K. Talbot

Advantages of routine next‐generation sequencing over standard genetic testing in the amyotrophic lateral sclerosis clinic
20236 citationsauthor #8
Primary care blood tests show lipid profile changes in pre-symptomatic amyotrophic lateral sclerosis
202311 citationsauthor #3
Aberrant dynein function promotes TDP-43 aggregation and upregulation of p62 in male mice harboring transgenic human TDP-43
20232 citationsauthor #4
Limited value of serum neurofilament light chain in diagnosing amyotrophic lateral sclerosis
202320 citationsauthor #7
Human iPSC co-culture model to investigate the interaction between microglia and motor neurons
202230 citationsauthor #14
Multicentre appraisal of amyotrophic lateral sclerosis biofluid biomarkers shows primacy of blood neurofilament light chain
202230 citationsauthor #20
A survey of current practice in genetic testing in amyotrophic lateral sclerosis in the UK and Republic of Ireland: implications for future planning
20229 citationsauthor #5
Profiling non-coding RNA expression in cerebrospinal fluid of amyotrophic lateral sclerosis patients
202211 citationsauthor #4
Poly(ADP-ribose) promotes toxicity of C9ORF72 arginine-rich dipeptide repeat proteins
202219 citationsauthor #15
Targeting phosphoglycerate kinase 1 with terazosin improves motor neuron phenotypes in multiple models of amyotrophic lateral sclerosis
202240 citationsauthor #10
Stress granule assembly in vivo is deficient in the CNS of mutant TDP-43 ALS mice.
202220 citationsauthor #5
071 Motor network remodelling in ALS and PLS
20220 citationsauthor #5
Hyperexcitability in young iPSC-derived C9ORF72 mutant motor neurons is associated with increased intracellular calcium release
20220 citationsauthor #3
A case of SOD1 deficiency: implications for clinical trials.
20221 citationsauthor #2
Atypical TDP‐43 protein expression in an ALS pedigree carrying a p.Y374X truncation mutation in TARDBP
20226 citationsauthor #7
Hyperexcitability in young iPSC-derived C9ORF72 mutant motor neurons is associated with increased intracellular calcium release
202214 citationsauthor #3
Corrigendum
20220 citationsauthor #17
The impact of age on genetic testing decisions in amyotrophic lateral sclerosis
202236 citationsauthor #12
Measuring disability in amyotrophic lateral sclerosis/motor neuron disease: the WHODAS 2.0-36, WHODAS 2.0-32, and WHODAS 2.0-12
20226 citationsauthor #7
Pathological laughter and crying in neurological disorders: recognition and treatment
20223 citationsauthor #2
Genetic testing in motor neurone disease
202236 citationsauthor #6
Prevalence of depression in amyotrophic lateral sclerosis/motor neuron disease: multi-attribute ascertainment and trajectories over 30 months
20229 citationsauthor #7
Creatine kinase and prognosis in amyotrophic lateral sclerosis: a literature review and multi-centre cohort analysis
202216 citationsauthor #5
Human iPSC co-culture model to investigate the interaction between microglia and motor neurons
20220 citationsauthor #14
Network Analysis of the CSF Proteome Characterizes Convergent Pathways of Cellular Dysfunction in ALS
20218 citationsauthor #5
Axonal TDP-43 condensates drive neuromuscular junction disruption through inhibition of local synthesis of nuclear encoded mitochondrial proteins
2021114 citationsauthor #12
Targeting the 5′ untranslated region of SMN2 as a therapeutic strategy for spinal muscular atrophy
202115 citationsauthor #10
A fine balance between Prpf19 and Exoc7 in achieving degradation of aggregated protein and suppression of cell death in spinocerebellar ataxia type 3
202112 citationsauthor #3
012 Volumetric and connectivity profile of regional thalamic abnormality in amyotrophic lateral sclerosis
20210 citationsauthor #6
A pilot trial to test whether terazosin treatment lowers the levels of biomarkers of neurodegeneration (nerve cell damage) in the blood, spinal fluid, and urine of amyotrophic lateral sclerosis patients over 6 months
20210 citationsauthor #1
The Role of Mitochondrial Dysfunction and ER Stress in TDP-43 and C9ORF72 ALS
202159 citationsauthor #3
Isolated homozygous R217X OPTN mutation causes knock-out of functional C-terminal optineurin domains and associated oligodendrogliopathy-dominant ALS–TDP
20214 citationsauthor #6
Modeling seeding and neuroanatomic spread of pathology in amyotrophic lateral sclerosis
202121 citationsauthor #5
Non-neuronal cells in amyotrophic lateral sclerosis — from pathogenesis to biomarkers
2021118 citationsauthor #7
Higher blood high density lipoprotein and apolipoprotein A1 levels are associated with reduced risk of developing amyotrophic lateral sclerosis
202146 citationsauthor #2
The use of biotelemetry to explore disease progression markers in amyotrophic lateral sclerosis
202017 citationsauthor #11
Motor Neuron Disease Register for England, Wales and Northern Ireland—an analysis of incidence in England
202015 citationsauthor #6
Quantitative patterns of motor cortex proteinopathy across ALS genotypes
20200 citationsauthor #11
Mice Carrying ALS Mutant TDP-43, but Not Mutant FUS, Display In Vivo Defects in Axonal Transport of Signaling Endosomes
202073 citationsauthor #7
Deep phenotyping of peripheral tissue facilitates mechanistic disease stratification in sporadic Parkinson's disease.
