B. Mannervik

A Preclinical Model for Parkinson’s Disease Based on Transcriptional Gene Activation via KEAP1/NRF2 to Develop New Antioxidant Therapies
202323 citationsauthor #2
Possible Approaches to Drug Delivery via Glutathione Transferase Proteins and Chitosan
20230 citationsauthor #3
Potent GST Ketosteroid Isomerase Activity Relevant to Ecdysteroidogenesis in the Malaria Vector Anopheles gambiae
20235 citationsauthor #4
Astrocytes protect dopaminergic neurons against aminochrome neurotoxicity
202229 citationsauthor #2
Neuroprotection against Aminochrome Neurotoxicity: Glutathione Transferase M2-2 and DT-Diaphorase
202222 citationsauthor #6
Characterization of Dog Glutathione Transferase P1-1, an Enzyme Relevant to Veterinary Medicine
20215 citationsauthor #4
Cellular Trafficking of Glutathione Transferase M2-2 Between U373MG and SHSY-S7 Cells is Mediated by Exosomes
202117 citationsauthor #9
Role of human glutathione transferases in biotransformation of the nitric oxide prodrug JS-K
20214 citationsauthor #2
Glutathione Transferases as Efficient Ketosteroid Isomerases
202118 citationsauthor #1
Marmoset glutathione transferases with ketosteroid isomerase activity
20212 citationsauthor #3
Interactions between Odorants and Glutathione Transferases in the Human Olfactory Cleft.
202024 citationsauthor #9
Crystal structure of Equus ferus caballus glutathione transferase A3-3 in complex with glutathione and triethyltin
20200 citationsauthor #5
Conservation of glutathione S-transferase mRNA and protein sequences similar to human and horse Alpha class GST A3-3 across dog, goat, and opossum species
20201 citationsauthor #4
Conservation of glutathione transferase mRNA and protein sequences similar to human GST Alpha 3 across diverse mammalian species
20201 citationsauthor #4
Structural and functional analysis of the inhibition of equine glutathione transferase A3-3 by organotin endocrine disrupting pollutants.
20204 citationsauthor #5
Mutational Analysis of the Binding of Alternative Substrates and Inhibitors to the Active Site of Human Glutathione Transferase P1–1
20203 citationsauthor #5
Crystal structure of Drosophila melanogaster glutathione S-transferase epsilon 14 in complex with glutathione and 2-methyl-2,4-pentanediol
20200 citationsauthor #6
Crystal structure of Equus ferus caballus glutathione transferase A3-3 in complex with glutathione
20200 citationsauthor #5
Structure and steroid isomerase activity of Drosophila glutathione transferase E14 essential for ecdysteroid biosynthesis
201916 citationsauthor #7
Potent inhibitors of equine steroid isomerase EcaGST A3-3
20195 citationsauthor #4
Abstract LB-B23: Prodrug activation by designer enzyme targeted to CD123-expressing tumors
20180 citationsauthor #1
Inhibition characteristics of equine steroid isomerase EcaGST A3-3
20180 citationsauthor #4
Glutathione Transferases
20180 citationsauthor #1
Novel Alpha-Synuclein Oligomers Formed with the Aminochrome-Glutathione Conjugate Are Not Neurotoxic
201815 citationsauthor #3
Design and synthesis of 2-substituted-5-(4-trifluoromethylphenyl-sulphonamido)benzoxazole derivatives as human GST P1-1 inhibitors
20189 citationsauthor #6
Abstract 5238: Characterization of the enzyme generating the cholesterol metabolite and tumor suppressor dendrogenin A in the breast and its deregulations in breast cancer
20180 citationsauthor #21
Exploring sequence-function space of a poplar glutathione transferase using designed information-rich gene variants
201716 citationsauthor #3
Expression of a Drosophila glutathione transferase in Arabidopsis confers the ability to detoxify the environmental pollutant, and explosive, 2,4,6-trinitrotoluene.
201721 citationsauthor #5
Characterization of equine GST A3-3 as a steroid isomerase.
201718 citationsauthor #4
Catalytic Conversion of Lipophilic Substrates by Phase constrained Enzymes in the Aqueous or in the Membrane Phase
20165 citationsauthor #9
Evolution of Negative Cooperativity in Glutathione Transferase Enabled Preservation of Enzyme Function*
201623 citationsauthor #6
Inhibitory effects of ethacrynic acid on glutathione S-transferase A1-1 from Callithrix jacchus
20150 citationsauthor #2
Glutathione S-transferase from Drosophila melanogaster - isozyme E7
20150 citationsauthor #3
Glutathione S-Transferase from Drosophila melanogaster - isozyme E6
20150 citationsauthor #3
Comparison of epsilon- and delta-class glutathione S-transferases: the crystal structures of the glutathione S-transferases DmGSTE6 and DmGSTE7 from Drosophila melanogaster.
