M. Okochi

γ-Secretase exosites as targets for substrate-selective lowering of Aβ generation.
20250 citationsauthor #9
Charting γ-secretase substrates by explainable AI
20252 citationsauthor #7
Polygenic effects on the risk of Alzheimer’s disease in the Japanese population
202413 citationsauthor #656
Correction: Polygenic effects on the risk of Alzheimer’s disease in the Japanese population
20240 citationsauthor #656
Different transmembrane domains determine the specificity and efficiency of the cleavage activity of the γ-secretase subunit presenilin
20233 citationsauthor #4
Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls
202310 citationsauthor #425
APLP2 is predominantly cleaved by β‐secretase and γ‐secretase in the human brain
20232 citationsauthor #5
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients
202219 citationsauthor #652
Switched Aβ43 generation in familial Alzheimer’s disease with presenilin 1 mutation
20218 citationsauthor #3
Successive cleavage of β-amyloid precursor protein by γ-secretase.
202031 citationsauthor #3
Production of BBF2H7‐derived small peptide fragments via endoplasmic reticulum stress‐dependent regulated intramembrane proteolysis
20204 citationsauthor #10
Presenilin 1 Regulates NF-κB Activation via Association with Breakpoint Cluster Region and Casein Kinase II
201815 citationsauthor #8
P2-m27 Determination of amino acid sequences of several thousand peptides in human cerebrospinal fluid (CSF)
20180 citationsauthor #1
Making the final cut: pathogenic amyloid-β peptide generation by γ-secretase
2018102 citationsauthor #4
[P3–201]: IDENTIFICATION OF SERUM MICRORNA AS A POTENTIAL BIOMARKER RELATED TO THE PROGRESSION OF ALZHEIMER's DISEASE
20170 citationsauthor #7
[Cerebrospinal Fluid and Blood Biomarkers in Alzheimer's Disease].
20171 citationsauthor #3
Identification of Small Peptides in Human Cerebrospinal Fluid upon Amyloid-β Degradation
20171 citationsauthor #11
Semagacestat Is a Pseudo-Inhibitor of γ-Secretase.
201758 citationsauthor #17
TRC8-dependent degradation of hepatitis C virus immature core protein regulates viral propagation and pathogenesis
201650 citationsauthor #10
Absolute quantitation of low abundance plasma APL1β peptides at sub-fmol/mL Level by SRM/MRM without immunoaffinity enrichment.
201427 citationsauthor #6
Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as an amyloid-β accumulation modifier
201439 citationsauthor #13
Fluvoxamine alleviates ER stress via induction of Sigma-1 receptor
201499 citationsauthor #6
γ-Secretase Associated with Lipid Rafts
201363 citationsauthor #3
[Discovery and characteristic of surrogate marker for Abeta42 production-possibility of diagnosis marker as pre-Alzheimer condition].
20130 citationsauthor #1
The AKT1 gene is associated with attention and brain morphology in schizophrenia
201329 citationsauthor #17
Relative Ratio and Level of Amyloid-β 42 Surrogate in Cerebrospinal Fluid of Familial Alzheimer Disease Patients with Presenilin 1 Mutations
20138 citationsauthor #2
γ-secretase modulators and presenilin 1 mutants act differently on presenilin/γ-secretase function to cleave Aβ42 and Aβ43.
2013103 citationsauthor #1
Involvement of endoplasmic reticulum stress in tauopathy.
20132 citationsauthor #7
P3‐033: Involvement of endoplasmic reticulum stress in tauopathy
201233 citationsauthor #5
Correction: Differential Regulation of Amyloid Precursor Protein/Presenilin 1 Interaction during Ab40/42 Production Detected Using Fusion Constructs
20121 citationsauthor #2
Differential Regulation of Amyloid Precursor Protein/Presenilin 1 Interaction during Ab40/42 Production Detected Using Fusion Constructs
20124 citationsauthor #2
Non‐pharmacological intervention for dementia patients
201276 citationsauthor #3
[Apolipoprotein E and neuro-psychiatric diseases].
20111 citationsauthor #6
Sigma-1Rs are upregulated via PERK/eIF2α/ATF4 pathway and execute protective function in ER stress.
