R. Shiekhattar

PROFILE

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Aliases
R Shiekhattar, R. Shiekhattar, Ramin Shiekhattar
Publication record
176 papers · 36,666 citations · H-index 74

PAPERS

Unbalanced chromatin binding of Polycomb complexes drives neurodevelopmental disorders.
20260 citationsauthor #27
Bypass of blocking lesions by RNAPII reveals a novel stress induced by DNA damage.
20260 citationsauthor #7
The MLLT3 YEATS domain is a dual reader of histone marks (H3K9/18/27ac/cr) and ncRNA (7SK), linking epigenetic and RNA signaling to regulate hematopoiesis
20250 citationsauthor #10
Fine-tuning of gene expression through the Mettl3-Mettl14-Dnmt1 axis controls ESC differentiation.
202523 citationsauthor #35
Integrator promotes the association of TFIID and RNA polymerase II to maintain pluripotency during development.
20250 citationsauthor #19
Retinoic acid and ascorbate synergize to suppress myeloid leukemia via TET2 activation
20250 citationsauthor #14
Bypass of Blocking Lesions by RNAPII Impairs the Transcriptional DNA Damage Response
20250 citationsauthor #7
Balancing Activation and Repression: CoREST-p300 Antagonism Controls Retinoic Acid-Driven Differentiation in AML
20250 citationsauthor #10
TAF1 is required for fetal but not adult hematopoiesis in mice.
20252 citationsauthor #11
Integrator 20th anniversary: a molecular machine indispensable in development and disease.
20250 citationsauthor #2
Synergistic targeting of KMT2A-rearranged AML with combined LSD1 and menin inhibitors
20250 citationsauthor #11
Co-targeting menin and LSD1 dismantles oncogenic programs and restores differentiation in MLL-rearranged AML
20250 citationsauthor #13
Enhancing transcriptome mapping with rapid PRO-seq profiling of nascent RNA.
20250 citationsauthor #7
Enhancing Transcriptome Mapping with Rapid PRO-seq Profiling of Nascent RNA
20241 citationsauthor #6
Tetrameric INTS6-SOSS1 complex facilitates DNA:RNA hybrid autoregulation at double-strand breaks
20247 citationsauthor #10
Neuronal differentiation requires BRAT1 complex to remove REST from chromatin
20248 citationsauthor #6
Arginine Methylation of BRD4 By CARM1 Regulates Its Function in AML
20230 citationsauthor #7
The LSD1 Inhibitor Ory-1001 (ladademstat) in Combination with Menin Inhibitor SNDX-5613 (revumenib) Has Synergistic in Vitro Activity in KMT2A-Rearranged AML Models
20231 citationsauthor #3
TAF1, the Largest Subunit of Tfiid, Is Dispensable for Adult Hematopoiesis
20230 citationsauthor #9
Oxidized mC modulates synthetic lethality to PARP inhibitors for the treatment of leukemia
202313 citationsauthor #20
BRAT1 associates with INTS11/INTS9 heterodimer to regulate key neurodevelopmental genes
20233 citationsauthor #5
Abstract 2436: The multi-faceted Integrator complex in Notch-driven esophageal cancer
20230 citationsauthor #5
PRAME induces genomic instability in uveal melanoma
202317 citationsauthor #16
PRAME induces genomic instability in uveal melanoma
20237 citationsauthor #14
It's a DoG-eat-DoG world-altered transcriptional mechanisms drive downstream-of-gene (DoG) transcript production.
202223 citationsauthor #2
AMPK Downregulates Histone Gene Expression Via Dissociation of a Chromatin-Associated Transcription Complex in Response to Metabolic Stress in Acute Lymphoblastic Leukemia
20220 citationsauthor #4
Protein Kinase D–Dependent Downregulation of Immediate Early Genes through Class IIA Histone Deacetylases in Acute Lymphoblastic Leukemia
20212 citationsauthor #6
NACK and INTEGRATOR act coordinately to activate Notch-mediated transcription in tumorigenesis
202111 citationsauthor #6
Age-Acquired Downregulation of Lmna Leads to Epigenetic Deregulation and Altered HSPC Function
20213 citationsauthor #5
A CADM3 variant causes Charcot-Marie-Tooth disease with marked upper limb involvement.
202115 citationsauthor #10
NACK and INT coordinately activate Notch-mediated transcription in tumorigenesis
20210 citationsauthor #6
RAC1 plays an essential role in estrogen receptor alpha function in breast cancer cells
202115 citationsauthor #8
