R. Widdop

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Aliases
Robert Widdop, Robert E Widdop, R.e. Widdop, R E Widdop, Robert E. Widdop, Robert e. Widdop, Robert Edward Widdop, R. E. Widdop
Publication record
285 papers · 7,880 citations · H-index 49

PAPERS

Investigational insights into the potential of angiotensin type II receptor agonists as therapeutics for idiopathic pulmonary fibrosis
20260 citationsauthor #2
The novel AT2 receptor ligand, β-Pro7 Ang III, induces equivalent anti-fibrotic effects to Compound 21 but broader anti-fibrotic effects than pirfenidone in mice with bleomycin-induced pulmonary fibrosis
20251 citationsauthor #6
Novel angiotensin receptor target as therapy for the diabetic heart: the AT2R.
20250 citationsauthor #3
Novel Mouse Model of Coronary Atherosclerosis With Myocardial Infarction: Insights Into Human CAD.
20253 citationsauthor #12
Hi1a Improves Sensorimotor Deficit following Endothelin-1-Induced Stroke in Rats but Does Not Improve Functional Outcomes following Filament-Induced Stroke in Mice.
20242 citationsauthor #7
Angiotensin-(1-9) Retro-Enantiomer Peptide With Cardioprotective Activity.
20243 citationsauthor #16
N-(Heteroaryl)thiophene sulfonamides as angiotensin AT2 receptor ligands.
20241 citationsauthor #13
Transition from Acute Kidney Injury to Chronic Kidney Disease: Mechanisms, Models, and Biomarkers.
202441 citationsauthor #2
The involvement of the Wnt/β-catenin signaling cascade in fibrosis progression and its therapeutic targeting by relaxin.
202426 citationsauthor #3
The protective effects of a novel AT2 receptor agonist, β-Pro7Ang III in ischemia-reperfusion kidney injury.
20236 citationsauthor #8
Inhibition of insulin-regulated aminopeptidase confers neuroprotection in a conscious model of ischemic stroke
20239 citationsauthor #3
Catch your breath: The protective role of the angiotensin AT2 receptor for the treatment of idiopathic pulmonary fibrosis.
202312 citationsauthor #3
The single-chain relaxin mimetic, B7-33, maintains the cardioprotective effects of relaxin and more rapidly reduces left ventricular fibrosis compared to perindopril in an experimental model of cardiomyopathy.
202312 citationsauthor #10
Novel AT2R agonist, β-Pro7Ang III, is cardio- and vaso-protective in diabetic spontaneously hypertensive rats.
202310 citationsauthor #13
Determination of Interstitial Collagen Deposition and Related Topography Using the Second Harmonic Generation-Based HistoIndex Platform.
20231 citationsauthor #2
The Angiotensin AT2 Receptor: From a Binding Site to a Novel Therapeutic Target
202259 citationsauthor #2
Abstract 062: Bone Marrow-derived Mesenchymal Stromal Cells Engineered To Release Anti-fibrotic Cargo, Evoke Renoprotective Effects Against Hypertensive Chronic Kidney Disease
20220 citationsauthor #4
The Novel AT2 Receptor Agonist β-Pro7-AngIII Exerts Cardiac and Renal Anti-Fibrotic and Anti-Inflammatory Effects in High Salt-Fed Mice
20228 citationsauthor #9
Functional crosstalk between angiotensin receptors (types 1 and 2) and relaxin family peptide receptor 1 (RXFP1): Implications for the therapeutic targeting of fibrosis
20228 citationsauthor #4
Using Conformational constraints at position 6 of Angiotensin II to generate compounds with enhanced AT2R selectivity and proteolytic stability.
20213 citationsauthor #9
Optimising the photothrombotic model of stroke in the C57BI/6 and FVB/N strains of mouse
202126 citationsauthor #3
Combining mesenchymal stem cells with serelaxin provides enhanced renoprotection against 1K/DOCA/salt‐induced hypertension
202118 citationsauthor #7
ACE2 CONTRIBUTES TO THE NORMAL REGULATION OF ARTERIAL PRESSURE AND IMMUNITY IN FEMALES OF REPRODUCTIVE AGE
20210 citationsauthor #4
Assessment of renal fibrosis and anti‐fibrotic agents using a novel diagnostic and stain‐free second‐harmonic generation platform
