O. Sibon

Energetic stress in combination with impaired fatty acid oxidation induces sequestration of CoA and adaptation of CoA metabolism.
20260 citationsauthor #15
Coenzyme A metabolism: a key driver of gut microbiota dynamics and metabolic profiles
20250 citationsauthor #2
Pantethine ameliorates dilated cardiomyopathy features in PPCS deficiency disorder in patients and cell line models
20250 citationsauthor #17
Opt1 imports CoA precursors as glutathione mixed disulfides
20250 citationsauthor #13
Dysregulation of Glial Gap Junction Protein Innexin2 Mediates Seizures and Disrupted Sleep in a Drosophila Model for North Sea Progressive Myoclonus Epilepsy
20250 citationsauthor #5
Impaired coenzyme A homeostasis in cardiac dysfunction and benefits of boosting coenzyme A production with vitamin B5 and its derivatives in the management of heart failure
20245 citationsauthor #2
Conventional and novel anti-seizure medications reveal a particular role for GABAA in a North Sea progressive myoclonus Epilepsy Drosophila model.
20242 citationsauthor #5
PKAN pathogenesis and treatment.
202224 citationsauthor #3
Coenzyme A precursors flow from mother to zygote and from microbiome to host.
202220 citationsauthor #18
The Coenzyme A Level Modulator Hopantenate (HoPan) Inhibits Phosphopantotenoylcysteine Synthetase Activity.
202115 citationsauthor #7
Coenzyme A levels influence protein acetylation, CoAlation and 4'-phosphopantetheinylation: expanding the impact of a metabolic nexus molecule.
202118 citationsauthor #4
Vps13 is required for timely removal of nurse cell corpses
20208 citationsauthor #12
Molecular insights into viral respiratory infections
20190 citationsauthor #6
CRISPR/Cas9 based genome editing of Drosophila for the generation of a Vps13 knockout mutant and Vps13-GFP flies
20190 citationsauthor #6
shining light on its localization and function
20190 citationsauthor #5
Human VPS13A is associated with multiple organelles and influences mitochondrial morphology and lipid droplet motility
2019130 citationsauthor #13
Astrocytic expression of the chaperone DNAJB6 results in non-cell autonomous protection in Huntington's disease.
201928 citationsauthor #6
Molecular insights into viral respiratory infections
20190 citationsauthor #6
CHAPTER 4 DNAJB 6 delays Neurodegeneration in a Drosophila melanogaster Model for Huntington ’ s Disease via Non-Cell Autonomous Mechanisms
20190 citationsauthor #7
North Sea progressive myoclonus epilepsy is exacerbated by heat, a phenotype primarily associated with affected glia.
201910 citationsauthor #9
CoA‐dependent activation of mitochondrial acyl carrier protein links four neurodegenerative diseases
201957 citationsauthor #11
4′‐Phosphopantetheine corrects CoA, iron, and dopamine metabolic defects in mammalian models of PKAN
201965 citationsauthor #22
Thermosensory perception regulates speed of movement in response to temperature changes in Drosophila melanogaster
201817 citationsauthor #3
Mutations in PPCS, Encoding Phosphopantothenoylcysteine Synthetase, Cause Autosomal-Recessive Dilated Cardiomyopathy.
201856 citationsauthor #37
Inhibition of NF-κB in astrocytes is sufficient to delay neurodegeneration induced by proteotoxicity in neurons
201852 citationsauthor #2
Unraveling VPS13A pathways: from Drosophila to human
20180 citationsauthor #9
CHAPTER 4 Drosophila Vps 13 mutants show overgrowth of larval neuromuscular junctions
20170 citationsauthor #3
On protein quality control, myofibrillar myopathies, and neurodegeneration
20170 citationsauthor #7
Modelling in miniature : Using Drosophila melanogaster to study human neurodegeneration
20176 citationsauthor #3
Expression of Concern: Guanine quadruplex structures localize to heterochromatin
20170 citationsauthor #13
Drosophila Vps13 Is Required for Protein Homeostasis in the Brain
201739 citationsauthor #12
Endoplasmic Reticulum Stress Is Associated With Autophagy and Cardiomyocyte Remodeling in Experimental and Human Atrial Fibrillation
2017104 citationsauthor #7
Acetyl-4′-phosphopantetheine is stable in serum and prevents phenotypes induced by pantothenate kinase deficiency
201726 citationsauthor #22
University of Groningen Drosophila Vps 13 Is Required for Protein Homeostasis in the Brain
20170 citationsauthor #13
On protein quality control, myofibrillar myopathies, and neurodegeneration
20170 citationsauthor #6
Eighth International Chorea–Acanthocytosis Symposium: Summary of Workshop Discussion and Action Points
20177 citationsauthor #16
Guanine quadruplex structures localize to heterochromatin
20179 citationsauthor #13
Characterization of a Drosophila model for Chorea‐Acanthocytosis
20170 citationsauthor #3
Implications of the cardiomyocyte stress response on protein homeostasis in atrial fibrillation
20160 citationsauthor #8
Coenzyme A: to make it or uptake it?
