E. Pearlman

Neutrophils use a novel NLRP3 inflammasome-independent mechanism to release bioactive IL-1β in response to lysosomal disruption
20231 citationsauthor #2
Pyroptosis in neutrophils: Multimodal integration of inflammasome and regulated cell death signaling pathways
202346 citationsauthor #3
CCR2-positive monocytes contribute to the pathogenesis of early diabetic retinopathy in mice
202321 citationsauthor #8
Immunity to pathogenic fungi in the eye.
202326 citationsauthor #7
The NLRP3 inflammasome selectively drives IL-1β secretion by Pseudomonas aeruginosa infected neutrophils and regulates bacterial killing in vivo
20230 citationsauthor #10
The role of IL-1a during early-stage Pseudomonas aeruginosa infection of the corneas
20220 citationsauthor #5
Differential Roles for IL-1α and IL-1β in Pseudomonas aeruginosa Corneal Infection
20226 citationsauthor #6
American Academy of Optometry Microbial Keratitis Think Tank
202127 citationsauthor #13
Pathogenic Aspergillus and Fusarium as important causes of blinding corneal infections - the role of neutrophils in fungal killing, tissue damage and cytokine production.
202134 citationsauthor #2
The impact of age-related hypomethylated DNA on immune signaling upon cellular demise
20218 citationsauthor #3
β-Glucan-stimulated neutrophil secretion of IL-1α is independent of GSDMD and mediated through extracellular vesicles
202128 citationsauthor #3
The genome of opportunistic fungal pathogen Fusarium oxysporum carries a unique set of lineage-specific chromosomes
202072 citationsauthor #19
Control of β-glucan exposure by the endo-1,3-glucanase Eng1 in Candida albicans modulates virulence
202046 citationsauthor #8
Ovol1 regulates psoriasis-like skin inflammation and epidermal hyperplasia.
202020 citationsauthor #11
N-GSDMD trafficking to neutrophil organelles facilitates IL-1β release independently of plasma membrane pores and pyroptosis
20200 citationsauthor #13
What Are the Functions of Chitin Deacetylases in Aspergillus fumigatus?
202044 citationsauthor #10
Synergistic Antimicrobial Activity of a Nanopillar Surface on a Chitosan Hydrogel.
202022 citationsauthor #4
N-GSDMD trafficking to neutrophil organelles facilitates IL-1β release independently of plasma membrane pores and pyroptosis
2020371 citationsauthor #13
Aspergillus fumigatus corneal infection is regulated by chitin synthases and by neutrophil–derived acidic mammalian chitinase
201923 citationsauthor #13
Infectious corneal ulceration: a proposal for neglected tropical disease status
201982 citationsauthor #24
Linked Toll-Like Receptor Triagonists Stimulate Distinct, Combination-Dependent Innate Immune Responses
201952 citationsauthor #14
Delineating the role of MITF isoforms in pigmentation and tissue homeostasis
201925 citationsauthor #6
NLRP3, NLRP12, and IFI16 Inflammasomes Induction and Caspase-1 Activation Triggered by Virulent HSV-1 Strains Are Associated With Severe Corneal Inflammatory Herpetic Disease
201958 citationsauthor #14
β-glucan priming enhances neutrophil Fcγ receptor-mediated antifungal activity during oral mucosal infection
20190 citationsauthor #7
Biomimetic Nanopillared Surfaces Inhibit Drug Resistant Filamentous Fungal Growth.
201911 citationsauthor #5
Breaching bacterial biofilm with neutrophil α‐mannosidase
20191 citationsauthor #2
Tuning Subunit Vaccines with Novel TLR Triagonist Adjuvants to Generate Protective Immune Responses against Coxiella burnetii
201927 citationsauthor #14
Atovaquone Impairs Growth of Aspergillus and Fusarium Keratitis Isolates by Modulating Mitochondrial Function and Zinc Homeostasis
201820 citationsauthor #6
Neutrophil Caspase-11 Is Required for Cleavage of Caspase-1 and Secretion of IL-1β in Aspergillus fumigatus Infection
201847 citationsauthor #7
Neutrophils Cause an Intravascular Traffic Jam.
20180 citationsauthor #2
Using ImageJ to quantify microbial keratitis related corneal opacification in a mouse model
20180 citationsauthor #5
Sustained release of decorin to the surface of the eye enables scarless corneal regeneration
201857 citationsauthor #12
Protein Deiminase 4 and CR3 Regulate Aspergillus fumigatus and β-Glucan-Induced Neutrophil Extracellular Trap Formation, but Hyphal Killing Is Dependent Only on CR3
201862 citationsauthor #6
EphA2 Is a Neutrophil Receptor for Candida albicans that Stimulates Antifungal Activity during Oropharyngeal Infection
201855 citationsauthor #7
Pseudomonas aeruginosa Effector ExoS Inhibits ROS Production in Human Neutrophils.
