Mauro Niso

PROFILE

Homepage
No homepage is listed.
ORCID
No ORCID is listed.
Affiliations
No affiliations are listed.
Aliases
No aliases are listed.
Publication record
116 papers · 2,557 citations · H-index 31

PAPERS

Development of Second-Generation Phenoxyethylpiperidines as Potent Sigma-1 Receptor Agonists with Neuroprotective Potential for Alzheimer's Disease.
20260 citationsauthor #6
Correction to "First-In-Class Thiosemicarbazone Metal Complexes Targeting the Sigma-2 Receptor (S2R) as an Innovative Strategy against Pancreatic Cancer".
20260 citationsauthor #4
Development of dual acting selenium-doped hydroxyapatite nanoparticles with platinum-bisphosphonate complexes for bone cancer therapy.
20260 citationsauthor #10
New oxaliplatin-zoledronate derivatives with potential antitumor activity towards bone tumors and metastases.
20252 citationsauthor #3
Exploring Selenium-Functionalized Hydroxyapatite Using Organic Selenocystine for Antitumor Applications
20251 citationsauthor #5
Hydrogen Sulfide (H2S)-Donating Formyl Peptide Receptor 2 (FPR2) Agonists: Design, Synthesis, and Biological Evaluation in Primary Mouse Microglia Culture
20251 citationsauthor #3
First-In-Class Thiosemicarbazone Metal Complexes Targeting the Sigma-2 Receptor (S2R) as an Innovative Strategy against Pancreatic Cancer.
20249 citationsauthor #4
Nature-Inspired 1-Phenylpyrrolo[2,1-a]isoquinoline Scaffold for Novel Antiproliferative Agents Circumventing P-Glycoprotein-Dependent Multidrug Resistance
20244 citationsauthor #8
Cytotoxic pathways activated by multifunctional thiosemicarbazones targeting sigma-2 receptors in breast and lung carcinoma cells
20238 citationsauthor #7
In-vitro and in-silico studies of annelated 1,4,7,8-tetrahydroazocine ester derivatives as nanomolar selective inhibitors of human butyrylcholinesterase.
20235 citationsauthor #7
Development of Fluorescent 4-[4-(3H-Spiro[isobenzofuran-1,4′-piperidin]-1′-yl)butyl]indolyl Derivatives as High-Affinity Probes to Enable the Study of σ Receptors via Fluorescence-Based Techniques
20234 citationsauthor #5
Sigma-2 Receptor Ligand Binding Modulates Association between TSPO and TMEM97
202310 citationsauthor #13
Design, Synthesis, and Characterization of a Fluoroprobe for Live Human Islet Cell Imaging of Serotonin 5-HT1A Receptor
20220 citationsauthor #3
Design, Synthesis, and Characterization of a Novel Fluoroprobe for Live Human Islet Cell Imaging of Serotonin 5‐HT1A Receptor
20225 citationsauthor #3
New Pharmacological Strategies against Pancreatic Adenocarcinoma: The Multifunctional Thiosemicarbazone FA4
20228 citationsauthor #2
Design, Synthesis, Biological Evaluation, and Computational Studies of Novel Ureidopropanamides as Formyl Peptide Receptor 2 (FPR2) Agonists to Target the Resolution of Inflammation in Central Nervous System Disorders.
202210 citationsauthor #6
Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase.
202211 citationsauthor #7
In Vitro and In Silico Analysis of the Residence Time of Serotonin 5-HT7 Receptor Ligands with Arylpiperazine Structure: A Structure-Kinetics Relationship Study.
20229 citationsauthor #2
Design and Synthesis of Arylpiperazine Serotonergic/Dopaminergic Ligands with Neuroprotective Properties
20225 citationsauthor #2
Knowledge-Based Design of Long-Chain Arylpiperazine Derivatives Targeting Multiple Serotonin Receptors as Potential Candidates for Treatment of Autism Spectrum Disorder.
202119 citationsauthor #2
Multifunctional thiosemicarbazones targeting sigma receptors: in vitro and in vivo antitumor activities in pancreatic cancer models
202115 citationsauthor #1
Multi-Target Directed Ligands (MTDLs) Binding the σ1 Receptor as Promising Therapeutics: State of the Art and Perspectives
202123 citationsauthor #2
Development of novel phenoxyalkylpiperidines as high-affinity Sigma-1 (σ1) receptor ligands with potent anti-amnesic effect.
20215 citationsauthor #3
σ2 Receptor and Its Role in Cancer with Focus on a MultiTarget Directed Ligand (MTDL) Approach
202121 citationsauthor #2
Why PB28 Could Be a Covid 2019 Game Changer?
20206 citationsauthor #7
