K. Stenmark

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Aliases
K Stenmark, K. R. Stenmark, K.r. Stenmark, Kurt R. Stenmark, K R Stenmark, Kurt Stenmark, Kurt R Stenmark
Publication record
536 papers · 26,109 citations · H-index 76

PAPERS

Single cell transcriptomic analyses reveal diverse and dynamic changes of distinct populations of lung interstitial macrophages in hypoxia-induced pulmonary hypertension.
202415 citationsauthor #12
SIRT3 Affects Adventitial Fibroblasts Phenotype in Pulmonary Hypertension Through Regulation of Mitochondrial Function
20230 citationsauthor #10
Local Complement Contributes to Pathogenic Activation of Lung Endothelial Cells in SARS-CoV-2 Infection
20234 citationsauthor #13
Local Production and Activation of Complements by the Adventitial Fibroblast Play a Crucial Role in Pulmonary Hypertension
20230 citationsauthor #9
Macrophage Xanthine Oxidoreductase Links LPS Induced Lung Inflammatory Injury to NLRP3 Inflammasome Expression and Mitochondrial Respiration
20234 citationsauthor #14
Histone deacetylase inhibitors synergize with sildenafil to suppress purine metabolism and proliferation in pulmonary hypertension.
202311 citationsauthor #10
PFKFB3 Inhibits Fructose Metabolism in Pulmonary Microvascular Endothelial Cells.
20235 citationsauthor #17
Single-cell Transcriptomics Analysis Affirms Phenotypic Changes and Altered Cellular Communication in Pulmonary Arteries From Hypoxia-induced PH Calves
20230 citationsauthor #9
Acute Pressure Overload in the Right Ventricle (RV) Changes the Tortuosity, Orientation, and Hemodynamics of the Microcirculation
20230 citationsauthor #3
Transaortic Constriction Improves Ventricular Performance in Mice With Right Ventricular Pressure Overload
20230 citationsauthor #4
Association of Cerebrovascular Remodeling With Chronic Pulmonary Vascular Remodeling; Is Uric Acid the Missing Link?
20230 citationsauthor #2
Complement Cascade Peptide Levels in the Peripheral Circulation of PAH Patients Are Related to Hemodynamic Measures of Vascular Function
20230 citationsauthor #6
Functional and Molecular Determinants of Right Ventricular Response to Severe Pulmonary Hypertension in a Large Animal Model.
20238 citationsauthor #21
Tensions in Taxonomies: Current Understanding and Future Directions in the Pathobiologic Basis and Treatment of Group 1 and Group 3 Pulmonary Hypertension.
20237 citationsauthor #7
Microenvironmental regulation of T-cells in pulmonary hypertension
202317 citationsauthor #12
Cardiac Macrophages Are the Primary Complement C3a Receptor (C3aR) Expressing Cells in the Rat Myocardium and Remain Stable in Late Sugen Hypoxia Pulmonary Hypertension
20230 citationsauthor #6
The Lectin Complement Pathway Contributes to Schistosoma-induced Pulmonary Hypertension
20230 citationsauthor #6
Repetitive schistosoma exposure causes perivascular lung fibrosis and persistent pulmonary hypertension
20237 citationsauthor #11
Isolation of vasa vasorum endothelial cells from pulmonary artery adventitia: Implementation to vascular biology research.
20232 citationsauthor #6
SIRT3 Is a Critical Regulator of Mitochondrial Function of Fibroblasts in Pulmonary Hypertension.
202311 citationsauthor #13
Complement Activation in Lung Endothelial Cells Contributes to Endothelial Inflammation Induced by SARS-CoV-2 in Hypoxia
20230 citationsauthor #11
Extracellular Vesicle Size Reveals Cargo Specific to Coagulation and Inflammation in Pediatric and Adult Sickle Cell Disease
20230 citationsauthor #14
Complement C3/C3a Loaded Small Extracellular Vesicles Generated by Pulmonary Hypertensive Fibroblasts Cause Metabolic Reprogramming and Proinflammatory Activation of Macrophage
20230 citationsauthor #10
Characterizing the Spatiotemporal Transcriptomic Response of the Right Ventricle to Acute Pressure Overload
20231 citationsauthor #9
The Effect of HIF Inhibition on the Phenotype of Fibroblasts in Human and Bovine Pulmonary Hypertension.
20232 citationsauthor #11
