F. Forouhar

Systematic enhancement of protein crystallization efficiency by bulk lysine-to-arginine (KR) substitution
20236 citationsauthor #4
Computational protein engineering for systematic enhancement of crystallization propensity
20230 citationsauthor #4
The TINCR ubiquitin-like microprotein is a tumor suppressor in squamous cell carcinoma
202331 citationsauthor #5
Pharmacological inhibition of NT5C2 reverses genetic and non-genetic drivers of 6-MP resistance in acute lymphoblastic leukemia.
20223 citationsauthor #4
Oligomeric interactions maintain active‐site structure in a noncooperative enzyme family
202220 citationsauthor #4
Development of optimized drug-like small molecule inhibitors of the SARS-CoV-2 3CL protease for treatment of COVID-19
202271 citationsauthor #6
Small-molecule allosteric inhibitors of GPX4.
202271 citationsauthor #2
Computational structure prediction methods enable the systematic identification of oncogenic mutations
20222 citationsauthor #7
Author Correction: Lead compounds for the development of SARS-CoV-2 3CL protease inhibitors
20215 citationsauthor #2
Crystal structure of SARS-CoV-2 3CL protease in complex with compound 4 in space group P1
20210 citationsauthor #2
Lead compounds for the development of SARS-CoV-2 3CL protease inhibitors
202160 citationsauthor #2
Characterization of a patient-derived variant of GPX4 for precision therapy
202180 citationsauthor #2
Crystal structure of SARS-CoV-2 3CL protease in complex with compound 4
20210 citationsauthor #2
Crystal structure of SARS-CoV-2 3CL in apo form
20210 citationsauthor #2
Crystal structure of SARS-CoV-2 3CL protease in complex with MAC5576
20210 citationsauthor #2
Crystal structure of SARS-CoV-2 3CL protease in complex with GC376
20210 citationsauthor #2
Sensory Domains That Control Cyclic di-GMP-Modulating Proteins: A Critical Frontier in Bacterial Signal Transduction
20207 citationsauthor #3
Lead compounds for the development of SARS-CoV-2 3CL protease inhibitors
202044 citationsauthor #2
Crystal structure of the double mutant (D52N/L375F) of NT5C2-537X in the active state, Northeast Structural Genomics Target
20180 citationsauthor #1
Ligand binding to a remote site thermodynamically corrects the F508del mutation in the human cystic fibrosis transmembrane conductance regulator
201810 citationsauthor #4
Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia.
201848 citationsauthor #3
Crystal structure of the double mutant (D52N/R367Q) of NT5C2-537X in the basal state, Northeast Structural Genomics Consortium Target
20180 citationsauthor #1
Crystal structure of the doublt mutant (R39Q/D52N) of the full-length NT5C2 in the basal state
20180 citationsauthor #1
Crystal structure of the single mutant (D52N) of the full-length NT5C2 in the active state
20180 citationsauthor #1
Crystal structure of the single mutant (D52N) of NT5C2-537X in the basal state, Northeast Structural Genomics Consortium Target
20180 citationsauthor #1
Nucleotide-binding domain 1 of the human cystic fibrosis transmembrane conductance regulator (CFTR) with 5-methyl-UTP
20180 citationsauthor #4
Crystal structure of the double mutant (D52N/L375F) of the full-length NT5C2 in the active state
20180 citationsauthor #1
Crystal structure of the single mutant (D52N) of the full-length NT5C2 in the basal state
20180 citationsauthor #1
Crystal structure of the double mutant (D52N/D407A) of NT5C2-537X in the active state
20180 citationsauthor #1
Crystal Structure of the Alr8543 protein in complex with Oleic Acid and magnesium ion from Nostoc sp. PCC 7120, Northeast Structural Genomics Consortium Target NsR141
20180 citationsauthor #1
Crystal structure of the single mutant (D52N) of NT5C2-Q523X in the active state
20180 citationsauthor #1
Crystal structure of the double mutant (R39Q/D52N) of the full-length NT5C2 in the active state
20180 citationsauthor #1
Thermodynamic correction of F 508 del-CFTR 1 Ligand binding to a remote site thermodynamically corrects the F 508 del mutation in the human cystic fibrosis transmembrane conductance regulator
20180 citationsauthor #4
Crystal structure of the double mutant (D52N/R367Q) of the full-length NT5C2 in the basal state
20180 citationsauthor #1
Crystal structure of methyl transferase from Methanosarcina acetivorans at 1.6 Angstroms resolution, Northeast Structural Genomics Consortium (NESG) Target MvR53.
20180 citationsauthor #2
Crystal structure of human indoleamime 2,3-dioxygenase (IDO1) in complex with L-Trp and cyanide, Northeast Structural Genomics Target HR6160
20180 citationsauthor #1
Expression system for structural and functional studies of human glycosylation enzymes.