Privileged scaffold-based design to identify a novel drug-like 5-HT7 receptor-preferring agonist to target Fragile X syndrome.
202014 citationsauthor #2
Cannabinoid Receptor Subtype 2 (CB2R) in a Multitarget Approach: Perspective of an Innovative Strategy in Cancer and Neurodegeneration.
202030 citationsauthor #6
PB28, the Sigma-1 and Sigma-2 Receptors Modulator With Potent Anti–SARS-CoV-2 Activity: A Review About Its Pharmacological Properties and Structure Affinity Relationships
202025 citationsauthor #2
Knowledge-Based Design of Long-Chain Arylpiperazine Derivatives Targeting Multiple Serotonin Receptors as Potential Candidates for Treatment of Autism Spectrum Disorder
20200 citationsauthor #3
Mitochondrial Membranes of Human SH-SY5Y Neuroblastoma Cells Express Serotonin 5-HT7 Receptor
20208 citationsauthor #2
1,2,3,4-Tetrahydroisoquinoline/2H-chromen-2-one conjugates as nanomolar P-glycoprotein inhibitors: Molecular determinants for affinity and selectivity over multidrug resistance associated protein 1.
201914 citationsauthor #2
High-affinity sigma-1 (σ1) receptor ligands based on the σ1 antagonist PB212.
20196 citationsauthor #1
3-benzazecine-based cyclic allene derivatives as highly potent P-glycoprotein inhibitors overcoming doxorubicin multidrug resistance.
20198 citationsauthor #2
Sigma-2 receptor: past, present and perspectives on multiple therapeutic exploitations.
201841 citationsauthor #2
A New Class of 1‐Aryl‐5,6‐dihydropyrrolo[2,1‐a]isoquinoline Derivatives as Reversers of P‐Glycoprotein‐Mediated Multidrug Resistance in Tumor Cells
201819 citationsauthor #4
Multifunctional thiosemicarbazones and deconstructed analogues as a strategy to study the involvement of metal chelation, Sigma-2 (σ2) receptor and P-gp protein in the cytotoxic action: In vitro and in vivo activity in pancreatic tumors.
201837 citationsauthor #2
Structural Determinants in the Binding of BB2 Receptor Ligands: In Silico, X-Ray and NMR Studies in PD176252 Analogues.
20177 citationsauthor #7
Functional N‐Formyl Peptide Receptor 2 (FPR2) Antagonists Based on the Ureidopropanamide Scaffold Have Potential To Protect Against Inflammation‐Associated Oxidative Stress
201712 citationsauthor #4
CCDC 891200: Experimental Crystal Structure Determination
20170 citationsauthor #7
Sigma‐2 receptor and progesterone receptor membrane component 1 (PGRMC1) are two different proteins: Proofs by fluorescent labeling and binding of sigma‐2 receptor ligands to PGRMC1
201742 citationsauthor #5
Sigma-2 receptor agonist derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) induce cell death via mitochondrial superoxide production and caspase activation in pancreatic cancer
20174 citationsauthor #3
Structure-activity relationship study towards non-peptidic positron emission tomography (PET) radiotracer for gastrin releasing peptide receptors: Development of [18F] (S)-3-(1H-indol-3-yl)-N-[1-[5-(2-fluoroethoxy)pyridin-2-yl]cyclohexylmethyl]-2-methyl-2-[3-(4-nitrophenyl)ureido]propionamide.
20174 citationsauthor #5
Sigma-2 receptor agonist derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) induce cell death via mitochondrial superoxide production and caspase activation in pancreatic cancer
201739 citationsauthor #3
Rigid versus flexible anilines or anilides confirm the bicyclic ring as the hydrophobic portion for optimal σ2 receptor binding and provide novel tools for the development of future σ2 receptor PET radiotracers
201613 citationsauthor #1
Design, synthesis, biological evaluation, NMR and DFT studies of structurally simplified trimethoxy benzamides as selective P‐glycoprotein inhibitors: the role of molecular flatness
20165 citationsauthor #6
18th European Symposium on Radiopharmacy and Radiopharmaceuticals
20163 citationsauthor #220
Structural modifications of the serotonin 5-HT7 receptor agonist N-(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve in vitro microsomal stability: A case study.
201615 citationsauthor #4
Novel and Selective Fluorescent σ2‐Receptor Ligand with a 3,4‐Dihydroisoquinolin‐1‐one Scaffold: A Tool to Study σ2 Receptors in Living Cells
201526 citationsauthor #1
Arylpiperazine agonists of the serotonin 5-HT1A receptor preferentially activate cAMP signaling versus recruitment of β-arrestin-2.