201517 citationsauthor #4
Identification of new inhibitors for human hematopoietic prostaglandin D2 synthase among FDA-approved drugs and other compounds.
201516 citationsauthor #3
On the biosynthesis of 15-HETE and eoxin C4 by human airway epithelial cells.
201526 citationsauthor #7
Substrate specificities of two tau class glutathione transferases inducible by 2,4,6-trinitrotoluene in poplar.
201513 citationsauthor #2
Glutathione Transferase-M2-2 Secreted from Glioblastoma Cell Protects SH-SY5Y Cells from Aminochrome Neurotoxicity
201545 citationsauthor #6
Drosophila GSTs display outstanding catalytic efficiencies with the environmental pollutants 2,4,6-trinitrotoluene and 2,4-dinitrotoluene
20158 citationsauthor #2
Evolution of the active site of human glutathione transferase A2-2 for enhanced activity with dietary isothiocyanates.
20159 citationsauthor #3
Mapping of amino acid substitutions conferring herbicide resistance in wheat glutathione transferase.
201537 citationsauthor #2
Glutathione transferases immobilized on nanoporous alumina: flow system kinetics, screening, and stability.
201412 citationsauthor #4
Transgenic Overexpression of Glutathione Transferase E7 in Drosophila Attenuates Toxicity of Organic Isothiocyanates Affecting Survival and Oviposition
20140 citationsauthor #3
Glutathione transferases in the bioactivation of azathioprine.
201426 citationsauthor #2
Isomerization of Δ5-androstene-3,17-dione into Δ4-androstene-3,17-dione catalyzed by human glutathione transferase A3-3: a computational study identifies a dual role for glutathione.
201416 citationsauthor #3
Glutathione transferase mu 2 protects glioblastoma cells against aminochrome toxicity by preventing autophagy and lysosome dysfunction
201464 citationsauthor #10
Overexpression of Glutathione Transferase E7 in Drosophila Differentially Impacts Toxicity of Organic Isothiocyanates in Males and Females
201412 citationsauthor #3
Glutathione Transferase-M2-2 Secreted from Glioblastoma Cell Protects SH-SY5Y Cells from Aminochrome Neurotoxicity
20141 citationsauthor #6
Fluorogenic probes using 4-substituted-2-nitrobenzenesulfonyl derivatives as caging groups for the analysis of human glutathione transferase catalyzed reactions.
201315 citationsauthor #8
3 FDA-approved drugs and other compounds tested as inhibitors of human
20130 citationsauthor #4
Mechanism of glutathione transferase P1-1-catalyzed activation of the prodrug canfosfamide (TLK286, TELCYTA).
201334 citationsauthor #4
Enzymatic Detoxication, Conformational Selection, and the Role of Molten Globule Active Sites*
201346 citationsauthor #4
FDA-approved drugs and other compounds tested as inhibitors of human glutathione transferase P1-1.
201343 citationsauthor #4
Hidden allostery in human glutathione transferase p1-1 unveiled by unnatural amino acid substitutions and inhibition studies.
201318 citationsauthor #3
Evolution of increased ß-lactam resistance in an engineered Metallo-ß-lactamase
20120 citationsauthor #3
Multidimensional epistasis and fitness landscapes in enzyme evolution.
201235 citationsauthor #5
Inhibition of human glutathione transferase P1-1 by novel benzazole derivatives
201210 citationsauthor #7
Five Decades with Glutathione and the GSTome
201245 citationsauthor #1
Mutational analysis of human glutathione transferase A2-2 identifies structural elements supporting high activity with the prodrug azathioprine.
20125 citationsauthor #3
Evolution of Broad Spectrum β-Lactam Resistance in an Engineered Metallo-β-lactamase*
201216 citationsauthor #3
Structure-based redesign of GST A2-2 for enhanced catalytic efficiency with azathioprine.
201218 citationsauthor #4
Universal Caging Group for the in‐Cell Detection of Glutathione Transferase Applied to 19F NMR and Bioluminogenic Probes
201214 citationsauthor #8
An improved dual-tube megaprimer approach for multi-site saturation mutagenesis
20123 citationsauthor #2
Functional studies of single-nucleotide polymorphic variants of human glutathione transferase T1-1 involving residues in the dimer interface.
20115 citationsauthor #4
Experimental conditions affecting functional comparison of highly active glutathione transferases.