201796 citationsauthor #4
The impact of lens care solutions on corneal epithelial changes during daily silicone hydrogel contact lens wear as measured by in vivo confocal microscopy.
201711 citationsauthor #10
GADD34 Function in Protein Trafficking Promotes Adaptation to Hyperosmotic Stress in Human Corneal Cells.
201733 citationsauthor #13
JAK/STAT regulation of Aspergillus fumigatus corneal infections and IL‐6/23‐stimulated neutrophil, IL‐17, elastase, and MMP9 activity
201645 citationsauthor #7
Histidine biosynthesis plays a crucial role in metal homeostasis and virulence of Aspergillus fumigatus
201666 citationsauthor #7
Neutrophils from F 508 del cystic fibrosis patients produce IL-17 A and express IL-23-dependent IL-17 RC
20161 citationsauthor #4
Chapter 6 – General and ocular pharmacology
20164 citationsauthor #5
Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP
2016388 citationsauthor #4
Neutrophils from F508del cystic fibrosis patients produce IL-17A and express IL-23 - dependent IL-17RC.
201630 citationsauthor #4
Chapter 2 – Embryology and early development of the eye and adnexa
201612 citationsauthor #5
Polymeric Nanofiber/Antifungal Formulations Using a Novel Co-extrusion Approach
201621 citationsauthor #6
Development of a hydrogel flowable dressing for the prevention of corneal scarring
20161 citationsauthor #4
Zinc and Manganese Chelation by Neutrophil S100A8/A9 (Calprotectin) Limits Extracellular Aspergillus fumigatus Hyphal Growth and Corneal Infection
2016130 citationsauthor #10
Interleukin-17 Pathophysiology and Therapeutic Intervention in Cystic Fibrosis Lung Infection and Inflammation
201646 citationsauthor #9
IL-17A production by neutrophils.
201610 citationsauthor #2
Overview of Zoonoses affecting the eye
20160 citationsauthor #1
The ExoU genomic island is responsible for the greatly increased virulence of P. aeruginosa strain 19660 in the cornea.
20160 citationsauthor #5
Immune Interactions with Pathogenic and Commensal Fungi: A Two-Way Street.
2015114 citationsauthor #2
SHP-2 Mediates C-type Lectin Receptors-induced Syk Activation and Anti-fungal TH17 Responses
201538 citationsauthor #20
Interleukin 17 expression in peripheral blood neutrophils from fungal keratitis patients and healthy cohorts in southern India.
201532 citationsauthor #5
Inhibition of Corneal Inflammation by the Resolvin E1.
201543 citationsauthor #4
Bacterial induced corneal inflammation is inhibited by Mesenchymal Stem Cells (MSCs)
20150 citationsauthor #3
Tyrosine phosphatase SHP-2 mediates C-type lectin receptor–induced activation of the kinase Syk and anti-fungal TH17 responses
201584 citationsauthor #20
Neutrophil IL-1β Processing Induced by Pneumolysin Is Mediated by the NLRP3/ASC Inflammasome and Caspase-1 Activation and Is Dependent on K+ Efflux
2015222 citationsauthor #10
CCL3 Production by Microglial Cells Modulates Disease Severity in Murine Models of Retinal Degeneration
201476 citationsauthor #4
Diversity of Virulence Phenotypes among Type III Secretion Negative Pseudomonas aeruginosa Clinical Isolates
201430 citationsauthor #6
Aspergillus and Fusarium Corneal Infections Are Regulated by Th17 Cells and IL-17–Producing Neutrophils
201497 citationsauthor #4
Myeloid Wnt Ligands and a Fetal Light Response Pathway Regulate Vascular Development in the Eye
20140 citationsauthor #2
Inhibition of Corneal Inflammation by the Lipid Mediator of Resolvin
20140 citationsauthor #3
Animal models to investigate fungal biofilm formation.
201412 citationsauthor #2
The paradoxical role of CCL3 in acute and chronic retinal degeneration
20140 citationsauthor #4
Mgat2 ablation in the myeloid lineage leads to defective glycoantigen T cell responses.
20149 citationsauthor #4
The protein phosphatase PhzA of A. fumigatus is involved in oxidative stress tolerance and fungal virulence.