201657 citationsauthor #1
Rescue strategies in Drosophila models of neurodegenerative diseases
20160 citationsauthor #16
Implications of the cardiomyocyte stress response on protein homeostasis in atrial fibrillation
20160 citationsauthor #8
Implications of the cardiomyocyte stress response on protein homeostasis in atrial fibrillation
20160 citationsauthor #8
University of Groningen Overexpression of Cystathionine gamma-Lyase Suppresses Detrimental Effects of Spinocerebellar Ataxia Type 3 Snijder,
20160 citationsauthor #19
Implications of the cardiomyocyte stress response on protein homeostasis in atrial fibrillation
20160 citationsauthor #8
Guanine quadruplex structures localize to heterochromatin
201569 citationsauthor #13
Overexpression of Cystathionine γ-Lyase Suppresses Detrimental Effects of Spinocerebellar Ataxia Type 3
201540 citationsauthor #19
Extracellular 4'-phosphopantetheine is a source for intracellular coenzyme A synthesis.
2015114 citationsauthor #16
Modeling PKAN in Mice and Flies
20151 citationsauthor #1
Specific protein homeostatic functions of small heat‐shock proteins increase lifespan
201550 citationsauthor #6
PARP1 inhibition attenuates NAD depletion and protects against experimental and human Atrial Fibrillation
20150 citationsauthor #9
Synthesis and Characterizationof 4-Thiobutyl-triphenylphosphonium -pantetheine, aPantetheine Derivative
20140 citationsauthor #5
Impairment of Drosophila Orthologs of the Human Orphan Protein C19orf12 Induces Bang Sensitivity and Neurodegeneration
201441 citationsauthor #2
Coenzyme A, more than 'just' a metabolic cofactor.
201444 citationsauthor #2
Coenzyme A and its derivatives: renaissance of a textbook classic.
201473 citationsauthor #2
University of Groningen Impairment of Drosophila orthologs of the human orphan protein C19orf12 induces bang sensitivity and neurodegeneration Iuso,
20140 citationsauthor #2
P55 Overexpression of cystathionine gamma-lyase supresses spinocerebellar ataxia type 3-associated neurodegeneration in drosophila
20140 citationsauthor #5
Activation of Histone Deacetylase-6 Induces Contractile Dysfunction Through Derailment of &agr;-Tubulin Proteostasis in Experimental and Human Atrial Fibrillation
2014160 citationsauthor #10
Treat Iron-Related Childhood-Onset Neurodegeneration (TIRCON) - an integrated strategy under FP7 to improve research, treatment, and care in neurodegeneration with brain iron accumulation
20131 citationsauthor #2
Identification of heart rate–associated loci and their effects on cardiac conduction and rhythm disorders
201339 citationsauthor #264
Identification of heart rate-associated loci and genes
20133 citationsauthor #15
Pantethine treatment is effective in recovering the disease phenotype induced by ketogenic diet in a pantothenate kinase-associated neurodegeneration mouse model
201397 citationsauthor #9
1 Activation of Histone Deacetylase-6 ( HDAC 6 ) Induces Contractile Dysfunction through Derailment of-Tubulin Proteostasis in Experimental and Human Atrial Fibrillation Running title :
20130 citationsauthor #10
Overexpression of cystathionine gamma-lyase partly rescues the phenotype of spinocerebellar ataxia type 3 in Drosophila Melanogaster
20130 citationsauthor #6
Brain, blood, and iron: perspectives on the roles of erythrocytes and iron in neurodegeneration.