202118 citationsauthor #7
Esterase-Mediated Sustained Release of Peptide-Based Therapeutics from a Self-Assembled Injectable Hydrogel.
202116 citationsauthor #10
Relaxin Attenuates Organ Fibrosis via an Angiotensin Type 2 Receptor Mechanism in Aged Hypertensive Female Rats
202110 citationsauthor #8
Comparing the renoprotective effects of BM-MSCs versus BM-MSC-exosomes, when combined with an anti-fibrotic drug, in hypertensive mice.
202117 citationsauthor #5
Preclinical rodent models of cardiac fibrosis
202130 citationsauthor #4
In Aged Females, the Enhanced Pressor Response to Angiotensin II Is Attenuated By Estrogen Replacement via an Angiotensin Type 2 Receptor-Mediated Mechanism
202120 citationsauthor #8
Single Peptide Backbone Surrogate Mutations to Regulate Angiotensin GPCR Subtype Selectivity.
20208 citationsauthor #21
N-(Methyloxycarbonyl)thiophene sulfonamides as high affinity AT2 receptor ligands.
20208 citationsauthor #11
Enhancement of glioblastoma multiforme therapy through a novel Quercetin-Losartan hybrid.
202021 citationsauthor #11
The anti‐fibrotic actions of relaxin are mediated through AT2R‐associated protein phosphatases via RXFP1‐AT2R functional crosstalk in human cardiac myofibroblasts
202020 citationsauthor #3
Renin-Angiotensin System Role in the Pathophysiological Progression of Coronary Dysfunction in Prediabetic Female Rats
20200 citationsauthor #8
Renal functional effects of the highly selective AT2R agonist, β-Pro7 Ang III, in normotensive rats
202016 citationsauthor #9
Serelaxin and the AT2 Receptor Agonist CGP42112 Evoked a Similar, Nonadditive, Cardiac Antifibrotic Effect in High Salt-Fed Mice That Were Refractory to Candesartan Cilexetil.
202021 citationsauthor #10
Cover Feature: Single Peptide Backbone Surrogate Mutations to Regulate Angiotensin GPCR Subtype Selectivity (Chem. Eur. J. 47/2020)
20200 citationsauthor #21
A Novel Epigenetic Drug-Eluting Balloon Angioplasty Device: Evaluation in a Large Animal Model of Neointimal Hyperplasia
20194 citationsauthor #8
A Series of Analogues to the AT2R Prototype Antagonist C38 Allow Fine Tuning of the Previously Reported Antagonist Binding Mode
20198 citationsauthor #7
AT1R-AT2R-RXFP1 Functional Crosstalk in Myofibroblasts: Impact on the Therapeutic Targeting of Renal and Cardiac Fibrosis.
201941 citationsauthor #16
Abstract 119: Ccl18 as a Potential Mediator of the Pro-Fibrotic Actions of M2 Macrophages in the Vessel Wall During Hypertension
20190 citationsauthor #5
High Blood Pressure Research Council of Australia Abstracts from the Joint HBPRCA, AAS and AVBS
20190 citationsauthor #8
Abstract 131: Insulin Regulated Aminopeptidase Inhibitors are More Effective Than the ACE Inhibitor, Perindopril in Preventing Unilateral Ureteral Obstruction-Induced Renal Fibrosis in Mice
20192 citationsauthor #6
Evidence of AT1R-AT2R-RXFP1 Functional Crosstalk in Myofibroblasts and its Impact on the Therapeutic Targeting of Renal and Cardiac Fibrosis
20191 citationsauthor #16
Abstract 101: Novel AT2 Receptor Agonists are Cardio- and Reno-Protective In Vitro and In Vivo
20190 citationsauthor #5
Morphology and Function of the Lamb Ileum following Preterm Birth
20189 citationsauthor #3
A9684 Comparing anti-fibrotic effects of the irap inhibitor, hfi-419 to an angiotensin receptor blocker and ace inhibitor in a high salt-induced mouse model of kidney disease
20185 citationsauthor #7
Dapagliflozin attenuates human vascular endothelial cell activation and induces vasorelaxation: A potential mechanism for inhibition of atherogenesis
2018115 citationsauthor #6
A9871 Insulin regulated aminopeptidase (irap) inhibition completely reverses age-induced cardiac fibrosis and improves cardiac function
20185 citationsauthor #10
A8011 A novel angiotensin AT2 receptor ligand for the treatment of cardiac fibrosis
