐cell engager therapeutics in a humanized mouse model
202310 citationsauthor #7
Identification of a humanized mouse model for functional testing of immune-mediated biomaterial foreign body response
202318 citationsauthor #16
Humanized mouse models for immuno-oncology research
2023259 citationsauthor #7
NOD-scid IL2rγnull mice lacking TLR4 support human immune system development and the study of human-specific innate immunity.
20235 citationsauthor #2
Immunosuppressive reprogramming of neutrophils by lung mesenchymal cells promotes breast cancer metastasis
202385 citationsauthor #6
Generation of the NeoThy mouse model for human immune system studies
20235 citationsauthor #9
Abstract 6354: A new tumor-bearing humanized mouse model to evaluate the efficacy of bispecific T cell engager and monoclonal checkpoint antibodies
20230 citationsauthor #8
Abstract 2049: A novel, rapid, sensitive, and reproducible in vivo platform to assess efficacy and toxicity of bispecific antibodies
20220 citationsauthor #6
Lung fibroblasts facilitate pre-metastatic niche formation by remodeling the local immune microenvironment.
2022167 citationsauthor #7
Lipid-laden lung mesenchymal cells foster breast cancer metastasis via metabolic reprogramming of tumor cells and natural killer cells.
202287 citationsauthor #5
Survival Advantage of Both Human Hepatocyte Xenografts and Survival Advantage of Both Human Hepatocyte Xenografts and Genome-Edited Hepatocytes for Treatment of alpha-1 Antitrypsin Genome-Edited Hepatocytes for Treatment of alpha-1 Antitrypsin Deficiency Deficiency
20220 citationsauthor #8
Analysis of Salmonella Typhi Pathogenesis in a Humanized Mouse Model.
20220 citationsauthor #6
Enhanced development of functional human NK cells in NOD‐ scid‐IL2rgnull mice expressing human IL15
202237 citationsauthor #6
Abstract 2875: Development of a new tumor-bearing humanized mouse model to evaluate the efficacy and toxicity of bispecific T cell engagers
20220 citationsauthor #5
Abstract 1655: Development of humanized diffuse large B-cell lymphoma mouse models
20220 citationsauthor #3
Abstract 1640: Enhanced development of functional human innate immune cells in a novel FLT3nullNSG mouse strain expressing human FLT3L
20223 citationsauthor #5
Dengue virus infection and virus-specific HLA-A2 restricted immune responses in humanized NOD-scid IL2rgammanull mice
202111 citationsauthor #4
Targeting critical kinases and anti-apoptotic molecules overcomes steroid resistance in MLL-rearranged leukaemia
20212 citationsauthor #19
Novel phosphatidylserine-binding molecule enhances antitumor T-cell responses by targeting immunosuppressive exosomes in human tumor microenvironments
202133 citationsauthor #11
A novel clinically relevant graft‐versus‐leukemia model in humanized mice
20213 citationsauthor #11
Circulating CD34+ cells of primary myelofibrosis patients contribute to myeloid-dominant hematopoiesis and bone marrow fibrosis in immunodeficient mice
20212 citationsauthor #8
Distinct Differences on Neointima Formation in Immunodeficient Distinct Differences on Neointima Formation in Immunodeficient and Humanized Mice after Carotid or Femoral Arterial Injury and Humanized Mice after Carotid or Femoral Arterial Injury
20210 citationsauthor #5
Inactive rhomboid proteins RHBDF1 and RHBDF2 (iRhoms): a decade of research in murine models
202111 citationsauthor #4
Clathrin light chain‐conjugated drug delivery for cancer
20214 citationsauthor #4
Preclinical evaluation of cancer immune therapy using patient‐derived tumor antigen‐specific T cells in a novel xenograft platform
20215 citationsauthor #10
Combined inhibition of XIAP and BCL2 drives maximal therapeutic efficacy in genetically diverse aggressive acute myeloid leukemia
202122 citationsauthor #24
Role of MicroRNA in Inflammatory Bowel Disease: Clinical Evidence and the Development of Preclinical Animal Models
202132 citationsauthor #4
RFX6-mediated dysregulation defines human β cell dysfunction in early type 2 diabetes
20217 citationsauthor #21
The Motheaten (me) and Viable Motheaten (mev) Mutations, Chromosome 6
20200 citationsauthor #1
CXCR4-Expressing Anti-CD25 CAR T-Cells Effectively Eliminate Human AML Cells In Vivo
202018 citationsauthor #11
Characterization and use of human insulin transgenic mouse models for type 1 diabetes
20201 citationsauthor #2
TEG011 persistence averts extramedullary tumor growth without exerting off‐target toxicity against healthy tissues in a humanized HLA‐A*24:02 transgenic mice
20209 citationsauthor #8
Lung mesenchymal cells elicit lipid storage in neutrophils that fuel breast cancer lung metastasis
20200 citationsauthor #11
Abstract B72: Humanized NSG-Tg(Hu-IL15) mice support preclinical immune-oncology efficacy for testing of NK cell-based immunotherapy
20201 citationsauthor #3
Dual roles of neutrophils in metastatic colonization are governed by the host NK cell status
2020130 citationsauthor #7
Genes adapt to outsmart gene-targeting strategies in mutant mouse strains by skipping exons to reinitiate transcription and translation
20208 citationsauthor #6
Improved mouse models and advanced genetic and genomic technologies for the study of neutrophils.