202047 citationsauthor #22
Impairment of Mitochondrial Calcium Buffering Links Mutations in C9ORF72 and TARDBP in iPS-Derived Motor Neurons from Patients with ALS/FTD
2020115 citationsauthor #10
Detection and quantification of novel C‐terminal TDP‐43 fragments in ALS‐TDP
202033 citationsauthor #9
Improving clinical trial outcomes in amyotrophic lateral sclerosis
2020235 citationsauthor #3
Identification of a potential non-coding RNA biomarker signature for amyotrophic lateral sclerosis
202047 citationsauthor #5
Amyotrophic lateral sclerosis with a heterozygous D91A SOD1 variant and classical ALS-TDP neuropathology
202014 citationsauthor #4
An ALS-linked mutation in TDP-43 disrupts normal protein interactions in the motor neuron response to oxidative stress.
202037 citationsauthor #14
A proposal for new diagnostic criteria for ALS.
2020454 citationsauthor #15
Amyotrophic Lateral Sclerosis: network vulnerability and monosynaptic connections
20200 citationsauthor #1
Leukoencephalopathy with calcifications and cysts: Genetic and phenotypic spectrum
202025 citationsauthor #59
Measuring coping in people with amyotrophic lateral sclerosis using the Coping Index-ALS: A patient derived, Rasch compliant scale.
20201 citationsauthor #8
Neurotrophic Properties of C-Terminal Domain of the Heavy Chain of Tetanus Toxin on Motor Neuron Disease
20202 citationsauthor #3
Truncated stathmin-2 is a marker of TDP-43 pathology in frontotemporal dementia.
2020160 citationsauthor #23
Quantitative patterns of motor cortex proteinopathy across ALS genotypes
202042 citationsauthor #11
Regional callosal integrity and bilaterality of limb weakness in amyotrophic lateral sclerosis
202020 citationsauthor #4
Interaction of Axonal Chondrolectin with Collagen XIXa1 Is Necessary for Precise Neuromuscular Junction Formation.
20203 citationsauthor #10
Erratum: Interaction of Axonal Chondrolectin with Collagen XIXa1 Is Necessary for Precise Neuromuscular Junction Formation (Cell Reports (2019) 29(5) (1082–1098.e10), (S2211124719312215), (10.1016/j.celrep.2019.09.033))
20200 citationsauthor #10
Correction to: Do pain, anxiety and depression influence quality of life for people with amyotrophic lateral sclerosis/motor neuron disease? A national study reconciling previous conflicting literature
20201 citationsauthor #10
Correction to: Do pain, anxiety and depression influence quality of life for people with amyotrophic lateral sclerosis/motor neuron disease? A national study reconciling previous conflicting literature (Journal of Neurology, (2019), 10.1007/s00415-019-09615-3)
20200 citationsauthor #9
Development of LNA Gapmer Oligonucleotide-Based Therapy for ALS/FTD Caused by the C9orf72 Repeat Expansion.
20203 citationsauthor #6
CSF extracellular vesicle proteomics demonstrates altered protein homeostasis in amyotrophic lateral sclerosis
20200 citationsauthor #6
Measuring quality of life in ALS/MND: validation of the WHOQOL-BREF
202019 citationsauthor #13
CSF chitinases before and after symptom onset in amyotrophic lateral sclerosis
202034 citationsauthor #5
Pathogenic Huntingtin Repeat Expansions in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis.
