Shigeki Kiyonaka

Oxidative stress in metastatic progression.
20250 citationsauthor #2
[Next-Generation Chemogenetics for Elucidating Higher Brain Functions].
20230 citationsauthor #4
Bioorthogonal chemical labelling of endogenous neurotransmitter receptors in living mouse brains
20232 citationsauthor #7
Development of Coordination Chemogenetics for Cell-type-specific Activation of Glutamate Receptors
20230 citationsauthor #1
[Coordination chemogenetics for regulation of glutamate receptors in neuron].
20220 citationsauthor #3
[Quantification of AMPA-type glutamate receptors trafficking by ligand-directed two-step labeling].
20220 citationsauthor #3
Chemogenetics of cell surface receptors: beyond genetic and pharmacological approaches
20228 citationsauthor #4
[Frontier of Photopharmacology for High-speed Molecular Movies of Proteins].
20220 citationsauthor #2
Superresolution imaging of native surface AMPA receptors in brain tissue
20220 citationsauthor #2
Revisiting PFA-mediated tissue fixation chemistry: FixEL enables trapping of small molecules in the brain to visualize their distribution changes
202216 citationsauthor #9
Coordination chemogenetics for activation of GPCR-type glutamate receptors in brain tissue
202112 citationsauthor #15
Tethering-based chemogenetic approaches for the modulation of protein function in live cells.
20215 citationsauthor #3
Orthogonal Activation of Metabotropic Glutamate Receptor Using Coordination Chemogenetics
20211 citationsauthor #6
Ligand-directed two-step labeling to quantify neuronal glutamate receptor trafficking
202034 citationsauthor #9
Construction of a Fluorescent Screening System of Allosteric Modulators for the GABAA Receptor Using a Turn-On Probe
201916 citationsauthor #7
Chemical labeling of glutamate receptors for revealing their cellular dynamics in neuron
20190 citationsauthor #1
On-cell coordination chemistry: Chemogenetic activation of membrane-bound glutamate receptors in living cells.
20192 citationsauthor #2
Molecular Technologies in Life Innovation: Novel Molecular Technologies for Labeling and Functional Control of Proteins Under Live Cell Conditions
20190 citationsauthor #2
Construction of ligand assay systems by protein-based semisynthetic biosensors.
20199 citationsauthor #2
Structural domains critical for the selectivity of diamide activators to lepidopterous ryanodine receptors
20180 citationsauthor #5
DNA Origami Scaffolds as Templates for Functional Tetrameric Kir3 K+ Channels.
201829 citationsauthor #2
Fluorescent imaging of in vivo H2O2 levels reveals contribution of oxidative microenvironment to tumor malignancy
20180 citationsauthor #2
P 3-a 16 The RIM 1 mutation associated with an autosomal dominant cone-rod dystrophy , CORD 7 , alters effects of RIM 1 on VDCC currents
20180 citationsauthor #7
Intracellular thermometry with fluorescent sensors for thermal biology
2018116 citationsauthor #4
Ligand-Directed Chemistry of AMPA Receptors Confers Live-Cell Fluorescent Biosensors.
201822 citationsauthor #1
Title Chemical labelling for visualizing native AMPA receptors inlive neurons
20180 citationsauthor #2
Chemogenetic Approach Using Ni(II) Complex–Agonist Conjugates Allows Selective Activation of Class A G-Protein-Coupled Receptors
20187 citationsauthor #5
Shank and Zinc Mediate an AMPA Receptor Subunit Switch in Developing Neurons
201857 citationsauthor #4
Construction of Protein-Based Biosensors Using Ligand-Directed Chemistry for Detecting Analyte Binding.
20172 citationsauthor #2
Molecular characterization of mutations in cytoplasmic domain of RyR of Plutella xylostella resistant to diamide insecticides
20170 citationsauthor #5
Affinity-Guided Oxime Chemistry for Selective Protein Acylation in Live Tissue Systems.
201748 citationsauthor #6
TRP channels in oxygen physiology: distinctive functional properties and roles of TRPA1 in O2 sensing
201723 citationsauthor #4
A Set of Organelle-Localizable Reactive Molecules for Mitochondrial Chemical Proteomics in Living Cells and Brain Tissues.
201658 citationsauthor #6
A conditional proteomics approach to identify proteins involved in zinc homeostasis
201655 citationsauthor #4