201523 citationsauthor #2
4-Nitro-2,1,3-benzoxadiazole derivatives as potential fluorescent sigma receptor probes
201520 citationsauthor #5
Novel metal chelators thiosemicarbazones with activity at the σ2 receptors and P-glycoprotein: an innovative strategy for resistant tumor treatment
201518 citationsauthor #2
The controversial identity of the sigma-2 receptor with PGRMC1: is the PGRMC1/sigma-2 protein, that binds Abeta oligomer, made of two independent molecular entities?
20150 citationsauthor #2
Deconstruction of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety to separate P-glycoprotein (P-gp) activity from σ2 receptor affinity in mixed P-gp/σ2 receptor agents.
201512 citationsauthor #7
From mixed sigma-2 receptor/P-glycoprotein targeting agents to selective P-glycoprotein modulators: small structural changes address the mechanism of interaction at the efflux pump.
201512 citationsauthor #6
Elements in support of the 'non-identity' of the PGRMC1 protein with the σ2 receptor.
201567 citationsauthor #2
Design, Synthesis, Lipophilic Properties, and Binding Affinities of Potential Ligands in Positron Emission Tomography (PET) for Visualization of Brain Dopamine D4 Receptors
20147 citationsauthor #6
Collateral Sensitivity of sigma-2 Receptor ligands: Potentials in the Treatment of Multidrug Resistant Tumors
20144 citationsauthor #1
Synthesis, radiolabeling and in vivo evaluation of [(11)C](R)-1-[4-[2-(4-methoxyphenyl)phenyl]piperazin-1-yl]-3-(2-pyrazinyloxy)-2-propanol, a potential PET radioligand for the 5-HT(7) receptor.
201431 citationsauthor #13
Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding.
201423 citationsauthor #3
Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HT₇ receptor.
201423 citationsauthor #2
Novel derivatives of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with improved fluorescent and σ receptors binding properties.
201421 citationsauthor #2
Selective agonists for serotonin 7 (5-HT7) receptor and their applications in preclinical models: an overview
201452 citationsauthor #2
Inside Cover: Sigma‐2 Receptor Agonists as Possible Antitumor Agents in Resistant Tumors: Hints for Collateral Sensitivity (ChemMedChem 12/2013)
20130 citationsauthor #1
Sigma-2 Receptor: Biomarker for Solid Tumor Diagnosis and Target for Tumor Treatment
20130 citationsauthor #1
The interaction of celecoxib with MDR transporters enhances the activity of mitomycin C in a bladder cancer cell line
20131 citationsauthor #3
Towards metabolically stable 5-HT7 receptor ligands: a study on 1-arylpiperazine derivatives and related isosters
20130 citationsauthor #4
The interaction of celecoxib with MDR transporters enhances the activity of mitomycin C in a bladder cancer cell line
201316 citationsauthor #3
Development of 3,4-dihydroisoquinolin-1(2H)-one derivatives for the Positron Emission Tomography (PET) imaging of σ₂ receptors.
201344 citationsauthor #9
Investigation of σ receptors agonist/antagonist activity through N-(6-methoxytetralin-1-yl)- and N-(6-methoxynaphthalen-1-yl)alkyl derivatives of polymethylpiperidines.
20139 citationsauthor #1
Novel highly potent serotonin 5-HT7 receptor ligands: structural modifications to improve pharmacokinetic properties.
20136 citationsauthor #10
Sigma‐2 Receptor Agonists as Possible Antitumor Agents in Resistant Tumors: Hints for Collateral Sensitivity
201358 citationsauthor #1
Towards metabolically stable 5-HT7 receptor ligands: a study on 1-arylpiperazine derivatives and related isosters
201314 citationsauthor #4
A Benzopyrane Derivative as a P‐Glycoprotein Stimulator: A Potential Agent to Decrease β‐Amyloid Accumulation in Alzheimer’s Disease
201217 citationsauthor #5
Investigations on the 1-(2-biphenyl)piperazine motif: identification of new potent and selective ligands for the serotonin(7) (5-HT(7)) receptor with agonist or antagonist action in vitro or ex vivo.
201238 citationsauthor #5
2-Aminopyiridine derivatives as potential sigma 2 receptor antagonists
20123 citationsauthor #3
2‐Aminopyridine Derivatives as Potential σ2 Receptor Antagonists
201228 citationsauthor #3
