S. Briddon

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Aliases
Stephen Briddon, Steve Briddon, Steve J Briddon, S.j. Briddon, S. Briddon, Stephen J. Briddon, Steven J Briddon, Stephen J Briddon, S J Briddon
Publication record
114 papers · 2,893 citations · H-index 35

PAPERS

Two-Step Ligand-Directed Covalent Fluorescent Labeling of the Adenosine A1-Receptor That Maintains Its Orthosteric Binding Site's Availability to Bind Ligands.
20260 citationsauthor #4
Differential inhibition of the diverse behavioural effects of mu-opioid receptor agonists by progressive receptor depletion.
20260 citationsauthor #5
An Industrial Perspective on Ligand Bias in GPCR Drug Discovery.
20250 citationsauthor #4
Agonist efficacy at the β2AR is driven by the faster association rate of the Gs protein
20251 citationsauthor #9
A high-affinity, cis-on photoswitchable beta blocker to optically control β2-adrenergic receptors in vitro and in vivo.
20245 citationsauthor #11
A time-resolved Förster resonance energy transfer assay to investigate drug and inhibitor binding to ABCG2.
20241 citationsauthor #7
Agonist efficacy at the β2AR is driven by agonist-induced differences in receptor affinity for the Gs protein, not ligand binding kinetics
20242 citationsauthor #5
Ligand-Directed Labeling of the Adenosine A1 Receptor in Living Cells
20248 citationsauthor #9
A time-resolved Förster resonance energy transfer assay to investigate inhibitor binding to ABCG2
20230 citationsauthor #7
Small Molecule Fluorescent Ligands for the Atypical Chemokine Receptor 3 (ACKR3)
20233 citationsauthor #12
Small-Molecule Fluorescent Ligands for the CXCR4 Chemokine Receptor.
202310 citationsauthor #7
Key phosphorylation sites for robust β-arrestin2 binding at the MOR revisited
202315 citationsauthor #7
Bitter taste sensitivity in domestic dogs (Canis familiaris) and its relevance to bitter deterrents of ingestion
202210 citationsauthor #8
Advances in the application of fluorescence correlation spectroscopy to study detergent purified and encapsulated membrane proteins.
20224 citationsauthor #3
Probing the binding of interleukin-23 to individual receptor components and the IL-23 heteromeric receptor complex in living cells using NanoBRET
202110 citationsauthor #4
Probing the Binding of Interleukin-23 to Individual Receptor Components and the IL23 Heteromeric Receptor Complex in Living Cells Using NanoBRET
20210 citationsauthor #4
Acylation of the Incretin Peptide Exendin-4 Directly Impacts Glucagon-Like Peptide-1 Receptor Signaling and Trafficking
202123 citationsauthor #12
Author response for "Detection of Genome-Edited and Endogenously Expressed G Protein-Coupled Receptors"
20210 citationsauthor #6
A lipid-anchored neurokinin 1 receptor antagonist prolongs pain relief by a three-pronged mechanism of action targeting the receptor at the plasma membrane and in endosomes
202117 citationsauthor #14
Simple methods for quantifying super-resolved cortical actin
202116 citationsauthor #3
Analysis of Sequence Divergence in Mammalian ABCGs Predicts a Structural Network of Residues That Underlies Functional Divergence
20217 citationsauthor #4
Kinetic Profiling of Ligands and Fragments Binding to GPCRs by TR-FRET
20210 citationsauthor #7
RAMPs regulate signalling bias and internalisation of the GIPR
202114 citationsauthor #16
Subtype selective fluorescent ligands based on ICI 118,551 to study the human β2‐adrenoceptor in CRISPR/Cas9 genome‐edited HEK293T cells at low expression levels
202111 citationsauthor #5
Functional solubilization of the β2-adrenoceptor using diisobutylene maleic acid
202111 citationsauthor #7
The use of fluorescence correlation spectroscopy to monitor cell surface β2‐adrenoceptors at low expression levels in human embryonic stem cell‐derived cardiomyocytes and fibroblasts
20219 citationsauthor #9
