C. Proud

Modifying dietary protein impacts mTOR signaling and brain deposition of amyloid beta in a knock-in mouse model of Alzheimer's disease.
20235 citationsauthor #5
Pathophysiology of obesity and its associated diseases
2023369 citationsauthor #7
From Translation to Treatment
20230 citationsauthor #2
Da-Chai-Hu-Tang Protects From Acute Intrahepatic Cholestasis by Inhibiting Hepatic Inflammation and Bile Accumulation via Activation of PPARα
202213 citationsauthor #11
The role of eIF2 phosphorylation in cell and organismal physiology: new roles for well-known actors.
202218 citationsauthor #2
Glutamine deficiency in solid tumor cells confers resistance to ribosomal RNA synthesis inhibitors
202219 citationsauthor #16
Eukaryotic elongation factor 2 kinase regulates foam cell formation via translation of CD36
20225 citationsauthor #20
MAPK-interacting kinase 1 (Mnk1) regulates platelet production, activation, and thrombosis.
202222 citationsauthor #16
Eukaryotic Elongation Factor 2 Kinase Activity Is Required for the Phenotypes of the Rpl24Bst Mouse
20222 citationsauthor #2
Elongation factor eEF2 kinase and autophagy jointly promote survival of cancer cells.
20212 citationsauthor #5
TSC-insensitive Rheb mutations induce oncogenic transformation through a combination of constitutively active mTORC1 signalling and proteome remodelling
20215 citationsauthor #9
capCLIP: a new tool to probe translational control in human cells through capture and identification of the eIF4E–mRNA interactome
202121 citationsauthor #7
Vanishing white matter: Eukaryotic initiation factor 2B model and the impact of missense mutations
202126 citationsauthor #8
The Inhibition of Metabolic Inflammation by EPA Is Associated with Enhanced Mitochondrial Fusion and Insulin Signaling in Human Primary Myotubes.
202116 citationsauthor #7
Age-related changes in tau and autophagy in human brain in the absence of neurodegeneration
202115 citationsauthor #14
Rpl24Bst mutation suppresses colorectal cancer by promoting eEF2 phosphorylation via eEF2K
202120 citationsauthor #6
Deletion of Rptor in Preosteoblasts Reveals a Role for the Mammalian Target of Rapamycin Complex 1 (mTORC1) Complex in Dietary‐Induced Changes to Bone Mass and Glucose Homeostasis in Female Mice
20214 citationsauthor #7
Gut Microbiome Regulation of Autophagic Flux and Neurodegenerative Disease Risks
202111 citationsauthor #4
Inhibiting mTOR activity using AZD2014 increases autophagy in the mouse cerebral cortex.
202112 citationsauthor #5
Progress in developing MNK inhibitors.
202138 citationsauthor #4
MRTF-A-NF-κB/p65 axis-mediated PDL1 transcription and expression contributes to immune evasion of non-small-cell lung cancer via TGF-β
202152 citationsauthor #6
The mTORC1 complex in pre-osteoblasts regulates whole-body energy metabolism independently of osteocalcin
202113 citationsauthor #9
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
20213,716 citationsauthor #2010
mTOR Signaling Pathways
20212 citationsauthor #2
The composition of the gut microbiota following early-life antibiotic exposure affects host health and longevity in later life.
202142 citationsauthor #20
Erratum for “Constitutively active Rheb mutants [T23M] and [E40K] drive increased production and secretion of recombinant protein in Chinese hamster ovary cells” (Vol. 118, Issue 7, pp. 2422–2434)
20210 citationsauthor #4
Faculty Opinions recommendation of Adaptive mutability of colorectal cancers in response to targeted therapies.
20202 citationsauthor #1
Reciprocal signaling between mTORC1 and MNK2 controls cell growth and oncogenesis
202021 citationsauthor #23
Regulation | mTOR and its Substrates
20200 citationsauthor #1
MNK inhibition sensitizes KRAS-mutant colorectal cancer to mTORC1 inhibition by reducing eIF4E phosphorylation and c-MYC expression.
