J. Keck

Biochemical characterization of Escherichia coli DnaC variants that alter DnaB helicase loading onto DNA
20243 citationsauthor #2
The intrinsically disordered linker in the single-stranded DNA-binding protein influences DNA replication restart and recombination pathways in Escherichia coli K-12
20244 citationsauthor #5
Spatiotemporal Dynamics of Single-stranded DNA Intermediates in Escherichia coli
20231 citationsauthor #6
Replication fork binding triggers structural changes in the PriA helicase that govern DNA replication restart in E. coli
202311 citationsauthor #10
Biochemical properties of naturally occurring human bloom helicase variants
20232 citationsauthor #4
Interaction with the carboxy-terminal tip of SSB is critical for RecG function in E. coli
202314 citationsauthor #5
Biochemical Properties of Naturally Occurring Human Bloom Helicase Variants
20232 citationsauthor #4
A 3.2 Å Resolution Structure of the PriA/PriB/Replication Fork Complex Reveals Mechanistic Insight into Bacterial DNA Replication Restart.
20230 citationsauthor #4
Identification of recG genetic interactions in Escherichia coli by transposon sequencing
20236 citationsauthor #5
Generation and Repair of Postreplication Gaps in Escherichia coli
202315 citationsauthor #3
X-ray crystal structure of the Escherichia coli RadD DNA repair protein bound to ADP reveals a novel zinc ribbon domain
20226 citationsauthor #4
Use of an unnatural amino acid to map helicase/DNA interfaces via photoactivated crosslinking.
20221 citationsauthor #2
Identification of genetic interactions with priB links the PriA/PriB DNA replication restart pathway to double-strand DNA break repair in Escherichia coli
20229 citationsauthor #5
G-quadruplexes in bacteria: insights into the regulatory roles and interacting proteins of non-canonical nucleic acid structures
202218 citationsauthor #3
Interaction with single-stranded DNA-binding protein modulates Escherichia coli RadD DNA repair activities
20228 citationsauthor #3
Mismatch discrimination and sequence bias during end-joining by DNA ligases
20228 citationsauthor #5
Examination of the roles of a conserved motif in the PriA helicase in structure-specific DNA unwinding and processivity
20214 citationsauthor #3
Natural Transformation Protein ComFA Exhibits Single-Stranded DNA Translocase Activity
20217 citationsauthor #6
Escherichia coli K‐12 has two distinguishable PriA‐PriB replication restart pathways
20218 citationsauthor #4
PD-1 Blockade Aggravates Epstein–Barr Virus+ Post-Transplant Lymphoproliferative Disorder in Humanized Mice Resulting in Central Nervous System Involvement and CD4+ T Cell Dysregulations
202128 citationsauthor #15
Minor Alterations in Core Promoter Element Positioning Reveal Functional Plasticity of a Bacterial Transcription Factor
20214 citationsauthor #3
Evaluating Scalable Supervised Learning for Synthesize-on-Demand Chemical Libraries
202113 citationsauthor #7
E. coli Rep helicase and RecA recombinase unwind G4 DNA and are important for resistance to G4-stabilizing ligands
202029 citationsauthor #6
Abstract 2749: Age-related cancer drug toxicity and efficacy, and immune modulation in C57BL6J syngeneic model
20200 citationsauthor #4
Interaction with single‐stranded DNA‐binding protein localizes ribonuclease HI to DNA replication forks and facilitates R‐loop removal
202018 citationsauthor #6
Re-interpretation of ppGpp (G4P) electron density in the deposited crystal structure of Xanthine phosphoribosyltransferase (XPRT) (1Y0B).