Efficient G protein coupling is not required for agonist‐mediated internalization and membrane reorganization of the adenosine A3 receptor
20212 citationsauthor #5
Acylation of the incretin peptide exendin-4 directly impacts GLP-1 receptor signalling and trafficking
20215 citationsauthor #12
Detection of genome‐edited and endogenously expressed G protein‐coupled receptors
202117 citationsauthor #6
Heterodimeric analogues of the potent Y1R antagonist 1229U91, lacking one of the pharmacophoric C-terminal structures, retain potent Y1R affinity and show improved selectivity over Y4R.
20202 citationsauthor #5
Application of fluorescence correlation spectroscopy to study substrate binding in styrene maleic acid lipid copolymer encapsulated ABCG2
202018 citationsauthor #4
Single molecule binding of a ligand to a G-protein-coupled receptor in real time using fluorescence correlation spectroscopy, rendered possible by nano-encapsulation in styrene maleic acid lipid particles.
202033 citationsauthor #7
Monitoring Allosteric Interactions with CXCR4 Using NanoBiT Conjugated Nanobodies
202024 citationsauthor #6
is an essential subunit of an ADAM10 scissor complex
20200 citationsauthor #30
Monitoring ligand-induced changes in receptor conformation with NanoBiT conjugated nanobodies
20202 citationsauthor #6
is an essential subunit of an ADAM10 scissor complex
20201 citationsauthor #30
Functional solubilisation of the β2-adrenoceptor (β2AR) using Diisobutylene maleic acid (DIBMA)
20206 citationsauthor #7
The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex
202037 citationsauthor #28
Ligand-directed covalent labelling of a GPCR with a fluorescent tag in live cells
202037 citationsauthor #8
Fluorescent ligands: Bringing light to emerging GPCR paradigms
201963 citationsauthor #2
GRK Mediates μ-Opioid Receptor Plasma Membrane Reorganization
201921 citationsauthor #4
Context-Dependent Signaling of CXC Chemokine Receptor 4 and Atypical Chemokine Receptor 3
201931 citationsauthor #6
Molecular Pharmacology of a Conformational‐Specific Extracellular Nanobody Against CXCR4
20192 citationsauthor #4
NanoBiT Complementation to Monitor Agonist-Induced Adenosine A1 Receptor Internalization
201936 citationsauthor #4
Probe dependency in the determination of ligand binding kinetics at a prototypical G protein-coupled receptor
201921 citationsauthor #8
A live cell NanoBRET binding assay allows the study of ligand-binding kinetics to the adenosine A3 receptor
201936 citationsauthor #6
Structure-based exploration and pharmacological evaluation of N-substituted piperidin-4-yl-methanamine CXCR4 chemokine receptor antagonists.
201919 citationsauthor #12
Modulators of CXCR4 and CXCR7/ACKR3 Function
201953 citationsauthor #10
Investigating the mode of action of intracellular loop 1 pepducins at the CXCR4 receptor
20180 citationsauthor #4
Fluorescently Labeled Morphine Derivatives for Bioimaging Studies.
201820 citationsauthor #5
Micro-pharmacokinetics: Quantifying local drug concentration at live cell membranes
201834 citationsauthor #2
Development of novel fluorescent histamine H1-receptor antagonists to study ligand-binding kinetics in living cells
201853 citationsauthor #9
A Non-imaging High Throughput Approach to Chemical Library Screening at the Unmodified Adenosine-A3 Receptor in Living Cells
201717 citationsauthor #4
Gherbi, Karolina and May, Lauren T. and Baker, Jillian G. and Briddon, Stephen J. and Hill, Stephen J. (2015) Negative cooperativity across 1-adrenoceptor homodimers provides insights into the nature of the secondary low-affinity CGP 12177 1-adrenoceptor
20170 citationsauthor #3
Corriden, Ross and Kilpatrick, Laura E. and Kellam, Barrie and Briddon, Stephen J. and Hill, Stephen J. (2014) Kinetic analysis of antagonist-occupied adenosine-A3 receptors within membrane microdomains of individual cells provides evidence of receptor