2018200 citationsauthor #6
Crystal Structure of human ST6GALNAC2
20170 citationsauthor #1
Mechanisms of NT5C2 mutations Driving Thiopurine Resistance in Acute Lymphoblastic Leukemia
20170 citationsauthor #3
Abstract PR02: Mechanisms of NT5C2 activating mutations driving thiopurine resistance in relapsed lymphoblastic leukemia
20170 citationsauthor #3
Crystal Structure of human ST6GALNAC2 in complex with CMP
20170 citationsauthor #1
Spectroscopic evidence for cofactor-substrate interaction in the radical-SAM enzyme TYW1.
20178 citationsauthor #5
Crystal structure of human TDO in complex with Trp, Northeast Structural Genomics Consortium Target HR6161
20160 citationsauthor #1
Molecular basis for catalysis and substrate-mediated cellular stabilization of human tryptophan 2,3-dioxygenase
201679 citationsauthor #2
Crystal structure of human TDO in complex with Trp and dioxygen, Northeast Structural Genomics Consortium Target HR6161
20160 citationsauthor #1
Unanticipated coordination of tris buffer to the Radical SAM cluster of the RimO methylthiotransferase
20160 citationsauthor #6
Insights On Mammalian Glycosylation Enzymes From High‐Throughput Expression Studies
20160 citationsauthor #3
Redox Behavior of the S-Adenosylmethionine (SAM)-Binding Fe-S Cluster in Methylthiotransferase RimO, toward Understanding Dual SAM Activity.
201613 citationsauthor #4
A Comparative Study of Gamma Subunits of A.Thaliana and O.Sativa
20160 citationsauthor #10
Unanticipated coordination of tris buffer to the Radical SAM cluster of the RimO methylthiotransferase
20167 citationsauthor #6
Members of a Novel Kinase Family (DUF1537) Can Recycle Toxic Intermediates into an Essential Metabolite.
201614 citationsauthor #7
A community resource of experimental data for NMR / X‐ray crystal structure pairs
201626 citationsauthor #10
Crystal Structure of AlkB T208A mutant protein in complex with Co(II), 2-oxoglutarate, and methylated trinucleotide T-meA-T
20150 citationsauthor #4
Crystal structure of human phosphofructokinase-1 in complex with ATP and Mg, Northeast Structural Genomics Consortium Target HR9275
20150 citationsauthor #1
Structures of human phosphofructokinase-1 and atomic basis of cancer-associated mutations
2015148 citationsauthor #2
Crystal structure of cytosolic nucleotidase II (LPG0095) in complex with GMP from Legionella pneumophila, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET LGR1
20140 citationsauthor #2
A Robust High-Throughput Assay for Thermodynamic Correctors of the Predominant Molecular Defect Causing Cystic Fibrosis
20140 citationsauthor #6
Mitochondrial COQ9 is a lipid-binding protein that associates with COQ7 to enable coenzyme Q biosynthesis
2014115 citationsauthor #2
Crystal structure of human COQ9 in complex with a phospholipid, Northeast Structural Genomics Consortium Target HR5043
20140 citationsauthor #1
Plant, Animal, and Fungal Micronutrient Queuosine Is Salvaged by Members of the DUF2419 Protein Family
201454 citationsauthor #4
Allosteric regulation and substrate activation in cytosolic nucleotidase II from Legionella pneumophila
201424 citationsauthor #2
Wybutosine biosynthesis: Structural and mechanistic overview
201444 citationsauthor #3
A novel architecture of 600 kDa bacterial citrate lyase complex
20140 citationsauthor #1
Crystal structure of Thermotoga maritima holo RimO in complex with pentasulfide, Northeast Structural Genomics Consortium Target VR77
20130 citationsauthor #1
Crystal Structure of Malonyl-CoA decarboxylase from Rhodopseudomonas palustris, Northeast Structural Genomics Consortium Target RpR127
20130 citationsauthor #1
Crystal Structure of Malonyl-CoA decarboxylase (Rmet_2797) from Cupriavidus metallidurans, Northeast Structural Genomics Consortium Target CrR76
20130 citationsauthor #1
Crystal structure of a putative, de novo designed unnatural amino acid dependent metalloprotein, northeast structural genomics consortium target OR61
20130 citationsauthor #1
Computational design of an unnatural amino acid dependent metalloprotein with atomic level accuracy.
2013102 citationsauthor #4
Enzymatic Basis for N-Glycan Sialylation
2013113 citationsauthor #2
Crystal Structures of Malonyl-Coenzyme A Decarboxylase Provide Insights into Its Catalytic Mechanism and Disease-Causing Mutations
201321 citationsauthor #2
Two Fe-S clusters catalyze sulfur insertion by radical-SAM methylthiotransferases.
