J. Dietschy

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Aliases
John M. Dietschy, J M Dietschy, John M Dietschy, J. M. Dietschy, J. M Dietschy, John Dietschy
Publication record
242 papers · 23,851 citations · H-index 90

PAPERS

Low and high density lipoproteins and chylomicrons as regulators of rate of cholesterol synthesis in rat liver in vivo (cholesterol esters/lipoprotein clearance/lipoprotein transport)
20160 citationsauthor #3
Delineation of biochemical, molecular, and physiological changes accompanying bile acid pool size restoration in Cyp7a1(-/-) mice fed low levels of cholic acid.
201219 citationsauthor #4
Unesterified Cholesterol Accumulation in Late Endosomes/Lysosomes Causes Neurodegeneration and Is Prevented by Driving Cholesterol Export from This Compartment
2011147 citationsauthor #10
Quantitative role of LAL, NPC2, and NPC1 in lysosomal cholesterol processing defined by genetic and pharmacological manipulations
201170 citationsauthor #7
Cyclodextrin overcomes the transport defect in nearly every organ of NPC1 mice leading to excretion of sequestered cholesterol as bile acid
2010168 citationsauthor #6
Weekly Cyclodextrin Administration Normalizes Cholesterol Metabolism in Nearly Every Organ of the Niemann-Pick Type C1 Mouse and Markedly Prolongs Life
2010157 citationsauthor #8
Multiple mechanisms limit the accumulation of unesterified cholesterol in the small intestine of mice deficient in both ACAT2 and ABCA1.
201032 citationsauthor #4
343 Cyclodextrin Overcomes the Sterol Transport Defect in the Liver of the Niemann Pick Type C2 Mouse
20100 citationsauthor #4
Weekly cyclodextrin administration normalizes cholesterol metabolism in nearly every organ of the Niemann-Pick type C1 mouse and markedly prolongs life.
20106 citationsauthor #8
Reversal of defective lysosomal transport in NPC disease ameliorates liver dysfunction and neurodegeneration in the npc1−/− mouse
2009386 citationsauthor #6
M1009 2-Hydroxypropyl-β-Cyclodextrin Restores Liver Function in Niemann-Pick Type C Disease
20090 citationsauthor #4
Mutations in NPC1 and cholesterol metabolism in the brain
20091 citationsauthor #1
565 Acute Reversal of the Lysosomal Transport Defect in the Liver of the Niemann Pick Type C Mouse
20090 citationsauthor #4
Central nervous system: cholesterol turnover, brain development and neurodegeneration
2009343 citationsauthor #1
Genetic variations and treatments that affect the lifespan of the NPC1 mouse Published, JLR Papers in Press, December 12, 2007.
200886 citationsauthor #5
102 Treatment of the Liver Disease Associated with Niemann Pick Type C Disease with Ezetemibe and 2-Hydroxypropyl Beta Cyclodextrin Results in Near Normalization of ALT and AST
20081 citationsauthor #3
Inhibiting intestinal NPC1L1 activity prevents diet-induced increase in biliary cholesterol in Golden Syrian hamsters.
200867 citationsauthor #4
Lysosomal unesterified cholesterol content correlates with liver cell death in murine Niemann-Pick type C disease Published, JLR Papers in Press, January 14, 2007.
200760 citationsauthor #3
Receptor-mediated and bulk-phase endocytosis cause macrophage and cholesterol accumulation in Niemann-Pick C disease Published, JLR Papers in Press, May 2, 2007.
200737 citationsauthor #5
Liver X Receptor Activation Enhances Cholesterol Loss from the Brain, Decreases Neuroinflammation, and Increases Survival of the NPC1 Mouse
2007145 citationsauthor #7
Cholesterol substrate pools and steroid hormone levels are normal in the face of mutational inactivation of NPC1 protein Published, JLR Papers in Press, February 3, 2006.
200644 citationsauthor #4
Delineation of molecular changes in intrahepatic cholesterol metabolism resulting from diminished cholesterol absorption Published, JLR Papers in Press, January 16, 2005. DOI 10.1194/jlr.M400475-JLR200
200594 citationsauthor #4
Cholesterol accumulation and liver cell death in mice with Niemann‐Pick type C disease
2005128 citationsauthor #5