20170 citationsauthor #4
Stoddart, Leigh A. and Kellam, Barrie and Briddon, Stephen J. and Hill, Stephen J. (2014) Effect of a toggle switch mutation in TM6 of the human adenosine A3 receptor on Gi protein-dependent signalling and Gi-
20170 citationsauthor #3
Studying GPCR Pharmacology in Membrane Microdomains: Fluorescence Correlation Spectroscopy Comes of Age.
201755 citationsauthor #1
Real-time analysis of the binding of fluorescent VEGF165a to VEGFR2 in living cells: Effect of receptor tyrosine kinase inhibitors and fate of internalized agonist-receptor complexes
201748 citationsauthor #7
Plasma membrane dynamics and tetrameric organisation of ABCG2 transporters in mammalian cells revealed by single particle imaging techniques.
201653 citationsauthor #2
Corriden, Ross and Self, Tim and Akong-Moore, Kathryn and Nizet, Victor and Kellam, Barrie and Briddon, Stephen J. and Hill, Stephen J. (2013) Adenosine-A3 receptors in neutrophil microdomains promote the formation of bacteria-tethering cytonemes. EMBO
20160 citationsauthor #6
Kilpatrick, Laura E. and Briddon, Stephen J. and Holliday, Nicholas D. (2012) Fluorescence correlation spectroscopy, combined with bimolecular fluorescence complementation, reveals the effects of β-arrestin complexes and endocytic targeting on the membrane
20160 citationsauthor #1
Differences in pharmacology of monomeric and dimeric NPY Y1 receptor fluorescent antagonists revealed by high content imaging
20160 citationsauthor #6
Direct visualisation of internalization of the adenosine A3 receptor and localization with arrestin3 using a fluorescent agonist.
201528 citationsauthor #3
Probing the pharmacology of G protein-coupled receptors with fluorescent ligands.
201567 citationsauthor #3
Synthesis, Biological Evaluation, and Utility of Fluorescent Ligands Targeting the μ-Opioid Receptor.
201522 citationsauthor #3
Negative cooperativity across β1-adrenoceptor homodimers provides insights into the nature of the secondary low-affinity CGP 12177 β1-adrenoceptor binding conformation
201539 citationsauthor #4
Effect of a toggle switch mutation in TM6 of the human adenosine A3 receptor on Gi protein-dependent signalling and Gi-independent receptor internalization
201433 citationsauthor #3
Kinetic analysis of antagonist-occupied adenosine-A3 receptors within membrane microdomains of individual cells provides evidence of receptor dimerization and allosterism
201455 citationsauthor #4
Detection of the secondary, low-affinity β1-adrenoceptor site in living cells using the fluorescent CGP 12177 derivative BODIPY-TMR-CGP
201415 citationsauthor #2
Adenosine-A3 receptors in neutrophil microdomains promote the formation of bacteria-tethering cytonemes
201342 citationsauthor #6
Extracellular adenosine modulates neutrophil host‐pathogen interactions via activation of the A3‐adenosine receptor
20130 citationsauthor #2
Conversion of a non-selective adenosine receptor antagonist into A3-selective high affinity fluorescent probes using peptide-based linkers.
201344 citationsauthor #3
Characterization of a novel, high‐affinity and selective fluorescent antagonist for the 5HT1A receptor
20130 citationsauthor #4
Fluorescent ligands for G protein-coupled receptors: illuminating receptor-ligand interactions for drug discovery.
20132 citationsauthor #2
Visualizing trafficking of the adenosine‐A3 receptor using a fluorescent agonist: a tool for delineating intracellular signalling
20130 citationsauthor #1
A novel fluorescent histamine H1 receptor antagonist demonstrates the advantage of using fluorescence correlation spectroscopy to study the binding of lipophilic ligands
201251 citationsauthor #2
Highly potent and selective fluorescent antagonists of the human adenosine A₃ receptor based on the 1,2,4-triazolo[4,3-a]quinoxalin-1-one scaffold.