Structure–activity relations of leucine derivatives reveal critical moieties for cellular uptake and activation of mTORC1-mediated signaling
20160 citationsauthor #6
Allosteric activation of membrane-bound glutamate receptors using coordination chemistry within living cells.
201621 citationsauthor #1
Running title : Neurotrophic Action of Novel TRPC Channel Activators
20160 citationsauthor #11
Discovery of allosteric modulators for GABAA receptors by ligand-directed chemistry.
201656 citationsauthor #2
Screening of Transient Receptor Potential Canonical Channel Activators Identifies Novel Neurotrophic Piperazine Compounds
201625 citationsauthor #12
Structure–activity relations of leucine derivatives reveal critical moieties for cellular uptake and activation of mTORC1-mediated signaling
201652 citationsauthor #6
Screening of TRPC Channel Activators Identifies Novel Neurotrophic Piperazine Compounds
20160 citationsauthor #12
Validating subcellular thermal changes revealed by fluorescent thermosensors
201579 citationsauthor #1
Rab3 interacting molecule 3 mutations associated with autism alter regulation of voltage-dependent Ca²⁺ channels.
201515 citationsauthor #3
Visualization of native AMPA receptors in central nervous systems using a novel chemical labeling technique
20150 citationsauthor #1
Fluorescent sensors reveal subcellular thermal changes.
201538 citationsauthor #2
Compromised maturation of GABAergic inhibition underlies abnormal network activity in the hippocampus of epileptic Ca2+ channel mutant mice, tottering
20140 citationsauthor #6
Inhibition of N-type Ca2+ channels ameliorates an imbalance in cardiac autonomic nerve activity and prevents lethal arrhythmias in mice with heart failure.
201424 citationsauthor #17
Visualization of Intracellular Temperature Distribution Using A Thermoresponsive Fluorescent Protein
20140 citationsauthor #1
Transnitrosylation Directs TRPA1 Selectivity in N-Nitrosamine Activators
201425 citationsauthor #4
TRPV4 channel activity is modulated by direct interaction of the ankyrin domain to PI(4,5)P2
2014105 citationsauthor #12
Live cell off-target identification of lapatinib using ligand-directed tosyl chemistry.
201412 citationsauthor #6
LDAI-based chemical labeling of intact membrane proteins and its pulse-chase analysis under live cell conditions.
201465 citationsauthor #5
Compromised maturation of GABAergic inhibition underlies abnormal network activity in the hippocampus of epileptic Ca2+ channel mutant mice, tottering
201411 citationsauthor #6
Nuclear life of the voltage-gated Cacnb4 subunit and its role in gene transcription regulation
201328 citationsauthor #2
Supramolecular hydrogels based on bola-amphiphilic glycolipids showing color change in response to glycosidases.
201340 citationsauthor #4
Molecular architecture of Ca2+ channel complexes organized by CaVβ subunits in presynaptic active zones
20133 citationsauthor #4
Genetically encoded fluorescent thermosensors visualize subcellular thermoregulation in living cells
2013217 citationsauthor #1
Molecular determinants for cardiovascular TRPC6 channel regulation by Ca2+/calmodulin‐dependent kinase II
201335 citationsauthor #4
Physical and functional interaction of the active zone protein CAST/ERC2 and the β-subunit of the voltage-dependent Ca(2+) channel.
201259 citationsauthor #1
Cacnb4 directly couples electrical activity to gene expression, a process defective in juvenile epilepsy
201269 citationsauthor #2
The juvenile myoclonic epilepsy-related protein EFHC1 interacts with the redox-sensitive TRPM2 channel linked to cell death.
201254 citationsauthor #5
Zinc-finger proteins for site-specific protein positioning on DNA-origami structures.
2012127 citationsauthor #4
Genetic and pharmacologic inhibition of the Ca2+ influx channel TRPC3 protects secretory epithelia from Ca2+-dependent toxicity.
2011111 citationsauthor #6
Chemical cell-surface receptor engineering using affinity-guided, multivalent organocatalysts.
2011100 citationsauthor #5
Molecular basis for species-selective insecticidal actitiy of flubendiamide
20110 citationsauthor #1
Activation of TRP Channels in Mammalian Systems
201132 citationsauthor #2