Molecular, anatomical, and biochemical events associated with neurodegeneration in mice with Niemann-Pick type C disease.
2005119 citationsauthor #7
Niemann-Pick C1 expression is not regulated by the amount of cholesterol flowing through cells in the mouse Published, JLR Papers in Press, June 1, 2005. DOI 10.1194/jlr.M500130-JLR200
200521 citationsauthor #5
EFFECT OF EZETIMIBE ADMINISTERED FROM BIRTH ON HEPATIC CHOLESTEROL ACCUMULATION IN THE NIEMANN-PICK TYPE C (NPC) MOUSE: 959
20040 citationsauthor #4
P0807 HEPATIC CHOLESTEROL ACCUMULATION IN THE NIEMANN‐PICK TYPE C (NPC) MOUSE: REDUCTION WITH EZETIMIBE
20040 citationsauthor #5
ACAT2 deficiency limits cholesterol absorption in the cholesterol‐fed mouse: Impact on hepatic cholesterol homeostasis
2004120 citationsauthor #4
Thematic review series: Brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal Published, JLR Papers in Press, May 16, 2004. DOI 10.1194/jlr.R400004-JLR200
2004866 citationsauthor #1
Knockout of the Cholesterol 24-Hydroxylase Gene in Mice Reveals a Brain-specific Mechanism of Cholesterol Turnover*
2003409 citationsauthor #5
Quantitation of two pathways for cholesterol excretion from the brain in normal mice and mice with neurodegeneration Published, JLR Papers in Press, June 16, 2003. DOI 10.1194/jlr.M300164-JLR200
2003169 citationsauthor #5
How cholesterol metabolism and transport present novel targets for lipid treatment
20032 citationsauthor #1
The intestinal absorption of biliary and dietary cholesterol as a drug target for lowering the plasma cholesterol level.
200344 citationsauthor #2
Ontogenesis and regulation of cholesterol metabolism in the central nervous system of the mouse.
2003173 citationsauthor #3
Sterol absorption by the small intestine
2003159 citationsauthor #2
Neurodegeneration in the Niemann-Pick C mouse: glial involvement.
2002170 citationsauthor #6
Control of Cholesterol Turnover in the Mouse*
2002287 citationsauthor #1
Statins and beyond the elemination of coronary artery disease
20020 citationsauthor #1
Inhibition of cholesterol absorption by SCH 58053 in the mouse is not mediated via changes in the expression of mRNA for ABCA1, ABCG5, or ABCG8 in the enterocyte Published, JLR Papers in Press, August 16, 2002. DOI 10.1194/jlr.M200144-JLR200
200287 citationsauthor #2
Fatty acids differentially regulate hepatic cholesteryl ester formation and incorporation into lipoproteins in the liver of the mouse DOI 10.1194/jlr.M200146-JLR200
200241 citationsauthor #4
INHIBITION OF CHOLESTEROL ABSORPTION BY SCH 58053 IN THE MOUSE IS NOT MEDIATED VIA CHANGES IN EITHER THE INTESTINAL BILE ACID POOL OR THE EXPRESSION OF mRNA FOR ABCA1, ABCG5 OR ABCG8 IN THE ENTEROCYTE
20026 citationsauthor #2
Alternate pathways of bile acid synthesis in the cholesterol 7alpha-hydroxylase knockout mouse are not upregulated by either cholesterol or cholestyramine feeding.
2001163 citationsauthor #3
Cholesterol metabolism in the brain
2001931 citationsauthor #1
Selective neurodegeneration, without neurofibrillary tangles, in a mouse model of Niemann‐Pick C disease
2001122 citationsauthor #7
Induction of bile acid synthesis by cholesterol and cholestyramine feeding is unimpaired in mice deficient in apolipoprotein AI
200044 citationsauthor #2
Is there a connection between the concentration of cholesterol circulating in plasma and the rate of neuritic plaque formation in Alzheimer disease?
200075 citationsauthor #2
Alzheimer's Disease and disordered cholesterol metabolism another illness to treat with statins?
20000 citationsauthor #1
Disruption of the Sterol 27-Hydroxylase Gene in Mice Results in Hepatomegaly and Hypertriglyceridemia
2000189 citationsauthor #6
Cholesterol Is Sequestered in the Brains of Mice with Niemann‐Pick Type C Disease but Turnover Is Increased
2000107 citationsauthor #4
Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers.
20001,359 citationsauthor #9
Centripetal cholesterol flow from the extrahepatic organs through the liver is normal in mice with mutated Niemann-Pick type C protein (NPC1).
200052 citationsauthor #3