20181 citationsauthor #6
Assessment of collagen in human idiopathic pulmonary fibrosis using second harmonics on Genesis 200
20181 citationsauthor #8
Abstract 043: Targeting the Angiotensin Type 2 Receptor With Relaxin Confers Protection Against Renal Fibrosis and Vascular Dysfunction in Female Stroke Prone-Spontaneously Hypertensive Rats
20180 citationsauthor #6
CCL18 as a potential mediator of the pro-fibrotic actions of M2 macrophages in the vessel wall during hypertension
20180 citationsauthor #7
[PP.07.23] SERELAXIN ATTENTUATES THE PRESSOR RESPONSE TO ANGIOTENSIN II IN AGEING FEMALES VIA AN ANGIOTENSIN TYPE 2 RECEPTOR MEDIATED PATHWAY
20170 citationsauthor #5
Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a
2017198 citationsauthor #10
Faculty of 1000 evaluation for Combined angiotensin receptor/neprilysin inhibitors: a review of the new paradigm in the management of chronic heart failure.
20170 citationsauthor #1
F1000Prime recommendation of Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes.
20170 citationsauthor #1
P3473Effect of insulin resistance on compound 21 mediated coronary microvascular dilation in female rats in vivo
20170 citationsauthor #11
F1000Prime recommendation of Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes.
20170 citationsauthor #1
Faculty Opinions recommendation of Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover trial.
20170 citationsauthor #1
Faculty Opinions recommendation of Hypertension: renin-angiotensin-aldosterone system alterations.
20170 citationsauthor #1
The effect of tocopheryl phosphates (TPM) on the development of atherosclerosis in apolipoprotein‐E deficient mice
201712 citationsauthor #4
Abstract 016: Combined AT2 Receptor Stimulation/ AT1 Receptor Blockade Does Not Cause Renal Dysfunction
20170 citationsauthor #5
Novel approaches for treating hypertension
201711 citationsauthor #3
Faculty Opinions recommendation of Combined angiotensin receptor antagonism and neprilysin inhibition.
20170 citationsauthor #1
Anti-fibrotic Potential of AT2 Receptor Agonists
201766 citationsauthor #10
Faculty Opinions recommendation of Angiotensin converting enzyme 2 and diminazene: role in cardiovascular and blood pressure regulation.
20170 citationsauthor #1
CCL18 as a Mediator of the Pro‐Fibrotic Actions of M2 Macrophages in the Vessel Wall during Hypertension
20173 citationsauthor #8
Abstract 052: Chronic Angiotensin Type 2 Receptor Stimulation Abolishes the Sex-difference in Ang II-induced Hypertension
20170 citationsauthor #6
Compound 21, a selective agonist of angiotensin AT2 receptors, prevents endothelial inflammation and leukocyte adhesion in vitro and in vivo
201651 citationsauthor #11
Decorated self-assembling β(3)-tripeptide foldamers form cell adhesive scaffolds.
201621 citationsauthor #4
PS 07-27 ANTI-FIBROTIC EFFECTS OF AT2 RECEPTOR AND MAS RECEPTOR STIMULATION IN STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS
20160 citationsauthor #1
Angiotensin AT2-receptor stimulation improves survival and neurological outcome after experimental stroke in mice
201648 citationsauthor #9
Molecular and cellular mechanisms of glucagon-like peptide-1 receptor agonist-mediated attenuation of cardiac fibrosis
201643 citationsauthor #6
Angiotensin AT2-receptor stimulation improves survival and neurological outcome after experimental stroke in mice
20160 citationsauthor #9
Effect of a Selective Mas Receptor Agonist in Cerebral Ischemia In Vitro and In Vivo
201527 citationsauthor #5
Abstract P006: Liraglutide Attenuates Cardiac Fibrosis and Vascular Dysfunction in a Non-diabetic Angiotensin II-infusion Model via Anti-inflammatory and Anti-oxidant Mechanisms
20150 citationsauthor #3
AT2R, vascular effects, and blood pressure
20150 citationsauthor #11
Chapter 19 – Angiotensin-Based Peptides as AT2R Agonists