201184 citationsauthor #6
S4‐01‐05: The 28‐amino acid form of an APLP1‐derived abeta‐like peptide is a surrogate marker for Abeta42 production
201127 citationsauthor #1
O1‐05‐03: Identification of a gene which controls Abeta accumulation using APP Tg mice with mixed genetic Background Splicing variant specific effect of Kinesin Light Chain 1 (Klc1)
20110 citationsauthor #4
Protein kinase C stabilizes X‐linked inhibitor of apoptosis protein (XIAP) through phosphorylation at Ser87 to suppress apoptotic cell death
201117 citationsauthor #10
Pharmacogenomics of Alzheimer's disease
20111 citationsauthor #5
Editorial: New drugs for Alzheimer's disease in Japan
201118 citationsauthor #3
[Behavioral and psychological symptoms of dementia].
2011572 citationsauthor #1
Human CRB2 Inhibits γ-Secretase Cleavage of Amyloid Precursor Protein by Binding to the Presenilin Complex*
201029 citationsauthor #7
AD-FTLD Spectrum: New Understanding of the Neurodegenerative Process from the Study of Risk Genes
20100 citationsauthor #4
Levels of the surrogate marker for Aβ42 (i.e., APL1β) in CSF of sporadicAlzheimer disease patients increase before the onset of its clinical symptoms
20100 citationsauthor #2
The chitinase 3-like 1 gene and schizophrenia: evidence from a multi-center case-control study and meta-analysis.
201025 citationsauthor #19
Analysis of CSF of patients suffering from PS1-mutated familial AD indicates that the level of Aβ42 generation does not increase in brain of these patients
20100 citationsauthor #2
Determination of amino acid sequences of several thousand peptides in human cerebrospinal fluid (CSF)
20100 citationsauthor #2
KIBRA Genetic Polymorphism Influences Episodic Memory in Alzheimer’s Disease, but Does Not Show Association with Disease in a Japanese Cohort
201023 citationsauthor #22
Apolipoprotein E and central nervous system disorders: Reviews of clinical findings
201069 citationsauthor #5
O1‐03‐06: Identification of a gene which controls Abeta accumulation using App Tg mice with mixed genetic background
20100 citationsauthor #7
Contents Vol. 6, 2009
20100 citationsauthor #5
The production ratios of AICDε51 and Aβ42 by intramembrane proteolysis of βAPP do not always change in parallel
201011 citationsauthor #2
Association study of KIBRA gene with memory performance in a Japanese population
201037 citationsauthor #13
[Surrogate marker for ABeta42].
20100 citationsauthor #1
The impact of a genome‐wide supported psychosis variant in the ZNF804A gene on memory function in schizophrenia
201063 citationsauthor #16
O4‐03‐01: The Ratio of Csf Apl1beta28, a Surrogate Marker for Abeta42, Increases Before Onset of Sporadic Alzheimer'S Disease
20100 citationsauthor #1
PERSONALITY TRAITS AND SCHIZOPHRENIA: EVIDENCE FROM A CASE-CONTROL STUDY AND META-ANALYSIS
20100 citationsauthor #10
Subject Index Vol. 6, 2009
20100 citationsauthor #5
Laughter and humor as complementary and alternative medicines for dementia patients
201093 citationsauthor #4
Analysis of APL1β28, a Surrogate Marker for Alzheimer Aβ42, Indicates Altered Precision of γ-Cleavage in the Brains of Alzheimer Disease Patients
20101 citationsauthor #1
Association study of the G72 gene with schizophrenia in a Japanese population: a multicenter study.
200940 citationsauthor #23
P1‐169: Transmembrane domain of CRB2 is indispensable for inhibition of γ‐secretase activity
20090 citationsauthor #6
The 28-amino acid form of an APLP1-derived Aβ-like peptide is a surrogate marker for Aβ42 production in the central nervous system
200976 citationsauthor #2
P1‐171: Analysis of an Aβ‐like peptide in CSF to reveal whether and how the cleavage precision of presenilin/γ‐secretase is altered in AD patients
20090 citationsauthor #2
P1‐176: Clinical correlates of caregiver burden in Alzheimer's disease
20090 citationsauthor #2
A GENETIC VARIATION OF KIBRA GENE IS ASSOCIATED WITH MEMORY PERFORMANCE IN JAPANESE HEALTHY SUBJECTS
20090 citationsauthor #13
Destruxin E Decreases Beta-Amyloid Generation by Reducing Colocalization of Beta-Amyloid-Cleaving Enzyme 1 and Beta-Amyloid Protein Precursor
200913 citationsauthor #2
P1‐172: Attempt to identify novel presenilin‐like proteases affecting canonical Wnt signaling
20090 citationsauthor #2
TATA Box‐Binding Protein gene is associated with risk for schizophrenia, age at onset and prefrontal function
200923 citationsauthor #14
P4‐144: Loose membrane‐bound endogenous factors might modulates the intramembrane cleavages of βAPP
20090 citationsauthor #2
P4‐296: Novel APLP1 Peptide In CSF Is Useful For Diagnosis Of Sporadic Alzheimer's Disease
20090 citationsauthor #1
Prevention of psychiatric illness in the elderly, I: Path to prevention of dementia
20099 citationsauthor #7
O4‐03–07: Characteristics of a novel Aβ‐like peptide which corresponds to Aβ42
20080 citationsauthor #1
Impaired prepulse inhibition and habituation of acoustic startle response in Japanese patients with schizophrenia.
