L. Kleynhans

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Aliases
L Kleynhans, Leanie Kleynhans, Léanie Kleynhans
Publication record
64 papers · 1,202 citations · H-index 20

PAPERS

Characterizing the tuberculosis and type 2 diabetes mellitus comorbidity in a South African cohort using untargeted GCxGC-TOFMS metabolomics
20260 citationsauthor #2
Pre-existing adipose tissue signaling profile related to obesity determines disease outcome of COVID-19: addressing obesity should be a priority for future pandemic preparedness
20251 citationsauthor #11
Impact of Puberty on Immune Responses to Mycobacterium tuberculosis in South African Adolescents
20250 citationsauthor #1
Immune, metabolic, anatomical, and functional features of people after successful tuberculosis treatment: an exploratory analysis
20251 citationsauthor #15
Optimisation of bronchoalveolar lavage fluid preparation for mononuclear cell isolation and cytologic evaluation in free-ranging African elephants (Loxodonta africana).
20250 citationsauthor #8
Human alveolar macrophage function is impaired in tuberculosis contacts with diabetes
20251 citationsauthor #1
Human alveolar macrophage response to Mycobacterium tuberculosis: immune characteristics underlying large inter-individual variability
20257 citationsauthor #17
Prevalence of non‐communicable diseases among household contacts of people with tuberculosis: A systematic review and individual participant data meta‐analysis
20246 citationsauthor #22
Characterizing poorly controlled type 2 diabetes using 1H-NMR metabolomics
20245 citationsauthor #5
HUMAN ALVEOLAR MACROPHAGE FUNCTION IS IMPAIRED IN TUBERCULOSIS CONTACTS WITH DIABETES
20241 citationsauthor #2
T cell receptor repertoires associated with control and disease progression following Mycobacterium tuberculosis infection
202380 citationsauthor #50
Optimising the yield from bronchoalveolar lavage on human participants in infectious disease immunology research
20235 citationsauthor #22
PA-318 Comparative analysis of multiplex immunoassays for host biomarker profiling in tuberculosis diagnosis and TB treatment response
20230 citationsauthor #3
DETECTION OF ELEPHANT ENDOTHELIOTROPIC HERPESVIRUS (EEHV) IN FREE-RANGING AFRICAN ELEPHANTS (LOXODONTA AFRICANA) IN THE KRUGER NATIONAL PARK, SOUTH AFRICA
20235 citationsauthor #4
Understanding the biology, morbidity and social contexts of adolescent tuberculosis: a prospective observational cohort study protocol (Teen TB)
202212 citationsauthor #8
African wild dogs (Lycaon pictus) from the Kruger National Park, South Africa are currently not inbred but have low genomic diversity
20226 citationsauthor #7
cis-eQTL mapping of TB-T2D comorbidity elucidates the involvement of African ancestry in TB susceptibility
20225 citationsauthor #12
Neutrophil degranulation, NETosis and platelet degranulation pathway genes are co-induced in whole blood up to six months before tuberculosis diagnosis
202213 citationsauthor #4
Transcriptional profiles predict treatment outcome in patients with tuberculosis and diabetes at diagnosis and at two weeks after initiation of anti-tuberculosis treatment
202215 citationsauthor #10
Impaired resolution of blood transcriptomes through tuberculosis treatment with diabetes comorbidity
20224 citationsauthor #11
Culture-Independent PCR Detection and Differentiation of Mycobacteria spp. in Antemortem Respiratory Samples from African Elephants (Loxodonta Africana) and Rhinoceros (Ceratotherium Simum, Diceros Bicornis) in South Africa
202210 citationsauthor #3
Interplay Between the Immune and Endocrine Systems in the Lung: Implications for TB Susceptibility
202219 citationsauthor #4
Development of a cytokine gene expression assay for the relative quantification of the African elephant (Loxodonta africana) cell-mediated immune responses.
20212 citationsauthor #2
Cell-Mediated Immunological Biomarkers and Their Diagnostic Application in Livestock and Wildlife Infected With Mycobacterium bovis
202126 citationsauthor #2
Diagnosis of Mycobacterium bovis Infection in Free-Ranging Common Hippopotamus (Hippopotamus amphibius).
20217 citationsauthor #7
Mycobacterium tuberculosis-stimulated whole blood culture to detect host biosignatures for tuberculosis treatment response.
20216 citationsauthor #6
Improved detection of Mycobacterium tuberculosis and M. bovis in African wildlife samples using cationic peptide decontamination and mycobacterial culture supplementation
202119 citationsauthor #2
SEROLOGICAL EVIDENCE OF COXIELLA BURNETII INFECTION IN THE WHITE RHINOCEROS (CERATOTHERIUM SIMUM) IN SOUTH AFRICA
20215 citationsauthor #6
Review of Diagnostic Tests for Detection of Mycobacterium bovis Infection in South African Wildlife
202145 citationsauthor #14
Optimisation of the tuberculin skin test for detection of Mycobacterium bovis in African buffaloes (Syncerus caffer).
202110 citationsauthor #12
Mycobacterium bovis Infection in Free-Ranging African Elephants
202114 citationsauthor #10
The Peripheral Blood Transcriptome Is Correlated With PET Measures of Lung Inflammation During Successful Tuberculosis Treatment