20204 citationsauthor #8
Abstract 5619: PBMC humanized NSG-(KbDb)null(IA)nullmouse model to evaluate immune-oncology drug efficacy
20201 citationsauthor #3
Understanding Normal and Malignant Human Hematopoiesis Using Next-Generation Humanized Mice.
202028 citationsauthor #2
255-OR: ADA Presidents’ Select Abstract: Glucagon Receptor Antagonism Stimulates Beta-Cell Proliferation in Mouse and Human Islets
20200 citationsauthor #6
Genes adapt to outsmart gene-targeting strategies in mutant mouse strains by skipping exons to reinitiate transcription and translation
202023 citationsauthor #6
Abstract 584: TGN1412 induces dose and time dependent human cytokines in a humanized PBMC mouse model for cytokine release syndrome
20200 citationsauthor #7
The Flaky Skin (fsn) Mutation, Chromosome ?
20201 citationsauthor #3
Direct Tumor Killing and Immunotherapy through Anti-SerpinB9 Therapy.
202071 citationsauthor #12
Abstract 5632: PBMC-humanized mouse model for the assessment of cytokine release syndrome caused by checkpoint and bispecific immunotherapy
20200 citationsauthor #8
Tacrolimus- and sirolimus-induced human β cell dysfunction is reversible and preventable.
202054 citationsauthor #13
A rapid, sensitive, and reproducible in vivo PBMC humanized murine model for determining therapeutic‐related cytokine release syndrome
202036 citationsauthor #4
The Severe Combined Immunodeficiency (scid) Mutation, Chromosome 16
20200 citationsauthor #2
Abstract 3320: Humanized NSG-Tg(Hu-IL15) mice support preclinical immune-oncology efficacy for testing of NK cells based immunology
20200 citationsauthor #4
Innovations, challenges, and minimal information for standardization of humanized mice
2020102 citationsauthor #23
Lung mesenchymal cells elicit lipid storage in neutrophils that fuel breast cancer lung metastasis
2020196 citationsauthor #11
Dapagliflozin does not directly affect human α or β cells.
202011 citationsauthor #11
Enhanced development of functional human innate immune cells in a novel mouse FLT3null NSG mouse strain expressing human FLT3L
20203 citationsauthor #6
Humanized mouse models of immunological diseases and precision medicine
201987 citationsauthor #1
AK002, a Humanized Sialic Acid-Binding Immunoglobulin-Like Lectin-8 Antibody that Induces Antibody-Dependent Cell-Mediated Cytotoxicity against Human Eosinophils and Inhibits Mast Cell-Mediated Anaphylaxis in Mice
201987 citationsauthor #8
Recovery of viable endocrine‐specific cells and transcriptomes from human pancreatic islet‐engrafted mice
20198 citationsauthor #8
Identification of a tumor-specific allo-HLA-restricted γδTCR.
201935 citationsauthor #22
A laminin 511 matrix is regulated by TAZ and functions as the ligand for the alpha6Bbeta1 integrin to sustain breast cancer stem cells
201923 citationsauthor #5
Regulated splicing of the alpha6 integrin cytoplasmic domain determines the fate of breast cancer stem cells
201930 citationsauthor #5
Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop
201978 citationsauthor #22
Co-activation of macrophages and T cells contribute to chronic GVHD in human IL-6 transgenic humanised mouse model
201926 citationsauthor #18
Human iPSC-derived microglia assume a primary microglia-like state after transplantation into the neonatal mouse brain
2019159 citationsauthor #10
alpha Cell Function and Gene Expression Are Compromised in Type 1 Diabetes
201921 citationsauthor #15
Correction to: Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop
20196 citationsauthor #22
Abstract 3902: Increased sensitivity for detecting cytokine release syndrome with cancer immunotherapy using a PBMC humanized NSG-SGM3 mouse model
20190 citationsauthor #4
Development of a humanized mouse model for functional testing of biomaterial fibrosis
20190 citationsauthor #6
Abstract 4990: An in vivo method for determining cancer immunotherapy induced cytokine release syndrome utilizing PBMC humanized mice
20190 citationsauthor #5
Human NK cell development in hIL-7 and hIL-15 knockin NOD/SCID/IL2rgKO mice
201955 citationsauthor #20
Functional profiling of single CRISPR/Cas9-edited human long-term hematopoietic stem cells
201936 citationsauthor #8
Humanized immune system mouse models: progress, challenges and opportunities
2019188 citationsauthor #10
Abstract 1522: NovelNOD-scid IL2rgnull(NSG)mice for preclinical evaluation of TLR agonists in cancer immunotherapy
20190 citationsauthor #5
Targeting Critical Kinases and Anti-Apoptotic Molecules Overcomes Steroid Resistance in Infant MLL-Rearranged Leukemia
20190 citationsauthor #17
Genome-wide Analysis of Salmonellaenterica serovar Typhi in Humanized Mice Reveals Key Virulence Features.
