B. Ogretmen

Abstract PS2-11-07: Linc00152-regulated pde4d is a mediator of drug resistance and metastasis in highly aggressive breast cancer
20260 citationsauthor #18
Sphingolipid signaling links elastin deficiency to arterial hyper-muscularization and congenital heart disease
20260 citationsauthor #2
Abstract LB019: LINC00152-regulated PDE4D mediates drug resistance and metastasis in highly aggressive breast cancer
20250 citationsauthor #18
Phosphatidylcholine regulation via sphingosine kinase 2 inhibition drives immunogenic reprogramming of myeloid-derived suppressor cells 3701
20250 citationsauthor #14
Abstract 929: Altered lipid metabolism drives immunotherapy resistance via an EGFR/CERS4/PD-L1/PGE2 signaling axis in solid tumors
20250 citationsauthor #13
Beyond the Pseudogene: p17/PERMIT as a Mitochondrial Trafficking Protein Linking Aging and Neurodegeneration
20250 citationsauthor #3
Ceramide-Induced Metabolic Stress Depletes Fumarate and Drives Mitophagy to Mediate Tumor Suppression.
20251 citationsauthor #19
S1P transporter SPNS2 expression modulates T cell immune response 4732
20250 citationsauthor #5
Phosphorylation of an RNA‐Binding Protein Rck/Me31b by Hippo Is Essential for Adipose Tissue Aging
20255 citationsauthor #9
Alterations of Ceramide Synthesis Induce PD-L1 Internalization and Signaling to Regulate Tumor Metastasis and Immunotherapy Response 2131
20250 citationsauthor #1
Pilot clinical trial of neoadjuvant toll-like receptor 7 agonist (Imiquimod) immunotherapy in early-stage oral squamous cell carcinoma
20258 citationsauthor #30
Alzheimer's Disease-Associated Amyloid Beta Precursor Protein Prevents Aging Stress-Induced Mitophagy and Fumarate Depletion to Improve Anti-Tumor Immunity.
20251 citationsauthor #19
Sphingosine-1-Phosphate Inhibition Increases Endoplasmic Reticulum Stress to Enhance Oxaliplatin Sensitivity in Pancreatic Cancer
20241 citationsauthor #7
Transcriptome analysis of polyploid giant cancer cells and their progeny reveals a functional role for p21 in polyploidization and depolyploidization
202415 citationsauthor #6
Abstract 1570: Lipid metabolism alterations promote TNBC metastasis and immunotherapy resistance via PD-L1 internalization and signaling
20240 citationsauthor #14
Developing Catchment Area Data Dashboards for Cancer Centers: A Stakeholder-engaged Approach.
20240 citationsauthor #7
Targeting SNAI1-Mediated Colorectal Cancer Chemoresistance and Stemness by Sphingosine Kinase 2 Inhibition
20243 citationsauthor #7
H2S-Prdx4 axis mitigates Golgi stress to bolster tumor-reactive T cell immunotherapeutic response
202410 citationsauthor #23
Developing Catchment Area Data Dashboards for Cancer Centers: A Stakeholder-engaged Approach
20241 citationsauthor #7
Abstract 3969: Alzheimer's disease-associated amyloid precursor protein improves anti-tumor immunity by inhibiting ceramide-mediated lethal mitophagy and restoring mitochondrial fumarate metabolism in aging T-cells
20240 citationsauthor #11
The psychosine and galactosylceramide brain spatial distribution and its correlation with neuropathogenic processes
20240 citationsauthor #3
Alterations of ceramide synthesis induce PD-L1 internalization and signaling to regulate tumor metastasis and immunotherapy response
20247 citationsauthor #17
Targeting LINC00152 activates cAMP/Ca2+/ferroptosis axis and overcomes tamoxifen resistance in ER+ breast cancer
202423 citationsauthor #18
Opportunistic pathogen Porphyromonas gingivalis targets the LC3B-ceramide complex and mediates lethal mitophagy resistance in oral tumors
20241 citationsauthor #12
Abstract LB343: Golgihi T cells exhibit reduced susceptibility to exhaustion and improved tumor control
20240 citationsauthor #13
p17/C18-ceramide–mediated mitophagy is an endogenous neuroprotective response in preclinical and clinical brain injury
20245 citationsauthor #12
A first-in-human phase 1 study of BXQ-350, a first-in-class sphingolipid metabolism regulator, in patients with advanced/recurrent solid tumors or high-grade gliomas.
20242 citationsauthor #10
Mitophagy As a Novel Cell-Protective Mechanism Against Mitochondrial Ferroptosis in Acute Myeloid Leukemia
20231 citationsauthor #13
Sphingolipid metabolism and complement signaling in cancer progression.