201243 citationsauthor #3
Adenylyl cyclase AC8 directly controls its micro-environment by recruiting the actin cytoskeleton in a cholesterol-rich milieu
201235 citationsauthor #2
Plaque‐like A3 Adenosine Receptor Microdomains Are Associated with Bacteria‐Tethering Nanotubes in Human Neutrophils
20120 citationsauthor #3
Fragment Screening at Adenosine-A3 Receptors in Living Cells Using a Fluorescence-Based Binding Assay
201288 citationsauthor #4
Fluorescence correlation spectroscopy, combined with bimolecular fluorescence complementation, reveals the effects of β-arrestin complexes and endocytic targeting on the membrane mobility of neuropeptide Y receptors
201240 citationsauthor #2
Design and use of fluorescent ligands to study ligand-receptor interactions in single living cells.
201132 citationsauthor #1
A3 Adenosine Receptors are Localized to Plaque‐like Microdomains in Chemotaxing Cells
20110 citationsauthor #2
Allosteric interactions across native adenosine-A3 receptor homodimers: quantification using single-cell ligand-binding kinetics
201193 citationsauthor #4
Antagonist Selective Modulation of Adenosine A1 and A3 Receptor Pharmacology by the Food Dye Brilliant Black BN: Evidence for Allosteric Interactions
201035 citationsauthor #2
Bimolecular fluorescence complementation: lighting up seven transmembrane domain receptor signalling networks
201054 citationsauthor #2
The Effect of Allosteric Modulators on the Kinetics of Agonist-G Protein-Coupled Receptor Interactions in Single Living Cells
201050 citationsauthor #3
Agonist-dependent Changes in the Membrane Organisation of the-Opioid Receptor in HEK 293 Cells
20100 citationsauthor #1
A novel fluorescence-based live cell binding assay for screening of adenosine-A3 receptor ligands
20100 citationsauthor #3
Studying the Diffusion Characteristics of Different Activity States of the Human Adenosine-A3 Receptor Using Fluorescence Correlation Spectroscopy
20100 citationsauthor #3
RESEARCH PAPER Quantitative analysis of neuropeptide Y receptor association with b-arrestin2 measured by bimolecular fluorescence complementation
20100 citationsauthor #2
Influence of fluorophore and linker composition on the pharmacology of fluorescent adenosine A1 receptor ligands
201083 citationsauthor #5
THEMED SECTION: IMAGING IN PHARMACOLOGY RESEARCH PAPER Influence of fluorophore and linker composition on the pharmacology of fluorescent adenosine A1 receptor ligands
20100 citationsauthor #5
Use of Fluorescence Correlation Spectroscopy to Study the Diffusion of G Protein‐coupled Receptors
20104 citationsauthor #1
Membrane Receptors & Signal Transduction II
20090 citationsauthor #3
Using fluorescent pH-sensitive nanosensors to report their intracellular location after Tat-mediated delivery.
200928 citationsauthor #2
An Investigation Into the Membrane Diffusion and Organisation of Adenosine Receptor Homo-oligomers
20090 citationsauthor #1
Live Cell Imaging Of The Kinetics Of Ligand Binding At The Human Adenosine A3 Receptor
20090 citationsauthor #2
The Effect of Agonist Activation and Homodimerisation on the Membrane Diffusion of the Human Histamine H1 Receptor
20091 citationsauthor #2
Acknowledgement to Reviewers
20090 citationsauthor #75

TIMELINE

1991 24 citations

1997 55 citations

1998 183 citations

1999 25 citations

2000 101 citations

2001 34 citations

2004 202 citations

2007 204 citations

2008 128 citations

2009 66 citations

2010 226 citations

2011 125 citations

2012 257 citations

2013 88 citations

2014 103 citations

2015 156 citations

2016 53 citations

2017 120 citations

2018 107 citations

2019 282 citations

2020 160 citations

2021 142 citations

2022 14 citations

2023 28 citations

2024 16 citations

2025 1 citations

2026 0 citations

S. Briddon

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