L. Beese

Accurate identification of periplasmic urea-binding proteins by structure- and genome context-assisted functional analysis.
20241 citationsauthor #4
Library Screening, In Vivo Confirmation, and Structural and Bioinformatic Analysis of Pentapeptide Sequences as Substrates for Protein Farnesyltransferase
20242 citationsauthor #12
Chromophore carbonyl twisting in fluorescent biosensors encodes direct readout of protein conformations with multicolor switching
20232 citationsauthor #4
Thermally controlled intein splicing of engineered DNA polymerases provides a robust and generalizable solution for accurate and sensitive molecular diagnostics
20236 citationsauthor #4
Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase.
202210 citationsauthor #8
Structure-guided design of Cryptococcus neoformans protein farnesyltransferase inhibitors with antifungal activity
20210 citationsauthor #2
Structural basis for the 3′ – 5′ exonuclease activity of Escherichia coli DNA polymerase I: a two metal ion mechanism
20203 citationsauthor #1
Investigation of ATP-induced global motions of the human DNA mismatch repair sensor complex using time-lapse crystallography
20200 citationsauthor #3
Cocrystal structure of an editing complex of Klenow fragment with DNA
20200 citationsauthor #3
MutL (cid:1) and Proliferating Cell Nuclear Antigen Share Binding Sites on MutS (cid:2) * □ S
20200 citationsauthor #5
Crystal structure of BF DNA polymerase F710Y mutant bound to tetrahydrofuran and dATP
20200 citationsauthor #2
Structural Biochemistry
20209 citationsauthor #1
Using time-resolved crystallography and cryo-EM to investigate human DNA repair nucleases
20190 citationsauthor #1
Crystal structure of human exonuclease 1 Exo1 (WT) in complex with 5' flap DNA (f5I)
20170 citationsauthor #2
Crystal structure of human exonuclease 1 Exo1 (D225A) in complex with 5' recessed-end DNA (rVIII)
20170 citationsauthor #2
Crystal structure of human exonuclease 1 Exo1 (WT) in complex with 5' flap DNA (f2II)
20170 citationsauthor #2
Sensing and Processing of DNA Interstrand Crosslinks by the Mismatch Repair Pathway.
201756 citationsauthor #7
Crystal structure of human exonuclease 1 Exo1 (WT) in complex with 5' flap DNA (f2I)
20170 citationsauthor #2
Interplay of catalysis, fidelity, threading, and processivity in the exo- and endonucleolytic reactions of human exonuclease I
201745 citationsauthor #3
A Farnesyltransferase Acts to Inhibit Ectopic Neurite Formation in C. elegans
20162 citationsauthor #7
A Unified Picture of Nucleotide Selection by a High Fidelity DNA Polymerase I
20150 citationsauthor #1
The Closing Mechanism of DNA Polymerase I at Atomic Resolution.
201534 citationsauthor #2
Crystal structures of the fungal pathogen Aspergillus fumigatus protein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design
201421 citationsauthor #5
Rapid Analysis of Protein Farnesyltransferase Substrate Specificity Using Peptide Libraries and Isoprenoid Diphosphate Analogues
201430 citationsauthor #3
Crystal structure of Aspergillus fumigatus protein farnesyltransferase binary complex with farnesyldiphosphate
20140 citationsauthor #3
Aspergillus fumigatus protein farnesyltransferase complex with farnesyldiphosphate and tipifarnib
20140 citationsauthor #3
Aspergillus fumigatus protein farnesyltransferase ternary complex with farnesyldiphosphate and ethylenediamine scaffold inhibitor 5
20140 citationsauthor #3
Crystal structure of Aspergillus fumigatus protein farnesyltransferase complexed with the FII analog, FPT-II, and the KCVVM peptide
20140 citationsauthor #3
Bacillus DNA Polymerase I Large Fragment Complex 2
20130 citationsauthor #2
Bacillus DNA Polymerase I Large Fragment Complex 1
20130 citationsauthor #2
DNA Polymerase I Large Fragment complex 4
20130 citationsauthor #2
DNA Polymerase I Large Fragment Complex 5
20130 citationsauthor #2
Visualization of Synaptic Inhibition with an Optogenetic Sensor Developed by Cell-Free Protein Engineering Automation
201398 citationsauthor #5
DNA Polymerase I Large Fragment Complex 6
20130 citationsauthor #2
Bacillus DNA Polymerase I Large Fragment complex 7
20130 citationsauthor #2
DNA Polymerase I Large Fragment complex 3
20130 citationsauthor #2
Ternary complex of Bacillus DNA Polymerase I Large Fragment, DNA duplex, and ddCTP (paired with dG of template)
20120 citationsauthor #2
Structural Factors That Determine Selectivity of a High Fidelity DNA Polymerase for Deoxy-, Dideoxy-, and Ribonucleotides*
201263 citationsauthor #4
Binary complex of Bacillus DNA Polymerase I Large Fragment E658A and duplex DNA
20120 citationsauthor #2
Covalent protein-oligonucleotide conjugates by copper-free click reaction.