U-shaped association of uric acid to overall-cause mortality and its impact on clinical management of hyperuricemia
2022161 citationsauthor #3
Plasma-Derived Small Extracellular Vesicles from Hypoxic Calves Drive Pro-Inflammatory and Metabolic Reprogramming in Macrophages
20220 citationsauthor #12
Isolation of Vasa Vasorum Endothelial Cells from Pulmonary Artery Adventitia: Implementation to Vascular Biology Research
20220 citationsauthor #6
Classical Dendritic Cells Are Determinant in Driving and Maintaining Hypoxia Induced Pulmonary Hypertension
20220 citationsauthor #8
ATAC Seq Reveals That Genes Involved in the Persistently Activated Phenotype of PH Fibroblasts Exhibit Open Enhancers and Promoters That Are Enriched in Binding Sites for Several Transcription Factors
20220 citationsauthor #4
The role of macrophages in right ventricular remodeling in experimental pulmonary hypertension
20228 citationsauthor #10
Hypoxic Pulmonary Hypertension Results in Expansion of Right Ventricular CCR2+ Macrophages
20220 citationsauthor #8
Peripheral Blood Inflammation Profile of Patients with Pulmonary Arterial Hypertension Using the High-Throughput Olink Proteomics Platform.
20224 citationsauthor #10
Computational platform for doctor–artificial intelligence cooperation in pulmonary arterial hypertension prognostication: a pilot study
20228 citationsauthor #10
Combined Inhibition of Histone Deacetylases and Bromodomain Proteins Normalizes Persistent Activation of Pulmonary Hypertensive Adventitial Fibroblasts
20220 citationsauthor #7
Abstract 15464: Mitochondrial Function of Adventitial Fibroblasts in Pulmonary Hypertension is Regulated Through Sirt3 Deacetylase Activity
20220 citationsauthor #5
Overexpression of Pericyte HIF2α Exacerbates Hypoxia Induced Pulmonary Hypertension and Right Ventricular Hypertrophy
20220 citationsauthor #9
SIRT3 Regulates Mitochondrial Function of Adventitial Fibroblasts in Pulmonary Hypertension
20220 citationsauthor #7
A Protocol for Fabrication and on-Chip Cell Culture to Recreate PAH-Afflicted Pulmonary Artery on a Microfluidic Device
20229 citationsauthor #4
Predicting Survival in Pulmonary Arterial Hypertension by Combining Machine Learning and Game Theory - A - Platform for Patient Tailored Treatment
20220 citationsauthor #4
Abstract 15671: Targeting Chromatin Structure: The Combined Inhibition of Histone Deacetylases and Bromodomain Proteins in Normalizing Persistently Activated Pulmonary Hypertensive Fibroblasts
20220 citationsauthor #4
Hypoxia, Cytokines, and Growth Factors Exhibit Distinct and Synergistic Roles in Transforming Normal Pulmonary Fibroblasts into Persistently Activated Fibroblasts
20220 citationsauthor #9
CCR2-CCL2 Axis in Hypoxic Pulmonary Hypertension
20220 citationsauthor #9
Perspectives on Cognitive Phenotypes and Models of Vascular Disease.
20226 citationsauthor #14
Defining Interstitial Macrophage Heterogeneity in Response to Hypoxia
20220 citationsauthor #12
HIF1A-dependent induction of alveolar epithelial PFKFB3 dampens acute lung injury
202224 citationsauthor #9
Single-cell RNA sequencing and binary hierarchical clustering define lung interstitial macrophage heterogeneity in response to hypoxia
20226 citationsauthor #16
Microenvironmental Regulation of Macrophage Transcriptomic and Metabolomic Profiles in Pulmonary Hypertension
202131 citationsauthor #17
Endothelial Cell PHD2-HIF1α-PFKFB3 Contributes to Right Ventricle Vascular Adaptation in Pulmonary Hypertension.
202111 citationsauthor #9
1 17-estradiol and estrogen receptor-protect right ventricular function in pulmonary 1 hypertension via BMPR 2 and apelin 2
20210 citationsauthor #14
The Short-Chain Fatty Acid Butyrate Attenuates Pulmonary Vascular Remodeling and Inflammation in Hypoxia-Induced Pulmonary Hypertension
202165 citationsauthor #8
Brief report: The uricase mutation in humans increases our risk for cancer growth
20210 citationsauthor #9
Metabolite G-Protein Coupled Receptors in Cardio-Metabolic Diseases