20150 citationsauthor #6
Structural determinants for binding to angiotensin converting enzyme 2 (ACE2) and angiotensin receptors 1 and 2
201516 citationsauthor #4
PcTx1 affords neuroprotection in a conscious model of stroke in hypertensive rats via selective inhibition of ASIC1a.
201563 citationsauthor #5
Chapter 17 – Sex Differences in AT2R Expression and Action
20153 citationsauthor #3
Abstract 002: Dynamic T Cell-Antigen Presenting Cell Interactions and Direct T Cell Activation Within the Vascular Wall During Hypertension
20150 citationsauthor #5
β-Pro7Ang III is a novel highly selective angiotensin II type 2 receptor (AT2R) agonist, which acts as a vasodepressor agent via the AT2R in conscious spontaneously hypertensive rats.
201530 citationsauthor #11
Relaxin requires the angiotensin II type 2 receptor to abrogate renal interstitial fibrosis.
2014117 citationsauthor #7
Role of Inflammation and the Angiotensin Type 2 Receptor in the Regulation of Arterial Pressure During Pregnancy in Mice
201422 citationsauthor #5
Sex- and age-related differences in the chronic pressure-natriuresis relationship: role of the angiotensin type 2 receptor.
201461 citationsauthor #6
Pressor responsiveness to angiotensin II in female mice is enhanced with age: role of the angiotensin type 2 receptor
20141 citationsauthor #4
Angiotensin Type 2 Receptor Stimulation Increases Renal Function in Female, but Not Male, Spontaneously Hypertensive Rats
201450 citationsauthor #6
Direct Angiotensin AT2 Receptor Stimulation Using a Novel AT2 Receptor Agonist, Compound 21, Evokes Neuroprotection in Conscious Hypertensive Rats
201481 citationsauthor #7
Electronic Sculpting of Ligand-GPCR Subtype Selectivity: The Case of Angiotensin II
201431 citationsauthor #13
Vasoactive Role for Angiotensin II Type 2 Receptors in Human Radial Artery
201411 citationsauthor #4
The Protective Arms of the Renin-Angiontensin System in Stroke
201417 citationsauthor #3
Differential Phenotypes of Tissue-Infiltrating T Cells during Angiotensin II-Induced Hypertension in Mice
201449 citationsauthor #5
Serelaxin Is a More Efficacious Antifibrotic Than Enalapril in an Experimental Model of Heart Disease
201493 citationsauthor #4
A Novel Agent with Histone Deacetylase Inhibitory Activity Attenuates Neointimal Hyperplasia
20145 citationsauthor #6
Abstract 463: The Effect of Intrauterine Inflammation on the Early Development of Atherosclerosis
20140 citationsauthor #6
Pressor responsiveness to angiotensin II in female mice is enhanced with age: role of the angiotensin type 2 receptor
201432 citationsauthor #4
CALL FOR PAPERS Sex and Gender Differences in Renal Physiology Sex- and age-related differences in the chronic pressure-natriuresis relationship: role of the angiotensin type 2 receptor
20140 citationsauthor #6
Abstract 417: AT2R Stimulation Prevents TNFa-Induced Vascular Inflammation In Vitro and Ex Vivo
20130 citationsauthor #5

TIMELINE

1928 0 citations

1986 9 citations

1987 63 citations

1988 85 citations

1989 1 citations

1990 127 citations

1992 236 citations

1993 75 citations

1994 59 citations

1995 64 citations

1996 24 citations

1997 65 citations

1998 79 citations

1999 256 citations

2000 142 citations

2001 47 citations

2002 187 citations

2003 440 citations

2004 283 citations

2005 545 citations

2006 79 citations

2007 171 citations

2008 819 citations

2009 145 citations

2010 383 citations

2011 823 citations

2012 518 citations

2013 348 citations

2014 570 citations

2015 139 citations

2016 163 citations

2017 290 citations

2018 136 citations

2019 56 citations

2020 94 citations

2021 158 citations

2022 75 citations

2023 50 citations

2024 73 citations

2025 4 citations

2026 0 citations

Unknown 0 citations

R. Widdop

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