202325 citationsauthor #4
Abstract 1313: Sphingosine-1-phosphate signaling regulates intracellular complement activation to induce cancer metastasis
20230 citationsauthor #2
Targeting LINC00152 activates cAMP/Ca2+/ferroptosis axis and overcomes tamoxifen resistance in ER+ breast cancer
202311 citationsauthor #16
Inhibition of Sphingosine Kinase 2 Enhances Immunotherapy in Mouse Model of Multiple Myeloma
20230 citationsauthor #7
Biomimetic Nanomaterials for the Immunomodulation of the Cardiosplenic Axis Postmyocardial Infarction
20235 citationsauthor #15
Alterations of lipid‐mediated mitophagy result in aging‐dependent sensorimotor defects
202310 citationsauthor #12
Abstract 2867: Ceramide-dependent mitophagy leads to metabolic reprogramming in aging T-cells associated with reduced anti-tumor T-cell functions
20230 citationsauthor #9
Sphingosine 1-phosphate / Acetyl CoA Carboxylase1 Axis regulates the Differentiation and Function of Tumor-associated Myeloid-Derived Suppressor Cells
20230 citationsauthor #8
Ceramide synthase 6 (CerS6) is upregulated in alcohol-associated liver disease and exhibits sex-based differences in the regulation of energy homeostasis and lipid droplet accumulation
20239 citationsauthor #11
Sphingolipid metabolism in T cell responses after allogeneic hematopoietic cell transplantation
20225 citationsauthor #2
Polyploid giant cancer cells are dependent on cholesterol for progeny formation through amitotic division
202224 citationsauthor #7
Abstract 1312: Pro-survival lipid metabolism activates intracellular complement signaling to induce inflammasome-mediated tumor metastasis
20220 citationsauthor #2
Crosstalk between pro-survival sphingolipid metabolism and complement signaling induces inflammasome-mediated tumor metastasis
202224 citationsauthor #19
Ceramide synthase 6 (CerS6) promotes alcohol-induced fatty liver by promoting metabolic dysfunction and upregulating lipid droplet-associated proteins
20220 citationsauthor #8
Depletion of COPI in cancer cells: the role of reactive oxygen species in the induction of lipid accumulation, noncanonical lipophagy and apoptosis
202212 citationsauthor #9
Pro‐survival lipid metabolism activates intracellular complement signaling to induce inflammasome‐mediated tumor metastasis
20220 citationsauthor #2
Targeting Sphingolipid Metabolism as a Therapeutic Strategy in Cancer Treatment
202254 citationsauthor #2
Phase I study of opaganib, an oral sphingosine kinase 2-specific inhibitor, in relapsed and/or refractory multiple myeloma
202214 citationsauthor #13
Ceramide synthase 6 impacts T-cell allogeneic response and graft-versus-host disease through regulating N-RAS/ERK Pathway
202215 citationsauthor #18
S1P/S1PR1 signaling differentially regulates the allogeneic response of CD4 and CD8 T cells by modulating mitochondrial fission
202228 citationsauthor #10
Crystal structures reveal catalytic and regulatory mechanisms of the dual-specificity ubiquitin/FAT10 E1 enzyme Uba6
202213 citationsauthor #11
Dietary Folic Acid Alters Metabolism of Multiple Vitamins in a CerS6- and Sex-Dependent Manner
20213 citationsauthor #2
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
20213,716 citationsauthor #1846
1HN, 13C, and 15N backbone resonance assignments of the SET/TAF-1β/I2PP2A oncoprotein (residues 23–225)
20211 citationsauthor #6
Dependence of ABCB1 transporter expression and function on distinct sphingolipids generated by ceramide synthases-2 and -6 in chemoresistant renal cancer
202114 citationsauthor #9
Comparative analysis of antibodies to SARS-CoV-2 between asymptomatic and convalescent patients
202113 citationsauthor #17
Ceramide Synthase 6 mediates sex-specific metabolic response to dietary folic acid in mice.
20215 citationsauthor #2
Aging-dependent mitochondrial dysfunction mediated by ceramide signaling inhibits antitumor T cell response
202165 citationsauthor #15
S1P/S1PR1 Signalis Required for Optimal T-Cell Pathogenicity to Induce Gvhd By RegulatingDrp1/mTOR Axis
20210 citationsauthor #9
Alterations of lipid metabolism provide serologic biomarkers for the detection of asymptomatic versus symptomatic COVID-19 patients
202135 citationsauthor #10
Crystal Structure of SET/I2PP2A/TAF-1Beta core
20210 citationsauthor #3
Phase II trial of opaganib in patients with metastatic castration-resistant prostate cancer progressing on abiraterone or enzalutamide (NCT04207255).
20212 citationsauthor #4
The Role of Ceramide Metabolism and Signaling in the Regulation of Mitophagy and Cancer Therapy
202162 citationsauthor #2
Ceramide Synthase 6 Maximizes p53 Function to Prevent Progeny Formation from Polyploid Giant Cancer Cells
202119 citationsauthor #5
Targeting tyrosine phosphatase SHP2 in oral cancers
20200 citationsauthor #7
Targeting Acid Ceramidase to Improve the Radiosensitivity of Rectal Cancer
202023 citationsauthor #10
The Evolution of Care of Cancers of the Head and Neck Region: State of the Science in 2020
202028 citationsauthor #8
mTOR inhibitor use in head and neck squamous cell carcinoma: A meta‐analysis on survival, tumor response, and toxicity
202019 citationsauthor #3
The NMR‐based characterization of the FTY720‐SET complex reveals an alternative mechanism for the attenuation of the inhibitory SET‐PP2A interaction
201935 citationsauthor #9
Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma
201998 citationsauthor #7
Thioredoxin-1 confines T cell alloresponse and pathogenicity in graft-versus-host disease.