201422 citationsauthor #6
CD14 mediates TLR4 endocytosis and Syk and IRF3 activation in epithelial cells, and impairs neutrophil infiltration and Pseudomonas aeruginosa killing in vivo
20132 citationsauthor #3
Targeting Iron Acquisition Blocks Infection with the Fungal Pathogens Aspergillus fumigatus and Fusarium oxysporum
2013100 citationsauthor #12
Host Defense at the Ocular Surface
2013115 citationsauthor #1
Correction: Targeting Iron Acquisition Blocks Infection with the Fungal Pathogens Aspergillus fumigatus and Fusarium oxysporum
201318 citationsauthor #12
CD14 Mediates Toll-like Receptor 4 (TLR4) Endocytosis and Spleen Tyrosine Kinase (Syk) and Interferon Regulatory Transcription Factor 3 (IRF3) Activation in Epithelial Cells and Impairs Neutrophil Infiltration and Pseudomonas aeruginosa Killing in Vivo*
201349 citationsauthor #3
Host Response and Bacterial Virulence Factor Expression in Pseudomonas aeruginosa and Streptococcus pneumoniae Corneal Ulcers
201379 citationsauthor #7
Ocular Pathology and Immunopathology of Blau's Syndrome: First Cases
20130 citationsauthor #8
MyD88-Dependent Pathways in Leukocytes Affect the Retina in Diabetes
201350 citationsauthor #5
Corneal Stroma and Endothelial Cell Changes in Contact Lens Wearers Visualized with Confocal Microscopy
20130 citationsauthor #9
Autocrine IL-17A–IL-17RC neutrophil activation in fungal infections is regulated by IL-6, IL-23, RORγt and Dectin-2
2013363 citationsauthor #8
Corneal Inflammation Is Inhibited by the LFA-1 Antagonist, Lifitegrast (SAR 1118)
201339 citationsauthor #5
The RodA Hydrophobin on Aspergillus fumigatus Spores Masks Dectin-1– and Dectin-2–Dependent Responses and Enhances Fungal Survival In Vivo
2013176 citationsauthor #6
Photoreceptor Proteins Initiate Microglial Activation via Toll-like Receptor 4 in Retinal Degeneration Mediated by All-trans-retinal*
2013169 citationsauthor #4
Monosodium Urate and Tumor Necrosis Factor-α Increase Apoptosis in Human Chondrocyte Cultures
201240 citationsauthor #3
Is Independent of NLRC4 and Caspase-1 and Mediated by Neutrophil Serine Proteases Infection Is Pseudomonas aeruginosa Processing during b Cutting Edge: IL-1
20120 citationsauthor #1
The role of cytokines and pathogen recognition molecules in fungal keratitis - Insights from human disease and animal models.
201265 citationsauthor #2
Hydrophobin RodA protein is essential for masking the host immune response and enhancing fungal survival of Aspergillus fumigatus during corneal infection (55.9)
20120 citationsauthor #4
Proposal for a new ISHAM working group on clinical Fusarium
20121 citationsauthor #5
Neutrophil mediated IL-1{beta} processing in Pseudomonas aeruginosa infection is IPAF and Caspase-1 independent and mediated by serine proteases
20120 citationsauthor #5
Innate immune regulation of Serratia marcescens-induced corneal inflammation and infection.
201221 citationsauthor #6
TLR9 ligand CpG-ODN applied to the injured mouse cornea elicits retinal inflammation.
201248 citationsauthor #7
ExoS and ExoT ADP Ribosyltransferase Activities Mediate Pseudomonas aeruginosa Keratitis by Promoting Neutrophil Apoptosis and Bacterial Survival
2012107 citationsauthor #5
Bacterial Survival Keratitis by Promoting Neutrophil Apoptosis and Pseudomonas aeruginosa Activities Mediate ExoS and ExoT ADP Ribosyltransferase
20120 citationsauthor #1
Cutting Edge: IL-1β Processing during Pseudomonas aeruginosa Infection Is Mediated by Neutrophil Serine Proteases and Is Independent of NLRC4 and Caspase-1
2012137 citationsauthor #5
Characterization Of Pseudomonas Aeruginosa Type Three Secretory System (TTSS) Effector Molecules (Exo U/S/T) From Human Corneal Ulcer
20120 citationsauthor #4
Fungal antioxidant pathways promote survival against neutrophils during infection.
2012133 citationsauthor #7
Neutrophil mediated IL-1β processing in Pseudomonas aeruginosa infection is IPAF and Caspase-1 independent and mediated by serine proteases (118.1)
20120 citationsauthor #5
Differential induction of Th2- and Th1-associated responses by filarial antigens and endosymbiotic Wolbachia in a murine model of river blindness.
20123 citationsauthor #3
Characterization of fusarium keratitis outbreak isolates: contribution of biofilms to antimicrobial resistance and pathogenesis.
201293 citationsauthor #5
Effectors Exos And Exot Synergize To Promote P. Aeruginosa Corneal Infections
20110 citationsauthor #4
IFN-γ-INDUCED MD2 EXPRESSION AND LPS RESPONSIVENESS IN CORNEAL EPITHELIAL CELLS IS MEDIATED BY JAK 2 ACTIVATION AND DIRECT BINDING OF STAT 1 TO THE MD2 PROMOTER
20110 citationsauthor #3
Photoreceptor cells constitutively express functional TLR4.
201138 citationsauthor #7
Cestode stem cells : their role in host-induced larval development and their utilization to achieve parasite transgenesis
20110 citationsauthor #7

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