M. Kranendonk

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Aliases
M Kranendonk, M. Kranendonk, Michel Kranendonk
Publication record
59 papers · 1,351 citations · H-index 20

PAPERS

The Adaptation of MCF-7 Breast Cancer Spheroids to the Chemotherapeutic Doxorubicin: The Dynamic Role of Phase I Drug Metabolizing Enzymes
20253 citationsauthor #4
Book of abstracts of the 6th CHRC Annual Summit
20250 citationsauthor #76
Challenges of the Application of In Vitro Digestion for Nanomaterials Safety Assessment
20248 citationsauthor #6
Pleiotropy of Progesterone Receptor Membrane Component 1 in Modulation of Cytochrome P450 Activity
20243 citationsauthor #3
Single Mutations in Cytochrome P450 Oxidoreductase Can Alter the Specificity of Human Cytochrome P450 1A2-Mediated Caffeine Metabolism
202310 citationsauthor #9
“Commandeuring” Xenobiotic Metabolism: Advances in Understanding Xenobiotic Metabolism
202213 citationsauthor #5
The Complex Dynamic of Phase I Drug Metabolism in the Early Stages of Doxorubicin Resistance in Breast Cancer Cells
202216 citationsauthor #5
Toxicological Assessment of Cellulose Nanomaterials: Oral Exposure
202221 citationsauthor #3
The Central Role of Cytochrome P450 in Xenobiotic Metabolism—A Brief Review on a Fascinating Enzyme Family
2021372 citationsauthor #3
Front Cover: Electrochemical Activity of Cytochrome P450 1A2: The Relevance of O 2 Control and the Natural Electron Donor (ChemElectroChem 3/2021)
20210 citationsauthor #6
ADVANCED PRECLINICAL MODELS FOR EVALUATION OF DRUG INDUCED LIVER INJURY - CONSENSUS STATEMENT BY THE EUROPEAN DRUG-INDUCED LIVER INJURY NETWORK [PRO-EURO-DILI-NET].
202194 citationsauthor #19
Motor dysfunction in Drosophila melanogaster as a biomarker for developmental neurotoxicity
202114 citationsauthor #5
Corrigendum: The Role of the FMN-Domain of Human Cytochrome P450 Oxidoreductase in Its Promiscuous Interactions With Structurally Diverse Redox Partners
20203 citationsauthor #9
The Role of the FMN-Domain of Human Cytochrome P450 Oxidoreductase in Its Promiscuous Interactions With Structurally Diverse Redox Partners
202026 citationsauthor #9
Electrochemical Activity of Cytochrome P450 1A2: The Relevance of O 2 Control and the Natural Electron Donor
20204 citationsauthor #6
Interaction Modes of Microsomal Cytochrome P450s with Its Reductase and the Role of Substrate Binding
202012 citationsauthor #5
A personally guided tour on some of our data with the Ames assay-A tribute to Professor Bruce Ames.
20194 citationsauthor #3
Accurate Determination of Human CPR Conformational Equilibrium by smFRET using Dual Orthogonal Non-Canonical Amino Acid Labeling
201818 citationsauthor #3
Probing the Role of the Hinge Segment of Cytochrome P450 Oxidoreductase in the Interaction with Cytochrome P450
201823 citationsauthor #9
Correction: The Hinge Segment of Human NADPH-Cytochrome P450 Reductase in Conformational Switching: The Critical Role of Ionic Strength
20183 citationsauthor #7
Role of Protein-Protein Interactions in Metabolism: Genetics, Structure, Function
20180 citationsauthor #4
Human cytochrome P450 expression in bacteria: Whole‐cell high‐throughput activity assay for CYP1A2, 2A6 and 3A4
20187 citationsauthor #8
The Hinge Segment of Human NADPH-Cytochrome P450 Reductase in Conformational Switching: The Critical Role of Ionic Strength
201719 citationsauthor #7
Editorial: Role of Protein-Protein Interactions in Metabolism: Genetics, Structure, Function
20176 citationsauthor #4
Prototype Systems Containing Human Cytochrome P450 for High-Throughput Real-Time Detection of DNA Damage by Compounds That Form DNA-Reactive Metabolites.
20162 citationsauthor #4
Cytochrome P450 expression system for high-throughput real-time detection of genotoxicity: Application to the study of human CYP1A2 variants.
20163 citationsauthor #5
Instability of the Human Cytochrome P450 Reductase A287P Variant Is the Major Contributor to Its Antley-Bixler Syndrome-like Phenotype*
201627 citationsauthor #6
Human sulfotransferase 1A1-dependent mutagenicity of 12-hydroxy-nevirapine: the missing link?
20147 citationsauthor #1
Functional characterization of eight human CYP1A2 variants: the role of cytochrome b5
201323 citationsauthor #5
Altered human CYP3A4 activity caused by Antley-Bixler Syndrome-related variants of NADPH-cytochrome P450 oxidoreductase measured in a robust in vitro system
20120 citationsauthor #6
Altered human CYP3A4 activity caused by Antley-Bixler Syndrome-related variants of NADPH-cytochrome P450 oxidoreductase measured in a robust in vitro system
20120 citationsauthor #6
Altered Human CYP3A4 Activity Caused by Antley-Bixler Syndrome-Related Variants of NADPH-Cytochrome P450 Oxidoreductase Measured in a Robust In Vitro System
201228 citationsauthor #6
Functional characterization of eight human cytochrome P450 1A2 gene variants by recombinant protein expression