201257 citationsauthor #2
Cofilin/Twinstar Phosphorylation Levels Increase in Response to Impaired Coenzyme A Metabolism
201215 citationsauthor #5
The role of impaired de novo Coenzyme A biosynthesis in pantothenate kinase-associated neurodegeneration
20110 citationsauthor #1
The role of impaired de novo Coenzyme A biosynthesis in pantothenate kinase-associated neurodegeneration
20110 citationsauthor #7
The role of impaired de novo Coenzyme A biosynthesis in pantothenate kinase-associated neurodegeneration
2011100 citationsauthor #2
Effects of various doses of pantethine in healthy mice
20110 citationsauthor #1
Effects of different small HSPB members on contractile dysfunction and structural changes in a Drosophila melanogaster model for Atrial Fibrillation.
201182 citationsauthor #5
A Genome-Wide analysis of the specificity of RNAi in Drosophila melanogaster using the novel tool RNAiSelect
20110 citationsauthor #2
Small heat shock proteins, protein degradation and protein aggregation diseases
201155 citationsauthor #4
Pantethine Reduces Levels of Increased Oxidative Damage of Proteins in dPANK/fbl Mutants
20110 citationsauthor #10
Impaired Coenzyme A metabolism affects histone and tubulin acetylation in Drosophila and human cell models of pantothenate kinase associated neurodegeneration
201187 citationsauthor #10
The role of impaired de novo Coenzyme A biosynthesis in pantothenate kinase-associated neurodegeneration
20110 citationsauthor #4
RNAi-induced off-target effects in Drosophila melanogaster: frequencies and solutions.
201125 citationsauthor #4
Studying cell cycle checkpoints using Drosophila cultured cells.
20112 citationsauthor #3
Hdac6 and Sirtuin Inhibitors Protect Against Tachypacing-Induced Contractile Dysfunction in in vitro and in vivo Models for Atrial Fibrillation.
20100 citationsauthor #4
Pantethine rescues a Drosophila model for pantothenate kinase–associated neurodegeneration
201071 citationsauthor #10
Identification of the Drosophila Ortholog of HSPB8
2010100 citationsauthor #9
RNAi Experiments in D. melanogaster: Solutions to the Overlooked Problem of Off-Targets Shared by Independent dsRNAs
201019 citationsauthor #4
HSPB7 is the most potent polyQ aggregation suppressor within the HSPB family of molecular chaperones.
2010175 citationsauthor #8
A high throughput experimental approach to identify miRNA targets in human cells
2009124 citationsauthor #5
Contribution of Deregulated miRNAs to the Phenotypic Characteristic of Hodgkin Lymphoma
20090 citationsauthor #6
A long‐term flow cytometry assay to analyze the role of specific genes of Drosophila melanogaster S2 cells in surviving genotoxic stress
20083 citationsauthor #7
Establishment of cell fate during early Drosophila embryogenesis requires transcriptional Mediator subunit dMED31.
200818 citationsauthor #3
Stwl modifies chromatin compaction and is required to maintain DNA integrity in the presence of perturbed DNA replication.
200827 citationsauthor #14
A High Throughput Experimental Approach to Identify miRNA Target Genes in Hodgkin Lymphoma
20081 citationsauthor #7
Physiological implications of impaired de novo Coenzyme A Biosynthesis in Drosophila
20080 citationsauthor #8
Physiological implications of impaired de novo Coenzyme A Biosynthesis in Drosophila
20080 citationsauthor #8
Physiological implications of impaired de novo Coenzyme A Biosynthesis in Drosophila
20080 citationsauthor #8
Drosophila phosphopantothenoylcysteine synthetase is required for tissue morphogenesis during oogenesis
200817 citationsauthor #5
De novo CoA biosynthesis is required to maintain DNA integrity during development of the Drosophila nervous system.
2008124 citationsauthor #7
Polarised Asymmetric Inheritance of Accumulated Protein Damage in Higher Eukaryotes
2006258 citationsauthor #9
De novo Coa-SH biosynthesis is required for neurological integrity in Drosophila melanogasteri
20060 citationsauthor #5
Contribution of Growth and Cell Cycle Checkpoints to Radiation Survival in Drosophila
200642 citationsauthor #8
Drosophila melanogaster as a model for the human neurodegenerative disorder PKAN
20060 citationsauthor #3
Hsp70 protects mitotic cells against heat-induced centrosome damage and division abnormalities.
200581 citationsauthor #3
Dysfunctional BRCA1 is only indirectly linked to multiple centrosomes
200519 citationsauthor #7

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