2013111 citationsauthor #1
Crystal Structure of Malonyl-CoA decarboxylase from Agrobacterium vitis, Northeast Structural Genomics Consortium Target RiR35
20130 citationsauthor #1
Crystal structure of rat Beta-galactoside alpha-2,6-sialyltransferase 1 (ST6GAL1), Northeast Structural Genomics Consortium Target RnR367A
20130 citationsauthor #1
Structural and biochemical characterization of the bilin lyase CpcS from Thermosynechococcus elongatus.
201334 citationsauthor #3
Computational design of catalytic dyads and oxyanion holes for ester hydrolysis.
2012164 citationsauthor #16
Comparative genomic analysis of the DUF71/COG2102 family predicts roles in diphthamide biosynthesis and B12 salvage
201218 citationsauthor #2
Comparative genomic analysis of the DUF71/COG2102 family predicts roles in diphthamide biosynthesis and B12 salvage
20121 citationsauthor #2
Crystal structure of cytosolic IMP-GMP specific 5'-nucleotidase (lpg0095) in complex with phosphate ions from Legionella pneumophila, Northeast Structural Genomics Consortium Target LgR1
20120 citationsauthor #1
The methylthiolation reaction mediated by the Radical-SAM enzymes.
201227 citationsauthor #7
Structure of a specialized acyl carrier protein essential for lipid A biosynthesis with very long-chain fatty acids in open and closed conformations.
201213 citationsauthor #3
Crystal structure of the esterase YqiA (YE3661) from Yersinia enterocolitica, Northeast Structural Genomics Consortium Target YeR85
20121 citationsauthor #1
X-ray crystal structure of a MucBP domain of the protein LBA1460 from Lactobacillus acidophilus, Northeast structural genomics consortium target LaR80A
20110 citationsauthor #3
X-ray crystal structure of protein mll3774 from Mesorhizobium loti, Northeast Structural Genomics Consortium Target MlR405.
20110 citationsauthor #1
Structural conservation of the myoviridae phage tail sheath protein fold.
201147 citationsauthor #4
Crystal Structure and RNA Binding Properties of the RNA Recognition Motif (RRM) and AlkB Domains in Human AlkB Homolog 8 (ABH8), an Enzyme Catalyzing tRNA Hypermodification*
201166 citationsauthor #3
A large conformational change in the putative ATP pyrophosphatase PF0828 induced by ATP binding.
20115 citationsauthor #1
X-ray crystal structure of the VHS domain of human TOM1-like protein, Northeast Structural Genomics Consortium Target HR3050E
20110 citationsauthor #1
Crystal structure and RNA binding properties of the RRM/AlkB domains in human ABH8, an enzyme catalyzing tRNA hypermodification, Northeast Structural Genomics Consortium Target HR5601B
20110 citationsauthor #3
THREE DIMENSIONAL STRUCTURE OF DE NOVO DESIGNED CYSTEINE ESTERASE ECH19, Northeast Structural Genomics Consortium Target OR49
20110 citationsauthor #4
X-ray crystal Structure of the putative N-type ATP pyrophosphatase (PF0828) in complex with AMP from Pyrococcus furiosus, Northeast Structural Genomics Consortium Target PfR23
20110 citationsauthor #1
Crystal structure of bacterial citrate lyase
20110 citationsauthor #1
Indoleamine 2,3‐Dioxygenase and Tryptophan 2,3‐Dioxygenase
20112 citationsauthor #4
Novel C-terminal Motif within Sec7 Domain of Guanine Nucleotide Exchange Factors Regulates ADP-ribosylation Factor (ARF) Binding and Activation*
201117 citationsauthor #6
X-ray crystal structure of protein MLL2253 from Mesorhizobium loti, Northeast Structural Genomics Consortium Target MlR404.
20110 citationsauthor #1
Methyl esterase 1 (StMES1) is required for systemic acquired resistance in potato.
201090 citationsauthor #3
Crystal Structure of specialized acyl carrier protein (RPA2022) from Rhodopseudomonas palustris, Northeast Structural Genomics Consortium Target RpR324
20100 citationsauthor #1
Crystal Structure of the Biosynthetic Arginine decarboxylase SpeA from Campylobacter jejuni, Northeast Structural Genomics Consortium Target BR53
20100 citationsauthor #1
Crystal Structure of the N-terminal domain of DNA-binding protein SATB1 from Homo sapiens, Northeast Structural Genomics Consortium Target HR4435B
20102 citationsauthor #1
Crystal Structure of Nmul_A1745 protein from Nitrosospira multiformis, Northeast Structural Genomics Consortium Target NmR72
20100 citationsauthor #1
Crystal Structure of Molybdopterin-guanine dinucleotide biosynthesis protein A from Archaeoglobus fulgidus, Northeast Structural Genomics Consortium Target GR189
20100 citationsauthor #1

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