20116 citationsauthor #2
Synthesis and characterization of a series of highly fluorogenic substrates for glutathione transferases, a general strategy.
2011112 citationsauthor #6
Quantitative and selective polymerase chain reaction analysis of highly similar human alpha-class glutathione transferases.
201112 citationsauthor #2
Cys-X Scanning for Expansion of Active-site Residues and Modulation of Catalytic Functions in a Glutathione Transferase*
20119 citationsauthor #3
Engineering GST M2-2 for high activity with indene 1,2-oxide and indication of an H-site residue sustaining catalytic promiscuity.
201120 citationsauthor #2
Crystal structure of mutant GST A2-2 with enhanced catalytic efficiency with azathioprine
20110 citationsauthor #4
Characterization of porcine alpha-class glutathione transferase A1-1.
20118 citationsauthor #3
Differences among allelic variants of human glutathione transferase A2-2 in the activation of azathioprine.
201033 citationsauthor #3
Biosynthesis of 14,15-Hepoxilins in Human L1236 Hodgkin Lymphoma Cells and Eosinophils
201016 citationsauthor #4
Residue 234 is a master switch of the alternative-substrate activity profile of human and rodent theta class glutathione transferase T1-1.
201010 citationsauthor #2
Substrate specificity combined with stereopromiscuity in glutathione transferase A4-4-dependent metabolism of 4-hydroxynonenal.
201047 citationsauthor #7
Structural basis for featuring of steroid isomerase activity in alpha class glutathione transferases.
201045 citationsauthor #3
A novel quasi-species of glutathione transferase with high activity towards naturally occurring isothiocyanates evolves from promiscuous low-activity variants.
201019 citationsauthor #2
Molecular evolution of Theta-class glutathione transferase for enhanced activity with the anticancer drug 1,3-bis-(2-chloroethyl)-1-nitrosourea and other alkylating agents.
20109 citationsauthor #3
Porcine glutathione transferase Alpha 2-2 is a human GST A3-3 analogue that catalyses steroid double-bond isomerization.
201018 citationsauthor #3
Glutathione transferase A1-1: catalytic importance of arginine 15.
201017 citationsauthor #3
The quest for molecular quasi‐species in ligand‐activity space and its application to directed enzyme evolution
201011 citationsauthor #1
Single-nucleotide polymorphic variants of human glutathione transferase T1-1 differ in stability and functional properties.
200915 citationsauthor #3
Identification of emerging quasi-species in directed enzyme evolution.
200933 citationsauthor #2
Multi-substrate-activity space and quasi-species in enzyme evolution: Ohno's dilemma, promiscuity and functional orthogonality.
200918 citationsauthor #1
Structural analysis of a glutathione transferase A1-1 mutant tailored for high catalytic efficiency with toxic alkenals.
200924 citationsauthor #6
Minor Modifications of the C-terminal Helix Reschedule the Favored Chemical Reactions Catalyzed by Theta Class Glutathione Transferase T1-1*
200912 citationsauthor #2
Emergence of a novel highly specific and catalytically efficient enzyme from a naturally promiscuous glutathione transferase.
200817 citationsauthor #4
Emergence of novel enzyme quasi-species depends on the substrate matrix.
200813 citationsauthor #3
Targeting human glutathione transferase A3-3 attenuates progesterone production in human steroidogenic cells.
200828 citationsauthor #5
Diverging catalytic capacities and selectivity profiles with haloalkane substrates of chimeric alpha class glutathione transferases.
200813 citationsauthor #3
Glutathione transferase A2-2 in complex with glutathione
20080 citationsauthor #3
Glutathione transferase A2-2 in complex with delta-4-andostrene-3-17- dione
20080 citationsauthor #3
Glutathione transferase: new model for glutathione activation.
200863 citationsauthor #3
Modulating catalytic activity by unnatural amino acid residues in a GSH-binding loop of GST P1-1.
200814 citationsauthor #4
Structural determinants of glutathione transferases with azathioprine activity identified by DNA shuffling of alpha class members.
200827 citationsauthor #4
Glutathione transferase activity with a novel substrate mimics the activation of the prodrug azathioprine.
200823 citationsauthor #5
MOLECULAR ENZYMOLOGY OF THE GLYOXALASE SYSTEM
200873 citationsauthor #1
Glutathione transferase A3-3 in complex with glutathione and delta-4- androstene-3-17-dione
20080 citationsauthor #3
Engineering the enantioselectivity of glutathione transferase by combined active-site mutations and chemical modifications.
20078 citationsauthor #4

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