202112 citationsauthor #8
Evidence supporting a role for circulating macrophages in the regression of vascular remodeling following sub-chronic exposure to hemoglobin plus hypoxia
20215 citationsauthor #8
Hypoxic Remodeling of Neonatal Pulmonary Artery and Myocardium
20210 citationsauthor #5
Brief Report: Case Comparison of Therapy With the Histone Deacetylase Inhibitor Vorinostat in a Neonatal Calf Model of Pulmonary Hypertension
20214 citationsauthor #12
Potential long-term effects of SARS-CoV-2 infection on the pulmonary vasculature: a global perspective
202173 citationsauthor #4
Hemodynamically Unloading the Distal Pulmonary Circulation in Pulmonary Hypertension - A Modeling Study.
20211 citationsauthor #3
Book review on hypoxic respiratory failure in the newborn – from origins to clinical management
20212 citationsauthor #1
Brief report: The uricase mutation in humans increases our risk for cancer growth
202114 citationsauthor #9
17β-estradiol and estrogen receptor-α protect right ventricular function in pulmonary hypertension via BMPR2 and apelin.
202162 citationsauthor #13
Brief Report: An Evolutionary Basis to Cancer Growth
20210 citationsauthor #8
Complement-containing small extracellular vesicles from adventitial fibroblasts induce proinflammatory and metabolic reprogramming in macrophages
202136 citationsauthor #12
Study of ER Stress and Apoptotic Proteins in the Heart and Tumor Exposed to Doxorubicin.
202129 citationsauthor #9
Short‐Term Effects of Inhaled Nitric Oxide on Right Ventricular Flow Hemodynamics by 4‐Dimensional–Flow Magnetic Resonance Imaging in Children With Pulmonary Arterial Hypertension
20219 citationsauthor #5
Mechanisms of SARS-CoV-2-induced lung vascular disease: potential role of complement
202142 citationsauthor #1
New insights into the pathobiological and pharmacological basis of the sex-disparity in patients with pulmonary arterial hypertension.
202113 citationsauthor #6
Mechanisms Contributing to the Dysregulation of miRNA-124 in Pulmonary Hypertension
202122 citationsauthor #3
Design, synthesis and biological evaluations of a long-acting, hypoxia-activated prodrug of fasudil, a ROCK inhibitor, to reduce its systemic side-effects.
202127 citationsauthor #7
Activation of Pulmonary and Cardiac Cell Populations in Response to Environmental Hypoxia or Lung Injury Using Transgenic Mouse Strains Expressing Phenotype-Sensitive Fluorescent Reporter Proteins
20200 citationsauthor #6
Targeting Rho Kinase in Pulmonary Hypertension Due to Left Heart Disease Using a Novel Humanized Model of HFpEF-PH
20200 citationsauthor #5
Perspective: Pathobiological paradigms in pulmonary hypertension, time for reappraisal.
202011 citationsauthor #2
Pulmonary-arterial-hypertension (PAH)-on-a-chip: fabrication, validation and application
202025 citationsauthor #12
RNA-Binding Proteins in Pulmonary Hypertension
202010 citationsauthor #3
Chromatin Structure Alterations in Genes Involved in the Persistently Activated Phenotype of PH Vascular Cells
20200 citationsauthor #6
Epigenetic-Targeted Therapies in Pulmonary Hypertension Combined Inhibition of Histone Deacetylases and Bromodomain Proteins Normalizes the Persistent Activation of Pulmonary Vascular Adventitial Fibroblasts In Vitro
20200 citationsauthor #8
Immunoglobulin-driven Complement Activation Regulates Proinflammatory Remodeling in Pulmonary Hypertension
202080 citationsauthor #20
Lectin Complement Activation Pathway Initiates the Alternative Pathway-Driven Hypoxia-Induced Pulmonary Inflammation and Cell Proliferation
20200 citationsauthor #7
HDAC Inhibitor Butyrate Cooperates with A1 and A2B Receptors to Attenuate Pulmonary Artery Vasa Vasorum Dysfunction in Hypoxia
20200 citationsauthor #10
Impact Of Cell-free Hemoglobin On Exercising Muscle Vascular Control In Rats
20200 citationsauthor #5
Selective Depletion of Vascular EC-SOD Reprograms Interstitial Macrophages Via PLC-NFAT Axis in a Murine Model of Hypoxic Pulmonary Hypertension