Clinical Responsiveness to All-trans Retinoic Acid Is Potentiated by LSD1 Inhibition and Associated with a Quiescent Transcriptome in Myeloid Malignancies
202135 citationsauthor #12
Identification of long noncoding RNAs in injury-resilient and injury-susceptible mouse retinal ganglion cells
20214 citationsauthor #6
The Integrator complex regulates microRNA abundance through RISC loading
202121 citationsauthor #9
NACK and INTEGRATOR act coordinately to activate Notch-mediated transcription in tumorigenesis
20210 citationsauthor #6
ATAD3A has a scaffolding role regulating mitochondria inner membrane structure and protein assembly
202155 citationsauthor #8
Erratum to: A CADM3 variant causes Charcot-Marie-Tooth disease with marked upper limb involvement.
20211 citationsauthor #10
Dietary palmitic acid promotes a prometastatic memory via Schwann cells
2021226 citationsauthor #14
Identification of Long Noncoding RNAs in Distinct Subtypes of Mouse Retinal Ganglion Cells
20210 citationsauthor #4
Integrator enforces the fidelity of transcriptional termination at protein-coding genes
202140 citationsauthor #14
The Integrator complex at the crossroad of coding and noncoding RNA.
202051 citationsauthor #4
Targeted chemotherapy overcomes drug resistance in melanoma
202029 citationsauthor #13
Integrator restrains paraspeckles assembly by promoting isoform switching of the lncRNA NEAT1
202035 citationsauthor #12
Integrator restrains paraspeckles assembly by promoting isoform switching of the lncRNA NEAT1.
202012 citationsauthor #12
The Human Integrator Complex Facilitates Transcriptional Elongation by Endonucleolytic Cleavage of Nascent Transcripts
202098 citationsauthor #12
NELF Regulates a Promoter-Proximal Step Distinct from RNA Pol II Pause-Release.
2020147 citationsauthor #8
2035 – AGE-RELATED DOWNREGULATION OF LMNA IMPACTS HUMAN HEMATOPOIETIC STEM CELL FUNCTION
20190 citationsauthor #5
Abstract 1289: AICAR inhibits protein kinase D1 activity leading to epigenetic downregulation of immediate early genes via the NF-kB pathway in acute lymphoblastic leukemia
20190 citationsauthor #6
TAF1 plays a critical role in AML1-ETO driven leukemogenesis
201942 citationsauthor #18
NELF establishes a 5 ’ cap protection checkpoint distinct from RNA polymerase II pause-release
20190 citationsauthor #17
Genomic positional conservation identifies topological anchor point RNAs linked to developmental loci
201825 citationsauthor #14
Acadesine Elicits a Rapid Epigenetic Reprograming of Immediate Early Genes through the Protein Kinase D1 Pathway in Acute Lymphoblastic Leukemia Cells Undergoing Energy/Metabolic Stress
20180 citationsauthor #6
Polycomb complexes associate with enhancers and promote oncogenic transcriptional programs in cancer through multiple mechanisms
2018115 citationsauthor #10
The Lysine-Specific Demethylase 1 (LSD1) Inhibitor Tranylcypromine (TCP) in Combination with ATRA Is Tolerable and Has Anti-Leukemic Activity in Adult Patients with Relapsed/Refractory AML and MDS
201810 citationsauthor #16
RNA Binding to CBP Stimulates Histone Acetylation and Transcription.
2017329 citationsauthor #4
Abstract P5-07-13: Identification of a cancer stem sell-specific function for the histone deacetylases, HDAC1 and HDAC7, in breast and ovarian cancer
20170 citationsauthor #15
PAF1 regulation of promoter-proximal pause release via enhancer activation
2017114 citationsauthor #11
Loss of p300 accelerates MDS-associated leukemogenesis
201736 citationsauthor #17
Integrator orchestrates RAS/ERK1/2 signaling transcriptional programs
201748 citationsauthor #6
ZMYND8 Reads the Dual Histone Mark H3K4me1-H3K14ac to Antagonize the Expression of Metastasis-Linked Genes.
2016129 citationsauthor #12
Retraction: A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function
20165 citationsauthor #16
Diverse regulatory interactions of long noncoding RNAs.
201632 citationsauthor #2
TAFII250 Is Critical in AML1-ETO Mediated Leukemogenesis
20160 citationsauthor #9
Detection and Analysis of Long Noncoding RNAs.
201610 citationsauthor #3
A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy
