R. Iozzo

Catabolic degradation of endothelial VEGFA via autophagy.
20250 citationsauthor #4
Conditional expression of endorepellin in the tumor vasculature attenuates breast cancer growth, angiogenesis and hyaluronan deposition.
20235 citationsauthor #7
Global impact of proteoglycan science on human diseases
202331 citationsauthor #3
The centrality of proteoglycan research: Expect the unexpected
20230 citationsauthor #1
Abstract 1636: Progranulin modulates RYK and EGFR activity in mesothelioma cells
20230 citationsauthor #2
Decorin suppresses tumor lymphangiogenesis: A mechanism to curtail cancer progression
20237 citationsauthor #4
Progranulin and EGFR modulate RYK (Receptor like Tyrosine Kinase) sorting and stability in mesothelioma cells.
20234 citationsauthor #3
Corneal injury is associated with stromal and vascular alterations within cranial dura mater
20231 citationsauthor #8
Emilin2 fosters vascular stability by promoting pericyte recruitment.
20237 citationsauthor #9
Progranulin Oncogenic Network in Solid Tumors
202317 citationsauthor #8
Decorin evokes reversible mitochondrial depolarization in carcinoma and vascular endothelial cells.
20226 citationsauthor #3
Oncosuppressive roles of decorin through regulation of multiple receptors and diverse signaling pathways.
202243 citationsauthor #5
Complexity of progranulin mechanisms of action in mesothelioma
20226 citationsauthor #5
The Role of Decorin Proteoglycan in Mitophagy
202214 citationsauthor #2
Abstract 97: Mechanisms of action and regulation of the progranulin/EphA2 axis in mesothelioma
20220 citationsauthor #5
Decorin regulates collagen fibrillogenesis during corneal wound healing in mouse in vivo.
202234 citationsauthor #6
POS-675 DECORIN DEFICIENCY EXACERBATES PERITONEAL INFLAMMATION AND FIBROSIS IN A MURINE MODEL OF PERITONEAL DIALYSIS
20220 citationsauthor #4
Multimerin-2 orchestrates the cross-talk between endothelial cells and pericytes: A mechanism to maintain vascular stability
202113 citationsauthor #12
388 Haemodynamic arterial changes in heart failure: a proposed new paradigm of heart and vessels failure. The Copernican revolution?
20210 citationsauthor #3
Novel regulatory roles of small leucine-rich proteoglycans in remodeling of the uterine cervix in pregnancy.
202117 citationsauthor #6
miR-21 Plays a Dual Role in Tumor Formation and Cytotoxic Response in Breast Tumors
202140 citationsauthor #11
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
20213,716 citationsauthor #1048
The functional role of decorin in corneal neovascularisation in vivo.
202126 citationsauthor #9
89A novel ocular function for decorin in the aqueous humor outflow.
202118 citationsauthor #6
Extracellular matrix guidance of autophagy: a mechanism regulating cancer growth
202129 citationsauthor #2
Hemodynamic arterial changes in heart failure: a proposed new paradigm of "Heart and Vessels Failure (HVF)".
20215 citationsauthor #3
A functional outside-in signaling network of proteoglycans and matrix molecules regulating autophagy.
202123 citationsauthor #5
Hemodynamic arterial changes in heart failure. a proposed new paradigm of heart and vessels failure. The Copernican revolution
20210 citationsauthor #3
Decorin—An Antagonist of TGF-β in Astrocytes of the Optic Nerve
202116 citationsauthor #4
The Role of Decorin and Biglycan Signaling in Tumorigenesis
202156 citationsauthor #5
A simplified aortic ring assay: A useful ex vivo method to assess biochemical and functional parameters of angiogenesis
202033 citationsauthor #3
Complexity of matrix phenotypes
202024 citationsauthor #1
Discoidin Domain Receptor 1 functionally interacts with the IGF-I system in bladder cancer
20207 citationsauthor #8
Proteoglycan signaling in tumor angiogenesis and endothelial cell autophagy.
