J. Sallenave

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Aliases
Jean Michel Sallenave, J M Sallenave, Jean‐michel Sallenave, J.-m Sallenave, J-m. Sallenave, J Sallenave, Jean Sallenave, Jean-michel Sallenave, J-m Sallenave, J.-m. Sallenave
Publication record
153 papers · 7,022 citations · H-index 54

PAPERS

Multiparameter Optimization of Pseudomonas aeruginosa Elastase Inhibitors for Systemic Administration.
20260 citationsauthor #14
Repeated exposures to PM2.5 alter the mitochondria and the influenza-mediated interferon response in an air-liquid interface bronchial epithelium.
20251 citationsauthor #6
Intrapulmonary-administered myeloid derived suppressor cells rescue mice from Pseudomonas aeruginosa infection and promote a regulatory/repair phenotype.
20250 citationsauthor #6
Exposure to PM2.5 modulate the pro-inflammatory and interferon responses against influenza virus infection in a human 3D bronchial epithelium model.
202414 citationsauthor #10
COVID-19 PBMCs are doubly harmful, through LDN-mediated lung epithelial damage and monocytic impaired responsiveness to live Pseudomonas aeruginosa exposure
20241 citationsauthor #11
Abnormal functional lymphoid tolerance and enhanced myeloid exocytosis are characteristics of resting and stimulated PBMCs in cystic fibrosis patients
20243 citationsauthor #6
Editorial overview: The lung, the gut, and the genital mucosae: microbial targets and therapeutic playgrounds.
20241 citationsauthor #1
Pulmonary delivery of silver nanoparticles prevents influenza infection by recruiting and activating lymphoid cells.
202420 citationsauthor #7
Pseudomonas aeruginosa-infected Myeloid-derived suppressor cells (MDSC) down-regulate lymphocyte activity and improves mice survival, following in vivo lung transfer
20240 citationsauthor #5
74 Impact of Air Pollution on Lung Immune Responses in a Mouse Model of Influenza Infection
20230 citationsauthor #4
Acute Influenza Infection Promotes Lung Tumor Growth by Reprogramming the Tumor Microenvironment.
20237 citationsauthor #22
Eosinophils Recruited During Pulmonary Vaccination Regulate Mucosal Antibody Production.
20229 citationsauthor #6
Pseudomonas Aeruginosa Lung Infection Subverts Lymphocytic Responses through IL-23 and IL-22 Post-Transcriptional Regulation
202210 citationsauthor #7
To Vaccinate or not: Influenza Virus and Lung Cancer Progression.
202116 citationsauthor #4
IL-6-elafin genetically modified macrophages as a lung immunotherapeutic strategy against Pseudomonas aeruginosa infections
202113 citationsauthor #4
Use of IL-6-elafin genetically modified regulatory macrophages as an immunotherapy against acute Pseudomonas aeruginosa infection in the lung
20210 citationsauthor #4
423: The antiinflammatory and antimicrobial elafin synergizes with IL-6 to induce regulatory macrophages, which protect mice when adoptively transferred during Pseudomonas aeruginosa infections
20210 citationsauthor #1
Influenza A Virus Pre-Infection Exacerbates Pseudomonas aeruginosa-Mediated Lung Damage Through Increased MMP-9 Expression, Decreased Elafin Production and Tissue Resilience
202026 citationsauthor #7
Host signaling and proteolytic pathways in the resolution or the exacerbation of coronavirus (CoV-2) infection in COVID-19 disease: what therapeutic targets?
20202 citationsauthor #1
Innate Immune Signaling and Proteolytic Pathways in the Resolution or Exacerbation of SARS-CoV-2 in Covid-19: Key Therapeutic Targets?
2020109 citationsauthor #1
Use of IL-6-elafin genetically modified regulatory macrophages as an immunotherapeutic against acute bacterial infection in the lung
20200 citationsauthor #4
Silver nanoparticle-adjuvanted vaccine protects against lethal influenza infection through inducing BALT and IgA-mediated mucosal immunity.
201962 citationsauthor #9
Author Correction: Airway surface liquid acidification initiates host defense abnormalities in Cystic Fibrosis