Genetic differences in cholesterol absorption in 129/Sv and C57BL/6 mice: effect on cholesterol responsiveness.
199959 citationsauthor #2
Cholesterol balance and metabolism in mice with loss of function of Niemann-Pick C protein.
199912 citationsauthor #4
Cholesterol accumulation in tissues of the Niemann-pick type C mouse is determined by the rate of lipoprotein-cholesterol uptake through the coated-pit pathway in each organ.
1999101 citationsauthor #3
Cholesterol balance and metabolism in mice with loss of function of Niemann-Pick C protein.
1999113 citationsauthor #4
Symposium : Evolution of Ideas about the Nutritional Value of Dietary Fat Dietary Fatty Acids and the Regulation of Plasma Low Density Lipoprotein Cholesterol Concentrations 1
19983 citationsauthor #1
Marked reduction in bile acid synthesis in cholesterol 7alpha-hydroxylase-deficient mice does not lead to diminished tissue cholesterol turnover or to hypercholesterolemia.
1998258 citationsauthor #3
Centripetal cholesterol flux to the liver is dictated by events in the peripheral organs and not by the plasma high density lipoprotein or apolipoprotein A-I concentration.
1998105 citationsauthor #4
Elimination of coronary heart disease: the sequel!
19980 citationsauthor #1
Dietary fatty acids and the regulation of plasma low density lipoprotein cholesterol concentrations.
1998235 citationsauthor #1
Preferential utilization of newly synthesized cholesterol for brain growth in neonatal lambs.
199866 citationsauthor #3
Gender‐related differences in bile acid and sterol metabolism in outbred CD‐1 mice fed low‐ and high‐cholesterol diets
1998114 citationsauthor #4
Identification of a metabolic difference accounting for the hyper- and hyporesponder phenotypes of cynomolgus monkey.
199740 citationsauthor #3
CENTRIPETAL FLUX OF CHOLESTEROL IS UNALTERED BY DELETION OF APO A‐I:131
19970 citationsauthor #3
Overview of cholesterol and lipoprotein metabolism in the brain, liver and extrahepatic organs
19976 citationsauthor #1
Regulation of fecal bile acid excretion in male golden Syrian hamsters fed a cereal‐based diet with and without added cholesterol
199737 citationsauthor #3
Theoretical considerations of what regulates low-density-lipoprotein and high-density-lipoprotein cholesterol.
199779 citationsauthor #1
Theoreticalconsiderations of whatregulateslow-density lipoprotein and high-density-lipoprotein cholesterol1'2
19970 citationsauthor #1
Regional variation in cholesterol synthesis and low density lipoprotein transport in the brain of the fetus, newborn and adult animal
199713 citationsauthor #2
Effect of feeding psyllium and cholestyramine in combination on low density lipoprotein metabolism and fecal bile acid excretion in hamsters with dietary-induced hypercholesterolemia.
199648 citationsauthor #3
Centripetal cholesterol flux from extrahepatic organs to the liver is independent of the concentration of high density lipoprotein-cholesterol in plasma.
199686 citationsauthor #5
Brain does not utilize low density lipoprotein-cholesterol during fetal and neonatal development in the sheep.
1996111 citationsauthor #4
Dietary trans fatty acids and lipoprotein cholesterol.
19959 citationsauthor #2
Apolipoprotein E competitively inhibits receptor-dependent low density lipoprotein uptake by the liver but has no effect on cholesterol absorption or synthesis in the mouse.
199556 citationsauthor #4
Regulation of hepatic cholesterol metabolism in the rat in vivo: effect of a synthetic fat-free diet on sterol synthesis and low-density lipoprotein transport.
199524 citationsauthor #3
Mechanisms of LDL-cholesterol lowering action of psyllium hydrophillic mucilloid in the hamster.
199537 citationsauthor #2
Relationship between the plasma low-density lipoprotein cholesterol concentration and sterol metabolism in the central nervous system
19950 citationsauthor #3
Role of the low density lipoprotein receptor in the flux of cholesterol through the plasma and across the tissues of the mouse.
1995194 citationsauthor #4