202066 citationsauthor #30
The Lifeact-EGFP mouse is a translationally controlled fluorescent reporter of T cell activation
202010 citationsauthor #11
037 Eukaryotic Elongation Factor 2 Kinase (eEF2k) Regulates Foam Cell Formation and Atherosclerosis by Promoting Translation and Glycosylation of CD36 Scavenger Receptor Expression in Macrophages
20200 citationsauthor #13
Identification of DNA response elements regulating expression of CCAAT/enhancer-binding protein (C/EBP) β and δ during early adipogenesis
20202 citationsauthor #4
eEF2 kinase enhances the expression of PD-L1 by promoting the translation of its mRNA
20200 citationsauthor #10
Chloroquine and bafilomycin A mimic lysosomal storage disorders and impair mTORC1 signalling
202088 citationsauthor #2
TSC-Insensitive Rheb Mutations Induce Oncogenic Transformation Through a Combination of Hyperactive mTORC1 Signalling and Metabolic Reprogramming
20202 citationsauthor #8
Identification of DNA response elements regulating expression of CCAAT/enhancer-binding protein (C/EBP) β and δ and MAP kinase-interacting kinases during early adipogenesis
202023 citationsauthor #4
Disabling MNK protein kinases promotes oxidative metabolism and protects against diet-induced obesity
202025 citationsauthor #11
The gene for the lysosomal protein LAMP3 is a direct target of the transcription factor ATF4
202024 citationsauthor #5
eEF2/eEF2K Pathway in the Mature Dentate Gyrus Determines Neurogenesis Level and Cognition.
202028 citationsauthor #6
eEF2K enhances expression of PD-L1 by promoting the translation of its mRNA.
202033 citationsauthor #10
The prohibitin-binding compound fluorizoline affects multiple components of the translational machinery and inhibits protein synthesis
20209 citationsauthor #9
MAPK-interacting kinase 2 (MNK2) regulates adipocyte metabolism independently of its catalytic activity.
20205 citationsauthor #4
capCLIP: a new tool to probe protein synthesis in human cells through capture and identification of the eIF4E-mRNA interactome
20202 citationsauthor #7
The eEF2 kinase-induced STAT3 inactivation inhibits lung cancer cell proliferation by phosphorylation of PKM2
202031 citationsauthor #11
Constitutively active Rheb mutants [T23M] and [E40K] drive increased production and secretion of recombinant protein in Chinese hamster ovary cells
20203 citationsauthor #4
Cyclosporin A but not FK506 activates the integrated stress response in human cells
20209 citationsauthor #5
Eicosapentaenoic Acid-Induced Inhibition of Metabolic Inflammation Is Associated with Preserved Mitochondrial Function and Insulin Sensitivity in Human Primary Myotubes
20200 citationsauthor #5
Bicuculline regulated protein synthesis is dependent on Homer1 and promotes its interaction with eEF2K through mTORC1‐dependent phosphorylation
20205 citationsauthor #7
Eukaryotic elongation factor 2 kinase promotes angiogenesis in hepatocellular carcinoma via PI3K/Akt and STAT3
202049 citationsauthor #10
Faculty Opinions recommendation of Translational reprogramming marks adaptation to asparagine restriction in cancer.
20190 citationsauthor #1
Ablation of elongation factor 2 kinase enhances heat-shock protein 90 chaperone expression and protects cells under proteotoxic stress
201919 citationsauthor #4
Regulation of the Elongation Phase of Protein Synthesis Enhances Translation Accuracy and Modulates Lifespan.
201974 citationsauthor #10
Thioflavin T Monitoring of Guanine Quadruplex Formation in the rs689-Dependent INS Intron 1
20196 citationsauthor #2
Design, synthesis and activity of Mnk1 and Mnk2 selective inhibitors containing thieno[2,3-d]pyrimidine scaffold.
201932 citationsauthor #12
Eukaryotic Elongation Factor 2 Kinase (eEF2k) Regulates Cholesterol Uptake by Macrophages via CD36 Scavenger Receptor Expression
20190 citationsauthor #12
Faculty Opinions recommendation of Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring.
20190 citationsauthor #1
The MAP kinase-interacting kinases (MNKs) as targets in oncology
201929 citationsauthor #4
The ability to utilise ammonia as nitrogen source is cell type specific and intricately linked to GDH, AMPK and mTORC1
201937 citationsauthor #4
Transcriptional and metabolic rewiring of colorectal cancer cells expressing the oncogenic KRASG13D mutation
201947 citationsauthor #13
The ability to utilise ammonia as nitrogen source is cell type specific and intricately linked to GDH, AMPK and mTORC1
20195 citationsauthor #4
Faculty Opinions recommendation of Drug Synergy Slows Aging and Improves Healthspan through IGF and SREBP Lipid Signaling.
20180 citationsauthor #1
Adult mouse eIF2Bε Arg191His astrocytes display a normal integrated stress response in vitro
201811 citationsauthor #7
Faculty of 1000 evaluation for Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.
20180 citationsauthor #1
Faculty Opinions recommendation of Increased Amino Acid Uptake Supports Autophagy-Deficient Cell Survival upon Glutamine Deprivation.
20180 citationsauthor #1
Lysosomal N-acetyltransferase interacts with ALIX and is detected in extracellular vesicles.