20196 citationsauthor #20
Influenza A virus impairs antimicrobial molecules production in vitro in lung epithelial cells and in murine lung infection
20190 citationsauthor #6
Overexpression of Elastin Affects the Protease to Anti-Protease Balance and Protects Mice from Colitis
201911 citationsauthor #17
Airway surface liquid acidification initiates host defense abnormalities in Cystic Fibrosis
201972 citationsauthor #20
Silver Nanoparticles Impair Retinoic Acid-Inducible Gene I-Mediated Mitochondrial Antiviral Immunity by Blocking the Autophagic Flux in Lung Epithelial Cells.
201859 citationsauthor #14
Pseudomonas aeruginosa LasB Subverts Alveolar Macrophage Activity by Interfering With Bacterial Killing Through Downregulation of Innate Immune Defense, Reactive Oxygen Species Generation, and Complement Activation
201859 citationsauthor #9
Pseudomonas aeruginosa modulates the pulmonary immune response by affecting the IL17 / IL22 axis
20180 citationsauthor #6
Explorer Antimicrobial Activity of Murine Lung Cells against Staphylococcus aureus Is Increased In Vitro and In Vivo after
20180 citationsauthor #8
Pseudomonas aeruginosa LasB subverts innate immunity in alveolar macrophages and epithelial cells
20180 citationsauthor #7
Human airway trypsin-like protease, a serine protease involved in respiratory diseases.
201740 citationsauthor #4
The antimicrobial molecule trappin-2/elafin has anti-parasitic properties and is protective in vivo in a murine model of cerebral malaria
201712 citationsauthor #10
Systemic Human ILC Precursors Provide a Substrate for Tissue ILC Differentiation.
2017466 citationsauthor #21
FGF9 prevents pleural fibrosis induced by intrapleural adenovirus injection in mice.
201717 citationsauthor #7
Human airway trypsin‐like protease exerts potent, antifibrotic action in pulmonary fibrosis
20175 citationsauthor #14
Pseudomonas aeruginosa LasB protease impairs innate immunity in mice and humans by targeting a lung epithelial cystic fibrosis transmembrane regulator–IL-6–antimicrobial–repair pathway
201791 citationsauthor #11
Human Airway Trypsin-like protease exerts potent anti-fibrotic role in vivo
20170 citationsauthor #11
Fibroblast growth factor 9 (FGF9) modulates mesothelial cells plasticity to decrease differentiation and migrationin vitro
20160 citationsauthor #4
Cyclosporine Does Not Prevent Microvascular Loss in Transplantation but Can Synergize With a Neutrophil Elastase Inhibitor, Elafin, to Maintain Graft Perfusion During Acute Rejection
201515 citationsauthor #8
Editorial: Neutrophil elastase and the lung: is it degradation, repair, emphysema, or fibrosis? What tilts it left or right?
20152 citationsauthor #1
Pseudomonas aeruginosa elastase LasB modulates CFTR expression and innate immune responses in airway epithelial cells
20150 citationsauthor #5
Acute exposure to silica nanoparticles enhances mortality and increases lung permeability in a mouse model of Pseudomonas aeruginosa pneumonia
201584 citationsauthor #7
Acute exposure to silica nanoparticles enhances mortality and increases lung permeability in a mouse model of Pseudomonas aeruginosa pneumonia
20150 citationsauthor #7
Serine protease inhibitors protect better than IL-10 and TGF-β anti-inflammatory cytokines against mouse colitis when delivered by recombinant lactococci
2015116 citationsauthor #6
Cyclosporine Does Not Prevent Microvascular Loss in Transplantation but Can Synergize With a Neutrophil Elastase Inhibitor, Elafin, to Maintain Graft Perfusion During Acute Rejection
201515 citationsauthor #9
LasB elastase, a T2SS Pseudomonas aeruginosa virulence factor kills mice in part by subverting host alveolar macrophage activity, through IL-1β down-regulation
20150 citationsauthor #3
Phagocytic and signaling innate immune receptors: are they dysregulated in cystic fibrosis in the fight against Pseudomonas aeruginosa?
201415 citationsauthor #1
