Y. Gwack

Selective disruption of RORγt-CBFβ interaction by IMU-935 prevents RORγt-dependent Th17 autoimmunity but not thymocyte development
20260 citationsauthor #16
Mitochondrial reactive oxygen species regulate acetyl-CoA flux between cytokine production and fatty acid synthesis in effector T cells
20252 citationsauthor #13
T cell cholesterol transport links intestinal immune responses to dietary lipid absorption.
20255 citationsauthor #16
Correction to: Neutrophil CRACR2A Promotes Neutrophil Recruitment in Sterile Inflammation and Ischemic Stroke.
20250 citationsauthor #5
Anti-VEGF neutralizing antibody delays osteomucosal healing by reducing collagen formation in mice
20251 citationsauthor #11
Distinct RORγt-dependent Th17 immune responses are required for autoimmune pathogenesis and protection against bacterial infection
20246 citationsauthor #5
Abstract 105: Neutrophil Cracr2a Is Crucial For Calcium Signaling And Enhances Neutrophil Adhesive Function Under Thromboinflammatory Conditions
20240 citationsauthor #4
Neutrophil CRACR2A Promotes Neutrophil Recruitment in Sterile Inflammation and Ischemic Stroke
20246 citationsauthor #5
SRC2 controls CD4+ T cell activation via stimulating c-Myc-mediated upregulation of amino acid transporter Slc7a5
202313 citationsauthor #9
Orai inhibition modulates pulmonary ILC2 metabolism and alleviates airway hyperreactivity in murine and humanized models
202318 citationsauthor #8
Orai3 Calcium Channel Contributes to Oral/Oropharyngeal Cancer Stemness through the Elevation of ID1 Expression
202310 citationsauthor #10
Ncoa2 promotes CD8+ T cell-mediated anti-tumor immunity by stimulating T-cell activation via upregulation of PGC-1α critical for mitochondrial function.
202314 citationsauthor #8
Ca2+ Signaling Augmented by ORAI1 Trafficking Regulates the Pathogenic State of Effector T Cells
20224 citationsauthor #5
Decoupling the role of RORγt in the differentiation and effector function of TH17 cells
202213 citationsauthor #4
Long‐Term Ligature‐Induced Periodontitis Exacerbates Development of Bisphosphonate‐Related Osteonecrosis of the Jaw in Mice
202215 citationsauthor #6
Steroid nuclear receptor coactivator 2 controls immune tolerance by promoting induced Treg differentiation via up-regulating Nr4a2
202217 citationsauthor #6
Blue light opens the ORAI1 LOC(K).
20210 citationsauthor #2
Insulin-activated store-operated Ca2+ entry via Orai1 induces podocyte actin remodeling and causes proteinuria
202121 citationsauthor #6
NKD2 mediates stimulation-dependent ORAI1 trafficking to augment Ca2+ entry in T cells
20212 citationsauthor #8
NKD2 Mediates Stimulation-Dependent ORAI1 Trafficking to Augment Ca 2+ Entry in T Cells
20211 citationsauthor #8
Calcium Signaling in T Cells and Chronic Inflammatory Disorders of the Oral Cavity
202125 citationsauthor #2
ORAI1 establishes resistance to SARS-CoV-2 infection by regulating tonic type I interferon signaling
20217 citationsauthor #4
Biallelic mutations in calcium release activated channel regulator 2A (CRACR2A) cause a primary immunodeficiency disorder
202116 citationsauthor #11
Author response: Biallelic mutations in calcium release activated channel regulator 2A (CRACR2A) cause a primary immunodeficiency disorder
20210 citationsauthor #11
The short isoform of extended synaptotagmin-2 controls Ca2+ dynamics in T cells via interaction with STIM1
202014 citationsauthor #4
Histone Lys demethylase KDM3C demonstrates anti‐inflammatory effects by suppressing NF‐κB signaling and osteoclastogenesis
201927 citationsauthor #7
SRC3 Is a Cofactor for RORγt in Th17 Differentiation but Not Thymocyte Development
201916 citationsauthor #5
The Ca 2+ sensor STIM1 regulates type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum
201980 citationsauthor #19
Correction: CRACR2A-Mediated TCR Signaling Promotes Local Effector Th1 and Th17 Responses
20190 citationsauthor #9
A Report of Novel STIM1 Deficiency and 6-Year Follow-Up of Two Previous Cases Associated with Mild Immunological Phenotype
201914 citationsauthor #10
A report of novel STIM1 deficiency and 6 year follow up of two previous cases associated with mild immunological phenotype
20180 citationsauthor #10
The Ca2+ sensor STIM1 regulates type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum
2018304 citationsauthor #17
The Ca 2+ sensor STIM1 regulates type I interferon response by retaining 1 the signaling adaptor STING at the endoplasmic reticulum