2016217 citationsauthor #6
Genomic positional conservation identifies topological anchor point (tap)RNAs linked to developmental loci
201691 citationsauthor #13
Identification of a cancer stem cell-specific function for the histone deacetylases, HDAC1 and HDAC7, in breast and ovarian cancer
2016141 citationsauthor #15
Integrator mediates the biogenesis of enhancer RNAs
2015284 citationsauthor #4
PAF1, a Molecular Regulator of Promoter-Proximal Pausing by RNA Polymerase II.
2015228 citationsauthor #7
The many faces of long noncoding RNAs
201555 citationsauthor #2
Biogenesis and Mechanism of Action of Enhancer RNAs
20150 citationsauthor #1
Architectural and Functional Commonalities between Enhancers and Promoters.
2015316 citationsauthor #2
Enhancer RNAs: the new molecules of transcription.
201450 citationsauthor #2
Inactivation of yeast Isw2 chromatin remodeling enzyme mimics longevity effect of calorie restriction via induction of genotoxic stress response.
201477 citationsauthor #14
Regulation of transcription by long noncoding RNAs.
2014395 citationsauthor #2
Integrator regulates transcriptional initiation and pause release following activation.
2014174 citationsauthor #9
Role of UTX in Retinoic Acid Receptor-Mediated Gene Regulation in Leukemia
201429 citationsauthor #5
Genome‐wide analysis reveals a role for BRCA1 and PALB2 in transcriptional co‐activation
201454 citationsauthor #4
Where long noncoding RNAs meet DNA methylation
201439 citationsauthor #2
Activating RNAs associate with Mediator to enhance chromatin architecture and transcription
2013811 citationsauthor #7
PINTing for p53
20130 citationsauthor #1
The Yin and Yang of enhancer‐like RNAs
20134 citationsauthor #1
Opening the Chromatin by eRNAs.
20139 citationsauthor #1
Long noncoding RNAs usher in a new era in the biology of enhancers.
2013239 citationsauthor #2
PINTing for p53
20135 citationsauthor #1
Abstract IA6: Elucidation of enhancer-like RNAs
20120 citationsauthor #1
The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure, evolution, and expression
20124,758 citationsauthor #22
Requirement for SNAPC1 in Transcriptional Responsiveness to Diverse Extracellular Signals
201219 citationsauthor #4
Long non‐coding RNAs in epigenetic regulation
20120 citationsauthor #1
Polycomb Repressive Complex 2-Dependent and -Independent Functions of Jarid2 in Transcriptional Regulation in Drosophila
201274 citationsauthor #12
Long non-coding RNAs and enhancers.
2011120 citationsauthor #2
Plant homeodomain fingers form a helping hand for transcription
201165 citationsauthor #2
Human GTPases Associate with RNA Polymerase II To Mediate Its Nuclear Import
201158 citationsauthor #2
Jarid2 regulates mouse epidermal stem cell activation and differentiation
201178 citationsauthor #7
Noncoding RNAs and enhancers: complications of a long-distance relationship.
201191 citationsauthor #2
Long noncoding RNAs as enhancers of gene expression.
201057 citationsauthor #4
PHF8 Targets Histone Methylation and RNA Polymerase II To Activate Transcription
2010118 citationsauthor #6
PHF8 Targets Histone Methylation and RNA Polymerase II To Activate Transcription
2010118 citationsauthor #7
Long noncoding RNAs as enhancers of gene expression.
201057 citationsauthor #5

TIMELINE

1990 4 citations

1991 535 citations

1992 196 citations

1995 522 citations

1996 392 citations

1998 533 citations

1999 129 citations

2000 1,293 citations

2001 531 citations

2002 681 citations

2003 892 citations

2004 3,133 citations

2005 6,375 citations

2006 1,962 citations

2007 4,438 citations

2008 272 citations

2009 2,377 citations

2010 1,909 citations

2011 412 citations

2012 4,851 citations

2013 1,068 citations

2014 818 citations

2015 883 citations

2016 625 citations

2017 527 citations

2018 150 citations

2019 42 citations

2020 372 citations

2021 428 citations

2022 23 citations

2023 41 citations

2024 16 citations

2025 25 citations

2026 0 citations

Unknown 50 citations

R. Shiekhattar

PROFILE

PAPERS

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