20200 citationsauthor #3
The molecular coupling between substrate recognition and ATP turnover in a AAA+ hexameric helicase loader
202011 citationsauthor #5
Development of a single-stranded DNA-binding protein fluorescent fusion toolbox
202022 citationsauthor #12
Molecular mechanism of regulation of the purine salvage enzyme XPRT by the alarmones pppGpp, ppGpp, and pGpp
202029 citationsauthor #4
The substrate-bound crystal structure of HPRT (hypoxanthine phosphoribosyltransferase)
20190 citationsauthor #5
Abstract 3902: Increased sensitivity for detecting cytokine release syndrome with cancer immunotherapy using a PBMC humanized NSG-SGM3 mouse model
20190 citationsauthor #6
A Potential Specificity Code for B. subtilis SsbA and SsbB Quaternary Structures
20190 citationsauthor #3
Antigenic Variation in Neisseria gonorrhoeae Occurs Independently of RecQ-Mediated Unwinding of the pilE G Quadruplex
201918 citationsauthor #6
The (p)ppGpp-bound crystal structure of HPRT (hypoxanthine phosphoribosyltransferase)
20190 citationsauthor #5
Humanized mouse models of immunological diseases and precision medicine
201987 citationsauthor #2
Decision letter: Homology sensing via non-linear amplification of sequence-dependent pausing by RecQ helicase
20190 citationsauthor #1
Abstract 1522: NovelNOD-scid IL2rgnull(NSG)mice for preclinical evaluation of TLR agonists in cancer immunotherapy
20190 citationsauthor #6
MA09.02 In Vivo, Ex Vivo and Early Clinical Activity of EGFR Monoclonal Antibody and Osimertinib in EGFR Exon 20 Insertion NSCLC
20190 citationsauthor #9
Structural Mechanisms of Cooperative DNA Binding by Bacterial Single-Stranded DNA-Binding Proteins.
201936 citationsauthor #8
The sulfate-bound crystal structure of HPRT (hypoxanthine phosphoribosyltransferase)
20191 citationsauthor #5
A guanine-flipping and sequestration mechanism for G-quadruplex unwinding by RecQ helicases
201851 citationsauthor #5
Crystal Structure of RecQ catalytic core from C. sakazakii bound to an unfolded G-quadruplex
20180 citationsauthor #2
Stage‐based Variation in the Effect of Primary Tumor Side on All Stages of Colorectal Cancer Recurrence and Survival
201832 citationsauthor #14
E. coli PriA helicase winged helix domain deletion protein
20180 citationsauthor #3
Function of a strand-separation pin element in the PriA DNA replication restart helicase
201819 citationsauthor #4
B. subtilis SsbA with DNA
20180 citationsauthor #4
Practical Model Selection for Prospective Virtual Screening
201865 citationsauthor #8
A High-Throughput Screening Strategy to Identify Inhibitors of SSB Protein–Protein Interactions in an Academic Screening Facility
201826 citationsauthor #6
Structure-specific DNA replication-fork recognition directs helicase and replication restart activities of the PriA helicase
201837 citationsauthor #5
Development of Protein-Protein Interaction Inhibitors for the Treatment of Infectious Diseases.
201816 citationsauthor #2
High-resolution deconstruction of evolution induced by chemotherapy treatments in breast cancer xenografts
201813 citationsauthor #14
Single molecule kinetics uncover roles for E. coli RecQ DNA helicase domains and interaction with SSB
201834 citationsauthor #7
Structural and Cellular Mechanisms of DNA Replication Restart in Escherichia coli
20180 citationsauthor #3
PriA helicase bound to dsDNA of a DNA replication fork
20180 citationsauthor #3
Evolution of an intratumoral ecology susceptible to successive treatment in breast cancer xenografts
20180 citationsauthor #14
Webinar | Humanized mouse models in checkpoint inhibitor development
20170 citationsauthor #2
Fix the Wrecks, RecA
20170 citationsauthor #4
OA10.01 Comprehensive Genomic Profiling and PDX Modeling of EGFR Exon 20 Insertions: Evidence for Osimertinib Based Dual EGFR Blockade
20174 citationsauthor #20
Abstract 2909: High-precision quantification of clonal evolution during comparative treatments of triple negative breast cancer
20170 citationsauthor #12
Abstract 1656: Comprehensive evaluation of human immune system reconstitution in NSGTMand NSGTM-SGM3 toward the development of a novel Onco-HuTMxenograft model
20170 citationsauthor #7
Integrase Move‐In Day: Mechanisms of HIV DNA Integration
20170 citationsauthor #6
Mechanisms of bacterial DNA replication restart
201768 citationsauthor #4
Abstract 2411: Evolution during propagation and treatment of patient-derived triple negative breast cancer xenografts
20160 citationsauthor #11
TMOD-39. A NOVEL EX VIVO TUMOR SLICE CULTURE SYSTEM AS A TOOL FOR BASIC AND CLINICAL RESEARCH
20160 citationsauthor #4
Applying humanized mouse models to immune therapy research
20161 citationsauthor #2
Structural and Functional Studies of H. seropedicae RecA Protein – Insights into the Polymerization of RecA Protein as Nucleoprotein Filament
20169 citationsauthor #9
Abstract IA13: The Patient-Derived Xenograft Program at The Jackson Laboratory
20160 citationsauthor #2
Protein‐protein interaction inhibitors of the Fanconi anemia DNA repair pathway
20160 citationsauthor #3
Solution Structure of the PriC DNA replication restart protein
20160 citationsauthor #4
A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway
201637 citationsauthor #3
Abstract IA29: Mice host selection for patient-derived xenograft (PDX) model development and other critical factors for success
20160 citationsauthor #8
An aromatic-rich loop couples DNA binding and ATP hydrolysis in the PriA DNA helicase
201614 citationsauthor #2
Crystal Structure of Herbaspirillum seropedicae RecA
20160 citationsauthor #9
Structure and Function of the PriC DNA Replication Restart Protein*
201619 citationsauthor #9
Molecular mechanism and evolution of guanylate kinase regulation by (p)ppGpp.