201949 citationsauthor #8
Ectonucleoside Triphosphate Diphosphohydrolase-3 Antibody Targets Adult Human Pancreatic β Cells for In Vitro and In Vivo Analysis.
201973 citationsauthor #17
Mesenchymal stem cells: From regeneration to cancer.
2019102 citationsauthor #3
Abstract 1070: Evaluation of human NK cell responses to PDX tumors in humanized NOD-scid IL2rgnull(NSG) mice expressing human IL15
20190 citationsauthor #6
ADAM17 is essential for ectodomain shedding of the EGF‐receptor ligand amphiregulin
201827 citationsauthor #4
RHBDF2-Regulated Growth Factor Signaling in a Rare Human Disease, Tylosis With Esophageal Cancer: What Can We Learn From Murine Models?
201810 citationsauthor #5
Lack of acute xenogeneic graft‐versus‐host disease, but retention of T‐cell function following engraftment of human peripheral blood mononuclear cells in NSG mice deficient in MHC class I and II expression
2018141 citationsauthor #9
Ectopic high endothelial venules in pancreatic ductal adenocarcinoma: A unique site for targeted delivery
201827 citationsauthor #12
Transgenic expression of human IL15 in NOD-scid IL2rg null (NSG) mice enhances the development and survival of functional human NK cells
20189 citationsauthor #5
Genetic Models of Macrophage Depletion.
201818 citationsauthor #3
3-6-2018 α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes
20180 citationsauthor #17
Abstract 5674: Transgenic expression of human IL15 in NOD-scid IL2rgnull(NSG) mice enhances the development and survival of functional human NK cells
20181 citationsauthor #5
Abstract 5676: Patient-derived tumor xenografts in humanized NSG-SGM3 mice: An improved immuno-oncology platform
20181 citationsauthor #7
Chapter 2 Humanized Mice as Models for Human Disease
20180 citationsauthor #2
Human Anti–HIV-1 gp120 Monoclonal Antibodies with Neutralizing Activity Cloned from Humanized Mice Infected with HIV-1
20187 citationsauthor #10
Dapagliflozin Treatment Impacts ß, but Not a, Cell Function in Normal Human Islets
20180 citationsauthor #13
NOD-scid IL2rg null (NSG) mice deficient in murine MHC Class I and Class II expression support engraftment of functional human T cells in the absence of acute xenogeneic GVHD following injection of PBMC
20180 citationsauthor #7
α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes
2018180 citationsauthor #15
Abstract 5665: NOD-scid IL2rgnull(NSG) mice deficient in murine MHC Class I and Class II expression support engraftment of functional human T cells in the absence of acute xenogeneic GVHD following injection of PBMC
20181 citationsauthor #9
Gene Therapy with an Adeno-Associated Viral Vector Expressing Human Interleukin-2 Alters Immune System Homeostasis in Humanized Mice
201714 citationsauthor #7
Early induction of NRF2 antioxidant pathway by RHBDF2 mediates rapid cutaneous wound healing.
201715 citationsauthor #7
Overcoming mutational complexity in acute myeloid leukemia by inhibition of critical pathways
201722 citationsauthor #12
ADAM17 is the Principal Ectodomain Sheddase of the EGF-Receptor Ligand Amphiregulin
20171 citationsauthor #4
Tissue-specific role of RHBDF2 in cutaneous wound healing and hyperproliferative skin disease
20176 citationsauthor #4
Genetic deletion of amphiregulin restores the normal skin phenotype in a mouse model of the human skin disease tylosis
201719 citationsauthor #3
I-Prevention and Treatment of DKA INV 1 Treatment of diabetic ketoacidosis in children : New perspectives on intravenous fluid protocols and risk of cerebral injury
20170 citationsauthor #10
Alloimmune Responses of Humanized Mice to Human Pluripotent Stem Cell Therapeutics
201735 citationsauthor #16
Survival Advantage of Both Human Hepatocyte Xenografts and Genome-Edited Hepatocytes for Treatment of α-1 Antitrypsin Deficiency
201765 citationsauthor #8

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