201027 citationsauthor #8
Human Cytochrome P450 Oxidoreductase Deficiency Caused by the Y181D Mutation: Molecular Consequences and Rescue of Defect
201051 citationsauthor #6
Alkylating potential of oxetanes.
20105 citationsauthor #4
Human P450 Reductase Y181D Variant, Molecular Effects of FMN Deficiency
20090 citationsauthor #1
Human Cytochrome P450 1A2: Comprehensive Study of Eight Polymorphic Variants
20090 citationsauthor #1
Human Cytochrome P450 Oxidoreductase Deficiency Caused by the Y181D Mutation: Molecular Consequences & Rescue of Defect
20090 citationsauthor #6
Impairment of human CYP1A2-mediated xenobiotic metabolism by Antley-Bixler syndrome variants of cytochrome P450 oxidoreductase.
200854 citationsauthor #1
Simple and sensitive antimalarial drug screening in vitro and in vivo using transgenic luciferase expressing Plasmodium berghei parasites.
200878 citationsauthor #7
Antley-Bixler Syndrome-Related Mutants of Human NADPH-Cytochrome P450 Reductase: Effects on Drug Metabolism and Mutagenesis
20070 citationsauthor #2
The stimulatory role of human cytochrome b5 in the bioactivation activities of human CYP1A2, 2A6 and 2E1: a new cell expression system to study cytochrome P450-mediated biotransformation (a corrigendum report on Duarte et al. (2005) Mutagenesis 20, 93-100).
200616 citationsauthor #8
Genotoxicity and endoreduplication inducing activity of the food flavouring eugenol.
200682 citationsauthor #4
The role of protein-protein interactions in the stimulation of the bioactivation by CYP1A2, 2A6 and 2E1 in the presence of cytochrome b5: A new cell system to study cytochrome P450 mediated biotransformation
20050 citationsauthor #2
Escherichia coli BTC, a human cytochrome P450 competent tester strain with a high sensitivity towards alkylating agents: involvement of alkyltransferases in the repair of DNA damage induced by aromatic amines.
200526 citationsauthor #6
The stimulatory role of human cytochrome b5 in the bioactivation activities of human CYP1A2, 2A6 and 2E1: a new cell expression system to study cytochrome P450 mediated biotransformation.
200533 citationsauthor #8
The stimulatory role of human cytochrome b5 in the bioactivation activities of human CYP1A2, 2A6 and 2E1: a new cell expression system to study cytochrome P450-mediated biotransformation
20040 citationsauthor #3
Development of PD1000: a new Escherichia coli strain, highly sensitive towards the detection of alkylating agents.
20020 citationsauthor #2
DNA Polymorphisms as Modulators of Genotoxicity and Cancer
200211 citationsauthor #3
Heterologous Expression of Xenobiotic Mammalian-Metabolizing Enzymes in Mutagenicity Tester Bacteria: An Update and Practical Considerations
200016 citationsauthor #1
Escherichia coli MTC, a NADPH cytochrome P450 reductase competent mutagenicity tester strain for the expression of human cytochrome P450: comparison of three types of expression systems.
199923 citationsauthor #1
Escherichia coli MTC, a human NADPH P450 reductase competent mutagenicity tester strain for the expression of human cytochrome P450 isoforms 1A1, 1A2, 2A6, 3A4, or 3A5: catalytic activities and mutagenicity studies.
199936 citationsauthor #1
Expression of human cytochrome P450 1A2 in Escherichia coli: a system for biotransformation and genotoxicity studies of chemical carcinogens.
199850 citationsauthor #1
P I.7 Expression of human cytochrome P450 1A2 in Escherichia coli: A new system for biotransformation and genotoxicity studies of chemical carcinogens
19974 citationsauthor #1
Characterization of enzyme activities and cofactors involved in bioactivation and bioinactivation of chemical carcinogens in the tester strains Escherichia coli K12 MX100 and Salmonella typhimurium LT2 TA100.
199729 citationsauthor #1
MX100, a new Escherichia coli tester strain for use in genotoxicity studies.
199622 citationsauthor #1
Isolation and prevalidation of an Escherichia coli tester strain for the use in mechanistic and metabolic studies of genotoxins.
199411 citationsauthor #1
Metabolic activation of mutagens by human haemoglobin
19901 citationsauthor #3
Non-Specific Binding of the Fluorescent B-Adrenergic Receptor Probe Alprenolol-NBD
19858 citationsauthor #4

TIMELINE

1985 8 citations

1990 1 citations

1994 11 citations

1996 22 citations

1997 33 citations

1998 50 citations

1999 59 citations

2000 16 citations

2002 11 citations

2004 0 citations

2005 59 citations

2006 98 citations

2007 0 citations

2008 132 citations

2009 0 citations

2010 83 citations

2012 28 citations

2013 23 citations

2014 7 citations

2016 32 citations

2017 25 citations

2018 51 citations

2019 4 citations

2020 45 citations

2021 480 citations

2022 50 citations

2023 10 citations

2024 11 citations

2025 3 citations

M. Kranendonk

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