K. Sakane

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Aliases
K Sakane, Kazuo Sakane
Publication record
109 papers · 916 citations · H-index 15

PAPERS

PROCESS FOR PREPARATION THEREOF
20170 citationsauthor #5
A Novel Chiral Oxycarbonyl Rearrangement.
20100 citationsauthor #2
Epimerization Induced by a Remote Cationic Center in Potent New Carbapenems.
20100 citationsauthor #5
anti‐Helicobacter pylori Agents. Part 5. 2‐(Substituted guanidino)‐4‐arylthiazoles and Aryloxazole Analogues.
20100 citationsauthor #4
A Concise, Practical Synthesis of the Pyrido(3.2.1-ij)cinnoline Ring System of Potent DNA Gyrase Inhibitors.
20101 citationsauthor #6
Metabolism investigation leading to novel drug design: orally active prostacyclin mimetics. Part 4.
20051 citationsauthor #9
Discovery of new diphenyloxazole derivatives containing a pyrrolidine ring: orally active prostacyclin mimetics. Part 2.
20059 citationsauthor #8
Discovery of diphenyloxazole and Ndelta-Z-ornithine derivatives as highly potent and selective human prostaglandin EP(4) receptor antagonists.
200514 citationsauthor #12
Discovery of diphenylcarbamate derivatives as highly potent and selective IP receptor agonists: orally active prostacyclin mimetics. Part 3.
200517 citationsauthor #10
Corrigendum to “Structure-Based de novo design of non-nucleoside adenosine deaminase inhibitors” [Bioorg. Med. Chem. Lett. 13 (2003) 1115]☆
20033 citationsauthor #10
Structure-based de novo design of non-nucleoside adenosine deaminase inhibitors.
200316 citationsauthor #10
Anti-Helicobacter pylori agents. 5. 2-(Substituted guanidino)-4-arylthiazoles and aryloxazole analogues.
200213 citationsauthor #4
Design, Synthesis and Biological Evaluation of a Novel Series of Potent, Orally Active Adenosine A1 Receptor Antagonists with High Blood—Brain Barrier Permeability.
20021 citationsauthor #7
Synthesis and antibacterial evaluation of novel 2-[N-Imidoylpyrrolidinyl] carbapenems.
200212 citationsauthor #6
Design, synthesis and biological evaluation of a novel series of potent, orally active adenosine A1 receptor antagonists with high blood-brain barrier permeability.
200121 citationsauthor #7
Orally active cephalosporins: synthesis, structure-activity relationships and oral absorption of 3-[(E) and (Z)-2-substituted vinyl]-cephalosporins.
200011 citationsauthor #6
In Vitro Activities of a New Lipopeptide Antifungal Agent, FK463, against a Variety of Clinically Important Fungi
2000299 citationsauthor #13
Synthesis and Biological Properties of a Novel Cephalosporin FR86521 Having Potent Activity Against Methicillin-Resistant Staphylococcus aureus (MRSA).
20000 citationsauthor #5
Novel adenosine A1 receptor antagonists. Synthesis and structure-activity relationships of a novel series of 3-(2-cyclohexenyl-3-oxo-2,3-dihydropyridazin-6-yl)-2-phenylpyrazolo[1,5 -a]pyridines.
200018 citationsauthor #7
A novel pyridazinone derivative as a nonprostanoid PGI2 agonist.
200021 citationsauthor #7
Orally active cephalosporins. Part 2: synthesis, structure-activity relationships and oral absorption of cephalosporins having a C-3 pyridyl side chain.
20005 citationsauthor #5
Anti-Helicobacter pylori Agents. Part 4. 2-(Substituted guanidino)-4-phenylthiazoles and Some Structurally Rigid Derivatives.
20002 citationsauthor #4
Discovery of FR166124, a Novel Water‐Soluble Pyrazolo[1,5‐a]pyridine Adenosine A1 Receptor Antagonist.
19990 citationsauthor #8
Synthesis of the water-soluble adenosine A1 receptor antagonist FR166124 through a novel sequential Horner-Emmons / isomerization reaction
19998 citationsauthor #8
Discovery of FR166124, a novel water-soluble pyrazolo-[1,5-a]pyridine adenosine A1 receptor antagonist.
199934 citationsauthor #8