20200 citationsauthor #3
Band on the Run: Insights Into Right Ventricular Reverse Remodeling.
20204 citationsauthor #3
P2Y Purinergic Receptors, Endothelial Dysfunction, and Cardiovascular Diseases
202038 citationsauthor #11
Hypoxic Activation of G6PD Controls the Expression of Genes Involved in the Pathogenesis of Pulmonary Hypertension Through the Regulation of DNA Methylation.
202032 citationsauthor #15
Pluripotent hematopoietic stem cells augment (cid:2) -adrenergic receptor-mediated contraction of pulmonary artery and contribute to the pathogenesis of pulmonary hypertension
20207 citationsauthor #8
Pulmonary Adventitial Fibroblasts Regulate Macrophage Transcriptional and Metabolic Programs in Pulmonary Hypertension
20200 citationsauthor #16
Therapeutic Actions of the Histone Deacetylase Inhibitor Vorinostat in a Neonatal Calf Model of Hypoxia-Induced Pulmonary Hypertension
20200 citationsauthor #11
C-Terminal Binding Protein-1 Regulates Adventitial Fibroblast Metabolic and Mitochondrial Reprogramming in Pulmonary Hypertension Through Sirtuins
20200 citationsauthor #7
Platelet activation contributes to hypoxia-induced inflammation.
202040 citationsauthor #9
c-Jun, Foxo3a, and c-Myc Transcription Factors are Key Regulators of ATP-Mediated Angiogenic Responses in Pulmonary Artery Vasa Vasorum Endothelial Cells
202018 citationsauthor #9
Extracellular adenosine enhances pulmonary artery vasa vasorum endothelium cell barrier function via the Gi/ELMO1/Rac1/PKA-dependent signaling mechanisms.
20207 citationsauthor #9
Publisher Correction: Stable isotope metabolomics of pulmonary artery smooth muscle and endothelial cells in pulmonary hypertension and with TGF-beta treatment
20200 citationsauthor #11
Fibroblast-Secreted Exosomal Complement Protein Promotes Macrophage Polarization Towards a Pro-Inflammatory Phenotype
20200 citationsauthor #8
Inflammation, immunity, and vascular remodeling in pulmonary hypertension; Evidence for complement involvement?
202030 citationsauthor #5
Cd4+ T Cells Subsets Are Decreased in Peripheral Blood Mononuclear Cells (PBMCs) of Idiopathic Pulmonary Arterial Hypertension (IPAH) Patients Compared to Healthy Controls
20200 citationsauthor #9
Pluripotent HSCs Augment a-Adrenergic Receptor-Mediated Contraction of Pulmonary Artery and Contribute to the Pathogenesis of Pulmonary Hypertension.
20207 citationsauthor #8
Clickable decellularized extracellular matrix as a new tool for building hybrid-hydrogels to model chronic fibrotic diseases in vitro.
202060 citationsauthor #9
Stable isotope metabolomics of pulmonary artery smooth muscle and endothelial cells in pulmonary hypertension and with TGF-beta treatment
202040 citationsauthor #11
Using an In Vitro System to Identify Signals That Are Essential to Transform Normal Pulmonary Vascular Cells to Persistently Activated Vascular Cells
20200 citationsauthor #5
The effect of dietary nitrate supplementation on the speed-duration relationship in mice with sickle cell disease.
202011 citationsauthor #9

TIMELINE

1983 220 citations

1984 111 citations

1985 131 citations

1986 33 citations

1987 533 citations

1988 66 citations

1989 181 citations

1990 149 citations

1991 86 citations

1992 112 citations

1993 109 citations

1994 368 citations

1995 588 citations

1996 40 citations

1997 276 citations

1998 518 citations

1999 108 citations

2000 199 citations

2001 296 citations

2002 784 citations

2003 368 citations

2004 2,252 citations

2005 1,124 citations

2006 1,849 citations

2007 655 citations

2008 486 citations

2009 2,859 citations

2010 330 citations

2011 1,000 citations

2012 1,408 citations

2013 1,199 citations

2014 988 citations

2015 2,010 citations

2016 384 citations

2017 852 citations

2018 535 citations

2019 1,739 citations

2020 425 citations

2021 458 citations

2022 226 citations

2023 79 citations

2024 15 citations

Unknown 0 citations

K. Stenmark

PROFILE

PAPERS

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