A personally guided tour on some of our data with the Ames assay-A tribute to Professor Bruce Ames.

In contributing to this Special Issue of Mutation Research dedicated to Professor Bruce N. Ames in recognition of his 90th birthday in December 2018, we intend to portray the importance not only of the Ames Salmonella/mammalian-microsome mutagenicity assay in some of our studies over the years, but also the importance of the insight that Bruce Ames brought to the field of genetic toxicology.

• Publication year

  2019

• Venue

  Mutation research

• Publication date

  2019-10-01

• Fields of study

  Biology, Medicine, Art

• Identifiers
  DOI 10.1016/j.mrgentox.2019.503094PMID 31585631
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Human sulfotransferase 1A1-dependent mutagenicity of 12-hydroxy-nevirapine: the missing link?

  2014cited by this paper
• Functional characterization of eight human CYP1A2 variants: the role of cytochrome b5

  2013cited by this paper
• Hepatic cell lines for drug hepatotoxicity testing: limitations and strategies to upgrade their metabolic competence by gene engineering.

  2013cited by this paper
• Altered Human CYP3A4 Activity Caused by Antley-Bixler Syndrome-Related Variants of NADPH-Cytochrome P450 Oxidoreductase Measured in a Robust In Vitro System

  2012cited by this paper
• Functional characterization of eight human cytochrome P450 1A2 gene variants by recombinant protein expression

  2010cited by this paper
• Human Cytochrome P450 Oxidoreductase Deficiency Caused by the Y181D Mutation: Molecular Consequences and Rescue of Defect

  2010cited by this paper
• Impairment of human CYP1A2-mediated xenobiotic metabolism by Antley-Bixler syndrome variants of cytochrome P450 oxidoreductase.

  2008cited by this paper
• Dietary flavonoids: effects on xenobiotic and carcinogen metabolism.

  2006cited by this paper
• The stimulatory role of human cytochrome b5 in the bioactivation activities of human CYP1A2, 2A6 and 2E1: a new cell expression system to study cytochrome P450-mediated biotransformation (a corrigendum report on Duarte et al. (2005) Mutagenesis 20, 93-100).

  2006cited by this paper
• The stimulatory role of human cytochrome b5 in the bioactivation activities of human CYP1A2, 2A6 and 2E1: a new cell expression system to study cytochrome P450 mediated biotransformation.

  2005cited by this paper
• Escherichia coli BTC, a human cytochrome P450 competent tester strain with a high sensitivity towards alkylating agents: involvement of alkyltransferases in the repair of DNA damage induced by aromatic amines.

  2005cited by this paper
• An Enthusiasm for Metabolism

  2003cited by this paper
• Heterologous Expression of Xenobiotic Mammalian-Metabolizing Enzymes in Mutagenicity Tester Bacteria: An Update and Practical Considerations

  2000cited by this paper
• Chemical features of flavonols affecting their genotoxicity. Potential implications in their use as therapeutical agents.

  2000cited by this paper
• Sulfotransferases: genetics and role in toxicology.

  2000cited by this paper
• Escherichia coli MTC, a NADPH cytochrome P450 reductase competent mutagenicity tester strain for the expression of human cytochrome P450: comparison of three types of expression systems.

  1999cited by this paper
• Escherichia coli MTC, a human NADPH P450 reductase competent mutagenicity tester strain for the expression of human cytochrome P450 isoforms 1A1, 1A2, 2A6, 3A4, or 3A5: catalytic activities and mutagenicity studies.

  1999cited by this paper
• The prevention of cancer.

  1998cited by this paper
• The causes and prevention of cancer: gaining perspective.

  1997cited by this paper
• Metabolism of galangin by rat cytochromes P450: relevance to the genotoxicity of galangin.

  1997cited by this paper
• Involvement of rat cytochrome 1A1 in the biotransformation of kaempferol to quercetin: relevance to the genotoxicity of kaempferol.

  1997cited by this paper
• Development and validation of alternative metabolic systems for mutagenicity testing in short-term assays.

  1996cited by this paper
• MX100, a new Escherichia coli tester strain for use in genotoxicity studies.

  1996cited by this paper
• The causes and prevention of cancer.

  1995cited by this paper
• Salmonella strains and mammalian cells genetically engineered for expression of sulfotransferases.

  1995cited by this paper
• Decade of the brain: the gray area of research on gray matter.

  1994cited by this paper
• Isolation and prevalidation of an Escherichia coli tester strain for the use in mechanistic and metabolic studies of genotoxins.

  1994cited by this paper
• Quercetin and the mutagenicity of wines.

  1993cited by this paper
• Oxygen species and the genotoxicity of quercetin.

  1992cited by this paper
• Activation of promutagens by porphyrinic biomimetic systems.

  1992cited by this paper
• High‐level expression of functional human cytochrome P450 1A2 in Escherichia coli

  1992cited by this paper
• Dietary pesticides (99.99% all natural).

  1990cited by this paper
• Expression of xenobiotic-metabolizing enzymes in propagatable cell cultures and induction of micronuclei by 13 compounds.

  1990cited by this paper
• Mutagenic activity in the wine-making process: correlations with rutin and quercetin levels.

  1990cited by this paper
• Too many rodent carcinogens: mitogenesis increases mutagenesis.

  1990cited by this paper
• Mutagenicity of rutin and the glycosidic activity of cultured cell-free microbial preparations of human faeces and saliva.

  1989cited by this paper
• DNA Damage and Oxygen Species

  1989cited by this paper
• Search for cell culture systems with diverse xenobiotic-metabolizing activities and their use in toxicological studies.

  1987cited by this paper
• Genetic toxicology of flavonoids: the role of metabolic conditions in the induction of reverse mutation, SOS functions and sister-chromatid exchanges.

  1986cited by this paper
• Testing Human lipoproteins for Mutagenic Activity in the Salmonella/Microsome Assay

  1985cited by this paper
• Mutagenicity in urine of workers in naval industry.

  1983cited by this paper
• Revised methods for the Salmonella mutagenicity test.

  1983cited by this paper
• VLDL-associated mutagenic activity.

  1982cited by this paper
• Urinary mutagenicity in occupational exposure to mineral oils and iron oxide particles.

  1982cited by this paper
• Effect of low-density lipoprotein on the incorporation of benzo(a)pyrene by cultured cells.

  1981cited by this paper
• Fecalase: a model for activation of dietary glycosides to mutagens by intestinal flora.

  1980cited by this paper
• Benzo(a)pyrene uptake by human plasma lipoproteins in vitro.

  1979cited by this paper
• Mutagenicity of plant flavonoids: structural requirements for mutagenic activity in Salmonella typhimurium.

  1978cited by this paper
• Concentration of mutagens from urine by absorption with the nonpolar resin XAD-2: cigarette smokers have mutagenic urine.

  1977cited by this paper
• Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals.

  1975cited by this paper
• An improved bacterial test system for the detection and classification of mutagens and carcinogens.

  1973cited by this paper
• Liver microsomal metabolism of aflatoxin B 1 to a reactive derivative toxic to Salmonella typhimurium TA 1530.

  1972cited by this paper
• The Mutagenicity of Chemical Carcinogens: Correlations, Problems, and Interpretations

  1971cited by this paper
• Rapid detection of mutagens and carcinogens.

  1971cited by this paper
• Dimethylnitrosamine: formation of mutagenic compounds by interaction with mouse liver microsomes.

  1971cited by this paper
• Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture.

  1970cited by this paper

• Pioneering contribution of Professor Bruce Ames to early development in biochemical aspects of oxidatively generated damage to DNA

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