Synthesis and biological properties of a novel cephalosporin FR86521 having potent activity against methicillin-resistant Staphylococcus aureus (MRSA)
19992 citationsauthor #5
Anti-Helicobacter pylori Agents. Part 2. Structure Activity Relationships in a New Series of 2-Alkylguanidino-4-furylthiazoles.
19980 citationsauthor #4
Epimerization Induced by a Remote Cationic Center in Potent New Carbapenems
19975 citationsauthor #5
Studies on 3'-quaternary ammonium cephalosporins--IV. Synthesis and antibacterial activity of 3'-(2-alkyl-3-aminopyrazolium) cephalosporins related to FK037.
199710 citationsauthor #6
Studies on β-Lactam Antibiotics. Synthesis and Antibacterial Activity of Novel 1β-Methylcarbapenems Related to FR21818: 5- Membered Ring Analogues.
19970 citationsauthor #10
Anti-Helicobacter pylori agents. 1. 2-(Alkylguanidino)-4-furylthiazoles and related compounds.
199710 citationsauthor #4
Studies on 3'-quaternary ammonium cephalosporins--III. Synthesis and antibacterial activity of 3'-(3-aminopyrazolium) cephalosporins.
199714 citationsauthor #6
Studies on β‐Lactam Antibiotics. Synthesis and Antibacterial Activity of Novel C‐3 Alkyne‐Substituted Cephalosporins.
19971 citationsauthor #7
Synthesis and Biological Evaluation of Novel 2‐Vinyl Carbapenems. Remarkable DHP‐1 Stability of 1′‐Substituted Analogues.
19970 citationsauthor #6
Studies on beta-lactam antibiotics. Synthesis and antibacterial activity of novel C-3 alkyne-substituted cephalosporins.
19977 citationsauthor #7
Studies on β-lactam antibiotics. Synthesis and antibacterial activity of novel 1β-methylcarbapenems related to FR21818: 5-membered ring analogs
199710 citationsauthor #10
Synthesis and biological evaluation of novel 2-vinyl carbapenems. Remarkable DHP-1 stability of 1′-substituted analogs
19964 citationsauthor #6
Synthesis and Antibacterial Activity of FR21818, a New, Potent 1β‐ Methylcarbapenem.
19960 citationsauthor #12
Asymmetric Synthesis of FR165914: A Novel β3‐Adrenergic Agonist with a Benzocycloheptene Structure.
19963 citationsauthor #7
Alkylation of 1‐(N‐(Hydroxymethyl)‐N‐methylamino)‐4‐quinolones. An Improved Preparation of Intermediates for Novel Potent Tricyclic Quinolone Antibacterial Agents.
19960 citationsauthor #5
Synthesis of New 1,8-Bridged Tricyclic Quinolones by a Novel Intramolecular Arylation of N-1 Tethered Malonamides.
19960 citationsauthor #5
A Novel Synthesis of the Pyrazolo(1,5-a)quinoline Ring System. New N1- C2 Bridged DNA Gyrase Inhibitors via a Novel Tandem 1,4-Conjugate Addition-Michael (3 + 2) Annulation Process.
19960 citationsauthor #5
A novel synthesis of the pyrazolo[1,5-a]quinoline ring system. New N1-C2 bridged DNA gyrase inhibitors via a novel tandem 1,4-conjugate addition-Michael [3+2] annulation process
199615 citationsauthor #5
New reagents for controlled release of nitric oxide. Structure-stability relationships
199640 citationsauthor #9
A novel [3 + 2] annulation: synthesis and X-ray crystallographic structure of a novel tetrahydropyrazolo[1,5-a] quinoline, an intermediate towards new tricyclic quinolone antibacterials
19966 citationsauthor #4
A Novel (3 + 2) Annulation: Synthesis and X-Ray Crystallographic Structure of a Novel Tetrahydropyrazolo(1,5-a)quinoline, an Intermediate Towards New Tricyclic Quinolone Antibacterials.
19960 citationsauthor #4
Alkylation of 1-(N-(Hydroxymethyl)-N-methylamino)-4-quinolones. An Improved Preparation of Intermediates for Novel Potent Tricyclic Quinolone Antibacterial Agents.
19967 citationsauthor #5
Studies on 3′-Quaternary Ammonium Cephalosporins. Part 2. Synthesis and Antibacterial Activity of 7β-((Z)-2-(2-Aminothiazol-4-yl)-2- methoxyiminoacetamido)cephalosporin Derivatives Bearing Various Quaternary Ammonium Methyl Groups at the 3 Position.