TRPA1 underlies a sensing mechanism for O2.
2011256 citationsauthor #3
TRPC3-mediated Ca2+ influx contributes to Rac1-mediated production of reactive oxygen species in MLP-deficient mouse hearts.
201163 citationsauthor #5
Development of a GPCR Based Electrophysiological Biosensor
20110 citationsauthor #2
Transportsomes and channelsomes: Are they functional units for physiological responses?
20117 citationsauthor #2
TRPC3/6 as Potentially Novel Therapeutic Targets for The Treatment of Pulmonary Arterial Hypertension
20114 citationsauthor #3
Receptor signaling integration by TRP channelsomes.
201113 citationsauthor #5
[Diseases and ion dynamics of intracellular organelles as the target of drug designing. Preface].
20110 citationsauthor #1
Rab3-interacting Molecule γ Isoforms Lacking the Rab3-binding Domain Induce Long Lasting Currents but Block Neurotransmitter Vesicle Anchoring in Voltage-dependent P/Q-type Ca2+ Channels*
201049 citationsauthor #2
[Pharmacological properties of novel TRPC channel inhibitors].
20102 citationsauthor #1
Munc18a associated with voltage-dependent Ca2+ channel beta subunits to facilitate voltage-dependent inactivation of P/Q type channels
20100 citationsauthor #5
Pharmacological Properties of Novel TRPC Channel Inhibitors
20100 citationsauthor #1
Ca2+ influx and protein scaffolding via TRPC3 sustain PKCβ and ERK activation in B cells
201073 citationsauthor #3
S57-5 Physiological role of the oxidative stress-sensitive TRPM2 Ca channel in immunocytes
20100 citationsauthor #3
＜Syposium II＞Inactivation of voltage-gated Ca^2+ channels and cone-rod dystrophy CORD7
20100 citationsauthor #4
The Synthesis of a Reconstituted C60-Modified Protein.
20100 citationsauthor #3
Atrial and brain natriuretic peptides-guanylyl cyclase-A signaling pathway inhibits TRPC6-mediated pro-hypertrophic signaling in the hearts
20100 citationsauthor #6
Elucidation of function and physiological significance from Thermococcus kodakaraensis TK2009
20100 citationsauthor #2
Involvement of Ca2+ Channel Synprint Site in Synaptic Vesicle Endocytosis
201030 citationsauthor #4
Inactivation of voltage-gated CA^2+ channels and cone-rod dystrophy cord7. [Emerging Frontiers in Brain Research: Crossroads of metabolic regulaltion, stress response and disease. The 11th Meeting of Hirosaki International Forum of Medical Science. Communication Center of Hirosaki University School
20100 citationsauthor #4
INACTIVATION OF VOLTAGE-GATED CA CHANNELS AND CONE-ROD DYSTROPHY CORD7
20100 citationsauthor #4
Blockade of TRPC6 is a Novel Therapeutic Approach Against Pathological Cardiac Remodeling
20100 citationsauthor #5
An in vivo fluorescent sensor reveals intracellular ins(1,3,4,5)P4 dynamics in single cells.
201017 citationsauthor #6
A novel interaction of cardiac VDCC with troponin
20100 citationsauthor #3
Activation of TRPA1 channels by novel aliphatic N-nitrosamines
20100 citationsauthor #4
Development of a novel ROS sensing probe to visualize inflammatory macrophages
20100 citationsauthor #2
Inhibition of TRPC6 Channel Activity Contributes to the Antihypertrophic Effects of Natriuretic Peptides-Guanylyl Cyclase-A Signaling in the Heart
2010153 citationsauthor #6
This Week in The Journal F Cellular / Molecular Calcium Channels Interact With Endocytic Proteins
20100 citationsauthor #4
TRPC channels mediate cardiac hypertrophy
20100 citationsauthor #4
A Pathogenic C Terminus-truncated Polycystin-2 Mutant Enhances Receptor-activated Ca2+ Entry via Association with TRPC3 and TRPC7*
200931 citationsauthor #2
Sympathetic regulation of arterial tonus via TRPC3/NCX1 coupling
20090 citationsauthor #7
Tetrameric Orai1 Is a Teardrop-shaped Molecule with a Long, Tapered Cytoplasmic Domain*
200984 citationsauthor #6
A single circularly permuted GFP sensor for inositol-1,3,4,5-tetrakisphosphate based on a split PH domain.
200930 citationsauthor #7
Working mechanism of flubendiamide, a novel ryanodine receptor activator
20091 citationsauthor #4
Reply to Thinnes: Is There Competition in Trafficking of VDAC-cored VRAC and SOC in NE Differentiation of Cells?
20090 citationsauthor #7

PROFILE

PAPERS

TIMELINE

COAUTHOR MAP

CONCEPT FOOTPRINT