Potent galloyl-based selective modulators targeting multidrug resistance associated protein 1 and P-glycoprotein.
201236 citationsauthor #3
Inside Cover: 1‐Cyclohexyl‐4‐(4‐arylcyclohexyl)piperazines: Mixed σ and Human Δ8–Δ7 Sterol Isomerase Ligands with Antiproliferative and P‐Glycoprotein Inhibitory Activity (ChemMedChem 1/2011)
20111 citationsauthor #2
Analogues of σ receptor ligand 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with added polar functionality and reduced lipophilicity for potential use as positron emission tomography radiotracers.
201151 citationsauthor #2
Fluorescent derivatives of σ receptor ligand 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) as a tool for uptake and cellular localization studies in pancreatic tumor cells.
201135 citationsauthor #5
1‐Cyclohexyl‐4‐(4‐arylcyclohexyl)piperazines: Mixed σ and Human Δ8–Δ7 Sterol Isomerase Ligands with Antiproliferative and P‐Glycoprotein Inhibitory Activity
201144 citationsauthor #2
EGFR tyrosine kinase inhibitors and multidrug resistance: perspectives.
201118 citationsauthor #3
Perspectives of P-glycoprotein modulating agents in oncology and neurodegenerative diseases: pharmaceutical, biological, and diagnostic potentials.
2010116 citationsauthor #6
Phenylsulfonylfuroxans as modulators of multidrug-resistance-associated protein-1 and P-glycoprotein.
201049 citationsauthor #7
Interaction of the σ2 Receptor Ligand PB28 with the Human Nucleosome: Computational and Experimental Probes of Interaction with the H2A/H2B Dimer
201028 citationsauthor #3
ABC pumps and their role in active drug transport.
200967 citationsauthor #4
Exploring the importance of piperazine N-atoms for sigma(2) receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28).
200946 citationsauthor #6
The Tertiary Amine Nitrogen Atom of Piperazine Sulfonamides as a Novel Determinant of Potent and Selective β3‐Adrenoceptor Agonists
20099 citationsauthor #5
Multi‐Drug‐Resistance‐Reverting Agents: 2‐Aryloxazole and 2‐Arylthiazole Derivatives as Potent BCRP or MRP1 Inhibitors
200950 citationsauthor #7
In vitro and ex vivo characterization of sigma-1 and sigma-2 receptors: agonists and antagonists in biological assays.
200911 citationsauthor #4
F281, synthetic agonist of the sigma-2 receptor, induces Ca2+ efflux from the endoplasmic reticulum and mitochondria in SK-N-SH cells.
200955 citationsauthor #3
4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators.
200859 citationsauthor #7
Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives.
200875 citationsauthor #7
Novel 4-(4-aryl)cyclohexyl-1-(2-pyridyl)piperazines as Delta(8)-Delta(7) sterol isomerase (emopamil binding protein) selective ligands with antiproliferative activity.
200841 citationsauthor #7
Bicalutamide failure in prostate cancer treatment: involvement of Multi Drug Resistance proteins.
200846 citationsauthor #6
Novel 4-( 4-Aryl ) cyclohexyl-1-( 2-pyridyl ) piperazines as ∆ 8-∆ 7 Sterol Isomerase ( Emopamil Binding Protein ) Selective Ligands with Antiproliferative Activity
200813 citationsauthor #7
Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum.
20083 citationsauthor #5
PB183, a sigma receptor ligand, as a potential PET probe for the imaging of prostate adenocarcinoma.
200821 citationsauthor #5
Interaction of TK inhibitors, gefitinib and vandetanib, with MDR related proteins: stimulators, substrates or inhibitors?
20070 citationsauthor #3
Bivalent ligand approach on 4-[2-(3-methoxyphenyl)ethyl]-1-(2-methoxyphenyl)piperazine: synthesis and binding affinities for 5-HT(7) and 5-HT(1A) receptors.
20079 citationsauthor #4

TIMELINE

1984 71 citations

1987 9 citations

2004 194 citations

2005 7 citations

2006 258 citations

2007 47 citations

2008 258 citations

2009 238 citations

2010 193 citations

2011 149 citations

2012 122 citations

2013 148 citations

2014 161 citations

2015 178 citations

2016 36 citations

2017 108 citations

2018 97 citations

2019 28 citations

2020 83 citations

2021 83 citations

2022 48 citations

2023 27 citations

2024 13 citations

2025 4 citations

2026 0 citations

Unknown 0 citations

Mauro Niso

PROFILE

PAPERS

TIMELINE

COAUTHOR MAP

CONCEPT FOOTPRINT