Sheep Lung Segmental Delivery Strategy Demonstrates Adenovirus Priming of Local Lung Responses to Bacterial LPS and the Role of Elafin as a Response Modulator
20142 citationsauthor #5
Cystic fibrosis, a multi-systemic mucosal disease: 25 years after the discovery of CFTR.
20145 citationsauthor #2
LasB elastase, a T2SS Pseudomonas aeruginosa virulence factor subverts host alveolar macrophage activity through IL-1β down-regulation ex vivo and in vivo
20140 citationsauthor #6
Anti‐tumor effect of SLPI on mammary but not colon tumor growth
201314 citationsauthor #16
Antiviral Activity of Trappin-2 and Elafin In Vitro and In Vivo against Genital Herpes
201337 citationsauthor #3
WAPing Out Pathogens and Disease in the Mucosa: Roles for SLPI and Trappin-2
20130 citationsauthor #3
Neutrophil elastase degrades cystic fibrosis transmembrane conductance regulator via calpains and disables channel function in vitro and in vivo.
2013106 citationsauthor #16
Internalization of SiO2 nanoparticles by alveolar macrophages and lung epithelial cells and its modulation by the lung surfactant substitute Curosurf®
201336 citationsauthor #4
Overexpressing mouse model demonstrates the protective role of Muc5ac in the lungs
2012192 citationsauthor #7
Pulmonary Defence Mechanisms
20122 citationsauthor #2
Effects Of SiO2 Nanoparticles In Pseudomonas Aeruginosa Uptake By Alveolar Macrophages
20120 citationsauthor #6
Trappin-2/Elafin Modulate Innate Immune Responses of Human Endometrial Epithelial Cells to PolyI∶C
201216 citationsauthor #5
Endogenous antimicrobial molecules: Important mediators in alveolar macrophage–epithelial cell interaction in the lung
20120 citationsauthor #1
Ventilator-associated pneumonia is characterized by excessive release of neutrophil proteases in the lung.
201270 citationsauthor #11
Influenza A induces the major secreted airway mucin MUC5AC in a protease-EGFR-extracellular regulated kinase-Sp1-dependent pathway.
201279 citationsauthor #11
Human Airway Trypsin Mediates MUC5AC Expression Induced By Influenza A Virus But Not Viral Replication In Bronchial Epithelial Cells
20120 citationsauthor #6
Food-Grade Bacteria Expressing Elafin Protect Against Inflammation and Restore Colon Homeostasis
2012244 citationsauthor #14
C 5 a Mediates Peripheral Blood Neutrophil Dysfunction in Critically Ill Patients
201213 citationsauthor #12
Toll-like receptor 5 (TLR5), IL-1β secretion, and asparagine endopeptidase are critical factors for alveolar macrophage phagocytosis and bacterial killing
201298 citationsauthor #10
The WAP protein Trappin-2/Elafin: a handyman in the regulation of inflammatory and immune responses.
201254 citationsauthor #3
CXCL10 reduces melanoma proliferation and invasiveness in vitro and in vivo
201157 citationsauthor #6
WAP domain proteins as modulators of mucosal immunity.
201155 citationsauthor #4
Transcriptomic Analysis of Host Immune and Cell Death Responses Associated with the Influenza A Virus PB1-F2 Protein
201175 citationsauthor #8
Deletion of serpina1a, a murine α1-antitrypsin ortholog, results in embryonic lethality
201124 citationsauthor #6
Serine and Cysteine Proteases and Their Inhibitors as Antimicrobial Agents and Immune Modulators
201110 citationsauthor #3
Serine leucocyte proteinase inhibitor‐treated monocyte inhibits human CD4+ lymphocyte proliferation
201127 citationsauthor #11
Trypsin and neutrophil elastase regulate CFTR expression and function in cystic fibrosis
20100 citationsauthor #9
Lung protease/anti-protease network and modulation of mucus production and surfactant activity.
201041 citationsauthor #5
Immunopathology and Infectious Diseases Trappin-2 Promotes Early Clearance of Pseudomonas aeruginosa through CD 14-Dependent Macrophage Activation and Neutrophil Recruitment
201031 citationsauthor #12
Secretory leukocyte protease inhibitor and elafin/trappin-2: versatile mucosal antimicrobials and regulators of immunity.
2010133 citationsauthor #1