20183 citationsauthor #19
CRACR2A-Mediated TCR Signaling Promotes Local Effector Th1 and Th17 Responses
201820 citationsauthor #9
Deletion of Orai1 leads to bone loss aggravated with aging and impairs function of osteoblast lineage cells
201816 citationsauthor #6
Immunological Disorders: Regulation of Ca2+ Signaling in T Lymphocytes.
201726 citationsauthor #4
Targeted calcium influx boosts cytotoxic T lymphocyte function in the tumor microenvironment
20170 citationsauthor #11
Modulation of Orai1 and STIM1 by Cellular Factors
201713 citationsauthor #3
ORAI1 Activates Proliferation of Lymphatic Endothelial Cells in Response to Laminar Flow Through Krüppel-Like Factors 2 and 4
201761 citationsauthor #11
Phosphorylation of ROR-Dependent and-Independent α Regulation of Th 17 Differentiation by IKK
20170 citationsauthor #7
Regulation of Th17 Differentiation by IKKα-Dependent and -Independent Phosphorylation of RORγt
201725 citationsauthor #7
Laminar flow downregulates Notch activity to promote lymphatic sprouting
2017111 citationsauthor #14
A large Rab GTPase family in a small GTPase world
201736 citationsauthor #3
SRC1 promotes Th17 differentiation by overriding Foxp3 suppression to stimulate RORγt activity in a PKC-θ–dependent manner
201728 citationsauthor #6
Orai1 promotes tumor progression by enhancing cancer stemness via NFAT signaling in oral/oropharyngeal squamous cell carcinoma
201651 citationsauthor #6
A large Rab GTPase encoded by CRACR2A is a component of subsynaptic vesicles that transmit T cell activation signals
201639 citationsauthor #10
Orai1 mediates osteogenic differentiation via BMP signaling pathway in bone marrow mesenchymal stem cells.
201628 citationsauthor #7
Junctophilin-4, a component of the endoplasmic reticulum–plasma membrane junctions, regulates Ca2+ dynamics in T cells
201658 citationsauthor #6
Ubiquitination of RORγt at Lysine 446 Limits Th17 Differentiation by Controlling Coactivator Recruitment
201638 citationsauthor #6
Dental enamel cells express functional SOCE channels
201545 citationsauthor #7
The Role of ORAI1 in the Odontogenic Differentiation of Human Dental Pulp Stem Cells
201533 citationsauthor #10
Pathway To Drive Th17 Differentiation Induction of the Nuclear Orphan Receptor Calcium Signaling via Orai1 Is Essential for
20140 citationsauthor #1
Interplay Between the Oxidoreductase PDIA6 and microRNA-322 Controls the Response to Disrupted Endoplasmic Reticulum Calcium Homeostasis
2014107 citationsauthor #14
Methods to measure cytoplasmic and mitochondrial Ca(2+) concentration using Ca(2+)-sensitive dyes.
20144 citationsauthor #3
The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4+ T cells
2014232 citationsauthor #20
CRACR2A encodes a novel Ca2-binding Rab GTPase important for T cell receptor signalling (IRM10P.748)
20140 citationsauthor #1
Calcium Signaling via Orai1 Is Essential for Induction of the Nuclear Orphan Receptor Pathway To Drive Th17 Differentiation
201474 citationsauthor #12
Small molecule blockers reveal an important role for Orai1-NFAT-orphan receptor pathway in Th17 differentiation (P5169)
20130 citationsauthor #12
This information is current as Pathway To Drive Th 17 Differentiation Induction of the Nuclear Orphan Receptor Calcium Signaling via Orai 1 Is Essential for Waschek and Yousang Gwack
20130 citationsauthor #12
Molecular regulation of the pore component of CRAC channels, Orai1.
201322 citationsauthor #2
Measurement of intracellular Ca2+ concentration in single cells using ratiometric calcium dyes.
20139 citationsauthor #2
This information is current as Pathway To Drive Th 17 Differentiation Induction of the Nuclear Orphan Receptor Calcium Signaling via Orai 1 Is Essential for Waschek and Yousang Gwack Saki
20130 citationsauthor #12
Regulation of CRAC channels by protein interactions and post-translational modification
201320 citationsauthor #3
Orai1-NFAT signalling pathway triggered by T cell receptor stimulation
2013104 citationsauthor #2
Junctate is a Ca2+-sensing structural component of Orai1 and stromal interaction molecule 1 (STIM1)
2012112 citationsauthor #6
Orai1, STIM1, and their associating partners
201262 citationsauthor #2
ORAI1 Deficiency Impairs Activated T Cell Death and Enhances T Cell Survival
201176 citationsauthor #6
Protein Kinase D Orchestrates the Activation of DRAK2 in Response to TCR-Induced Ca2+ Influx and Mitochondrial Reactive Oxygen Generation