19960 citationsauthor #5
New Reagents for Controlled Release of Nitric Oxide. Structure‐ Stability Relationships.
19961 citationsauthor #9
Studies on 3'-Quaternary Ammonium Cephalosporins II1)
19954 citationsauthor #5
Studies on 3'-quaternary ammonium cephalosporins. II. Synthesis and antibacterial activity of 7 beta-[(Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-cephalospori n derivatives bearing various quaternary ammonium methyl groups at the 3 position.
19951 citationsauthor #5
A Concise, Practical Synthesis of the Pyrido[3,2,1-i,j]Cinnoline Ring System of Potent DNA Gyrase Inhibitors
199514 citationsauthor #6
Synthesis and antibacterial activity of FR21818, a new, potent 1β-methylcarbapenem
19958 citationsauthor #12
Asymmetric synthesis of FR165914: A novel β3-adrenergic agonist with a benzocycloheptene structure
199529 citationsauthor #7
[Research and development of new oral cephems, cefixime and cefdinir].
199319 citationsauthor #1
FK037, a new parenteral cephalosporin with a broad antibacterial spectrum: synthesis and antibacterial activity.
199319 citationsauthor #5
[A new oral cephem, cefdinir: its structure-activity relationships and biological profile].
199210 citationsauthor #1
Revised structure and the chemical transformations of FR900148.
19915 citationsauthor #2
A novel chiral oxycarbonyl rearrangement
19911 citationsauthor #2
Studies on FK482 (Cefdinir). Part 3. Synthesis and Structure-Activity Relationships of 7β-((Z)-2-Aryl-2-hydroxyiminoacetamido)-3-vinyl- 3-cephem-4-carboxylic Acid Derivatives.
19911 citationsauthor #2
Process for the preparation of 3,7-disubstituted-3-cephem-4-carboxylic acid
19910 citationsauthor #4
Studies on beta-lactam antibiotics. XIX. Structure-activity relationships of cephalosporins having a thiadiazolylthiomethyl group at the C-3 side chain.
19914 citationsauthor #3
Studies on FK482 (Cefdinir). Part 4. Synthesis and Structure—Activity Relationships of 7β-(Z-2- (2-Aminothiazol-4-yl)-2-hydroxyliminoacetamido)-3-Substituted Cephalosporin Derivatives.
19910 citationsauthor #2
Synthesis and antifungal activity of FR109615 analogs.
199127 citationsauthor #5
A process for preparing 2-methoxyimino-2- (5-amino-1,2,4-thiadiazol-3-yl) acetic acid or its salts.
19900 citationsauthor #1
[Studies on FK482 (Cefdinir). IV. Synthesis and structure-activity relationships of 7 beta-[(Z)-2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido]- 3-substituted cephalosporin derivatives].
19903 citationsauthor #2
Synthesis and antibacterial activity of 7 beta-[1-(2-aminothiazol-4-yl)-1-cyclopropanecarboxyamido]cephem derivatives.
19903 citationsauthor #4
Synthesis and β-Lactamase Inhibitory Activity of 3-Cyano-3-cephem Derivatives
19903 citationsauthor #6
Synthesis and biological activity of 3-vinylthio- and 3-vinylthiomethylcephem derivatives.
19907 citationsauthor #5
[Studies on FK482. II. Synthesis and structure-activity relationships of 7 beta-[(Z)-2-(2-aminothiazol-4-yl)-2-substituted acetamido]-3-vinyl-3-cephem-4-carboxylic acid derivatives].
19900 citationsauthor #3
Studies on FK482. Part 2. Synthesis and Structure-Activity Relationships of 7β-(Z-2-(2-Aminothiazol-4-yl)-2-Substituted-acetamido)-3-vinyl-3-cephem-4-# carboxylic Acid Derivatives.
19900 citationsauthor #3
Synthesis and beta-lactamase inhibitory activity of 7 alpha-hydroxyethyl cephem sulfone and sulfoxide derivatives.
19907 citationsauthor #6
[Studies on FK482 (Cefdinir). III. Synthesis and structure-activity relationships of 7 beta-[(Z)-2-aryl-2-hydroxyiminoacetamido]-3-vinyl-3- cephem-4-carboxylic acid derivatives].
19903 citationsauthor #2
Method for the preparation of pharmacologically valuable cephem compound
19890 citationsauthor #1
SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF A NEW ORALLY ACTIVE CEPHALOSPORIN, CEFIXIME, AND ITS RELATED COMPOUNDS
19890 citationsauthor #5
Synthesis and beta-lactamase inhibitory activity of 7 alpha-hydroxyethyl cephem derivatives.
19897 citationsauthor #6
Synthesis and biological activity of 7 alpha-hydroxyethyl-1-oxacephem derivatives.
198911 citationsauthor #6
Cephalosporin compounds and processes for their preparation
19890 citationsauthor #1
Water-soluble antibiotic preparation
19880 citationsauthor #1
A process for preparing pharmacologically valuable cephem compound
19880 citationsauthor #1
Foerfarande Foer framstaellning of pharmacologically anvaendbara vattenloesliga salts of cefemfoereningar
19880 citationsauthor #1
Cephem compounds and process for their preparation.
19860 citationsauthor #1
Structure activity relationships of synthetic antibiotic analogues of chryscandin.
19859 citationsauthor #2
Structure and total synthesis of chryscandin, a new antifungal antibiotic
198518 citationsauthor #7
SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF NOVEL CEPHALOSPORINS. CEPHALOSPORINS WITH AMINOHETEROAROMATICS AT THE 7-POSITION
19850 citationsauthor #1
Studies of 7 beta-[2-(aminoaryl)acetamido]-cephalosporin derivatives. II. Synthesis and structure-activity relationships in the aminopyrimidine series.
198417 citationsauthor #2
Chryscandin, a novel peptidyl nucleoside antibiotic. II. Structure determination and synthesis.
198419 citationsauthor #7
Studies of 7 beta-[2-(aminoaryl)acetamido]-cephalosporin derivatives. I. Synthesis and structure-activity relationships in the aminopyridine series.
19842 citationsauthor #2
Studies of 7 beta-[2-(aminoaryl)acetamido]-cephalosporin derivatives. III. Synthesis and structure-activity relationships in the aminothiadiazole series.
19846 citationsauthor #2
Intermediates for the production of cephem compounds, processes for their production and their application.
19830 citationsauthor #2
Novel cephem compound, its preparation and prophylactic or remedy for microbism
19800 citationsauthor #2
Cephem compounds, processes for their preparation, pharmaceutical compositions containing them, intermediates and their preparation
19800 citationsauthor #2
A process for preparing cephem derivatives and cepham
19790 citationsauthor #2
pyridine derivatives of Preparation Method and new products obtained
19790 citationsauthor #4
A process for preparing cephem compounds
19790 citationsauthor #2
Frefmgangsmaade for the preparation of cephalosporanic acid derivatives
19780 citationsauthor #4
Cephalosporansaeurederivate, methods for their manufacture and pharmaceutical-containing medium
19780 citationsauthor #4
Derivatives of cephalosporanic acid, processes for their preparation and pharmaceutical composition containing them
19780 citationsauthor #4
Acids 3-cephem-4-carboxylic 3,7-disubstituted and their use as antibacterial agents
19770 citationsauthor #6
3,7-disubstituted-3-cephem-4- carbonsaeureverbindungen, processes for their preparation and pharmaceutical compositions containing them
19770 citationsauthor #4

TIMELINE

1974 18 citations

1975 0 citations

1977 0 citations

1978 0 citations

1979 0 citations

1980 0 citations

1983 0 citations

1984 44 citations

1985 27 citations

1986 0 citations

1988 0 citations

1989 18 citations

1990 26 citations

1991 38 citations

1992 10 citations

1993 38 citations

1995 56 citations

1996 76 citations

1997 57 citations

1998 0 citations

1999 44 citations

2000 356 citations

2001 21 citations

2002 26 citations

2003 19 citations

2005 41 citations

2010 1 citations

2017 0 citations

K. Sakane

PROFILE

PAPERS

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