202055 citationsauthor #4
Endorepellin, the Angiostatic Module of Perlecan, Interacts with Both the (cid:1) 2 (cid:2) 1 Integrin and Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) A DUAL RECEPTOR ANTAGONISM
202010 citationsauthor #10
Angiostatic cues from the matrix: Endothelial cell autophagy meets hyaluronan biology
202013 citationsauthor #2
Deregulated expression of Elastin Microfibril Interfacer 2 (EMILIN2) in gastric cancer affects tumor growth and angiogenesis
202017 citationsauthor #12
Transcriptomic profiling of fetal membranes of mice deficient in biglycan and decorin as a model of preterm birth †
20204 citationsauthor #7
Proteoglycan-driven Autophagy: A Nutrient-independent Mechanism to Control Intracellular Catabolism
202017 citationsauthor #4
Progranulin/EphA2 axis: A novel oncogenic mechanism in bladder cancer.
202030 citationsauthor #6
Endorepellin evokes an angiostatic stress signaling cascade in endothelial cells
202022 citationsauthor #3
Angiostatic cues from the matrix: Endothelial cell autophagy meets hyaluronan biology.
20202 citationsauthor #2
Autophagic degradation of HAS2 in endothelial cells: A novel mechanism to regulate angiogenesis.
202028 citationsauthor #7
Catabolic degradation of endothelial VEGFA via autophagy
202031 citationsauthor #4
Decorin deficiency promotes epithelial-mesenchymal transition and colon cancer metastasis.
202052 citationsauthor #9
Multimerin-2 maintains vascular stability and permeability.
202042 citationsauthor #13
Catabolic degradation of endothelial VEGFA via autophagy
20200 citationsauthor #4
Tumor-suppressive functions of 4-MU on breast cancer cells of different ER status: Regulation of hyaluronan/HAS2/CD44 and specific matrix effectors.
201971 citationsauthor #6
Matrix Biologists in Action.
20192 citationsauthor #1
Prostate cancer sheds the αvβ3 integrin in vivo through exosomes.
201993 citationsauthor #14
Extracellular matrix: the gatekeeper of tumor angiogenesis.
201933 citationsauthor #5
Methods for Monitoring Matrix-Induced Autophagy.
201921 citationsauthor #3
Matrix modeling and remodeling: A biological interplay regulating tissue homeostasis and diseases.
2019226 citationsauthor #4
Biglycan evokes autophagy in macrophages via a novel CD44/Toll-like receptor 4 signaling axis in ischemia/reperfusion injury.
201999 citationsauthor #18
Second-harmonic generation microscopy analysis reveals proteoglycan decorin is necessary for proper collagen organization in prostate
201916 citationsauthor #4
Dissecting the role of hyaluronan synthases in the tumor microenvironment
201985 citationsauthor #4
Extracellular matrix: The driving force of mammalian diseases.
2018200 citationsauthor #1
Endorepellin remodels the endothelial transcriptome toward a pro-autophagic and pro-mitophagic gene signature
201819 citationsauthor #6
Analysis of Progranulin-Mediated Akt and MAPK Activation.
20188 citationsauthor #6
Serglycin promotes breast cancer cell aggressiveness: Induction of epithelial to mesenchymal transition, proteolytic activity and IL-8 signaling.
201857 citationsauthor #7
Systemic Factors Trigger Vasculature Cells to Drive Notch Signaling and Neurogenesis in Neural Stem Cells in the Adult Brain
201837 citationsauthor #4
Decorin modulates melanoma cell migration: Diverse effects caused by differential glycanation of the protein core
20180 citationsauthor #4
Proteoglycan Chemical Diversity Drives Multifunctional Cell Regulation and Therapeutics.
2018287 citationsauthor #14
Stepwise impairment of neural stem cell proliferation and neurogenesis concomitant with disruption of blood-brain barrier in recurrent ischemic stroke.
201821 citationsauthor #6
Metabolic reprogramming of murine cardiomyocytes during autophagy requires the extracellular nutrient sensor decorin
201825 citationsauthor #5
Autophagy regulates hyaluronan synthase 2 levels in vascular endothelial cells
20180 citationsauthor #6
OF THE ITALIAN SOCIETY FOR THE STUDY OF CONNECTIVE TISSUES SISC 2018 Pavia , 26-27 October 2018
20180 citationsauthor #17
Dual regulation of decorin by androgen and Hedgehog signaling during prostate morphogenesis
20185 citationsauthor #5
The angiostatic molecule Multimerin 2 is processed by MMP-9 to allow sprouting angiogenesis.