201242 citationsauthor #5
Binary complex of Bacillus DNA Polymerase I Large Fragment and duplex DNA with rC in primer terminus paired with dG of template
20120 citationsauthor #2
Ternary complex of Bacillus DNA Polymerase I Large Fragment E658A, DNA duplex, and rCTP (paired with dG of template) in presence of Mg2+
20120 citationsauthor #2
Engineered medium-affinity halide-binding protein derived from YFP: chloride complex
20120 citationsauthor #3
Engineered medium-affinity halide-binding protein derived from YFP: halide-free
20120 citationsauthor #3
Ternary complex of Bacillus DNA Polymerase I Large Fragment, DNA duplex, and rCTP in presence of Mg2+
20120 citationsauthor #2
Cryptococcus neoformans protein farnesyltransferase in complex with FPT-II and tipifarnib
20111 citationsauthor #2
Structures of Cryptococcus neoformans Protein Farnesyltransferase Reveal Strategies for Developing Inhibitors That Target Fungal Pathogens*
201153 citationsauthor #7
Crystal Structure of Bacillus DNA Polymerase I Large Fragment Bound to DNA and ddATP-dT in Closed Conformation
20110 citationsauthor #2
Crystal Structure of Bacillus DNA Polymerase I Large Fragment Bound to Duplex DNA with Cytosine-Adenine Mismatch at (n-3) Position
20110 citationsauthor #2
Structural Biochemistry of CaaX Protein Prenyltransferases
20113 citationsauthor #2
Cryptococcus neoformans protein farnesyltransferase in complex with farnesyl-DDPTASACNIQ product
20110 citationsauthor #2
Cryptococcus neoformans protein farnesyltransferase in complex with FPT-II and TKCVVM peptide
20110 citationsauthor #2
Structural evidence for the rare tautomer hypothesis of spontaneous mutagenesis
2011256 citationsauthor #3
Cryptococcus neoformans protein farnesyltransferase in complex with FPP and L-778,123
20110 citationsauthor #2
Crystal structure of human exonuclease 1 Exo1 (D173A) in complex with DNA (complex I)
20110 citationsauthor #7
Crystal Structure of Bacillus DNA Polymerase I Large Fragment Bound to Duplex DNA with Cytosine-Adenine Mismatch at (n-6) Position
20110 citationsauthor #2
Crystal structure of human exonuclease 1 Exo1 (WT) in complex with DNA (complex II)
20110 citationsauthor #7
The Structure of a High Fidelity DNA Polymerase Bound to a Mismatched Nucleotide Reveals an “Ajar” Intermediate Conformation in the Nucleotide Selection Mechanism*
2011104 citationsauthor #2
Cryptococcus neoformans protein farnesyltransferase in complex with FSPP and DDPTASACNIQ peptide
20110 citationsauthor #2
Crystal Structure of Bacillus DNA Polymerase I Large Fragment Bound to DNA and ddCTP-dA Mismatch (wobble) in Ajar Conformation
20110 citationsauthor #2
Crystal Structure of Bacillus DNA Polymerase I Large Fragment Bound to Duplex DNA with Cytosine-Adenine Mismatch at (n-4) Position
20110 citationsauthor #2
Cryptococcus neoformans protein farnesyltransferase, apo enzyme
20110 citationsauthor #2
Purification, crystallization and preliminary X-ray diffraction analysis of the human mismatch repair protein MutSβ.
20114 citationsauthor #7
Crystal Structure of Bacillus DNA Polymerase I Large Fragment Bound to DNA and ddCTP-dA Mismatch (tautomer) in Closed Conformation
20110 citationsauthor #2
Crystal structure of human exonuclease 1 Exo1 (WT) in complex with DNA and Mn2+ (complex III)
20110 citationsauthor #7
Cryptococcus neoformans protein farnesyltransferase in complex with FPT-II and ethylenediamine inhibitor 2
20111 citationsauthor #2
Structures of human exonuclease 1 DNA complexes suggest a unified mechanism for nuclease family.