Modifying the protease/anti-protease pattern protects from colitis in mice: benefits from elafin over-expression
20100 citationsauthor #17
Modifying the protease, antiprotease pattern by elafin overexpression protects mice from colitis.
2010115 citationsauthor #20
Flagellin/TLR5-dependent modulation of alveolar macrophage and epithelial cell activity by the antimicrobial molecule trappin-2
20100 citationsauthor #6
Diagnostic importance of pulmonary interleukin-1 beta and interleukin-8 in ventilator-associated pneumonia
200928 citationsauthor #20
Intranasal Mucosal Boosting with an Adenovirus-Vectored Vaccine Markedly Enhances the Protection of BCG-Primed Guinea Pigs against Pulmonary Tuberculosis
2009114 citationsauthor #3
Diagnostic importance of pulmonary interleukin-1β and interleukin-8 in ventilator-associated pneumonia
2009129 citationsauthor #17
Adenoviral Vector-Mediated Priming of Local Lung Responses to Bacterial Lipopolysaccharide and the Role of Elafin as a Response Modulator.
20090 citationsauthor #5
Trappin-2 promotes early clearance of Pseudomonas aeruginosa through CD14-dependent macrophage activation and neutrophil recruitment.
200914 citationsauthor #12
C5a mediates peripheral blood neutrophil dysfunction in critically ill patients.
2009121 citationsauthor #12
IL-33 Enhances Lipopolysaccharide-Induced Inflammatory Cytokine Production from Mouse Macrophages by Regulating Lipopolysaccharide Receptor Complex1
2009155 citationsauthor #6
Human neutrophil elastase: mediator and therapeutic target in atherosclerosis.
200887 citationsauthor #2
Altered secretory leukocyte protease inhibitor expression in the uterine decidua of tubal compared with intrauterine pregnancy.
200813 citationsauthor #2
Implication of proteases and anti-proteases during IAV infection and pulmonary inflammation
20080 citationsauthor #5
Modulation of the pro-inflammatory phenotype of CFTR mutated epithelial cells
20081 citationsauthor #7
Altered secretory leukocyte protease inhibitor expression in the uterine decidua of tubal compared with intrauterine pregnancy.
200813 citationsauthor #3
Aspergillus fumigatus-induced IL-8 synthesis by bronchial epithelial cells: lack of involvement of the TLR-MyD88 pathway
20080 citationsauthor #2
Aspergillus fumigatus-induced Interleukin-8 Synthesis by Respiratory Epithelial Cells Is Controlled by the Phosphatidylinositol 3-Kinase, p38 MAPK, and ERK1/2 Pathways and Not by the Toll-like Receptor-MyD88 Pathway*
2008104 citationsauthor #2
Neutrophil Elastase (NE) and NE Inhibitors: Canonical and Noncanonical Functions in Lung Chronic Inflammatory Diseases (Cystic Fibrosis and Chronic Obstructive Pulmonary Disease)
200862 citationsauthor #2
S1732 Elafin Is Protective Against the Development of Colitis in IBD Murine Models
20080 citationsauthor #1
NEUTROPHILS FROM PATIENTS WITH VENTILATOR-ASSOCIATED PNEUMONIA: PRO-INFLAMMATORY AND CYTOTOXIC INTERACTIONS WITH ALVEOLAR EPITHELIUM
20082 citationsauthor #8
Proteases and antiproteases in development, homeostasis and disease: The old, the new, and the unknown...
20088 citationsauthor #1
Scottish Thoracic Society
20070 citationsauthor #6

TIMELINE

1973 3 citations

1987 6 citations

1991 99 citations

1992 63 citations

1993 169 citations

1994 326 citations

1996 160 citations

1997 227 citations

1998 60 citations

1999 338 citations

2000 153 citations

2001 279 citations

2002 1 citations

2003 297 citations

2004 290 citations

2005 120 citations

2006 552 citations

2007 61 citations

2008 277 citations

2009 561 citations

2010 320 citations

2011 248 citations

2012 768 citations

2013 193 citations

2014 22 citations

2015 217 citations

2016 0 citations

2017 631 citations

2018 118 citations

2019 151 citations

2020 137 citations

2021 29 citations

2022 19 citations

2023 7 citations

2024 39 citations

2025 1 citations

2026 0 citations

J. Sallenave

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