201120 citationsauthor #4
The Third Transmembrane Segment of Orai1 Protein Modulates Ca2+ Release-activated Ca2+ (CRAC) Channel Gating and Permeation Properties*
201147 citationsauthor #3
THE THIRD TRANSMEMBRANE SEGMENT OF ORAI1 MODULATES Ca 2+ RELEASE-ACTIVATED Ca 2+ (CRAC) CHANNEL GATING AND PERMEATION PROPERTIES
20111 citationsauthor #3
Death and Enhances T Cell Survival ORAI1 Deficiency Impairs Activated T Cell
20110 citationsauthor #6
The intracellular loop of Orai1 plays a central role in fast inactivation of CRAC channels
20103 citationsauthor #4
Oxygen Generation Influx and Mitochondrial Reactive 2+of DRAK2 in Response to TCR-Induced Ca Protein Kinase D Orchestrates the Activation
20100 citationsauthor #1
A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells
2010238 citationsauthor #6
Viral Bcl-2-Mediated Evasion of Autophagy Aids Chronic Infection of γHerpesvirus 68
200985 citationsauthor #6
The Intracellular Loop of Orai1 Plays a Central Role in Fast Inactivation of Ca2+ Release-activated Ca2+ Channels*
200985 citationsauthor #4
Characterization of Immunologic Function in a Case of Hereditary Multiple Intestinal Atresia with Immunodeficiency
20090 citationsauthor #5
Hair Loss and Defective T- and B-Cell Function in Mice Lacking ORAI1
2008296 citationsauthor #1
Dynamic movement of the calcium sensor STIM1 and the calcium channel Orai1 in activated T-cells: puncta and distal caps.
2008153 citationsauthor #4
Dynamic Assembly of TRPC1-STIM1-Orai1 Ternary Complex Is Involved in Store-operated Calcium Influx
2007400 citationsauthor #8
Signalling to transcription: store-operated Ca2+ entry and NFAT activation in lymphocytes.
2007306 citationsauthor #1
Erratum: Dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in store-operated calcium influx. Evidence for similarities in store-operated and calcium release-activated calcium channel components (Journal of Biological Chemistry (2007) 282, (9105-9116))
20070 citationsauthor #8
Biochemical and Functional Characterization of Orai Proteins*
2007394 citationsauthor #1
Orai1 is an essential pore subunit of the CRAC channel
20061,403 citationsauthor #3
A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function
20062,300 citationsauthor #2
A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT
2006412 citationsauthor #1
A genome-wide RNAi screen in Drosophila identifies novel regulators of the Ca 2+ / calcineurin/ NFAT signalling pathway
20060 citationsauthor #1
Activation of CD21 and CD23 Gene Expression by Kaposi's Sarcoma-Associated Herpesvirus RTA
200543 citationsauthor #2
Modulation of T-Cell Receptor Signal Transduction by Herpesvirus Signaling Adaptor Protein
200411 citationsauthor #4
Kaposi ’ s sarcoma-associated herpesvirus K 8 protein interacts with hSNF 5
20032 citationsauthor #3
Global Changes in Kaposi's Sarcoma-Associated Virus Gene Expression Patterns following Expression of a Tetracycline-Inducible Rta Transactivator
2003323 citationsauthor #3
Principal Role of TRAP/Mediator and SWI/SNF Complexes in Kaposi's Sarcoma-Associated Herpesvirus RTA-Mediated Lytic Reactivation
2003121 citationsauthor #1
Kaposi's sarcoma-associated herpesvirus K8 protein interacts with hSNF5.
200326 citationsauthor #3
Poly(ADP-Ribose) Polymerase 1 and Ste20-Like Kinase hKFC Act as Transcriptional Repressors for Gamma-2 Herpesvirus Lytic Replication
200388 citationsauthor #1
Kaposi's Sarcoma-associated Herpesvirus Open Reading Frame 50 Stimulates the Transcriptional Activity of STAT3*
200279 citationsauthor #1
Functional Dissection of Latency-Associated Nuclear Antigen 1 of Kaposi's Sarcoma-Associated Herpesvirus Involved in Latent DNA Replication and Transcription of Terminal Repeats of the Viral Genome
2002122 citationsauthor #4
Kaposi's sarcoma-associated herpesvirus open reading frame (ORF) 50 transactivates K8 and ORF57 promoters via heterogeneous response elements.
200240 citationsauthor #2
Kaposi ’ s Sarcoma-associated Herpesvirus Open Reading Frame 50 Stimulates the Transcriptional Activity of STAT 3 *
20023 citationsauthor #1
The Kaposi ’ s Sarcoma-Associated Herpesvirus K 8 Protein Interacts with CREB-Binding Protein ( CBP ) and Represses CBP-Mediated Transcription
20010 citationsauthor #2
The Kaposi's Sarcoma-Associated Herpesvirus K8 Protein Interacts with CREB-Binding Protein (CBP) and Represses CBP-Mediated Transcription
200152 citationsauthor #2

PROFILE

PAPERS

TIMELINE

COAUTHOR MAP

CONCEPT FOOTPRINT