2011166 citationsauthor #7
Crystal Structure of Bacillus DNA Polymerase I Large Fragment Bound to Duplex DNA with Cytosine-Adenine Mismatch at (n-1) Position
20110 citationsauthor #2
Crystal Structures of Human Exonuclease I with DNA Provides Insight into Substrate Selectivity and Mechanism
20110 citationsauthor #4
The mechanism of the translocation step in DNA replication by DNA polymerase I: a computer simulation analysis.
201067 citationsauthor #3
Crystal structure of fragment DNA polymerase I from Bacillus stearothermophilus V713P mutant bound to G:dCTP
20100 citationsauthor #2
Crystal structure of fragment DNA polymerase I from Bacillus stearothermophilus F710Y mutant bound to G:T mismatch
20101 citationsauthor #2
Structure-based design and synthesis of potent, ethylenediamine-based, mammalian farnesyltransferase inhibitors as anticancer agents.
201045 citationsauthor #13
MutLα and Proliferating Cell Nuclear Antigen Share Binding Sites on MutSβ
201052 citationsauthor #5
Protein farnesyltransferase complexed with bisubstrate ethylenediamine scaffold inhibitor 5
20090 citationsauthor #2
Protein farnesyltransferase complexed with FPP and ethylenediamine-scaffold inhibitor 10
20090 citationsauthor #2
Cocrystal structure of Bacillus fragment DNA polymerase I with duplex DNA (open form)
20091 citationsauthor #5
Discrimination between right and wrong purine dNTPs by DNA polymerase I from Bacillus stearothermophilus.
200921 citationsauthor #7
Cocrystal structure of Bacillus fragment DNA polymerase I with duplex DNA , dCTP, and zinc (closed form).
20091 citationsauthor #5
Structural Analysis of Semi-specific Oligosaccharide Recognition by a Cellulose-binding Protein of Thermotoga maritima Reveals Adaptations for Functional Diversification of the Oligopeptide Periplasmic Binding Protein Fold*
200929 citationsauthor #2
Structural basis for binding and selectivity of antimalarial and anticancer ethylenediamine inhibitors to protein farnesyltransferase.
200938 citationsauthor #11
Protein farnesyltransferase complexed with FPP and ethylene diamine inhibitor 4
20090 citationsauthor #2
Chemical reaction dynamics MINNESOTA-TWIN CITIES
20090 citationsauthor #8
Structural adaptations that modulate monosaccharide, disaccharide, and trisaccharide specificities in periplasmic maltose-binding proteins.
200929 citationsauthor #3
Dissecting the differences between the alpha and beta anomers of the oxidative DNA lesion FaPydG.
200812 citationsauthor #6
Protein farnesyltransferase complexed with FPP and caged TKCVIM substrate
20080 citationsauthor #2
The MutSα-Proliferating Cell Nuclear Antigen Interaction in Human DNA Mismatch Repair*♦
200835 citationsauthor #6
Structure of Protein Geranylgeranyltransferase-I from the Human Pathogen Candida albicans Complexed with a Lipid Substrate*
200827 citationsauthor #2
Structural Analysis of a Periplasmic Binding Protein in the Tripartite ATP-independent Transporter Family Reveals a Tetrameric Assembly That May Have a Role in Ligand Transport*
200829 citationsauthor #4
Candida albicans protein geranylgeranyltransferase-I complexed with GGPP
20080 citationsauthor #2
Caged Protein Prenyltransferase Substrates: Tools for Understanding Protein Prenylation
200825 citationsauthor #5
Ligand-induced conformational changes in a thermophilic ribose-binding protein
2008106 citationsauthor #2
human MutSalpha (MSH2/MSH6) bound to DNA with a single base T insert
20070 citationsauthor #5
human MutSalpha (MSH2/MSH6) bound to ADP and an O6-methyl-guanine T mispair
20070 citationsauthor #5
human MutSalpha (MSH2/MSH6) bound to ADP and a G dU mispair
20070 citationsauthor #5
Thermus thermophilus maltotriose binding protein bound with maltotriose
20070 citationsauthor #3
Thermotoga maritima maltotriose binding protein, ligand free form
20071 citationsauthor #4
Structure of the human MutSalpha DNA lesion recognition complex.
2007375 citationsauthor #6
Resistance mutations at the lipid substrate binding site of Plasmodium falciparum protein farnesyltransferase.
200731 citationsauthor #7
Thermotoga maritima Ribose Binding Protein Unliganded Form
20070 citationsauthor #4

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