201932 citationsauthor #13
Mitochondrial protein import is regulated by p17/PERMIT to mediate lipid metabolism and cellular stress
201941 citationsauthor #8
Pro-Survival Lipid Sphingosine-1-Phosphate Metabolically Programs T Cells to Limit Anti-tumor Activity
201983 citationsauthor #22
Thioredoxin-1 improves the immunometabolic phenotype of antitumor T cells
201933 citationsauthor #18
Mechanisms of Ceramide-Dependent Cancer Cell Death.
201868 citationsauthor #3
Complement C3a and C5a receptors promote GVHD by suppressing mitophagy in recipient dendritic cells.
201830 citationsauthor #17
Ceramide Synthase 6 Deficiency Enhances Inflammation in the DSS model of Colitis
201837 citationsauthor #5
POLYPEPTIDES FOR IMPROVED RESPONSE TO ANTI-CANCER THERAPY
20180 citationsauthor #1
Receptor-interacting Ser/Thr kinase 1 (RIPK1) and myosin IIA–dependent ceramidosomes form membrane pores that mediate blebbing and necroptosis
201827 citationsauthor #15
Balance between senescence and apoptosis is regulated by telomere damage–induced association between p16 and caspase-3
201833 citationsauthor #8
Smoking-induced control of miR-133a-3p alters the expression of EGFR and HuR in HPV-infected oropharyngeal cancer
201824 citationsauthor #4
Crosstalk of sphingolipids and inflammasomes modulates tumor microenvironment and promotes cancer progression
20181 citationsauthor #4
EXTH-51. C18-CERAMIDE ANALOGUE DRUG OVERCOMES RESISTANCE TO TEMOZOLOMIDE IN GLIOBLASTOMA
20184 citationsauthor #5
CD38-NAD+Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response.
2018230 citationsauthor #25
SphK1/S1P Axis Regulate PPARγ Levels to Program Metabolically Fit Anti-Tumor T Cells
20180 citationsauthor #5
Abstract 5474: Sphingosine kinase 2/sphingosine 1-phosphate signaling regulates p16 mediated accelerated aging in normal somatic tissues and tcf21 mediated tumor suppression in lung cancer
20170 citationsauthor #6
Complement Promotes Gvhd through Suppressing Autophagy in Recipient Dendritic Cells after Allogeneic Hematopoietic Cell Transplantation in Mice
20171 citationsauthor #7
A Phase I Study of ABC294640, a First-in-Class Sphingosine Kinase-2 Inhibitor, in Patients with Advanced Solid Tumors
2017142 citationsauthor #5
Adoptive Transfer of Ceramide Synthase 6 Deficient Splenocytes Reduces the Development of Colitis
201729 citationsauthor #5
TGF-β receptor I/II trafficking and signaling at primary cilia are inhibited by ceramide to attenuate cell migration and tumor metastasis
201777 citationsauthor #11
S. pombe Uba1-Ubc15 Structure Reveals a Novel Regulatory Mechanism of Ubiquitin E2 Activity.
201748 citationsauthor #8
S1P/PPARγ axis metabolically reprograms the T cells to modulate their anti-tumor potential
20170 citationsauthor #6
Adoptive Transfer of Ceramide Synthase 6 Deficient Splenocytes Reduces the Development of Colitis
20170 citationsauthor #5
Sphingolipid metabolism in cancer signalling and therapy
2017983 citationsauthor #1
685 Fighting cancer with fat: Utilizing ceramide lipid to induce lethal mitophagy
20170 citationsauthor #2
Targeting Sphingosine kinase 2/S1P axis Decreases Immunosuppressive Potential of Myeloid Derived Suppressor Cells (MDSCs) and Improves Tumor Control
20170 citationsauthor #4
Ceramide synthesis regulates T cell activity and GVHD development.
201752 citationsauthor #16
HPV/E7 induces chemotherapy‐mediated tumor suppression by ceramide‐dependent mitophagy
201750 citationsauthor #11
Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356
201650 citationsauthor #1548
Abstract 4122: Ceramide is a key factor that regulates the crosstalk between TGF-ß and sonic hedgehog signaling at the basal cilia to control cell migration and tumor metastasis
20160 citationsauthor #4
TGF-β receptor I/II signaling at primary cilia membrane is regulated by ceramide to modulate cell migration
20160 citationsauthor #2
HPV16‐E7 Oncoprotein Enhances Ceramide‐Mediated Lethal Mitophagy by Regulating the Rb/E2F5/Drp1 Signaling Axis
20161 citationsauthor #3

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