202076 citationsauthor #124
CSF extracellular vesicle proteomics demonstrates altered protein homeostasis in amyotrophic lateral sclerosis
202047 citationsauthor #6
Primary lateral sclerosis: diagnosis and management
202031 citationsauthor #2
Objectively Monitoring Amyotrophic Lateral Sclerosis Patient Symptoms During Clinical Trials With Sensors: Observational Study
201949 citationsauthor #8
Correction of amyotrophic lateral sclerosis related phenotypes in induced pluripotent stem cell-derived motor neurons carrying a hexanucleotide expansion mutation in C9orf72 by CRISPR/Cas9 genome editing using homology-directed repair
201957 citationsauthor #9
Cerebellar tract alterations in PLS and ALS
201929 citationsauthor #3
Single-copy expression of an amyotrophic lateral sclerosis-linked TDP-43 mutation (M337V) in BAC transgenic mice leads to altered stress granule dynamics and progressive motor dysfunction.
201978 citationsauthor #13
Tracheostomy in motor neurone disease
201922 citationsauthor #6
The interactome of human TDP-43 in a cellular model of amyotrophic lateral sclerosis
20190 citationsauthor #11
Defective cholesterol metabolism in amyotrophic lateral sclerosis patient-oriented and epidemiological
20190 citationsauthor #7
004 A triaging blood test for neurology? Serum neurofilament levels in a cohort of GP referrals
20190 citationsauthor #5
Astrocyte adenosine deaminase loss increases motor neuron toxicity in amyotrophic lateral sclerosis
201992 citationsauthor #10
Interaction of Axonal Chondrolectin with Collagen XIXa1 Is Necessary for Precise Neuromuscular Junction Formation.
201914 citationsauthor #10
CSF chitinase proteins in amyotrophic lateral sclerosis
201984 citationsauthor #5
267 Motor system biomarkers in amyotrophic lateral sclerosis
20190 citationsauthor #4
Antisense oligonucleotides for neuromuscular disorders
20190 citationsauthor #1
The relationships between symptoms, disability, perceived health and quality of life in amyotrophic lateral sclerosis/motor neuron disease
201933 citationsauthor #10
The MND register for England, Wales and Northern Ireland
20190 citationsauthor #4
Wrangling RNA: Antisense oligonucleotides for neurological disorders
201911 citationsauthor #1
Neuronal over-expression of Oxr1 is protective against ALS-associated mutant TDP-43 mislocalisation in motor neurons and neuromuscular defects in vivo
201923 citationsauthor #6
Do pain, anxiety and depression influence quality of life for people with amyotrophic lateral sclerosis/motor neuron disease? A national study reconciling previous conflicting literature
201940 citationsauthor #10
Genome-wide Analyses Identify KIF5A as a Novel ALS Gene in and for Therapeutic
2018362 citationsauthor #158
Initial Identification of a Blood-Based Chromosome Conformation Signature for Aiding in the Diagnosis of Amyotrophic Lateral Sclerosis
201823 citationsauthor #14
ALS-associated missense and nonsense TBK1 mutations can both cause loss of kinase function
201876 citationsauthor #23
Oligogenic genetic variation of neurodegenerative disease genes in 980 postmortem human brains
201822 citationsauthor #5
Towards a TDP-43-Based Biomarker for ALS and FTLD
2018121 citationsauthor #4
Frequency and signature of somatic variants in 1461 human brain exomes
201826 citationsauthor #7
Neurodegeneration in SCA14 is associated with increased PKCγ kinase activity, mislocalization and aggregation
201847 citationsauthor #9
Advances in therapy for spinal muscular atrophy: promises and challenges
2018214 citationsauthor #2
Prediction of personalised prognosis in patients with amyotrophic lateral sclerosis: development and validation of a prediction model
20183 citationsauthor #39
A chromosomal conformation signature for a priori prediction of ALS progression subtypes
20180 citationsauthor #13
Regional thalamic MRI as a marker of widespread cortical pathology and progressive frontotemporal involvement in amyotrophic lateral sclerosis
201850 citationsauthor #3
UFLC‐Derived CSF Extracellular Vesicle Origin and Proteome
201833 citationsauthor #7
Increased cerebral functional connectivity in ALS
201832 citationsauthor #5
Amyotrophic lateral sclerosis: the complex path to precision medicine
201841 citationsauthor #1
HDAC6 is a therapeutic target in mutant GARS-induced Charcot-Marie-Tooth disease
2018106 citationsauthor #10
Prognosis for patients with amyotrophic lateral sclerosis: development and validation of a personalised prediction model.
2018427 citationsauthor #39
Development and validation of Spasticity Index—Amyotrophic Lateral Sclerosis
201813 citationsauthor #13

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