201769 citationsauthor #11
The nature and biology of basement membranes.
2017481 citationsauthor #3
Proteoglycan neofunctions: regulation of inflammation and autophagy in cancer biology
2017143 citationsauthor #4
Dissecting the CD93-Multimerin 2 interaction involved in cell adhesion and migration of the activated endothelium.
201765 citationsauthor #12
The perlecan-interacting growth factor progranulin regulates ubiquitination, sorting, and lysosomal degradation of sortilin.
201730 citationsauthor #9
Transcriptomic profiling of fetal membranes in a mouse model of preterm birth
20170 citationsauthor #6
Decorin-evoked paternally expressed gene 3 (PEG3) is an upstream regulator of the transcription factor EB (TFEB) in endothelial cell autophagy
201744 citationsauthor #4
A current view of perlecan in physiology and pathology: A mosaic of functions.
2017184 citationsauthor #3
c‐Src, Insulin‐Like Growth Factor I Receptor, G‐Protein‐Coupled Receptor Kinases and Focal Adhesion Kinase are Enriched Into Prostate Cancer Cell Exosomes
201792 citationsauthor #5
Decorin and biglycan are necessary for maintaining collagen fibril structure, fiber realignment, and mechanical properties of mature tendons.
2017185 citationsauthor #10
Steroid Hormones Are Key Modulators of Tissue Mechanical Function via Regulation of Collagen and Elastic Fibers
201774 citationsauthor #5
Abstract 1344: Progranulin promotes ubiquitination, sorting and lysosomal degradation of sortilin in castration-resistant prostate cancer cells
20170 citationsauthor #6
Decorin is a devouring proteoglycan: Remodeling of intracellular catabolism via autophagy and mitophagy.
201777 citationsauthor #3
Decorin-inducible Peg3 Evokes Beclin 1-mediated Autophagy and Thrombospondin 1-mediated Angiostasis*
201757 citationsauthor #3
Endorepellin-evoked Autophagy Contributes to Angiostasis *
201641 citationsauthor #5
MP61-13 PROGRANULIN TARGETING IN UROTHELIAL CANCER CELLS INHIBITS MOTILITY, ANCHORAGE-INDEPENDENT GROWTH, TUMOR FORMATION IN VIVO AND SENSITIZES CELLS TO CISPLATIN
20160 citationsauthor #13
EphA2 is a functional receptor for the growth factor progranulin
2016125 citationsauthor #8
Decorin as a multivalent therapeutic agent against cancer.
2016129 citationsauthor #3
Suppression of progranulin expression inhibits bladder cancer growth and sensitizes cancer cells to cisplatin
201629 citationsauthor #13
417. Intratumoral Delivery of Oncolytic Adenovirus Expressing Decorin Inhibits Growth and Metastases of 4T1 Breast Tumors in Syngeneic Immune Competent BALB/c Mice Model
20162 citationsauthor #9
A novel biological function of soluble biglycan: Induction of erythropoietin production and polycythemia
20160 citationsauthor #8
A novel biological function of soluble biglycan: Induction of erythropoietin production and polycythemia
201619 citationsauthor #8
αvβ6 Integrin Promotes Castrate-Resistant Prostate Cancer through JNK1-Mediated Activation of Androgen Receptor.
201630 citationsauthor #9
An Essential Role for SHARPIN in the Regulation of Caspase 1 Activity in Sepsis.
201625 citationsauthor #12
Oncogenic activin C interacts with decorin in colorectal cancer in vivo and in vitro
201617 citationsauthor #6
Altered matrix stiffness in decorin-null articular cartilage results in improved resistance to osteoarthritis induced by forced exercise
20160 citationsauthor #6
Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356
201650 citationsauthor #881
Decorin interacting network: A comprehensive analysis of decorin-binding partners and their versatile functions.
2016197 citationsauthor #4
Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation
201649 citationsauthor #20
Bimodal role of NADPH oxidases in the regulation of biglycan-triggered IL-1β synthesis.
201652 citationsauthor #11
Abstract 698: Progranulin targeting in urothelial cancer cells inhibits motility, tumor growthin vitroandin vivoand sensitizes cells to cisplatin
20160 citationsauthor #13
Endostatin and endorepellin: A common route of action for similar angiostatic cancer avengers.
2016117 citationsauthor #2

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