200860 citationsauthor #14
P2‐366: Inhibition of Aβ production without perturbing Notch and Neuregulin signaling
20080 citationsauthor #2
Mild cognitive impairment and subjective cognitive impairment
200810 citationsauthor #3
Processes of β-Amyloid and Intracellular Cytoplasmic Domain Generation by Presenilin/γ-Secretase
200815 citationsauthor #2
[Amyloid-beta 42 generating process may have a biological role in regulation of Notch signaling intensity].
20080 citationsauthor #2
Macrophage colony stimulating factor is associated with excretion of amyloid‐β peptides from cerebrospinal fluid to peripheral blood
20083 citationsauthor #2
マクロファージコロニー刺激因子は、アミロイド-βペプチドの脳脊髄液から末梢血への移行に関連する
20080 citationsauthor #2
Intramembrane Processing by Signal Peptide Peptidase Regulates the Membrane Localization of Hepatitis C Virus Core Protein and Viral Propagation
2008114 citationsauthor #5
Difficulty identifying spinocerebellar ataxia 17 from preceding psychiatric symptoms
20082 citationsauthor #8
P1‐415: Identification of a candidate gene associated with Aβ transport from brain to blood
20080 citationsauthor #2
Regulation of Notch Signaling by Dynamic Changes in the Precision of S3 Cleavage of Notch-1
2007119 citationsauthor #2
Biological markers as outcome measures for Alzheimer's disease interventions – real problems and future possibilities
20076 citationsauthor #2
Amyloid-β production inhibitor comprising a proton pump inhibitor
20070 citationsauthor #1
O1–02–03: Change of cleavage precision by presenilin–dependent gamma–secretase
20060 citationsauthor #1
P4–067: Development of In vitro Abeta sink assay, to identify the dissociation of soluble Abeta from fibrils
20060 citationsauthor #2
Effect of valine on the efficiency and precision at S4 cleavage of the Notch‐1 transmembrane domain
20068 citationsauthor #6
P4–051: Inhibition of endocytosis activates alternative degradation pathway of βAPP in cultured cells
20060 citationsauthor #3
Involvement of apoptosis and cholinergic dysfunction in Alzheimer’s disease
20065 citationsauthor #11
Presenilin-dependent gamma-secretase on plasma membrane and endosomes is functionally distinct.
200675 citationsauthor #2
P3–403: Comparison of S3 cleavage of Notch–1 with ϵ–cleavage of βAPP by presenilin/γ–secretase
20060 citationsauthor #2
P3–253: Aβ generation and degradation by BACE1
20060 citationsauthor #15
P3–241: Presenilin–dependent γ–secretases on plasma membrane and endosomes are functionally distinct
20060 citationsauthor #2
Development of new screening system for Alzheimer disease, in vitro Abeta sink assay, to identify the dissociation of soluble Abeta from fibrils.
20068 citationsauthor #2
The GxGD Motif of Presenilin Contributes to Catalytic Function and Substrate Identification of γ-Secretase
200621 citationsauthor #3
Secretion of the Notch-1 Aβ-like Peptide during Notch Signaling*
200693 citationsauthor #1
AbstractPoster presentation: Tuesday posterP3-251: Inhibition of Aβ production is possible without directly affecting secretases and notch signaling
20060 citationsauthor #2
Inhibition of endocytosis activates alternative degradation pathway of βAPP in cultured cells
20060 citationsauthor #10
Aβ induces endoplasmic reticulum stress causing possible proteasome impairment via the endoplasmic reticulum–associated degradation pathway
20062 citationsauthor #9

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