20188 citationsauthor #6
Osteocalcin‐dependent regulation of glucose metabolism and fertility: Skeletal implications for the development of insulin resistance
201819 citationsauthor #5
Role of Eukaryotic Initiation Factor eIF2B in Vanishing White Matter Disease
20182 citationsauthor #4
Eukaryotic elongation factor 2 kinase upregulates the expression of proteins implicated in cell migration and cancer cell metastasis
201837 citationsauthor #12
Adult mouse eIF2Bε Arg191His astrocytes display a normal integrated stress response in vitro
20180 citationsauthor #7
Who does TORC2 talk to?
201823 citationsauthor #3
Phosphorylation and Signal Transduction Pathways in Translational Control.
2018105 citationsauthor #1
Non‐high‐density lipoprotein cholesterol is more informative than traditional cholesterol indices in predicting diabetes risk for women with normal glucose tolerance
20189 citationsauthor #12
Proteomic and Metabolomic Analyses of Vanishing White Matter Mouse Astrocytes Reveal Deregulation of ER Functions
201716 citationsauthor #8
and mediate adverse effects of high-fat feeding in distinct ways
20170 citationsauthor #9
Oncogenic MNK signalling regulates the metastasis suppressor NDRG1
201718 citationsauthor #3
A novel fluorescent probe reveals starvation controls the commitment of amyloid precursor protein to the lysosome.
201720 citationsauthor #6
mTORC1 Plays an Important Role in Skeletal Development by Controlling Preosteoblast Differentiation
201796 citationsauthor #10
A Novel Role for CRTC 2 in Hepatic Cholesterol Synthesis via SREBP-2
20171 citationsauthor #14
Mycobacterium tuberculosis subverts negative regulatory pathways in human macrophages to drive immunopathology
201750 citationsauthor #14
A novel role for CRTC2 in hepatic cholesterol synthesis through SREBP‐2
201738 citationsauthor #14
Eukaryotic Elongation Factor 2 Kinase (eEF2K) in Cancer
201759 citationsauthor #3
MNK1 and MNK2 mediate adverse effects of high-fat feeding in distinct ways
201631 citationsauthor #9
Eukaryotic elongation factor 2 kinase as a drug target in cancer, and in cardiovascular and neurodegenerative diseases
201698 citationsauthor #2
Faculty Opinions recommendation of Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synergistically Extends Survival in MYC-Driven Lymphoma.
20161 citationsauthor #1
Faculty Opinions recommendation of Activating mTOR mutations in a patient with an extraordinary response on a phase I trial of everolimus and pazopanib.
20160 citationsauthor #1
Faculty Opinions recommendation of The dual mTORC1 and mTORC2 inhibitor AZD8055 has anti-tumor activity in acute myeloid leukemia.
20160 citationsauthor #1
mTORC2 is a tyrosine kinase
201612 citationsauthor #2
mTOR inhibitors in cancer therapy
2016342 citationsauthor #3
A high-throughput screening assay for eukaryotic elongation factor 2 kinase inhibitors
201612 citationsauthor #3
mTORC1 signalling and eIF4E/4E-BP1 translation initiation factor stoichiometry influence recombinant protein productivity from GS-CHOK1 cells
201650 citationsauthor #3
Elongation factor 2 kinase promotes cell survival by inhibiting protein synthesis without inducing autophagy
201640 citationsauthor #8
Depletion of ribosomal protein S19 causes a reduction of rRNA synthesis
201627 citationsauthor #8
eEF2K/eEF2 Pathway Controls the Excitation/Inhibition Balance and Susceptibility to Epileptic Seizures
201669 citationsauthor #22
Glycine restores the anabolic response to leucine in a mouse model of acute inflammation.
201634 citationsauthor #6
Role of AMPK in regulation of LC3 lipidation as a marker of autophagy in skeletal muscle.
201675 citationsauthor #8
Stoichiometry of the eIF2B complex is maintained by mutual stabilization of subunits.
201615 citationsauthor #5
Tuning Specific Translation in Cancer Metastasis and Synaptic Memory: Control at the MNK-eIF4E Axis.
201697 citationsauthor #3
Quantitative Non-canonical Amino Acid Tagging (QuaNCAT) Proteomics Identifies Distinct Patterns of Protein Synthesis Rapidly Induced by Hypertrophic Agents in Cardiomyocytes, Revealing New Aspects of Metabolic Remodeling
201620 citationsauthor #10
Quantitative Non-Canonical Amino acid Tagging based proteomics identifies distinct patterns of protein synthesis rapidly induced by hypertrophic agents in cardiomyocytes, revealing new aspects of metabolic remodeling Running title: Translational control by hypertrophic agents in heart cells
20160 citationsauthor #11

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