201588 citationsauthor #7
Abstract 318: Enhancing drug discovery and development throughput without sacrificing predictivity: ex vivo 3D drug response profiling (DRP) using patient-derived xenografts (PDX)
20150 citationsauthor #10
Structural mechanisms of DNA binding and unwinding in bacterial RecQ helicases
201567 citationsauthor #5
Patient-derived xenograft platform to guide precision medicine in bladder cancer.
20150 citationsauthor #5
Interaction with Single-stranded DNA-binding Protein Stimulates Escherichia coli Ribonuclease HI Enzymatic Activity*
201563 citationsauthor #5
Development and characterization of patient-derived xenografts to guide precision medicine in bladder cancer.
20150 citationsauthor #5
Patient-derived bladder cancer xenografts as a platform for drug development in bladder cancer.
20150 citationsauthor #6
RNase HI/SSB-Ct complex
20150 citationsauthor #2
Crystal structure of RecQ catalytic core from C. sakazakii bound to DNA
20150 citationsauthor #2
Mechanistic insights into PriA mediated DNA replication restart (924.2)
20140 citationsauthor #7
The JAX patient-derived xenograft program: A unique resource to advance genome-guided cancer medicine and therapeutic agent testing.
20141 citationsauthor #8
RecD2 Helicase Limits Replication Fork Stress in Bacillus subtilis
201435 citationsauthor #5
PriA Helicase Bound to SSB C-terminal Tail Peptide
20140 citationsauthor #4
PriA Helicase Bound to ADP
20140 citationsauthor #3
Grip it and rip it: Structural mechanisms of DNA helicase substrate binding and unwinding
201430 citationsauthor #2
Structural mechanisms of DNA replication restart (352.2)
20140 citationsauthor #1
Indispensible Replication Restart Helicase PriA Aids Bacterial Survival: A SMART Team Story
20130 citationsauthor #6
Structural mechanisms of PriA-mediated DNA replication restart
201398 citationsauthor #9
PriC-mediated DNA Replication Restart Requires PriC Complex Formation with the Single-stranded DNA-binding Protein*
201350 citationsauthor #7
Crystal Structure of DR_1245 from Deinococcus radiodurans
20130 citationsauthor #10
Protein Interactions in Genome Maintenance as Novel Antibacterial Targets
201342 citationsauthor #6
The Deinococcus radiodurans DR1245 Protein, a DdrB Partner Homologous to YbjN Proteins and Reminiscent of Type III Secretion System Chaperones
201323 citationsauthor #10
Neisseria gonorrhoeae RecQ Helicase HRDC Domains Are Essential for Efficient Binding and Unwinding of the pilE Guanine Quartet Structure Required for Pilin Antigenic Variation
201328 citationsauthor #4
Co-crystal structure of Escherichia coli uracil-DNA glycosylase and a C-terminal fragement of the single-stranded DNA-binding protein
20120 citationsauthor #4
Crystal structure of the yeast nicotinamidase Pnc1p bound to the inhibitor nicotinaldehyde
20120 citationsauthor #4
Binding mechanism of metal⋅NTP substrates and stringent-response alarmones to bacterial DnaG-type primases.
201274 citationsauthor #6

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