Role of liver in the synthesis of cholesterol and the clearance of low density lipoproteins in the cynomolgus monkey.
199577 citationsauthor #3
Sterol metabolism in fetal, newborn, and suckled lambs and their response to cholesterol after weaning.
199540 citationsauthor #3
Psyllium augments the cholesterol-lowering action of cholestyramine in hamsters by enhancing sterol loss from the liver.
1994102 citationsauthor #3
Does a low plasma cholesterol concentration cause madness
19940 citationsauthor #1
Effect of long-chain fatty acids on low-density-lipoprotein-cholesterol metabolism.
199429 citationsauthor #2
Trans-9-octadecenoic acid is biologically neutral and does not regulate the low density lipoprotein receptor as the cis isomer does in the hamster.
199449 citationsauthor #3
Reevaluation and application of the dual-isotope plasma ratio method for the measurement of intestinal cholesterol absorption in the hamster.
1994147 citationsauthor #3
Role of liver in the maintenance of cholesterol and low density lipoprotein homeostasis in different animal species, including humans.
1993868 citationsauthor #1
Regulation of plasma LDL-cholesterol levels by dietary cholesterol and fatty acids.
1993274 citationsauthor #3
The Interaction of Dietary Cholesterol and Specific Fatty Acids in the Regulation of LDL Receptor Activity and Plasma LDL‐Cholesterol Concentrations a
199353 citationsauthor #1
Fatty acids regulate hepatic low density lipoprotein receptor activity through redistribution of intracellular cholesterol pools.
1992133 citationsauthor #3
Fat: absorption and malabsorption
19920 citationsauthor #1
Saturated and unsaturated fatty acids independently regulate low density lipoprotein receptor activity and production rate.
1992236 citationsauthor #3
Regulatory effects of the saturated fatty acids 6:0 through 18:0 on hepatic low density lipoprotein receptor activity in the hamster.
1992124 citationsauthor #3
Cholesterol-lowering action of psyllium mucilloid in the hamster: sites and possible mechanisms of action.
1991107 citationsauthor #5
Cholesterol-lowering action of psyllium mucilloid in the hamster: sites and possible mechanisms of action.
1991107 citationsauthor #6
LDL cholesterol: its regulation and manipulation.
19905 citationsauthor #1
Effect of P/S ratio (0. 5 vs 0. 9) on hepatic LDL transport at three levels of dietary cholesterol in cynomolgus macaques
19900 citationsauthor #5
Inappropriate hepatic cholesterol synthesis expands the cellular pool of sterol available for recruitment by bile acids in the rat.
198951 citationsauthor #3
AHA Conference Report on Cholesterol. Basis for dietary treatment.
19895 citationsauthor #3
A rapid method to assess the hydrophobicity of the intestinal microvillus membrane in vivo.
19893 citationsauthor #2
Interaction of aging and dietary fat in the regulation of low density lipoprotein transport in the hamster.
198933 citationsauthor #2

TIMELINE

1964 140 citations

1965 210 citations

1966 306 citations

1967 338 citations

1968 665 citations

1969 235 citations

1970 573 citations

1971 532 citations

1972 532 citations

1973 264 citations

1974 884 citations

1975 101 citations

1976 469 citations

1977 392 citations

1978 1,317 citations

1979 555 citations

1980 309 citations

1981 538 citations

1982 279 citations

1983 1,117 citations

1984 394 citations

1985 732 citations

1986 295 citations

1987 125 citations

1988 504 citations

1989 184 citations

1990 5 citations

1991 107 citations

1992 493 citations

1993 1,195 citations

1994 327 citations

1995 437 citations

1996 245 citations

1997 175 citations

1998 781 citations

1999 285 citations

2000 1,826 citations

2001 1,216 citations

2002 591 citations

2003 956 citations

2004 986 citations

2005 362 citations

2006 44 citations

2007 242 citations

2008 154 citations

2009 730 citations

2010 363 citations

2011 217 citations

2012 19 citations

2016 0 citations

Unknown 0 citations

J. Dietschy

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