202111 citationsauthor #5
Novel molecular transport medium used in combination with Xpert MTB/RIF ultra provides rapid detection of Mycobacterium bovis in African buffaloes
202112 citationsauthor #7
Use of PrimeStore® Molecular Transport Medium and Xpert MTB/RIF Ultra for Rapid Detection of Mycobacterium Bovis in African buffaloes (Syncerus Caffer).
20211 citationsauthor #7
Screening diabetes mellitus patients for pulmonary tuberculosis: a multisite study in Indonesia, Peru, Romania and South Africa.
202013 citationsauthor #10
RISK6, a 6-gene transcriptomic signature of TB disease risk, diagnosis and treatment response
2020124 citationsauthor #54
Targeting Suppressor T Cells
20200 citationsauthor #1
Mycobacterium tuberculosis infection: interaction with type 2 diabetes
20201 citationsauthor #7
RISK6, a 6-gene transcriptomic signature of TB disease risk, diagnosis and treatment response
20200 citationsauthor #54
GPR183 Regulates Interferons, Autophagy, and Bacterial Growth During Mycobacterium tuberculosis Infection and Is Associated With TB Disease Severity
202036 citationsauthor #8
The VetMAX™ M. tuberculosis complex PCR kit detects MTBC DNA in antemortem and postmortem samples from white rhinoceros (Ceratotherium simum), African elephants (Loxodonta africana) and African buffaloes (Syncerus caffer)
202012 citationsauthor #3
Use of the MILLIPLEX® bovine cytokine/chemokine multiplex assay to identify Mycobacterium bovis-infection biomarkers in African buffaloes (Syncerus caffer).
20206 citationsauthor #2
A cholesterol receptor regulates interferons and bacterial growth during M. tuberculosis infection
20200 citationsauthor #8
Implications of Interspecies Transmission and Diagnosis of Mycobacterium bovis Infection in Free-Ranging Common Hippopotamus (Hippopotamus amphibius)
20200 citationsauthor #7
Higher SARS-CoV-2 seroprevalence in workers with lower socioeconomic status in Cape Town, South Africa
202054 citationsauthor #9
Impact of Intermediate Hyperglycemia and Diabetes on Immune Dysfunction in Tuberculosis
202049 citationsauthor #10
Impact of Intermediate Hyperglycemia and Diabetes on Immune Dysfunction in Tuberculosis
202049 citationsauthor #43
The Xpert MTB/RIF Ultra assay detects Mycobacterium tuberculosis complex DNA in white rhinoceros (Ceratotherium simum) and African elephants (Loxodonta africana)
202022 citationsauthor #3
Diabetes Mellitus Among Pulmonary Tuberculosis Patients From 4 Tuberculosis-endemic Countries: The TANDEM Study
202043 citationsauthor #10
Diabetes mellitus among pulmonary tuberculosis patients from four TB-endemic countries: the TANDEM study.
201946 citationsauthor #9
Comprehensive Characterization of the Attenuated Double Auxotroph Mycobacterium tuberculosisΔleuDΔpanCD as an Alternative to H37Rv
201936 citationsauthor #5
Distinct serum biosignatures are associated with different tuberculosis treatment outcomes
201929 citationsauthor #3
The potential of imaging tools as correlates of infection and disease for new TB vaccine development.
20187 citationsauthor #2
Patients with Concurrent Tuberculosis and Diabetes Have a Pro-Atherogenic Plasma Lipid Profile
201853 citationsauthor #3
Diabetes screen during tuberculosis contact investigations highlights opportunity for new diabetes diagnosis and reveals metabolic differences between ethnic groups.
201820 citationsauthor #2
Disease characteristics and treatment of patients with diabetes mellitus attending government health services in Indonesia, Peru, Romania and South Africa
201821 citationsauthor #17
Changes in Host Immune–Endocrine Relationships during Tuberculosis Treatment in Patients with Cured and Failed Treatment Outcomes
201718 citationsauthor #1
The Functional Response of B Cells to Antigenic Stimulation: A Preliminary Report of Latent Tuberculosis
201630 citationsauthor #2
B‐cells with a FasL expressing regulatory phenotype are induced following successful anti‐tuberculosis treatment
201620 citationsauthor #2
Clinical immunology and multiplex biomarkers of human tuberculosis.
201538 citationsauthor #4
Mycobacterium bovis BCG infection severely delays Trichuris muris expulsion and co-infection suppresses immune responsiveness to both pathogens
201412 citationsauthor #3
The Contraceptive Depot Medroxyprogesterone Acetate Impairs Mycobacterial Control and Inhibits Cytokine Secretion in Mice Infected with Mycobacterium tuberculosis
201336 citationsauthor #1
Acute helminth infection enhances early macrophage mediated control of mycobacterial infection
201239 citationsauthor #2
Medroxyprogesterone Acetate Alters Mycobacterium Bovis BCG-Induced Cytokine Production in Peripheral Blood Mononuclear Cells of Contraceptive Users
201138 citationsauthor #1

TIMELINE

2011 38 citations

2012 39 citations

2013 36 citations

2014 12 citations

2015 38 citations

2016 50 citations

2017 18 citations

2018 101 citations

2019 111 citations

2020 360 citations

2021 158 citations

2022 84 citations

2023 90 citations

2024 12 citations

2025 10 citations

2026 0 citations

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